Monoamine transporters in human endometrium and decidua.


BACKGROUND:Monoamines play important roles in decidualization, implantation, immune modulation and inflammation. Furthermore, monoamines are potent vasoactive mediators that regulate blood flow and capillary permeability. Regulation of the uterine blood flow is important both during menstruation and pregnancy. Adequate monoamine concentrations are essential for a proper implantation and physiological development of pregnancy. Unlike most transmitter substances, monoamines are recycled by monoamine transporters rather than enzymatically inactivated. Their intracellular fate is influenced by their lower affinity for inactivating enzymes than for vesicular transporters located in intracellular vesicles. Thus, cells are capable not only of recapturizing and degrading monoamines, but also of storing and releasing them in a controlled fashion. METHODS:The general objective of the present review is to summarize the role of the monoamine transporters in the female human reproduction. Since the transporter proteins critically regulate extracellular monoamine concentrations, knowledge of their distribution and cyclic variation is of great importance for a deeper understanding of the contribution of monoaminergic mechanisms in the reproductive process. MEDLINE was searched for relevant publications from 1950 to 2007. RESULTS:Two families of monoamine transporters, neuronal and extraneuronal monoamine transporters, are present in the human endometrium and deciduas. CONCLUSIONS:New knowledge about monoamine metabolism in the endometrium during menstruation and pregnancy will increase understanding of infertility problems and may offer new pharmacological approaches to optimize assisted reproduction.


Hum Reprod Update


Hansson SR,Bottalico B,Noskova V,Casslén B




Has Abstract


2009-03-01 00:00:00














  • Low-dose aspirin for in vitro fertilization: a systematic review and meta-analysis.

    abstract::Despite recent advances in ovarian stimulation regimens and laboratory techniques, the pregnancy rate of assisted reproduction remains relatively low. New methods that would potentially improve implantation rates are needed. One proposed strategy involves enhancement of blood flow at the implantation site with the use...

    journal_title:Human reproduction update

    pub_type: 杂志文章,meta分析,评审


    authors: Gelbaya TA,Kyrgiou M,Li TC,Stern C,Nardo LG

    更新日期:2007-07-01 00:00:00

  • Women's emotional adjustment to IVF: a systematic review of 25 years of research.

    abstract::This review provides an overview of how women adjust emotionally to the various phases of IVF treatment in terms of anxiety, depression or general distress before, during and after different treatment cycles. A systematic scrutiny of the literature yielded 706 articles that paid attention to emotional aspects of IVF t...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Verhaak CM,Smeenk JM,Evers AW,Kremer JA,Kraaimaat FW,Braat DD

    更新日期:2007-01-01 00:00:00

  • The impact of periconceptional maternal lifestyle on clinical features and biomarkers of placental development and function: a systematic review.

    abstract:BACKGROUND:Worldwide, placenta-related complications contribute to adverse pregnancy outcomes, such as pre-eclampsia, fetal growth restriction and preterm birth, with implications for the future health of mothers and offspring. The placenta develops in the periconception period and forms the interface between mother an...

    journal_title:Human reproduction update

    pub_type: 杂志文章


    authors: Reijnders IF,Mulders AGMGJ,van der Windt M,Steegers EAP,Steegers-Theunissen RPM

    更新日期:2019-01-01 00:00:00

  • Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis.

    abstract:BACKGROUND:Recurrent pregnancy loss (RPL) occurs in 1-3% of all couples trying to conceive. No consensus exists regarding when to perform testing for risk factors in couples with RPL. Some guidelines recommend testing if a patient has had two pregnancy losses whereas others advise to test after three losses. OBJECTIVE...

    journal_title:Human reproduction update

    pub_type: 杂志文章,meta分析


    authors: van Dijk MM,Kolte AM,Limpens J,Kirk E,Quenby S,van Wely M,Goddijn M

    更新日期:2020-04-15 00:00:00

  • Structure-function relationship of follicle-stimulating hormone and its receptor.

