Iodine-catalyzed etherification of morroniside.

Abstract:

:In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 microM.

authors

Sunghwa F,Sakurai H,Saiki I,Koketsu M

doi

10.1248/cpb.57.112

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

112-5

issue

1

eissn

0009-2363

issn

1347-5223

pii

JST.JSTAGE/cpb/57.112

journal_volume

57

pub_type

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