Abstract:
:A newly recognized and well-described connective tissue disease, eosinophilia-myalgia syndrome, is thought to relate to L-tryptophan ingestion. The suspect L-tryptophan made in Japan has been distributed in Japan and in the United States. Different from many case reports of eosinophilia-myalgia syndrome in the United States, it has not been reported in Japan. We describe the first case reports of two Japanese patients. Eosinophilia-myalgia syndrome developed in these patients simultaneously, during L-tryptophan treatment by the same physician using the same lot of prescribed L-tryptophan. Furthermore, both patients had the following HLA types: HLA-Aw33(w19), -B44(12), and -DR6. These findings implicate the existence of another factor in the development of eosinophilia-myalgia syndrome in addition to the suspect L-tryptophan.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Mizutani T,Mizutani H,Hashimoto K,Nakamura Y,Kishida M,Taniguchi H,Murata M,Kuzuhara S,Shimizu Mdoi
10.1016/0190-9622(91)70232-qsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
512-7issue
3eissn
0190-9622issn
1097-6787pii
0190-9622(91)70232-Qjournal_volume
25pub_type
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