Effect of food on the pharmacokinetics of YH439 and its metabolites in rats.


:The pharmacokinetics of YH439 and its metabolites were investigated after oral administration of YH439 to rats to investigate the food effect. After oral administration of YH439, its metabolites, M4 and M5 were detected in plasma. YH439 was not detected in the plasma for both fasted and fed rats for all doses studied. The pharmacokinetic parameters of the metabolites were not affected by food at all doses studied. The results of this study indicated that there are no significant food effects on the pharmacokinetics of YH439 and its metabolites in rats.


Arch Pharm Res


Kim MK,Ahn BN,Yoo JK,Lee JW




Has Abstract


1997-12-01 00:00:00










  • Determination of the frequency of heme cavity fluctuations in metmyoglobin and methaemoglobin based on the study of exchange rate of solvent water with paramagnetic Fe3+ ion of heme. 1H-NMR studies.

    abstract::The effects of solvent viscosity and temperature on the spin-spin relaxation rates 1/T2 of solvent water protons in metmyoglobin and methaemoglobin solutions in the temperature range of 5-50 degrees C have been studied. Solvent viscosity is altered by changing sucrose concentration from 0 to 25% by weight. The magnitu...

    journal_title:Folia biologica

    pub_type: 杂志文章


    authors: Käiväräinen AI,Goryunov AS,Sukhanova G

    更新日期:1984-01-01 00:00:00

  • Subcutaneous dirofilariasis.

    abstract::Subcutaneous dirofilariasis is a parasitic infestation found in endemic areas in Mediterranean countries such as Italy. It is occasionally reported in India, mostly from the state of Kerala. Presentation in an infant is extremely rare. We report a case of subcutaneous dirofilariasis in a child that was diagnosed by ul...

    journal_title:Singapore medical journal

    pub_type: 杂志文章


    authors: Acharya D,Chatra PS,Padmaraj SR,Ahamed A

    更新日期:2012-09-01 00:00:00

  • Dengue fever outbreak by more than one serotype in a municipal area of Kolkata, Eastern India.

    abstract::A dengue outbreak struck Baranagar municipality area of North 24 Parganas district, West Bengal in July 2016. This study presents the epidemiological and virology findings of this outbreak. The outbreak started from 17 July and continued until 17th December. Total 1660 dengue cases (overall attack rate: 7/1000) and tw...

    journal_title:Journal of vector borne diseases

    pub_type: 杂志文章


    authors: Debnath F,Provash CS,Chakraborty A,Dutta S

    更新日期:2019-10-01 00:00:00

  • How to Choose between the Implant Materials Steel and Titanium in Orthopedic Trauma Surgery: Part 1 - Mechanical Aspects.

    abstract::When choosing between metal implants of different materials the surgeon mainly needs to balance the pros and cons of steel and titanium. Economic constraints often do not permit both to be kept in stock and it is necessary to decide beforehand which to choose. The arguments for the use of the "preferred metal" vary. T...

    journal_title:Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

    pub_type: 杂志文章


    authors: Perren SM,Regazzoni P,Fernandez AA

    更新日期:2017-01-01 00:00:00

  • Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition.

    abstract::The highly conserved DNA-binding domain of the steroid hormone receptors contains two 'zinc finger'-like sequence motifs. The three-dimensional structure in solution has been determined using two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy and shows that the two 'zinc finger'-like motifs fold to form ...

    journal_title:Trends in biochemical sciences

    pub_type: 杂志文章,评审


    authors: Schwabe JW,Rhodes D

    更新日期:1991-08-01 00:00:00

  • A review of enteric outbreaks in child care centers: effective infection control recommendations.

    abstract::Child care environments facilitate the spread of enteric infections because of diapering, confined spaces, and children's unhygienic habits. This study reviews documented outbreaks of enteric illness in daycare centers (DCCs) to identify infectious agents, modes of transmission, morbidity/mortality, ages, secondary ca...

    journal_title:Journal of environmental health

    pub_type: 杂志文章,评审


    authors: Lee MB,Greig JD

    更新日期:2008-10-01 00:00:00

  • Scanning electron microscopy of the urinary tract.

    abstract::Scanning electron microscopy of the urinary tract. A scanning electron microscopic investigation of the luminal surface of the entire urinary tract of the Wistar rat was performed. This report defines criteria for identifying different segments of normal urinary tract on the basis of scanning electron microscopic obse...

