Developmental toxicity of indium: embryotoxicity and teratogenicity in experimental animals.


:Indium, a precious metal classified in group 13 (IIIB) in the periodic table, has been used increasingly in the semiconductor industry. Because indium is a rare metal, technology for indium recycling from transparent conducting films for liquid crystal displays is desired, and its safety evaluation is becoming increasingly necessary. The developmental toxicity of indium in experimental animals was summarized. The intravenous or oral administration of indium to pregnant animals causes growth inhibition and the death of embryos in hamsters, rats, and mice. The intravenous administration of indium to pregnant animals causes embryonic or fetal malformation, mainly involving digit and tail deformities, in hamsters and rats. The oral administration of indium also induces fetal malformation in rats and rabbits, but requires higher doses. No teratogenicity has been observed in mice. Caudal hypoplasia, probably due to excessive cell loss by increased apoptosis in the tailbud, in the early postimplantation stage was considered to account for indium-induced tail malformation as a possible pathogenetic mechanism. Findings from in vitro experiments indicated that the embryotoxicity of indium could have direct effects on the conceptuses. Toxicokinetic studies showed that the embryonic exposure concentration was more critical than the exposure time regarding the embryotoxicity of indium. It is considered from these findings that the risk of the developmental toxicity of indium in humans is low, unless an accidentally high level of exposure or unknown toxic interaction occurs because of possible human exposure routes and levels (i.e. oral, very low-level exposure).


Congenit Anom (Kyoto)


Congenital anomalies


Nakajima M,Usami M,Nakazawa K,Arishima K,Yamamoto M




Has Abstract


2008-12-01 00:00:00














  • Neuroanatomic and magnetic resonance imaging references for normal development of cerebral sulci of laboratory primate, cynomolgus monkeys (Macaca fascicularis).

    abstract::Cynomolgus monkey (Macaca fascicularis) is a popular laboratory primate belonging to Old World monkeys, which are the group most closely related to humans except for the apes. This paper summarizes a series of our studies regarding the development of cerebral sulci and gyri in this primate, and the stated possibility ...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Sawada K,Fukunishi K,Kashima M,Imai N,Saito S,Sakata-Haga H,Aoki I,Fukui Y

    更新日期:2012-03-01 00:00:00

  • Folic acid in the prevention of neural tube defects: awareness among laywomen and healthcare providers in Japan.

    abstract::It is known that neural tube defects are folic acid preventable congenital anomalies. We investigated to what extent this information was disseminated among laywomen and healthcare providers. Questionnaire studies were conducted twice, in 2002 and 2007, for four groups of laywomen and seven groups of healthcare provid...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Kondo A,Yamamoto S,Inoue H,Watanabe J,Tada K,Yoshimoto N

    更新日期:2009-09-01 00:00:00

  • Towards the understanding of Down syndrome using mouse models.

    abstract::Down syndrome (DS) is the most common cause of mental retardation. Several DS mouse models with partial trisomy 16 homologous to human chromosome 21 have been developed, and our research group has been studying those mouse models. We have shown a dosage-dependent overexpression of genes in the trisomic region of the m...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Yamakawa K

    更新日期:2012-06-01 00:00:00

  • Congenital polymicrogyria including the perisylvian region in early childhood.

    abstract::Six pediatric cases including four infants with congenital polymicrogyria including the perisylvian region are presented herein. Their clinical features were analyzed and compared with patients suffering from congenital bilateral perisylvian syndrome (CBPS). Two specific abnormalities were diagnosed as accompanying di...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Takano T,Matsuwake K,Yoshioka S,Takeuchi Y

    更新日期:2010-03-01 00:00:00

  • Herlyn-Werner-Wunderlich syndrome with pregnancy: a rare presentation.

    abstract::Müllerian duct anomalies are infrequently encountered clinical problems and often present with difficulty in diagnosis. A high level of suspicion is the key to diagnosis, which is usually made soon after menarche. However, this is the first reported case of uterus didelphys with obstructed hemivagina and pyocolpos wit...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Rana R,Pasrija S,Puri M

    更新日期:2008-09-01 00:00:00

  • Natural histories of patients with Wolf-Hirschhorn syndrome derived from variable chromosomal abnormalities.