    abstract::Follicle stimulating hormone (FSH) is one of the two pituitary gonadotrophins involved in the regulation of gonadal function. Structurally, this gonadotrophin is a heterodimer composed of two non-covalently associated subunits containing several heterogenous oligosaccharide residues which play an important role in bot...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Ulloa-Aguirre A,Timossi C

    更新日期:1998-05-01 00:00:00

  • Endometriosis and nuclear receptors.

    abstract:BACKGROUND:Endometriosis is recognized as a steroid-dependent disorder; however, the precise roles of nuclear receptors (NRs) in steroid responsiveness and other signaling pathways are not well understood. OBJECTIVE AND RATIONALE:Over the past several years, a number of paradigm-shifting breakthroughs have occurred in...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Yilmaz BD,Bulun SE

    更新日期:2019-07-01 00:00:00

  • The LHRH antagonist cetrorelix: a review.

    abstract::In those clinical situations in which an immediate and profound suppression of gonadotrophins is desired, LHRH agonists have the disadvantage of producing an initial stimulatory effect on hormone secretion. Therefore, the use of GnRH antagonists which cause an immediate and dose-related inhibition of LH and FSH by com...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Reissmann T,Schally AV,Bouchard P,Riethmiiller H,Engel J

    更新日期:2000-07-01 00:00:00

  • AMH and AMH receptor defects in persistent Müllerian duct syndrome.

    abstract::Anti-Müllerian hormone (AMH) produced by fetal Sertoli cells is responsible for regression of Müllerian ducts, the anlage for uterus and Fallopian tubes, during male sex differentiation. A member of the transforming growth factor-beta superfamily, AMH signals through two transmembrane receptors, type II which is speci...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Josso N,Belville C,di Clemente N,Picard JY

    更新日期:2005-07-01 00:00:00

  • Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome.

    abstract:BACKGROUND:Reproductive disorders and infertility are associated with the risk of obstetric complications and have a negative impact on pregnancy outcome. Affected patients often require assisted reproductive technologies (ART) to conceive, and advanced maternal age is a further confounding factor. The challenge is to ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Vannuccini S,Clifton VL,Fraser IS,Taylor HS,Critchley H,Giudice LC,Petraglia F

    更新日期:2016-01-01 00:00:00

  • Nitric oxide in the endometrium.

    abstract::Nitric oxide (NO) is an important mediator of paracrine interactions, especially within the vascular system. It is a powerful inhibitor of platelet aggregation and a potent vasodilator. NO is also a neurotransmitter and it plays a role in cell-mediated cytotoxicity. NO-generating enzymes (nitric oxide synthases, NOS) ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Cameron IT,Campbell S

    更新日期:1998-09-01 00:00:00

  • Double sodium and potassium sulphates revealed by microprobe analysis in dried cervical mucus: a mid-cycle crystallographic index.

    abstract::The use of physical techniques such as scanning electron microscopy and microprobe analysis permits the analysis of valuable details of the structure of dried samples of mid-cycle cervical mucus during the period of maximum ferning. From a crystallographic point of view, particular attention was paid to the location, ...

    journal_title:Human reproduction update

    pub_type: 杂志文章


    authors: Berthou J,Chrétien FC

    更新日期:1997-07-01 00:00:00

  • Mouse genetics provides insight into folliculogenesis, fertilization and early embryonic development.

    abstract::After colonization of the gonad, mouse female germ cells enter into the prophase of the first meiotic division as a mid-gestational hallmark of gender. Perinatally, oocytes interact with granulosa cells to form primordial follicles which, with cyclic periodicity, enter into a 3-week growth phase that culminates in mei...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Amleh A,Dean J

    更新日期:2002-09-01 00:00:00

  • The accuracy of multivariate models predicting ovarian reserve and pregnancy after in vitro fertilization: a meta-analysis.

    abstract::BACKGROUND To review the accuracy of multivariate models for the prediction of ovarian reserve and pregnancy in women undergoing IVF compared with the antral follicle count (AFC) as single test. METHODS We performed a computerized MEDLINE and EMBASE search to identify articles published on multivariate models for ovar...

