A review of panic and suicide in bipolar disorder: does comorbidity increase risk?


INTRODUCTION:Bipolar mood disorder carries a serious suicide risk. Panic disorder, which also confers an independent risk of suicide and psychiatric comorbidity, in general has been found to amplify suicidality in mood-disordered patients. This article assesses the available literature on how panic and suicide relate to each other in bipolar mood-disordered patients. METHODS:We conducted a search on Medline and PsycINFO using the keywords "anxiety", "attempted suicide", "completed suicide", "mortality", "self-harm" in combination with "bipolar", "manic depression" and "panic". Twenty-four articles were included in the evaluation. RESULTS:14 papers support increased risk, 9 papers do not support increased risk, and 3 papers are inconclusive. CONCLUSIONS:The presence of comorbid panic disorder in individuals with bipolar disorder may confer an increased risk of suicide risk. Some papers' reviewed have conflicting conclusions but the majority of papers support an increased risk. This is consistent with a recent (2008) literature review supporting increased risk of suicide in bipolar patients with comorbid anxiety disorders. Future research should study specific bipolar subgroups, focus on anxiety and panic symptoms rather than diagnosis, and look at the role of specific pharmacological treatment in patients with comorbid mood and anxiety disorders.


J Affect Disord


Kilbane EJ,Gokbayrak NS,Galynker I,Cohen L,Tross S




Has Abstract


2009-05-01 00:00:00














  • Machine learning-based discrimination of panic disorder from other anxiety disorders.

    abstract:BACKGROUNDS:Panic disorder is a highly prevalent psychiatric disorder that substantially impairs quality of life and psychosocial function. Panic disorder arises from neurobiological substrates and developmental factors that distinguish it from other anxiety disorders. Differential diagnosis between panic disorder and ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Na KS,Cho SE,Cho SJ

    更新日期:2021-01-01 00:00:00

  • Life events in bipolar patients: a comparative study with siblings and healthy controls.

    abstract:BACKGROUND:While many studies have focused on life events in depressive disorders, data regarding them in bipolar disorder are scant. The aim of this work was to explore the characteristics of life events in bipolar patients. METHODS:Sixty bipolar patients have been included in our study. The evaluation focused on the...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: El Kissi Y,Krir MW,Ben Nasr S,Hamadou R,El Hedda R,Bannour S,Ben Hadj Ali B

    更新日期:2013-10-01 00:00:00

  • Risky cyber behaviors in adolescents with depression: A case control study.

    abstract:OBJECTIVE:This study aimed to compare adolescents diagnosed with major depressive disorder (MDD) and healthy adolescents with regard to cyberbullying, cyber victimization, internet addiction, and digital game addiction. MATERIALS AND METHODS:This cross-sectional study was performed in Selçuk University Hospital. The s...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Uçar HN,Çetin FH,Ersoy SA,Güler HA,Kılınç K,Türkoğlu S

    更新日期:2020-06-01 00:00:00

  • Molecular imaging of striatal dopamine transporters in major depression--a meta-analysis.

    abstract:BACKGROUND:Increasing studies have revealed the dopamine transporter (DAT) availability altered in striatum associated with major depression. However, the results remain inconsistent. METHODS:To assess the alteration of striatal DAT availability in major depression, we performed a meta-analysis based on 12 case-contro...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审


    authors: Li Z,He Y,Tang J,Zong X,Hu M,Chen X

    更新日期:2015-03-15 00:00:00

  • Physical injury and depression in six low- and middle-income countries: A nationally representative study.

    abstract:BACKGROUND:Studies on the association between physical injury and depression in low- and middle-income countries (LMICs) are scarce. Therefore, our goal was to analyze the association between physical injury and depression using nationally representative data from six LMICs. METHODS:Cross-sectional data from the Study...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Jacob L,Pizzol D,Veronese N,Stubbs B,Koyanagi A

    更新日期:2019-04-01 00:00:00

  • Association of depression & health related quality of life with body composition in children and youth with obesity.

    abstract:BACKGROUND:There is an increasing recognition of the relationship between mental illness and obesity in the pediatric population. Our objective was to explore the individual, biological and family determinants of depressive symptoms and HRQOL in youth with obesity in a clinical setting. METHODS:We studied 244 youth ag...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Morrison KM,Shin S,Tarnopolsky M,Taylor VH

