One-carbon metabolism in psychiatric illness.

Abstract:

:The cost of psychiatric illness to the UK economy was recently estimated at pound77 billion annually. Despite years of research no firm aetiological explanation exists, and with no physiological or biochemical markers diagnosis is made entirely on a behavioural basis. All current pharmacological therapies are associated with serious long-term side effects. Substantial evidence supports the involvement of one-carbon cycle dysregulation in psychiatric illness, but this is not currently used as a basis for diagnosis or treatment. The present paper reviews the evidence for one-carbon cycle dysregulation in schizophrenic, bipolar, depressed and autistic patients. Also presented are novel findings from the field of epigenetics, which demonstrate how the one-carbon cycle-derived methyl donor S-adenosylmethionine influences the expression of key genes in the brain affecting memory, learning, cognition and behaviour, genes whose expression is reduced to varying degrees in these patient groups. Clinical evidence that nutritional supplements can rectify one-carbon cycle activity, and restore normal gene expression, suggests a novel approach to the development of biochemical tests and simple, non-harmful treatments for some psychiatric patients. Conversely, evidence from animal studies highlights the dangers of exposing the unborn fetus to very high dietary levels of folic acid, a one-carbon cycle cofactor. Fetal adaptations to a high-folate environment may interfere with folate metabolism postnatally, with serious consequences for the epigenetic regulation of gene expression. The public health implications of these diverse scenarios indicate an urgent need for further research in this field.

journal_name

Nutr Res Rev

authors

Sugden C

doi

10.1079/NRR2006119

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

117-36

issue

1

eissn

0954-4224

issn

1475-2700

pii

S0954422406000102

journal_volume

19

pub_type

杂志文章
  • Metabolism, bioenergetics and thermal physiology: influences of the human intestinal microbiota.

    abstract::The micro-organisms which inhabit the human gut (i.e. the intestinal microbiota) influence numerous human biochemical pathways and physiological functions. The present review focuses on two questions, 'Are intestinal microbiota effects measurable and meaningful?' and 'What research methods and variables are influenced...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422419000076

    authors: Armstrong LE,Casa DJ,Belval LN

    更新日期:2019-12-01 00:00:00

  • Functional foods for dyslipidaemia and cardiovascular risk prevention.

    abstract::A food can be regarded as 'functional' if it can demonstrate a beneficial efficacy on one or more target functions in the body in a convincing way. Beyond adequate nutritional qualities, functional foods should either improve the state of health and wellbeing and/or reduce the risk of disease. Functional foods that ar...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422409990187

    authors: Sirtori CR,Galli C,Anderson JW,Sirtori E,Arnoldi A

    更新日期:2009-12-01 00:00:00

  • Iron fortification of infant formula.

    abstract::The purpose of this review is to examine the need for and appropriate level of Fe fortification of infant formula, and to assess any adverse effects of Fe fortification. The appropriate level of Fe fortification of infant formula has been established through studies of Fe absorption or erythrocyte incorporation of Fe,...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/095442200108729070

    authors: Moy RJ

    更新日期:2000-12-01 00:00:00

  • The influence of sleep and sleep loss upon food intake and metabolism.

    abstract::The present review investigates the role of sleep and its alteration in triggering metabolic disorders. The reduction of the amount of time sleeping has become an endemic condition in modern society and the current literature has found important associations between sleep loss and alterations in nutritional and metabo...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1017/S0954422407810651

    authors: Crispim CA,Zalcman I,Dáttilo M,Padilha HG,Edwards B,Waterhouse J,Tufik S,de Mello MT

    更新日期:2007-12-01 00:00:00

  • Altering nutrient utilization in animals through transgenesis.

    abstract::Improved domestic animal productivity is necessary in order to provide for an increasing world population over the next two to three decades and such improvement would be aided by an increase in the efficiency of nutrient utilization. This can be achieved by conventional genetic selection protocols but progress by thi...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/095442299108728893

    authors: Ward KA

    更新日期:1999-06-01 00:00:00

  • Lipids and infant formulas.

