Influence of stable, long-term treatment with phenobarbital on the activity of serum alanine aminotransferase and gamma-glutamyltransferase.


:Phenobarbital, a long-acting barbiturate, is generally considered to be a fairly safe and effective drug; however, hepatotoxicity is an infrequent but potentially fatal adverse effect and there is little information on the serum activity of liver enzymes in patients on stable, long-term monotherapy. The serum activity of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) are measured along with phenobarbital as part of the routine biochemical measurement in 128 consecutive adult out-patients on stable, long-term phenobarbital treatment. The control population consists of 2468 consecutive outpatients matched for age and gender. The patients on long-term phenobarbital therapy had significantly higher serum activities of ALT (27 IU/L versus 23 IU/L, P < 0.001) and GGT (79 IU/L versus 24 IU /L, P < 0.001). The prevalence of subjects with abnormal GGT values, but not ALT, was significantly higher than that in the control population. No significant differences were observed in either the mean activity or the prevalence of abnormal values of ALT or GGT between patients with suboptimal and therapeutic concentrations of the drug. These results suggest that chronic phenobarbital therapy may be associated with a clinically significant elevation of serum GGT activity. If confirmed, a specific GGT reference range should be adopted. Moreover, in those patients presenting with high serum GGT activity, it would not be necessary to reduce the dosage, discontinue the drug or change to a different anti-epileptic medication.


Br J Biomed Sci


Lippi G,Montagnana M,Salvagno GL,Guidi GC




Has Abstract


2008-01-01 00:00:00










  • Alpha-fetoprotein assay in patients treated with low-dose oral contraceptives.

    abstract::AFP has proven to be a useful marker for liver neoplasms. The authors assayed AFP plasma levels in patients taking low-dose estro- progestinics . Patients were divided into three groups on the basis of their living habits. No difference was found in any group between AFP levels before and after treatment. However, in ...

    journal_title:Clinical and experimental obstetrics & gynecology

    pub_type: 杂志文章


    authors: Dessole S,Milia S,Piras G,Firinu C

    更新日期:1984-01-01 00:00:00

  • Ceftriaxone induced acute multi-organ failure syndrome in a Saudi boy with sickle cell disease.

    abstract::Multi-organ failure syndrome (MOFS) is a rare life threatening complication of sickle cell disease. It is precipitated by severe vaso-occlusive episodes. We report a Saudi boy with sickle cell anemia, who developed acute MOFS following anaphylaxis to ceftriaxone administration. He had a dramatic recovery after red blo...

    journal_title:Saudi medical journal

    pub_type: 杂志文章


    authors: Al-Hawsawi ZM,Turkistani WA,Al-Aidaros MA,Al-Harbi DL

    更新日期:2010-07-01 00:00:00

  • Polymorphism of p53 gene in Jordanian population and possible associations with breast cancer and lung adenocarcinoma.

    abstract:OBJECTIVE:To determine the prevalence of 3 polymorphisms in p53 gene in 3 healthy Jordanian groups and 2 cancer patient groups. METHODS:Genomic DNA was extracted from blood samples obtained from 84 cancer patients (breast and lung adenocarcinoma) and 136 healthy subjects (representing Jordanian general population, Bed...

    journal_title:Saudi medical journal

    pub_type: 杂志文章


    authors: Mahasneh AA,Abdel-Hafiz SS

    更新日期:2004-11-01 00:00:00

  • Drug resistance profile and serotype of streptococcus of pneumoniae infected pediatric patients.

    abstract::To investigate the surveillance of drug resistance and serotype monitoring of steptococcus pneumoniae in hospitalized children. the pathogenic bacteria isolation and identification methods were employed to do the bacteria isolation identification and drug sensitive test on the specimens from Women & Infants Hospital o...

    journal_title:Pakistan journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wang J,Huang N,Wang G,Yu F

    更新日期:2016-07-01 00:00:00

  • Evidence of validity of an inhalant-craving questionnaire.

    abstract::Inhalants are substances widely used as recreational drugs: their addictive potential has been demonstrated by many studies. There is no reported measurable evidence of craving in inhalant users. The main goal of this study was to design and obtain evidence of validity of the score of a questionnaire for the evaluatio...


    pub_type: 杂志文章


    authors: Alonso-Matías L,Páez-Martínez N,Reyes-Zamorano E,González-Olvera JJ

    更新日期:2015-12-15 00:00:00

  • [Pararectal miniinvazive retroperitoneal approach to the lumbosacral spine.].

    abstract::The authors describe the technique of the anterior miniinvasive retroperitoneal pararectal approach to the lumbosacral spine. The technique was verified on cadaveric specimens.The miniinvasive operation requires a special set of instruments (a fixed frame), long instruments and a light cable. The advantage of the appr...