    journal_title:Human reproduction update

    pub_type: 杂志文章,meta分析


    authors: Verhagen TE,Hendriks DJ,Bancsi LF,Mol BW,Broekmans FJ

    更新日期:2008-03-01 00:00:00

  • Results of conservative management of epithelial malignant and borderline ovarian tumours.

    abstract::Conservative management of at least part of both the ovary and uterus can be proposed in patients with borderline ovarian tumour, in order to preserve fertility potential. This conservative management could be carried out even in patients with borderline ovarian tumour associated with non-invasive peritoneal implants ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Morice P,Camatte S,Wicart-Poque F,Atallah D,Rouzier R,Pautier P,Pomel C,Lhommé C,Duvillard P,Castaigne D

    更新日期:2003-03-01 00:00:00

  • Role of serum biomarkers in the prediction of outcome in women with threatened miscarriage: a systematic review and diagnostic accuracy meta-analysis.

    abstract:BACKGROUND:Threatened miscarriage affects one in five women and is associated with significant emotional distress. The uncertainty around the prognosis of threatened miscarriage makes it equally challenging to the healthcare professionals. Various biochemical markers have been investigated in the past to predict the ou...

    journal_title:Human reproduction update

    pub_type: 杂志文章,meta分析,评审


    authors: Pillai RN,Konje JC,Tincello DG,Potdar N

    更新日期:2016-03-01 00:00:00

  • The estrogen-macrophage interplay in the homeostasis of the female reproductive tract.

    abstract:BACKGROUND:Estrogens are known to orchestrate reproductive events and to regulate the immune system during infections and following tissue damage. Recent findings suggest that, in the absence of any danger signal, estrogens trigger the physiological expansion and functional specialization of macrophages, which are immu...

    journal_title:Human reproduction update

    pub_type: 杂志文章


    authors: Pepe G,Locati M,Della Torre S,Mornata F,Cignarella A,Maggi A,Vegeto E

    更新日期:2018-11-01 00:00:00

  • Modern surgical approaches to female reproductive tract.

    abstract::Laparoscopic and hysteroscopic surgery have changed the management of many gynaecological disorders. Procedures that previously required a long duration of hospitalization can now be done on an outpatient basis or with a short hospital stay. Surgical treatment remains the definitive and universal treatment of ectopic ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Tulandi T

    更新日期:1996-09-01 00:00:00

  • Laparoscopic procedures for treatment of infertility related to polycystic ovarian syndrome.

    abstract::The use of laparoscopic techniques for the treatment of polycystic ovarian syndrome (PCOS) has included many different approaches in the 1980s and 90s. Broadly similiar results have been obtained using biopsy, cauterization, multi-electrocoagulation and laser surgery; i.e. > 50% ovulation and a mean pregnancy rate of ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Cohen J

    更新日期:1996-07-01 00:00:00

  • Anaerobes in ejaculates of subfertile men.

    abstract::The clinical significance of micro-organisms in semen samples of asymptomatic subfertile patients is a matter of constant debate. Usually little attention is paid to anaerobic bacteria as they are sensitive to transportation and culturing, and differentiation is difficult, costly and time-consuming. In the present stu...

    journal_title:Human reproduction update

    pub_type: 杂志文章


    authors: Eggert-Kruse W,Rohr G,Ströck W,Pohl S,Schwalbach B,Runnebaum B

    更新日期:1995-09-01 00:00:00

  • Mammalian reproductive tract mucins.

    abstract::Mucin glycoproteins are major constituents of the glycocalyx that covers mucosal epithelium. Two broad classes of mucins exist: membrane-associated and secretory. Of the secreted mucins, those with cysteine-rich regions are thought to polymerize through disulphide bonds. Among these gel-forming mucins are MUC2, MUC5AC...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Lagow E,DeSouza MM,Carson DD

    更新日期:1999-07-01 00:00:00

  • Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action.

    abstract::Syncytin is a membrane protein derived from the envelope gene of an endogenous retrovirus of the HERV-W family. The gene appears to be almost exclusively expressed in placenta; the protein was found in particular in syncytiotrophoblast. After transfection into various cell types it has proven to be a very fusogenic pr...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Pötgens AJ,Drewlo S,Kokozidou M,Kaufmann P

