Simultaneous development of two cases of eosinophilia-myalgia syndrome with the same lot of L-tryptophan in Japan.

Abstract:

:A newly recognized and well-described connective tissue disease, eosinophilia-myalgia syndrome, is thought to relate to L-tryptophan ingestion. The suspect L-tryptophan made in Japan has been distributed in Japan and in the United States. Different from many case reports of eosinophilia-myalgia syndrome in the United States, it has not been reported in Japan. We describe the first case reports of two Japanese patients. Eosinophilia-myalgia syndrome developed in these patients simultaneously, during L-tryptophan treatment by the same physician using the same lot of prescribed L-tryptophan. Furthermore, both patients had the following HLA types: HLA-Aw33(w19), -B44(12), and -DR6. These findings implicate the existence of another factor in the development of eosinophilia-myalgia syndrome in addition to the suspect L-tryptophan.

journal_name

J Am Acad Dermatol

authors

Mizutani T,Mizutani H,Hashimoto K,Nakamura Y,Kishida M,Taniguchi H,Murata M,Kuzuhara S,Shimizu M

doi

10.1016/0190-9622(91)70232-q

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

512-7

issue

3

eissn

0190-9622

issn

1097-6787

pii

0190-9622(91)70232-Q

journal_volume

25

pub_type

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