Neurite outgrowth promoting activity of marine algae from Japan against rat adrenal medulla pheochromocytoma cell line, PC12D.


:We screened for biological activity which induces neurite outgrowth in vitro from 300 species of marine algae from along the Japan coast for possible use as a treatment for the lack of neurotrophic factor which is considered to be a cause of Alzheimer's disease. In this study, we evaluated the neurite outgrowth promoting activity in a rat adrenal medulla pheochromocytoma cell line, PC12D, using a low level of NGF (nerve growth factor). Although most of the samples had no activity, MeOH extract from a brown alga, Sargassum macrocarpum and PBS extract from a red alga, Jania adharens, exhibited neurite outgrowth promoting activity and induced neuron specific dendrites and axons from the surfaces of PC12D cells. The active substance present in S. macrocarpumseemed to be lipid and heat stable with molecular weight of around 500 to 1000. These results suggest that marine algae may constitute a good source for development of promising novel agents with neurotrophic activity in brain nerve systems for future use in treatment of Alzheimer's disease.






Kamei Y,Sagara A




Has Abstract


2002-11-01 00:00:00












  • Production of immunoglobulin A in different reactor configurations.

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    pub_type: 杂志文章


    authors: Stoll T,Perregaux C,von Stockar U,Marison IW

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  • Evaluation of a simple protein free medium that supports high levels of monoclonal antibody production.

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    pub_type: 杂志文章


    authors: Qi YM,Greenfield PF,Reid S

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  • DNA and cell death.

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    pub_type: 杂志文章


    authors: Monti D,Troiano L,Tropea F,Grassilli E,Cossarizza A,Barozzi D,Bettuzzi S,Corti A,Franceschi C

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  • Differential expression of mRNAs encoding laminin chain variants during in vitro development of mouse blastocysts.

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    pub_type: 杂志文章


    authors: Azimi M,Niimi T,Yoshida N,Kitagawa Y

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  • Culture of major pelvic ganglion neurons from adult rat.

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    authors: Cheng S,Yang X,Zhang Y,Xiao C

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  • (-) Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c.

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    pub_type: 杂志文章


    authors: Kim H,Hiraishi A,Tsuchiya K,Sakamoto K

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  • Biological response of endothelial cells and its modulation by cytokines: prospects for therapy and bioprocesses.

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    pub_type: 杂志文章


    authors: Marique T,Blankaert D,Hendrick V,Raschella A,Declerck B,Alloin C,Teixera-Guerra I,Sandron D,Cherlet M,Parent D,Kirkpatrick C,Van Vooren JP,Wérenne J

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  • Cell Culture Derived AgMNPV Bioinsecticide: Biological Constraints and Bioprocess Issues.

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    pub_type: 杂志文章


    authors: Rodas VM,Marques FH,Honda MT,Soares DM,Jorge SA,Antoniazzi MM,Medugno C,Castro ME,Ribeiro BM,Souza ML,Tonso A,Pereira CA

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  • A high-yielding serum-free, suspension cell culture process to manufacture recombinant adenoviral vectors for gene therapy.

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    authors: Schoofs G,Monica TJ,Ayala J,Horwitz J,Montgomery T,Roth G,Castillo FJ

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    pub_type: 杂志文章


    authors: Tanaka H,Fukuda N,Shoyama Y

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  • Silver/silver chloride nanoparticles inhibit the proliferation of human glioblastoma cells.

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    pub_type: 杂志文章


    authors: Eugenio M,Campanati L,Müller N,Romão LF,de Souza J,Alves-Leon S,de Souza W,Sant'Anna C

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    pub_type: 杂志文章


    authors: Keen MJ,Steward TW

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    pub_type: 杂志文章,评审


    authors: Heike Y,Tsuruo T

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    authors: Rizzino A,Huebert C,Kuszynski C,Wilder PJ

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  • Construction and characterization of a multilayered gingival keratinocyte culture model: the TURK-U model.

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    authors: Gursoy UK,Gursoy M,Könönen E,Sintim HO,Uitto VJ,Syrjänen S

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    pub_type: 杂志文章


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    authors: Moon IS,Lee H,Park SD,Seog DH

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Bouhon IA,Ito A,Shinkai M,Honda H,Kobayashi T

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Horikawa I,Michishita E,Barrett JC

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Barnabé N,Butler M

    更新日期:2000-10-01 00:00:00