    journal_title:Clinical nephrology

    pub_type: 杂志文章


    authors: Burke JA

    更新日期:1976-08-01 00:00:00

  • Atypical adenolymphoma and glomus caroticum tumour: a rare coincidence.

    abstract::We describe the rare simultaneous appearance of an atypical adenolymphoma with a glomus caroticum tumour on the same side of the neck in a middle-aged man. This case report is the first to describe this coexistence. Due to the atypical, cyst-like presentation of the Warthin's tumour, a final diagnosis was made only af...


    pub_type: 杂志文章


    authors: Broes K,Vanderveken OM,Salgado R,Verfaillie J,Pauwels P,Van de Heyning PH,Van Laer C

    更新日期:2012-01-01 00:00:00

  • [Notions of epidemiology of value in dermatology].

    abstract::Epidemiology, which was initially confined to the distribution of diseases in populations (descriptive epidemiology) and the factors responsible for such distribution (analytical epidemiology), also involves the evaluation of diagnostic and therapeutic strategies, as well as prognostic factors. Epidemiology provides e...

    journal_title:Annales de dermatologie et de venereologie

    pub_type: 杂志文章


    authors: Brenaut E,Bastuji-Garin S

    更新日期:2018-02-01 00:00:00

  • [Renal tumors: The International Society of Urologic Pathology (ISUP) 2012 consensus conference recommendations].

    abstract::During the last 30 years many advances have been made in kidney tumor pathology. In 1981, 9 entities were recognized in the WHO Classification. In the latest classification of 2004, 50 different types have been recognized. Additional tumor entities have been described since and a wide variety of prognostic parameters ...

    journal_title:Annales de pathologie

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Rioux-Leclercq N,Ferran A,Mahul A,Argani P,Billis A,Bonsib S,Cheng L,Cheville J,Eble J,Egevad L,Epstein J,Grignon D,Hes O,Humphrey P,Magi-Galluzzi C,Martignoni G,McKenney J,Merino M,Moch H,Montironi R,Netto G,Re

    更新日期:2014-12-01 00:00:00

  • Extreme oral myiasis.

    abstract::Extreme oral myiasis is a rare condition, mostly affecting bedridden patients whose oral health care measures are neglected. Single stage manual removal of the maggots along with the necrotic tissue, debridement, and suturing under general anesthesia is the most effective way to treat the condition. Preventive measure...

    journal_title:Saudi medical journal

    pub_type: 杂志文章


    authors: Joseph B,Vyloppilli S,Ahsan A,Anirudhan A

    更新日期:2014-09-01 00:00:00

  • Factors that contribute to clopidogrel resistance in cardiovascular disease patients: environmental and genetic approach.

    abstract:BACKGROUND AND OBJECTIVE:Clopidogrel is a potent antiplatelet drug that reduces the risk of vascular events in patients with cardiovascular disease. However, several studies have shown that about a quarter of patients showed low or no response to clopidogrel therapy. In this study, factors that contribute to clopidogre...

    journal_title:International journal of clinical pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Al-Azzam SI,Alzoubi KH,Khabour OF,Nusair MB,Al-Hadidi H,Awidi A,Saleh A

    更新日期:2013-03-01 00:00:00

  • Management of penile fractures.

    abstract:OBJECTIVE:To present our experience with surgical and conservative management of penile fracture. METHODS:This prospective study was carried out in the Urology and Nephrology Center, at Al-Thawra Modern General and Teaching Hospital, Sana'a, Yemen from June 2003 to September 2007, and included 30 patients presenting w...

    journal_title:Saudi medical journal

    pub_type: 杂志文章


    authors: Ghilan AM,Al-Asbahi WA,Ghafour MA,Alwan MA,Al-Khanbashi OM

    更新日期:2008-10-01 00:00:00

  • The retention behavior of ginsenosides in HPLC and its application to quality assessment of Radix Ginseng.

    abstract::This study systematically investigated the retention behavior of seven neutral ginsenosides Rg(1), Re, Rf, Rb(1), Rb(2), Rc, Rd, and an acidic ginsenoside R(0), the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column ...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章,收录出版


    authors: Hu P,Luo GA,Wang Q,Zhao ZZ,Wang W,Jiang ZH

    更新日期:2009-05-01 00:00:00

  • Whole peripheral blood miR-146a and miR-155 expression levels in Systemic lupus erythematosus patients.