    abstract::Wolf-Hirschhorn syndrome (WHS) is a subtelomeric deletion syndrome affecting the short arm of chromosome 4. The main clinical features are a typical craniofacial appearance, growth deficiency, developmental delays, and seizures. Previous genotype-phenotype correlation analyses showed some candidate regions for each cl...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Yamamoto-Shimojima K,Kouwaki M,Kawashima Y,Itomi K,Momosaki K,Ozasa S,Okamoto N,Yokochi K,Yamamoto T

    更新日期:2019-09-01 00:00:00

  • Trend of congenital anomalies over 20 years ascertained by population-based monitoring in Ishikawa Prefecture, Japan.

    abstract::Monitoring in Ishikawa Prefecture (mean population; 1,150,000), during the 20-year period from 1981 to 2000, involved monitoring the prevalence of congenital anomalies starting at gestational week 22. The main objectives of the present study were (1) to investigate the trend over the past 20 years in the prevalence of...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Seto T,Nakagawa H,Morikawa Y,Nishijo M,Miura K,Kadoshima Y

    更新日期:2003-12-01 00:00:00

  • Epigenetic alterations in sperm associated with male infertility.

    abstract::The most common form of male infertility is a low sperm count, known as oligozoospermia. Studies suggest that oligozoospermia is associated with epigenetic alterations. Epigenetic alterations in sperm, which may arise due to the exposure of gametes to environmental factors or those that pre-exist in the sperm of infer...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Kitamura A,Miyauchi N,Hamada H,Hiura H,Chiba H,Okae H,Sato A,John RM,Arima T

    更新日期:2015-08-01 00:00:00

  • Characteristics of 2p15-p16.1 microdeletion syndrome: Review and description of two additional patients.

    abstract::Many new microdeletion syndromes have been characterized in the past decade, including 2p15-p16.1 microdeletion syndrome. More than 10 patients with this syndrome have been described. Recently, we encountered two additional patients with 2p15-p16.1 microdeletion syndrome. All patients showed variable degrees of intell...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Shimojima K,Okamoto N,Yamamoto T

    更新日期:2015-08-01 00:00:00

  • Prenatal findings of omphalocele-exstrophy of the bladder-imperforate anus-spinal defects (OEIS) complex.

    abstract::Omphalocele-exstrophy of the bladder (cloaca)-imperforate anus-spinal defects (OEIS) complex describes a rare grouping of more commonly occurring component malformations. We report two cases of OEIS complex diagnosed prenatally by ultrasound and magnetic resonance imaging (MRI). In both cases, OEIS complex was suspect...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Goto S,Suzumori N,Obayashi S,Mizutani E,Hayashi Y,Sugiura-Ogasawara M

    更新日期:2012-09-01 00:00:00

  • Historical control data on developmental toxicity studies in rodents.

    abstract::Historical control data on rodent developmental toxicity studies, performed between 1994 and 2010, were obtained from 19 laboratories in Japan, including 10 pharmaceutical and chemical companies and nine contract research organizations. Rats, mice, and hamsters were used for developmental toxicity studies. Data includ...

    journal_title:Congenital anomalies

    pub_type: 历史文章,杂志文章


    authors: Ema M,Endoh K,Fukushima R,Fujii S,Hara H,Hirata-Koizumi M,Hirose A,Hojo H,Horimoto M,Hoshino N,Hosokawa Y,Imai Y,Inada H,Inawaka K,Itoh K,Katsumata Y,Izumi H,Kato H,Maeda M,Matsumoto K,Matsuo S,Matsuoka T,Mats

    更新日期:2014-08-01 00:00:00

  • Cerebro-fronto-facial syndrome (Dandy-Walker Variant and frontofacial dysmorphisms): report of the first case identified by increased nuchal translucency beyond 13(+6) weeks.

    abstract::A 32-year-old gravida 2, para 1 woman, with a previous uneventful pregnancy, underwent first trimester ultrasound screening for Down syndrome at 13 weeks according to the Fetal Medicine Foundation guidelines ( The ultrasound showed increased nuchal transl...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Tonni G,Azzoni D,Ambrosetti F,de Felice C,Ventura A

    更新日期:2007-06-01 00:00:00

  • Using zebrafish in systems toxicology for developmental toxicity testing.

    abstract::With the high cost and the long-term assessment of developmental toxicity testing in mammals, the vertebrate zebrafish has become a useful alternative model organism for high-throughput developmental toxicity testing. Zebrafish is also very favorable for the 3R perspective in toxicology; however, the methodologies use...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Nishimura Y,Inoue A,Sasagawa S,Koiwa J,Kawaguchi K,Kawase R,Maruyama T,Kim S,Tanaka T