    journal_title:Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

    pub_type: 杂志文章


    authors: Krbec M,Stulík J

    更新日期:2000-01-01 00:00:00

  • Knowledge of the human papilloma virus vaccines, and opinions of gynaecologists on its implementation in Nigeria.

    abstract::The objective of this study was to determine the knowledge and perception of Nigerian Obstetricians and Gynaecologists towards human papilloma virus vaccine use in Nigeria. A cross sectional study was conducted amongst participants that attended the 42nd Society of Gynaecology and Obstetrics of Nigeria. The findings r...

    journal_title:African journal of reproductive health

    pub_type: 杂志文章


    authors: Morhason-Bello IO,Adesina OA,Adedokun BO,Awolude O,Okolo CA,Aimakhu CO,Akinwunmi BO,Oladokun A,Adewole IF

    更新日期:2013-06-01 00:00:00

  • Myelodysplastic syndrome with a t(2;11)(p21;q23-24) and translocation breakpoint close to miR-125b-1.

    abstract::The upregulation of oncogenes and the formation of fusion genes are commonly observed in hematological malignancies with recurring balanced translocations. However, in some malignancies exhibiting balanced chromosomal rearrangements, neither oncogene deregulation nor generation of fusion genes appears to be involved, ...

    journal_title:Cancer genetics

    pub_type: 杂志文章


    authors: Thorsen J,Aamot HV,Roberto R,Tjønnfjord GE,Micci F,Heim S

    更新日期:2012-10-01 00:00:00

  • Mediator Effects of Positive Emotions on Social Support and Depression among Adolescents Suffering from Mobile Phone Addiction.

    abstract:BACKGROUND:Depression is a common mental disorder that is widely seen among adolescents suffering from mobile phone addiction. While it is well known that both positive emtions in adolescents wiotions and social support can have a positive impact by helping individuals to maintain a positive attitude, the correlation b...

    journal_title:Psychiatria Danubina

    pub_type: 杂志文章,随机对照试验


    authors: Li M,Jiang X,Ren Y

    更新日期:2017-06-01 00:00:00

  • [Intracranial cavernous angioma].

    abstract::Cavernous angiomas are vascular malformations that belong to the group of hamartomas. Evidence to support the hypothesis that some intracranial cavernous angiomas are benign vascular tumors is lacking. As they are angiographically occult, cavernous angiomas were largely overlooked and were considered rare before CT sc...

    journal_title:Revue neurologique

    pub_type: 杂志文章,评审


    authors: Lechevalier B,Houtteville JP

    更新日期:1992-01-01 00:00:00

  • Dynamic organization of chromatin assembly and transcription factories in living cells.

    abstract::The interphase nucleus is an active organelle involved in processing genetic information. In higher order eukaryotes, information control is compartmentalized - for example at the scale of inter-chromosome territories and nuclear bodies. Regulatory proteins, nuclear bodies and chromatin assembly are found to be highly...

    journal_title:Methods in cell biology

    pub_type: 杂志文章,评审


    authors: Sinha B,Bhattacharya D,Sinha DK,Talwar S,Maharana S,Gupta S,Shivashankar GV

    更新日期:2010-01-01 00:00:00

  • Cheerful prospects and tranquil restoration: the visual experience of landscape as part of the therapeutic regime of the British asylum, 1800-60.

    abstract::The early nineteenth-century asylum in Britain was generally sited upon a hill with wide-ranging rural views, surrounded by agricultural land, gardens and landscaped grounds. A number of historians have discussed the role of these features as places for patients to partake in recreation, exercise and work. This paper ...

    journal_title:History of psychiatry

    pub_type: 历史文章,杂志文章


    authors: Hickman C

    更新日期:2009-12-01 00:00:00

  • [Chronic recurrent multifocal osteomyelitis: case series of four patients treated with biphosphonates].

    abstract:AIM:To report and describe a series of four cases of chronic recurrent multifocal osteomyelitis (CRMO) and to discuss therapeutic options, particularly bisphosphonate therapy. METHODS:Retrospective review of four CRMO cases in two Pediatric Units in Lisbon, between 2005 and 2010. RESULTS:Median age of first CRMO symp...

    journal_title:Acta reumatologica portuguesa

    pub_type: 杂志文章


    authors: Ferraria N,Marques JG,Ramos F,Lopes G,Fonseca JE,Neves MC

    更新日期:2014-01-01 00:00:00

  • Functional nausea and vomiting.

    abstract:BACKGROUND:There is a group of patients who have unexplained chronic nausea and/or vomiting. In the past these patients were labelled as having psychogenic vomiting. However, there is little evidence that such a condition exists. Rather, these patients usually have a functional gastrointestinal disorder (functional nau...

