Ceratitis capitata brain adenylate cyclase and its membrane environment.

Abstract:

:Adenylate cyclase activation by GTP and octopamine as well as basal activity (in the presence of Mg2+) have been studied as a function of membrane structure in plasma membranes from brain of the dipterous Ceratitis capitata. Benzyl alcohol and lidocaine, but not phenobarbital, inhibited the three activities to the same extent. Triton X-100-solubilized adenylate cyclase was also inhibited by benzyl alcohol and lidocaine, but not by phenobarbital. Results could be explained by an effect on the catalytic unit lipid environment, which would be maintained after solubilization, counteracting the effect of these drugs to facilitate lateral diffusion and coupling of adenylate cyclase components in the lipid bilayer. The observation that the insect adenylate cyclase is relatively insensitive to changes in bulk bilayer fluidity is strengthened by the absence of effect of phenobarbital on enzyme activities. Indeed, this compound was as active as lidocaine or benzyl alcohol in increasing bulk membrane fluidity. The response of C. capitata adenylate cyclase to changes in membrane fluidity is different from that recorded in mammalian systems. This may be functionally important and result from the fact that insects are not warm-blooded.

journal_name

Arch Biochem Biophys

authors

Guillen A,Haro A,Gavilanes FG,Municio AM

doi

10.1016/0003-9861(91)90085-w

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

591-5

issue

2

eissn

0003-9861

issn

1096-0384

pii

0003-9861(91)90085-W

journal_volume

286

pub_type

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