    abstract::The ultimate goal in the design of infant formula is to achieve the outcome seen in breast fed infants. This review of lipids in infant formulas for term infants begins by referring to the lipid composition of human milk, and relates that to differences in lipid digestion and metabolism which exist between breast fed ...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR19980018

    authors: Forsyth JS

    更新日期:1998-12-01 00:00:00

  • Putting the safety of organic food into perspective.

    abstract::The demand for organic foods is constantly increasing mainly due to consumers' perception that they are healthier and safer than conventional foods. There is a need for information related to food safety to inform consumers of the health benefits and/or hazards of food products of both origins, in order to optimise th...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR200361

    authors: Magkos F,Arvaniti F,Zampelas A

    更新日期:2003-12-01 00:00:00

  • Isoflavones and endothelial function.

    abstract::Dietary isoflavones are thought to be cardioprotective due to their structural similarity to oestrogen. Oestrogen is believed to have beneficial effects on endothelial function and may be one of the mechanisms by which premenopausal women are protected against CVD. Decreased NO production and endothelial NO synthase a...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR2005101

    authors: Hall WL,Rimbach G,Williams CM

    更新日期:2005-06-01 00:00:00

  • Modulating adult neurogenesis through dietary interventions.

    abstract::Three areas in the brain continuously generate new neurons throughout life: the subventricular zone lining the lateral ventricles, the dentate gyrus in the hippocampus and the median eminence in the hypothalamus. These areas harbour neural stem cells, which contribute to neural repair by generating daughter cells that...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422416000081

    authors: Heberden C

    更新日期:2016-12-01 00:00:00

  • Peripheral signalling involved in energy homeostasis control.

    abstract::The alarming prevalence of obesity has led to a better understanding of the molecular mechanisms controlling energy homeostasis. Regulation of energy intake and expenditure is more complex than previously thought, being influenced by signals from many peripheral tissues. In this sense, a wide variety of peripheral sig...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422412000145

    authors: Lancha A,Frühbeck G,Gómez-Ambrosi J

    更新日期:2012-12-01 00:00:00

  • A review and meta-analysis of the effect of weight loss on all-cause mortality risk.

    abstract::Overweight and obesity are associated with increased morbidity and mortality, although the range of body weights that is optimal for health is controversial. It is less clear whether weight loss benefits longevity and hence whether weight reduction is justified as a prime goal for all individuals who are overweight (n...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0954422409990035

    authors: Harrington M,Gibson S,Cottrell RC

    更新日期:2009-06-01 00:00:00

  • The transtheoretical model as applied to dietary behaviour and outcomes.

    abstract::The transtheoretical model (TTM) is a behavioural theory that describes behaviour change as occurring in five stages, ranging from precontemplation to maintenance. The purpose of the present paper is to review and synthesise the literature published since 1999 on applications of the TTM to dietary behaviour so that th...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1017/S0954422407747881

    authors: Spencer L,Wharton C,Moyle S,Adams T

    更新日期:2007-06-01 00:00:00

  • Interaction between physical activity and nutrition early in life and their impact on later development.

    abstract::It has been rare to find studies of the influence of nutrition on growth that have incorporated careful measurements of physical activity. This paper reviews interactions between physical activity and nutrition in early life and finds that such interactions have a significant influence on growth and later metabolism.Y...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR19980006

    authors: Parízková J

    更新日期:1998-06-01 00:00:00

  • Current evidence on the association of the metabolic syndrome and dietary patterns in a global perspective.

    abstract::The metabolic syndrome (MetS) is a key indicator of two main causes of death worldwide: CVD and diabetes. The present paper aimed to perform a review of the population-based research on the association of dietary patterns and the MetS in terms of methodology and findings. For the purpose of the present study, a scopin...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S095442241600007X

    authors: Hosseini Z,Whiting SJ,Vatanparast H

    更新日期:2016-12-01 00:00:00

  • Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs.

