Effect of food on the pharmacokinetics of YH439 and its metabolites in rats.

Abstract:

:The pharmacokinetics of YH439 and its metabolites were investigated after oral administration of YH439 to rats to investigate the food effect. After oral administration of YH439, its metabolites, M4 and M5 were detected in plasma. YH439 was not detected in the plasma for both fasted and fed rats for all doses studied. The pharmacokinetic parameters of the metabolites were not affected by food at all doses studied. The results of this study indicated that there are no significant food effects on the pharmacokinetics of YH439 and its metabolites in rats.

journal_name

Arch Pharm Res

authors

Kim MK,Ahn BN,Yoo JK,Lee JW

doi

10.1007/BF02975222

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

629-32

issue

6

eissn

0253-6269

journal_volume

20

pub_type

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