Initiation of lipid peroxidation in submitochondrial particles: effect of respiratory inhibitors.

Abstract:

:Initiation of lipid peroxidation in the inner mitochondrial membrane was investigated using respiratory substrates and inhibitors and various iron chelates. An iron chelate was required for initiation of lipid peroxidation in the presence of either NADH or NADPH. The two nicotinamide nucleotides exhibited different activities in initiating lipid peroxidation with regard to concentration and to the effects of rotenone and rhein. Succinate and both nicotinamide nucleotides supported lipid peroxidation in the presence of thenoyl trifluoroacetone (TTFA), without a requirement for exogenously added iron. ADP stimulated lipid peroxidation in the case of NAD(P)H and TTFA, but inhibited it in the case of succinate and TTFA. Lipid peroxidation is thought to be enzymatically induced in both the NADH and the succinate dehydrogenase regions of the respiratory chain, and evidence is presented for a novel pathway of NADPH oxidation that may also be involved. Possible initiation mechanisms are discussed.

journal_name

Arch Biochem Biophys

authors

Glinn M,Ernster L,Lee CP

doi

10.1016/0003-9861(91)90591-6

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

57-65

issue

1

eissn

0003-9861

issn

1096-0384

pii

0003-9861(91)90591-6

journal_volume

290

pub_type

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