    abstract::Objective: To evaluate the diagnostic value of peripheral blood microribonucleic acid (miRNA, miR)-146a and miR-155 expression in systemic lupus erythematosus (SLE). Methods: Expression levels of miR-155 and miR-146a in whole peripheral blood samples from 40 SLE patients and 32 healthy controls (HCs) were determined b...

    journal_title:Acta reumatologica portuguesa

    pub_type: 杂志文章


    authors: Shumnalieva R,Kachakova D,Shoumnalieva-Ivanova V,Miteva P,Kaneva R,Monov S

    更新日期:2018-07-01 00:00:00

  • Development of the Edmonson Psychiatric Fall Risk Assessment Tool.

    abstract::The purpose of this study was to develop a fall risk assessment instrument for the inpatient psychiatric population. Nine risk factors were identified through a review of the literature. The instrument was applied retrospectively to patient records, and the percentage of those who fell who triggered each of the items ...

    journal_title:Journal of psychosocial nursing and mental health services

    pub_type: 杂志文章


    authors: Edmonson D,Robinson S,Hughes L

    更新日期:2011-02-01 00:00:00

  • Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2.

    abstract::Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic act...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Liu R,Zhu T,Li D,Gu J,Xia W,Fang Y,HongbingLiu,Zhu W,Gu Q

    更新日期:2007-03-01 00:00:00

  • Steady-state bioequivalence 2-way crossover study of two quetiapine prolonged-release 400 mg tablet formulations in normal male and female healthy subjects under fasting conditions

    abstract:OBJECTIVE:The purpose of this study was to assess bioequivalence between a generic and a brand quetiapine 400 mg prolonged-release (PR) formulation (Pharmathen S.A.; AstraZeneca Seroquel Prolong®<) in healthy volunteers under steady-state conditions. METHODS:Randomized, open-label, steady-state, 2-way crossover design...

    journal_title:International journal of clinical pharmacology and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Trabelsi F,Gharavi N,Kalovidouris M,Nikolaidou M

    更新日期:2016-09-01 00:00:00

  • The determination of high-risk pregnancy: the use of antenatal scoring system.

    abstract:AIMS:A standardized antenatal scoring system is not available in order to detect high-risk pregnancies at primary health care units in Turkey. The authors aimed to evaluate the applicability of the "Knox scoring system" in Turkey. MATERIALS AND METHODS:One hundred and twenty-nine pregnant women were included in study....

    journal_title:Clinical and experimental obstetrics & gynecology

    pub_type: 杂志文章


    authors: Kuru A,Sogukpinar N,Akman L,Kazandi M

    更新日期:2013-01-01 00:00:00

  • Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics.

    abstract::Intramembrane proteolysis - cleavage of proteins within the plane of a membrane - is a widespread phenomenon that can contribute to the functional activation of substrates and is involved in several diseases. Although different families of intramembrane proteases have been discovered and characterized, we currently do...

    journal_title:Trends in biochemical sciences

    pub_type: 杂志文章,评审


    authors: Langosch D,Scharnagl C,Steiner H,Lemberg MK

    更新日期:2015-06-01 00:00:00

  • Dogs as a diagnostic tool for ill health in humans.

    abstract::Researchers have long reported that dogs and cats improve the physical and psychological health of their human caregivers, and while it is still inconclusive, a substantial amount of research now lends support for the commonly held view that pets are good for us. Recently, studies have directed attention toward explor...

    journal_title:Alternative therapies in health and medicine

    pub_type: 杂志文章,评审


    authors: Wells DL

    更新日期:2012-03-01 00:00:00

  • [Viral agents in patients with infectious processes of the central nervous system].

    abstract::Local statistics report a great number of cases of neurological diseases of unidentified cause. The purpose of this research was to determine the presence of viral agents in patients with affection of the central nervous system, in Zulia State, Venezuela. In different health centers throughout the state, we collected ...

    journal_title:Investigacion clinica

    pub_type: 杂志文章


    authors: Valero N,Henríquez R,Hernández C,Pomeda O,Romero M,Urdaneta F,Atencio R,Larreal Y,Espina LM,Rodríguez Z

    更新日期:2001-12-01 00:00:00

  • Effect of voglibose on the pharmacokinetics of metformin in healthy Korean subjects.

    abstract:OBJECTIVE:The objective of this study was to evaluate the effects of voglibose on the pharmacokinetics of metformin. METHODS:A randomized, open-label, two-way crossover study with a 7-day washout period was conducted. All subjects were given an oral dose of metformin with or without voglibose 3 x daily for 7 days. Pla...