    abstract::In the current post-antibiotic era, botanicals represent one of the most employed nutritional strategies to sustain antibiotic-free and no-antibiotic-ever production. Botanicals can be classified either as plant extracts, meaning the direct products derived by extraction from the raw plant materials (essential oils (E...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1017/S0954422420000013

    authors: Rossi B,Toschi A,Piva A,Grilli E

    更新日期:2020-12-01 00:00:00

  • Impact of meal fatty acid composition on postprandial lipaemia, vascular function and blood pressure in postmenopausal women.

    abstract::CVD are the leading cause of death in women globally, with ageing associated with progressive endothelial dysfunction and increased CVD risk. Natural menopause is characterised by raised non-fasting TAG concentrations and impairment of vascular function compared with premenopausal women. However, the mechanisms underl...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422418000033

    authors: Rathnayake KM,Weech M,Jackson KG,Lovegrove JA

    更新日期:2018-12-01 00:00:00

  • Comparative mammalian choline metabolism with emphasis on the high-yielding dairy cow.

    abstract::The present review examines the importance of choline in dairy cow nutrition. Choline is an essential nutrient for mammals when excess methionine and folate are not available in the diet. The requirement for choline can be met by dietary choline and by transmethylation reactions. Two types of functions for choline are...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR200247

    authors: Pinotti L,Baldi A,Dell'Orto V

    更新日期:2002-12-01 00:00:00

  • Trans-fatty acids and cancer: the evidence reviewed.

    abstract::The present review comes from the authors of the recent Scientific Advisory Committee on Nutrition (SACN) review Update on Trans Fatty Acids and Health, and focuses on assessing the strength of the evidence for a link between trans-fatty acid (trans-FA) intake and cancer. It evaluates a range of human ecological, case...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422408110964

    authors: Thompson AK,Shaw DI,Minihane AM,Williams CM

    更新日期:2008-12-01 00:00:00

  • Intestinal gene expression in pigs: effects of reduced feed intake during weaning and potential impact of dietary components.

    abstract::The weaning transition is characterised by morphological, histological and microbial changes, often leading to weaning-associated disorders. These intestinal changes can partly be ascribed to the lack of luminal nutrition arising from the reduced feed intake common in pigs after weaning. It is increasingly becoming cl...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422411000047

    authors: Bauer E,Metzler-Zebeli BU,Verstegen MW,Mosenthin R

    更新日期:2011-12-01 00:00:00

  • An evidence-based method for examining and reporting cognitive processes in nutrition research.

    abstract::Cognitive outcomes are frequently implemented as endpoints in nutrition research. To reduce the number of statistical comparisons it is commonplace for nutrition researchers to combine cognitive test results into a smaller number of broad cognitive abilities. However, there is a clear lack of understanding and consens...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422414000158

    authors: Pase MP,Stough C

    更新日期:2014-12-01 00:00:00

  • The use of proteomic techniques to explore the holistic effects of nutrients in vivo.

    abstract::The availability of 'omics' technologies is transforming scientific approaches to physiological problems from a reductionist viewpoint to that of a holistic viewpoint. This is of profound importance in nutrition, since the integration of multiple systems at the level of gene expression on the synthetic side through to...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1017/S0954422407249698

    authors: Griffiths HR,Grant MM

    更新日期:2006-12-01 00:00:00

  • A systematic review of nutritional risk factors of Parkinson's disease.

    abstract::A wide variety of nutritional exposures have been proposed as possible risk factors for Parkinson's disease (PD) with plausible biological hypotheses. Many studies have explored these hypotheses, but as yet no comprehensive systematic review of the literature has been available. MEDLINE, EMBASE, and WEB OF SCIENCE dat...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR2005108

    authors: Ishihara L,Brayne C

    更新日期:2005-12-01 00:00:00

  • A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.