    journal_title:Australian family physician

    pub_type: 杂志文章,评审


    authors: Talley NJ

    更新日期:2007-09-01 00:00:00

  • Content uniformity in granules for aceclofenac controlled release (CR) tablets determined using near-infrared spectroscopy and wide area illumination (WAI) Raman spectroscopy.

    abstract::Non-destructive and rapid determination methods were developed for aceclofenac controlled release (CR) tablets. The tablet is composed of two layers, rapid release and controlled release (CR) layers. The pharmaceutical manufacturing process for CR granules is very critical for dissolution control of CR tablets. During...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Woo YA

    更新日期:2012-02-01 00:00:00

  • [Metabolism of calcium in sarcoidosis].

    abstract::Sarcoidosis is a multisystemic disease of unknown etiology with characteristic picture of immunological disorders. As an unfavourable course of the disease both fibrosis and abnormal calcium metabolism may occur. The last one is reflected by hypercalcemia and/or hypercalcuria. In this paper the recent advances in the ...

    journal_title:Postepy higieny i medycyny doswiadczalnej

    pub_type: 杂志文章,评审


    authors: Podwysocki B

    更新日期:1994-01-01 00:00:00

  • The management of variceal bleeding.

    abstract::Fastidious resuscitation is essential in the initial management of acute variceal bleeding and requires adequate monitoring. Where endoscopic services are available diagnostic endoscopy should be performed ideally within 4-6 hours of admission and endoscopic therapy with injection sclerotherapy or binding ligation per...

    journal_title:Scottish medical journal

    pub_type: 杂志文章,评审


    authors: Hudson N,Murray FE

    更新日期:1996-06-01 00:00:00

  • Effects of dexmedetomidine on the deformability of erythrocyte in patients with laparoscopic cholecystectomy.

    abstract::This study aims to study the impact of dexmedetomidine on the deformability of erythrocyte in patients with laparoscopic cholecystectomy. 40 patients scheduled for laparoscopic cholecystectomy were randomly divided into 2 groups: Dexmedetomidine group (0.5µg/kg loading within 10 min and 0.5μg•kg-1•h-1maintenance to th...

    journal_title:Pakistan journal of pharmaceutical sciences

    pub_type: 杂志文章,随机对照试验


    authors: Yang X,Xie J,Liu J,Wang T

    更新日期:2016-09-01 00:00:00

  • [Valor terapéutico potencial de medicamentos en México: el caso de los antibióticos].

    abstract:Introduction:The relevance of medications for health depends on their quality, accessibility and appropriate use. Objective:To determine the potential therapeutic value of antibiotics that are not included in the World Health Organization Essential Medicines List (EML) but that are part of the National Essential Medic...

    journal_title:Gaceta medica de Mexico

    pub_type: 杂志文章,评审


    authors: Mino-León D,Hernández-Carvajal I,Peredo-Silva L,Búrbano-Martínez G

    更新日期:2019-01-01 00:00:00

  • Hypericum treatment of mild depressions with somatic symptoms.

    abstract::In a randomized, placebo-controlled, double-blind study, 39 patients with depression with somatic symptoms were treated with hypericum extract LI 160. The therapy lasted for 4 weeks; the dosage was 300 mg three times daily. At the onset of the study as well as after 2 and 4 weeks, the following criteria were analyzed:...

    journal_title:Journal of geriatric psychiatry and neurology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hübner WD,Lande S,Podzuweit H

    更新日期:1994-10-01 00:00:00

  • Zopfochytrium is a new genus in the Chytridiales with distinct zoospore ultrastructure.

    abstract::While surveying chytrid diversity in lakes and streams, we found on cellulosic bait a chytrid that had both monocentric and polycentric thallus forms. We brought this chytrid into axenic culture from three sites in eastern North America, studied its thallus development and zoospore ultrastructure, and compared its 28S...

    journal_title:Fungal biology

    pub_type: 杂志文章


    authors: Powell MJ,Letcher PM,Longcore JE,Blackwell WH

    更新日期:2018-11-01 00:00:00

  • Anthropometric data and acetylsalicylic acid pharmacokinetics.

    abstract::The relationship between anthropometric data and pharmacokinetic characteristics of acetylsalicylic acid (ASA) after administration of a single oral dose of 500 mg ASA, an oral and intravenous dose of 500 mg D,L-lysine-mono-acetylsalicylate (Lys-ASA) and an oral dose of 1,000 mg Lys-ASA were evaluated. Individual data...

    journal_title:International journal of clinical pharmacology and therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Koch HJ,Raschka C

    更新日期:2002-01-01 00:00:00

  • Thoughts on a neglected French medieval surgeon: Henri de Mondeville (+/-1260-1320).