    更新日期:2016-01-01 00:00:00

  • Precurrence risk of birth defects in Hawaii.

    abstract::The aim of the investigation was to describe the risk of selected types of birth defects among older siblings of infants and fetuses with specific birth defects. Using data from a population-based birth defects registry in Hawaii for deliveries during 1986-2000, the precurrence risk (risk among older siblings) for any...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Forrester MB,Merz RD

    更新日期:2008-03-01 00:00:00

  • Extraction of DNA from human embryos after long-term preservation in formalin and Bouin's solutions.

    abstract::The "Kyoto Collection of Human Embryos" at Kyoto University was begun in 1961. Although morphological analyses of samples in the Kyoto Collection have been performed, these embryos have been considered difficult to genetically analyze because they have been preserved in formalin or Bouin's solution for 20-50 years. Ow...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Nagai M,Minegishi K,Komada M,Tsuchiya M,Kameda T,Yamada S

    更新日期:2016-05-01 00:00:00

  • Congenital eye anomalies: More mosaic than thought?

    abstract::The eye is a sensory organ that primarily captures light and provides the sense of sight, as well as delivering non-visual light information involving biological rhythms and neurophysiological activities to the brain. Since the early 1990s, rapid advances in molecular biology have enabled the identification of develop...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Ohuchi H,Sato K,Habuta M,Fujita H,Bando T

    更新日期:2019-05-01 00:00:00

  • Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta.

    abstract::The rapid rise in the prevalence of autism spectrum disorders (ASD) and other psychiatric disorders displaying similar traits has increased the need to elucidate their molecular mechanisms. Epidemiological studies have shown that maternal infection during mid-pregnancy is associated with increased risk of neurodevelop...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Tsukada T,Shimada H,Sakata-Haga H,Iizuka H,Hatta T

    更新日期:2019-05-01 00:00:00

  • The initial development of motor neurons in the neural tube of rat embryos.

    abstract::The time of origin of motor neurons and their distribution in the spinal cord was studied in rat embryos by combining whole-embryo culture and the Islet-1 immunostaining technique. Cells immunostained for Islet-1 appeared in the trunk neural tube by 27 hours (corresponding to E10.625) in culture of E9.5 embryos, at wh...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Matsuda M

    更新日期:2002-06-01 00:00:00

  • Novel SYNGAP1 variant in a patient with intellectual disability and distinctive dysmorphisms.

    abstract::We describe a novel de novo heterozygous variant in SYNGAP1 (c.1741C>T, p.R581W), identified through targeted resequencing in an 8-year-old boy with intellectual disability, autism spectrum disorder, distinctive dysmorphic features, and no seizures. Our data strongly suggest that the SYNGAP1 variant is causative of in...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Kimura Y,Akahira-Azuma M,Harada N,Enomoto Y,Tsurusaki Y,Kurosawa K

    更新日期:2018-11-01 00:00:00

  • Suspected involvement of the X chromosome in placental mesenchymal dysplasia.

    abstract::So far, 46 cases of placental mesenchymal dysplasia have been reported worldwide. We encountered 15 cases of placental mesenchymal dysplasia (PMD) including 7 cases delivered in our hospital. The incidence of PMD in our hospital was therefore, 7/30,758 (0.02%). The PMD had a peculiar appearance. In the gross findings,...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Arizawa M,Nakayama M

    更新日期:2002-12-01 00:00:00

  • Cerebro-costo-mandibular syndrome: prognosis and proposal for classification.

    abstract::Cerebro-costo-mandibular syndrome (CCMS) is a very rare syndrome characterized by micrognathia and posterior rib gap, with a poor prognosis. To date, only 75 cases have been reported worldwide. The overall survival rate for patients with this disorder has not been reported, and a classification of the patients on the ...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Nagasawa H,Yamamoto Y,Kohno Y

    更新日期:2010-09-01 00:00:00

  • Studies on preliminary concentration methods for recovery of fetal nucleated red blood cells in maternal blood.

    abstract::Non-invasive prenatal diagnostic methods posing no danger to the embryo have been desired for many years in the field of prenatal medicine. We are in the process of improving the lectin method that we developed for recovering fetus-derived nucleated red blood cells (NRBC) in the maternal peripheral blood. We previousl...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Wachi T,Kitagawa M

    更新日期:2004-12-01 00:00:00

  • Drug safety in pregnancy: utopia or achievable prospect? Risk information, risk research and advocacy in Teratology Information Services.