    abstract::Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction. The metabolic demand from inefficiencies in anaerobic metabolism, mitochondrial and cellular dysfunction, increased cellular turnover, and free-radical damage result in the increased focus of micronutri...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422418000124

    authors: Belsky JB,Wira CR,Jacob V,Sather JE,Lee PJ

    更新日期:2018-12-01 00:00:00

  • Alcohol drinking and cardiac risk.

    abstract::The present paper provides a comprehensive review of the literature pertaining to the impact of alcohol intake on cardiovascular disease. Both cross-sectional and prospective studies have disclosed a negative association between moderate intake of alcoholic beverages and cardiovascular disease. The relationship appear...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR200235

    authors: Buemann B,Dyerberg J,Astrup A

    更新日期:2002-06-01 00:00:00

  • Physiological factors that regulate the use of endogenous fat and carbohydrate fuels during endurance exercise.

    abstract::Exercise causes a dramatic increase in energy requirements because of the metabolic needs of working muscles. Exercise-dependent factors regulate fuel use. Absolute exercise intensity determines the exercise-induced increase in energy demands, whereas exercise intensity relative to an individual's maximal aerobic capa...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR200357

    authors: Mittendorfer B,Klein S

    更新日期:2003-06-01 00:00:00

  • Biochemical markers for assessment of calcium economy and bone metabolism: application in clinical trials from pharmaceutical agents to nutritional products.

    abstract::Nutrition plays an important role in osteoporosis prevention and treatment. Substantial progress in both laboratory analyses and clinical use of biochemical markers has modified the strategy of anti-osteoporotic drug development. The present review examines the use of biochemical markers in clinical research aimed at ...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422414000183

    authors: Bonjour JP,Kohrt W,Levasseur R,Warren M,Whiting S,Kraenzlin M

    更新日期:2014-12-01 00:00:00

  • Nutrition and the homeless: the underestimated challenge.

    abstract::Homelessness is present in most societies and represents a situation in which the basic needs for survival including food are often limited. It is logical to surmise that the homeless person's diet is likely to be nutritionally deficient and yet there is a relative paucity in research regarding this issue with studies...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422416000068

    authors: Seale JV,Fallaize R,Lovegrove JA

    更新日期:2016-12-01 00:00:00

  • Current and future strategies for the nutritional management of cardiometabolic complications of androgen deprivation therapy for prostate cancer.

    abstract::Androgen deprivation therapy (ADT) is used widely as part of a combined modality for the treatment of prostate cancer. However, ADT has also been associated with the development of cardiometabolic complications that can increase mortality from cardiovascular events. There is emerging evidence to suggest that ADT-relat...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422417000087

    authors: Turner L,Poole K,Faithfull S,Griffin BA

    更新日期:2017-12-01 00:00:00

  • Mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotics.

    abstract::CVD affect a large proportion of the world's population, with dyslipidaemia as the major risk factor. The regular consumption of both probiotic bacteria and yeast has been associated with improvement in the serum lipid profile. Thus, the present review aims to describe and discuss the potential mechanisms responsible ...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章,评审

    doi:10.1017/S0954422416000226

    authors: Reis SA,Conceição LL,Rosa DD,Siqueira NP,Peluzio MCG

    更新日期:2017-06-01 00:00:00

  • Diet and haemostatic processes.

    abstract::Diet plays an important role in the primary and secondary prevention of cardiovascular disease. The growing perception that abnormal haemostatic processes of coagulation, platelet aggregation and fibrinolysis contribute to cardiovascular disease aetiology motivated this review on the relationships of diet, specific fo...

    journal_title:Nutrition research reviews

    pub_type: 杂志文章

    doi:10.1079/NRR19970007

    authors: Vorster HH,Cummings JH,Jerling JC

    更新日期:1997-01-01 00:00:00