    更新日期:2015-02-01 00:00:00

  • The cortisol suppressing effect of dexamethasone and oxazepam in depressed patients; significance of spontaneous levels and interindividual distribution.

    abstract::In 72 hospitalized depressed patients afternoon plasma cortisol (15.00-15.20) was measured in three ways: spontaneous (n = 72), 16 h after administration of 2 mg dexamethasone (n = 71) and 2 h after administration of 45 mg oxazepam (n = 28) or 60 mg oxazepam (n = 37). When cortisol values were log-transformed the hist...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Christensen P,Gram LF,Lolk A,Kragh-Sørensen P

    更新日期:1987-11-01 00:00:00

  • Pregnancy anxiety: A systematic review of current scales.

    abstract:BACKGROUND:Depression in pregnancy is a serious health issue; however, anxiety in pregnancy, with a reported higher prevalence, may also be a serious issue. Anxiety symptoms in pregnancy can relate to several anxiety types, such as general anxiety, anxiety disorders, and pregnancy-related anxiety (PrA), anxiety charact...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Brunton RJ,Dryer R,Saliba A,Kohlhoff J

    更新日期:2015-05-01 00:00:00

  • Psychological distress and the incident risk of functional disability in elderly survivors after the Great East Japan Earthquake.

    abstract:BACKGROUND:We conducted a prospective cohort study to investigate whether psychological distress would have increased the incident risk of functional disability after the 2011 Great East Japan Earthquake. METHODS:First phase data pertaining to psychological distress and other lifestyle factors were collected from 1037...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Tanji F,Sugawara Y,Tomata Y,Watanabe T,Sugiyama K,Kaiho Y,Tomita H,Tsuji I

    更新日期:2017-10-15 00:00:00

  • Differential effects of white matter hyperintensity on geriatric depressive symptoms according to APOE-ε4 status.

    abstract:BACKGROUND:We aimed to examine differential effects of WMH on progression of depressive symptoms according to APOE ε4 status in the elderly. METHODS:We obtained data from elderly Korean subjects (n=707) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A linear mixed model strat...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Chang KJ,Hong CH,Lee KS,Roh HW,Choi SH,Kim SY,Na DL,Seo SW,Kim DK,Kang DR,Kim J,Lee Y,Kim SH,Back JH,Chung YK,Lim KY,Noh JS,Oh BH,Son SJ

    更新日期:2015-12-01 00:00:00

  • Differential abnormalities of functional connectivity of the amygdala and hippocampus in unipolar and bipolar affective disorders.

    abstract:OBJECTIVE:The amygdala and hippocampus - two structures intimately associated with mood and cognition - have been reported to exhibit altered neural activity or volume in affective disorders. We hypothesized the amygdala and hippocampus would show altered and differential patterns of connectivity in patients with bipol...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Benson BE,Willis MW,Ketter TA,Speer A,Kimbrell TA,Herscovitch P,George MS,Post RM

    更新日期:2014-10-01 00:00:00

  • Functional connectivity of the prefrontal cortex and amygdala is related to depression status in major depressive disorder.

    abstract:BACKGROUND:We used resting-state functional magnetic resonance imaging to examine possible amygdala-prefrontal cortex functional connectivity abnormalities and to clarify the correlation of the abnormal connectivity with response to antidepressant medications. METHODS:We recruited 40 drug-naïve patients with first-epi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Zhang A,Yang C,Li G,Wang Y,Liu P,Liu Z,Sun N,Zhang K

    更新日期:2020-09-01 00:00:00

  • The relationship between posttraumatic stress disorder following spinal cord injury and locus of control.

    abstract:OBJECTIVE:This study examined whether locus of control was associated with spinal cord injury posttraumatic stress disorder (SCI-PTSD). METHODS:Sixty-two SCI patients and 54 people without SCI participated in the study. The patients were assessed using the Posttraumatic Stress Disorder Checklist (PCL), the General Hea...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Chung MC,Preveza E,Papandreou K,Prevezas N

    更新日期:2006-07-01 00:00:00

  • Body dysmorphic disorder in outpatients with major depression.