    abstract::Even though from preclinical testing to drug risk labeling, the situation with drugs in pregnancy has improved substantially since the thalidomide scandal, there is still an increasing need to provide healthcare professionals and patients with updated individualized risk information for clinical decision making. For t...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Schaefer C

    更新日期:2011-03-01 00:00:00

  • Significance of sugar chain recognition by galectins and its involvement in disease-associated glycosylation.

    abstract::Galectins are β-galactoside-binding lectins that participate in a wide range of biological processes. Galectins are distributed both inside and outside cells and are believed to have roles in both intra- and extracellular milieus. One of the well-recognized functions of galectins is stabilization of glycoproteins on t...

    journal_title:Congenital anomalies

    pub_type: 杂志文章,评审


    authors: Arikawa T,Simamura E,Shimada H,Nakamura T,Hatta T,Shoji H

    更新日期:2014-05-01 00:00:00

  • EFNB1 mutation at the ephrin ligand-receptor dimerization interface in a patient with craniofrontonasal syndrome.

    abstract::Craniofrontonasal syndrome (CFNS) is characterized by craniosynostosis, hypertelorism, a broad nasal tip and occasionally cleft lip and palate, and is caused by a mutation in the ephrin-B1 gene (EFNB1). The study of naturally occurring human EFNB1 mutations offers a unique opportunity to better define the critical por...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Torii C,Izumi K,Nakajima H,Takahashi T,Kosaki K

    更新日期:2007-03-01 00:00:00

  • Heart changes in 17-day-old fetuses of diabetic ICR (Institute of Cancer Research) mothers: improvement with maternal immune stimulation.

    abstract::Maternal diabetes mellitus is associated with increased fetal teratogenesis, including cardiovascular defects. Non-specific maternal immune stimulation with Freund's complete adjuvant (FCA) or interferon gamma (IFNgamma) has been associated with protection against birth malformations. Using a diabetic mouse model, lat...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Claudio Gutierrez J,Prater MR,Hrubec TC,Smith BJ,Freeman LE,Holladay SD

    更新日期:2009-03-01 00:00:00

  • Discrepancies in cytogenetic results between amniocytes and postnatally obtained blood: trisomy 9 mosaicism.

    abstract::When amniocentesis reveals a mosaic karyotype and the baby presents with multiple malformations, an analysis of the baby's peripheral blood typically reveals a mosaic karyotype. We present a boy who was prenatally diagnosed by amniocentesis as having trisomy 9 mosaicisim but who had normal G-banding results on postnat...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Kosaki R,Hanai S,Kakishima H,Okada MA,Hayashi S,Ito Y,Takahashi T,Kosaki K,Okuyama T

    更新日期:2006-06-01 00:00:00

  • Genome-wide screening of dioxin-responsive genes in fetal brain: bioinformatic and experimental approaches.

    abstract::Many of the effects of dioxins, which are potent environmental pollutants and teratogens, are mediated through the aryl hydrocarbon receptor, also known as the dioxin receptor. The purpose of the present study was to characterize dioxin-responsive genes in a comprehensive manner using two complementary approaches: bio...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Fujita H,Samejima H,Kitagawa N,Mitsuhashi T,Washio T,Yonemoto J,Tomita M,Takahashi T,Kosaki K

    更新日期:2006-09-01 00:00:00

  • Bifid choroid plexus: always a normal fetal brain structure variant?

    abstract::Choroid plexus, a fetal organ developing approximately from the sixth week of gestation, plays a fundamental role in developing fetal brain organization. As relatively little is known about the relationship between anomalies of choroid plexuses structure and their role in brain function, we examined cases of bifid cho...

    journal_title:Congenital anomalies

    pub_type: 杂志文章


    authors: Centini G,Imperatore A,Morelli M,Rosignoli L,Passamonti U,Caprioli F,Lituania M

    更新日期:2013-06-01 00:00:00

  • Neurological manifestations of 2q31 microdeletion syndrome.

    abstract::Microdeletion of 2q31 involving the HOXD gene cluster is a rare syndrome. The deletion of the HOXD gene cluster is thought to result in skeletal anomalies in these patients. HOX genes encode highly conserved transcription factors that control cell fate and the regional identities along the primary body and limb axes. ...

    journal_title:Congenital anomalies



    authors: Okamoto N,Kimura S,Shimojima K,Yamamoto T

    更新日期:2017-11-01 00:00:00