    journal_title:International journal of clinical pharmacology and therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Kim HS,Oh M,Kim EJ,Song GS,Ghim JL,Shon JH,Kim DH,Shin JG

    更新日期:2014-11-01 00:00:00

  • Efficacy of Ketamine in bipolar depression: focus on anhedonia.

    abstract::Bipolar depression (BD) is among the most severe psychiatric disorders. A significant number of patients do not achieve an entirely symptom-free state and experience residual sub-syndromal depression. Most of the treatment options approved for bipolar depression give no rapid symptom improvement. Ketamine is an anaest...

    journal_title:Psychiatria Danubina

    pub_type: 杂志文章,评审


    authors: Gałuszko-Węgielnik M,Wiglusz MS,Słupski J,Szałach Ł,Włodarczk A,Górska N,Szarmach J,Jakuszkowiak-Wojten K,Wilkowska A,Cubała WJ

    更新日期:2019-09-01 00:00:00

  • Pharmacological options in resistent ovary syndrome and premature ovarian failure.

    abstract:PURPOSE:To present methods of treating women in apparent ovarian failure to allow them to ovulate and conceive. METHODS:Ethinyl estradiol was used to lower elevated serum follicle stimulating hormone (FSH) levels to restore down-regulated FSH receptors on the follicle. Ovulation and pregnancy rates were then determine...

    journal_title:Clinical and experimental obstetrics & gynecology

    pub_type: 社论,评审


    authors: Check JH

    更新日期:2006-01-01 00:00:00

  • [Thyroid hemiagenesis. Report of 3 cases and review of the literature].

    abstract::The absence of one lobe of the thyroid gland is named thyroid hemiagenesis, the left is affected more frequently (80 percent), in the 50 percent is associate with isthmus agenesis. Predominant in the women, with relation 3:1, the oppose lobe may be of big size and in the 38-47 percent have alteration in the function, ...

    journal_title:Gaceta medica de Mexico

    pub_type: 杂志文章,评审


    authors: Vázquez-Chávez C,Acevedo-Rivera K,Sartorius C,Espinosa-Said L

    更新日期:1989-11-01 00:00:00

  • An extended three-stage treatment to correct a severe skeletal and dental discrepancy.

    abstract::A report of a case of extended treatment of a patient with severe mandibular retrognathism and an Angle Class II division 1 malocclusion. Initial fixed appliance treatment reduced incisor protrusion. A second phase utilising a Teuscher appliance achieved improved facial and dental relations through excellent mandibula...

    journal_title:Australian orthodontic journal

    pub_type: 杂志文章


    authors: Moore GJ

    更新日期:1999-11-01 00:00:00

  • Physiological and pathological levels of prostaglandin E2 in renal parenchyma and neoplastic renal tissue.

    abstract::Prostaglandin (PG)E2 seems to promote tumor proliferation by regulating cell growth, inhibiting apoptosis, promoting angiogenesis, and suppressing host immune surveillance of cancer cells. The suppression of prostaglandins biosynthesis is thought to be the main molecular mechanism for non-steroidal anti-inflammatory d...

    journal_title:Prostaglandins & other lipid mediators

    pub_type: 杂志文章


    authors: Verratti V,Brunetti L,Ferrante C,Orlando G,Recinella L,Chiavaroli A,Leone S,Wang R,Berardinelli F

    更新日期:2019-04-01 00:00:00

  • Synergistic effect of buthionine sulfoximine on the chlorin e6-based photodynamic treatment of cancer cells.

    abstract::In this study, we investigated the synergistic effect of L-buthionine sulfoximine (BSO) on the chlorin e6 (Ce6)-based photodynamic therapy (PDT) of cancer cells. Among various cancer cells, HCT116 cells have highest intracellular L-glutathione (GSH) level and SNU478 cells showed the lowest GSH level. BSO alone showed ...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Lee HM,Kim DH,Lee HL,Cha B,Kang DH,Jeong YI

    更新日期:2019-11-01 00:00:00

  • A survey of wound care provision within one English health care district.

    abstract::Wound healing remains a largely overlooked area despite the perceived large numbers of people with wounds and the high costs of treatment. The lack of visibility for wounds and wound healing may in part stem from the fragmented nature of the available data on wound occurrence often limited to descriptions of specific ...

    journal_title:Journal of tissue viability

    pub_type: 杂志文章,多中心研究


    authors: Vowden KR,Vowden P

    更新日期:2009-02-01 00:00:00