当前位置： SCI文献检索 > JOURNAL OF CLINICAL EPIDEMIOLOGY期刊下所有文献 > Non-Cochrane vs. Cochrane reviews were twice as likely to have positive conclusion statements: cross-sectional study.

Non-Cochrane vs. Cochrane reviews were twice as likely to have positive conclusion statements: cross-sectional study.

Abstract：

OBJECTIVES:To determine which factors predict favorable results and positive conclusions in systematic reviews (SRs) and to assess the level of agreement between SR results and conclusions. STUDY DESIGN AND SETTING:A sample of 296 English SRs indexed in MEDLINE (November, 2004) was obtained. Two investigators independently categorized SR characteristics, results, and conclusions. Descriptive analyses and logistic regression predicting favorable results (nonstatistically significant and statistically significant positive) and positive conclusions were conducted. The level of concordance between results and conclusions was assessed using a weighted-kappa statistic. RESULTS:Overall, 36.5% of the SRs had favorable results, increasing to 57.7% for Cochrane and 64.3% for non-Cochrane reviews with a meta-analysis of the primary outcome. Non-Cochrane reviews with a meta-analysis of the primary outcome were twice as likely to have positive conclusions as Cochrane reviews with such an analysis (P-value<0.05). The weighted kappa for agreement between SR results and conclusions was 0.55. It was lower for Cochrane (0.41) vs. non-Cochrane (0.67) reviews. CONCLUSION:SRs including a meta-analysis of the primary outcome may be affected by indirect publication bias in our sample. Differences between the results and conclusions of Cochrane and non-Cochrane reviews were apparent. Further research on publication-related issues of SRs is warranted.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Tricco AC,Tetzlaff J,Pham B,Brehaut J,Moher D

doi

10.1016/j.jclinepi.2008.08.008

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

380-386.e1

issue

4

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(08)00227-8

journal_volume

62

pub_type

杂志文章

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