    abstract:BACKGROUND:Body dysmorphic disorder (BDD) is a distressing and impairing preoccupation with an imagined or slight defect in appearance, with depression as its most frequent comorbid condition. The purpose of this study was to evaluate the rate of BDD in a cohort of consecutive outpatients with typical and atypical majo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Nierenberg AA,Phillips KA,Petersen TJ,Kelly KE,Alpert JE,Worthington JJ,Tedlow JR,Rosenbaum JF,Fava M

    更新日期:2002-05-01 00:00:00

  • The prognosis of undetected depression in older general practice patients. A one year follow-up study.

    abstract:BACKGROUND:Late-life depression often remains undetected in primary care. However, as there is evidence that GPs do identify those with the most severe and persistent disorders, it is important to know more about the prognosis of depressive disorders that are not detected by GPs. METHODS:A one-year follow-up study of ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Licht-Strunk E,Beekman AT,de Haan M,van Marwijk HW

    更新日期:2009-04-01 00:00:00

  • Excess mortality of bipolar and unipolar manic-depressive patients.

    abstract::To compare mortality in bipolar and unipolar manic-depressive patients, 2168 manic-depressive first admissions reported to the Danish Psychiatric Central Register were divided into a bipolar group (19%), i.e., patients with at least one admission for mania during an average observation period of six years, and a unipo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Weeke A,Vaeth M

    更新日期:1986-11-01 00:00:00

  • Age predicts low-frequency transcranial magnetic stimulation efficacy in major depression.

    abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) effectiveness in major depression has so far been studied mainly with high-frequency (>1 Hz) administration (HF-TMS). However, some available studies with low-frequency TMS (LF-TMS) have provided similar response rates to HF-TMS with better tolerance, but the evidence ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Aguirre I,Carretero B,Ibarra O,Kuhalainen J,Martínez J,Ferrer A,Salva J,Roca M,Gili M,Montoya P,Garcia-Toro M

    更新日期:2011-05-01 00:00:00

  • Short-term prognosis in primary and secondary major depression.

    abstract::Among inpatients treated without ECT, those with primary unipolar depression had significantly better outcomes at discharge than did those with secondary depression. This difference grew more striking during a 6-month follow-up; patients with secondary depression were clearly less likely to recover from the index depr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Coryell W,Zimmerman M,Pfohl B

    更新日期:1985-11-01 00:00:00

  • Polysomnographic features of early-onset depression: a meta-analysis.

    abstract:BACKGROUND:Undiagnosed major depressive disorder (MDD) is associated with increased morbidity in children and adolescents. This study evaluated features of sleep macro- and microarchitecture assessed by polysomnography (PSG) as diagnostic markers for MDD in children and adolescents. METHODS:MEDLINE, PSYCINFO, EMBASE a...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审


    authors: Augustinavicius JL,Zanjani A,Zakzanis KK,Shapiro CM

    更新日期:2014-04-01 00:00:00

  • Depression and anxiety through pregnancy and the early postpartum: an examination of prospective relationships.

    abstract:BACKGROUND:The aim of this study was to explore the prospective relationship between depressive symptoms and anxiety across pregnancy and the early postpartum. METHODS:Participants (N=207) completed the State-Trait Anxiety Inventory Trait subscale, Beck Depression Inventory, and social support and sleep quality measur...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Skouteris H,Wertheim EH,Rallis S,Milgrom J,Paxton SJ

    更新日期:2009-03-01 00:00:00

  • A very short visual analog form of the Center for Epidemiologic Studies Depression Scale (CES-D) for the idiographic measurement of depression.

    abstract:BACKGROUND:The experience sampling method, also referred to as ecological momentary assessment (ESM-EMA) has recently gained popularity in the study of depression. However, no psychometrically sound multidimensional depression questionnaires specifically designed for the ESM-EMA context are currently available. AIMS:T...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Moullec G,Maïano C,Morin AJ,Monthuy-Blanc J,Rosello L,Ninot G

    更新日期:2011-02-01 00:00:00

  • Impulsivity in anxiety disorder patients: is it related to comorbid cyclothymia?

    abstract:OBJECTIVE:The relationship between anxiety and impulsivity is controversial and not well explored. In a previous study we compared impulsivity, measured by different rating tools, in patients with anxiety disorders vs. healthy controls. In the same sample we now explore the influence of comorbid soft bipolar spectrum d...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Perugi G,Del Carlo A,Benvenuti M,Fornaro M,Toni C,Akiskal K,Dell'Osso L,Akiskal H

