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[Pharmacoeconomic results of introducing antimicrobial prophylaxis in surgery at a university hospital].

Abstract：

OBJECTIVES:The introduction of antimicrobial prophylaxis in surgery was designed and pre-intervention (controls) and post-intervention (cases) evaluations were carried out at a university tertiary hospital. PATIENTS AND METHOD:Prospective recording of information on prophylaxis in all patients undergoing non-emergency abdominal surgery was analysed during a 3-week period before and after implementing an antimicrobial prophylaxis program. Adequacy of prophylaxis was defined as prescription of antibiotics (type, dose and duration of treatment) according to the Guidelines. RESULTS:In the pre-intervention study: included 36 patients; prophylaxis was inadequate in all patients (long-term in 22 cases; antibiotic class and long-term in 2 cases; antibiotic class, dose and long-term in 12 cases); mean duration of prophylaxis was 6 days (range 1 to 10 days); mean antibiotic cost per patient was 77 euro (range 9 to 412 euro); overall antibiotic cost for the 36 patients was 2770 euro. In the post-intervention study: included 37 patients: prophylaxis was inadequate in 11 patients (long-term in 10 cases; antibiotic class and long-term in 1 case); mean duration of prophylaxis was 2 days (range 1 to 9 days); mean antibiotic cost per patient was 16 euro (range 2 to 78 euro); overall antibiotic cost for the 37 patients was 593 euro. In the pre-intervention period antibiotic cost was 38 times higher than expected. In the post-intervention period it was 1.6 times higher than expected. CONCLUSIONS:The most common reason of prophylaxis inadequacy is prolonged antibiotic treatment. A multidisciplinary intervention that comprises infectious diseases, surgical and pharmacy departments improves prophylaxis prescribing practice and avoids erroneous prescribing of antibiotics with both microbiological and economical cost savings.

journal_name

Cir Esp

journal_title

Cirugia espanola

authors

García-Vázquez E,Fernández Lobato B,Pareja A,Gómez J,de la Rubia A

doi

10.1016/s0009-739x(08)75045-0

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

333-6

issue

eissn

0009-739X

issn

1578-147X

pii

13129323

journal_volume

pub_type

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[Pharmacoeconomic results of introducing antimicrobial prophylaxis in surgery at a university hospital].