    abstract::Henri de Mondeville's manuscript, presented in this article, is based on an incomplete Latin manuscript, written from 1306 to 1320, translated into French by E. Nicaise and kept in the Manuscript section of the Bibliothbque Nationale de Paris (MS French 2030). ...

    journal_title:Acta chirurgica Belgica

    pub_type: 传,历史文章,杂志文章


    authors: Vrebos J

    更新日期:2011-03-01 00:00:00

  • Inpatient cardiology in a rural district general hospital.

    abstract::The pattern of cardiac admissions to a rural district general hospital has been analysed. Coronary artery disease is the major disorder, both as an acute and chronic problem. Other forms of heart disease are relatively uncommon. The absence of hypertension and hypertensive heart disease is striking. The deaths were ma...

    journal_title:Scottish medical journal

    pub_type: 杂志文章


    authors: Tulloch JA

    更新日期:1987-02-01 00:00:00

  • Involvement of Victorian general practitioners in obstetric and postnatal care.

    abstract:OBJECTIVE:To assess the current nature and extent of general practice (obstetric) involvement and the effect of gender on the provision of maternity care in Victoria. METHOD:A postal survey to a community derived sample of 1104 Victorian general practitioners (with oversampling of female GPs) in August 1994 with hiera...

    journal_title:Australian family physician

    pub_type: 杂志文章


    authors: Gunn J,Lumley J,Young D

    更新日期:1998-07-01 00:00:00

  • [Isolation of Escherichia coli O157:H7 in storm drains in the city of Mar del Plata with bacterial contamination of fecal origin].

    abstract::The present study was focused on the isolation and characterization of Escherichia coli, particularly the serotype O157:H7, from five combined-sewer outflows waters, which drain into the beaches of Mar del Plata. Seventeen hemolytic uremic syndrome cases were reported in Mar del Plata during the sampling period (May 1...

    journal_title:Revista Argentina de microbiologia

    pub_type: 杂志文章


    authors: Perez Guzzi JI,Folabella A,Miliwebsky E,Rivas M,Fernandez Pascua C,Gomez D,Zamora A,Zotta C,Cordoba M

    更新日期:2000-07-01 00:00:00

  • Development and validation of HPLC method for the determination of pioglitazone in human plasma.

    abstract::Pioglitazone is widely used for the management of type-II diabetes mellitus. The objective of the present study was to develop a simple and cost-effective HPLC method for the quantification of pioglitazone in human plasma. The mobile phase comprises of Acetonitrile, 0.1 M ammonium acetate and glacial acetic acid (25:2...

    journal_title:Pakistan journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ali SI,Razvi N,Hasan SMF

    更新日期:2018-07-01 00:00:00

  • Amino acid and protein intake in RDT patients. A nutritional and biochemical analysis.

    abstract::In 40 unselected RDT patients (20 center and 20 home dialysis patients) the intake of nutrients was measured using the precise weighing method of Wirths [1969]. The protein intake was found to be 0.97 plus or minus 0.19 g/kg predialysis body weight, the calorie intake 32.3 plus or minus 6.4 cal/kg. Two thirds (0.65 pl...

    journal_title:Clinical nephrology

    pub_type: 杂志文章


    authors: Schaeffer G,Heinze V,Jontofsohn R,Katz N,Rippich Th,Schäfer B,Südhoff A,Zimmermann W,Kluthe R

    更新日期:1975-06-01 00:00:00

  • The pattern of CagA and VacA proteins in Helicobacter pylori seropositive asymptomatic children in western Saudi Arabia.

    abstract:OBJECTIVE:This study aimed to determine antibody prevalence to Helicobacter pylori (H. pylori) virulence factors CagA and VacA in asymptomatic H. pylori seropositive children in Jeddah, Kingdom of Saudi Arabia (KSA). The possibility of differences in antibodies response patterns was also investigated in relation to gen...

    journal_title:Saudi medical journal

    pub_type: 杂志文章


    authors: Jaber SM

    更新日期:2005-09-01 00:00:00

  • A comparison of impact force reduction by polymer materials used for mouthguard fabrication.

    abstract:PURPOSE:The essential function of mouthguards is protection against the effects of injuries sustained during sports activities. This purpose will be successfully achieved if appropriate materials ensuring sufficient reduction of the injury force are used for mouthguard fabrication. OBJECTIVE:The objective of the study...

    journal_title:Acta of bioengineering and biomechanics

    pub_type: 杂志文章


    authors: Gawlak D,Mańka-Malara K,Mierzwińska-Nastalska E,Gieleta R,Kamiński T,Łuniewska M

    更新日期:2017-01-01 00:00:00