    更新日期:2004-11-01 00:00:00

  • The role of ovarian volume in reproductive medicine.

    abstract::The human ovary is a dynamic organ which continually changes in size and activity through life, as an integral part of the changes that the female is going through before during and after her reproductive life. Following the rapid increase in the use of transvaginal scan in recent years, the measurement of ovarian vol...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Lass A,Brinsden P

    更新日期:1999-05-01 00:00:00

  • Skeletal effects of selective oestrogen receptor modulators (SERMs).

    abstract::Women suffer a higher incidence of osteoporosis than men, in part due to oestrogen deficiency after menopause. In fact, the administration of oestrogen to post-menopausal women is associated with a decrease of bone resorption. Tamoxifen is a widely used selective oestrogen receptor modulator in women with breast cance...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Díez JL

    更新日期:2000-05-01 00:00:00

  • Clinical implications of uterine malformations and hysteroscopic treatment results.

    abstract::Uterine malformations consist of a group of miscellaneous congenital anomalies of the female genital system. Their mean prevalence in the general population and in the population of fertile women is approximately 4.3%, in infertile patients approximately 3.5% and in patients with recurrent pregnancy losses approximate...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Grimbizis GF,Camus M,Tarlatzis BC,Bontis JN,Devroey P

    更新日期:2001-03-01 00:00:00

  • Homocysteine--a pathophysiological cornerstone in obstetrical and gynaecological disorders?

    abstract::Homocysteine, a product of the methionine cycle, is known to play an important role in cardiovascular diseases, neurological disorders and embryology, and in very important, fast growing fields concerning obstetrics and gynaecology. Therefore, we attempted an actual overview on possible obstetrical and gynaecological ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Obwegeser R,Hohlagschwandtner M,Sinzinger H

    更新日期:1999-01-01 00:00:00

  • Signals and molecular pathways involved in apoptosis, with special emphasis on human endometrium.

    abstract::Apoptosis is a selective process for deletion of cells in various biological systems. This event, similar to proliferation, is tightly regulated, with both processes playing essential roles in the homeostasis of renewable tissues. In human endometrium, proliferation and apoptosis occur at opposing poles of the menstru...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Tabibzadeh S

    更新日期:1995-07-01 00:00:00

  • Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain.

    abstract:BACKGROUND:There have been conflicting results in randomized trials of the effects of laparoscopic uterosacral nerve ablation (LUNA) in chronic pelvic pain. Our objective was to perform a meta-analysis using individual patient data (IPD) to provide the most comprehensive and reliable assessment of the effectiveness of ...

    journal_title:Human reproduction update

    pub_type: 杂志文章,meta分析


    authors: Daniels JP,Middleton L,Xiong T,Champaneria R,Johnson NP,Lichten EM,Sutton C,Vercellini P,Gray R,Hills RK,Jones KD,Aimi G,Khan KS,International LUNA IPD Meta-analysis Collaborative Group.

    更新日期:2010-11-01 00:00:00

  • Cell volume regulation in oocytes and early embryos: connecting physiology to successful culture media.

    abstract:BACKGROUND:Preimplantation embryos are particularly susceptible to in vitro developmental blocks. These could be alleviated by lowering culture medium osmolarity. Because mammalian cells regulate their volumes by adjusting intracellular osmotic pressure, cell volume regulation could be critical to early embryos. METHO...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Baltz JM,Tartia AP

    更新日期:2010-03-01 00:00:00

  • Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.

    abstract:BACKGROUND:Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas is estimated as up to 75%. Except for hysterectomy, most therapies or treatments often provide only partial or temporary relief and are not succe...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Commandeur AE,Styer AK,Teixeira JM

    更新日期:2015-09-01 00:00:00

  • Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?

    abstract:BACKGROUND:The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did report how they foundered, the reasons why they failed are often completely uncle...

    journal_title:Human reproduction update

    pub_type: 杂志文章,评审


    authors: Guo SW,Groothuis PG

    更新日期:2018-09-01 00:00:00