    更新日期:2011-10-01 00:00:00

  • Breastfeeding and the use of psychotropic medication: a review.

    abstract::The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) ha...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Buist A,Norman TR,Dennerstein L

    更新日期:1990-07-01 00:00:00

  • Parental overprotection increases sociotropy with gender specificity in parents and recipients.

    abstract:BACKGROUND:There have been few studies which examined the developmental origins of cognitive vulnerability of depression. The purpose of the present study was to examine the effects of parental rearing on sociotropy and autonomy, the personality vulnerability factors in the cognitive theory of depression. METHODS:The ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Otani K,Suzuki A,Kamata M,Matsumoto Y,Shibuya N,Sadahiro R,Enokido M

    更新日期:2012-02-01 00:00:00

  • Burden of dysthymia and comorbid illness in adults in a Canadian primary care setting: high rates of psychiatric illness in the offspring.

    abstract:BACKGROUND:The burden of comorbid dysthymia and other comorbid psychiatric illnesses in a Canadian primary care setting was measured. Two groups of primary care patients: those who scored positive for comorbid dysthymia versus those who scored negative for any psychiatric disorder were compared. METHODS:This was a cro...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bell B,Chalklin L,Mills M,Browne G,Steiner M,Roberts J,Gafni A,Byrne C,Wallik D,Kraemer J,Webb M,Jamieson E,Whittaker S,Dunn E

    更新日期:2004-01-01 00:00:00

  • Perinatal depression among mothers in a South African birth cohort study: Trajectories from pregnancy to 18 months postpartum.

    abstract:BACKGROUND:Perinatal depression affects 21-50% of women in South Africa and poses significant health risks to mothers and children. Trajectories of depressive symptoms change over time and have not been well characterized during the perinatal period in low and middle-income countries. METHODS:Data from women enrolled ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Pellowski JA,Bengtson AM,Barnett W,DiClemente K,Koen N,Zar HJ,Stein DJ

    更新日期:2019-12-01 00:00:00

  • Lifetime psychiatric comorbidity rate in Israeli non-help-seeking patients with combat-related post-traumatic stress disorder.

    abstract:BACKGROUND:Most of the data on lifetime psychiatric comorbidity in combat-related posttraumatic stress disorder (CR-PTSD) were collected in help-seeking patients. METHODS:In the present study we used the Schedule for Affective Disorder and Schizophrenia-Lifetime Version to examine a relatively large sample (n=80) of I...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Spivak B,Segal M,Laufer N,Mester R,Weizman A

    更新日期:2000-01-01 00:00:00

  • The factor structure of depressive symptoms in patients with obesity enrolled in the RAINBOW clinical trial.

    abstract:BACKGROUND:Examining variability in the presenting symptoms of depression may be particularly important in characterizing depression in patients with comorbid conditions such as obesity. Identifying the underlying constructs of depression in such patients may produce phenotypic information to aid diagnosis and treatmen...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Majd M,Smyth JM,Lv N,Xiao L,Snowden MB,Venditti EM,Williams LM,Ajilore OA,Suppes T,Ma J

    更新日期:2021-02-15 00:00:00

  • Anxiety responses to CO2 inhalation in subjects at high-risk for panic disorder.

    abstract:BACKGROUND:A number of reports have shown that patients with panic disorder have greater anxiety responses to the inhalation of enhanced carbon dioxide mixtures than do well controls or patients with other psychiatric illnesses. Three earlier studies have shown that well individuals who have first-degree relatives with...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Coryell W,Pine D,Fyer A,Klein D

    更新日期:2006-05-01 00:00:00

  • Interventions that are helpful for depression and anxiety in young people: a comparison of clinicians' beliefs with those of youth and their parents.

    abstract:BACKGROUND:The aim of the research was to assess the consensus of clinicians about the appropriate treatments for depression and anxiety in youth, to discover any major differences between clinicians' beliefs and those of young people and their parents, and to assess whether clinicians' beliefs were consistent with cli...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Jorm AF,Morgan AJ,Wright A

    更新日期:2008-12-01 00:00:00