Allogeneic or haploidentical HSCT for refractory or relapsed solid tumors in children: toward a neuroblastoma model.

Abstract:

:New concepts of allogeneic hematopoietic SCT (allo-HSCT) for neuroblastoma and other solid tumors do not rely on escalation of chemotherapy intensity and tumor load reduction but rather on a graft-vs-tumor effect. At this point, this is still an investigational and unusual application of allogeneic transplant, with 78 neuroblastoma patients reported to the European Group for Blood and Marrow Transplantation activity survey from 2002 to 2007 and less than 100 published cases. Two trends can be observed in the reviewed data: some teams have used allo-HSCT in children with refractory or progressive disease and significant tumor burden and other teams in children with CR, PR or minimal residual disease earlier in their disease process. Early studies of allo-HSCT in children with high-risk neuroblastoma suggest that this is a feasible approach that may improve outcome in this deadly disease. However, the proper timing for allo-HSCT during the disease course remains to be determined.

journal_name

Bone Marrow Transplant

authors

Kanold J,Paillard C,Tchirkov A,Merlin E,Marabelle A,Lutz P,Rousseau R,Baldomero H,Deméocq F

doi

10.1038/bmt.2008.279

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

S25-30

eissn

0268-3369

issn

1476-5365

pii

bmt2008279

journal_volume

42 Suppl 2

pub_type

杂志文章,评审
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    doi:

    authors: Mehta J,Powles R,Horton C,Milan S,Singhal S,Treleaven J

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    authors: Grigg A,Gibson R,Bardy P,Szer J

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    更新日期:2008-12-01 00:00:00

  • Significant reduction of cytomegalovirus (CMV) disease by prophylaxis with CMV hyperimmune globulin plus oral acyclovir.

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    pub_type: 杂志文章

    doi:

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    pub_type: 临床试验,杂志文章

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  • Flow-cytometric immunophenotyping of acute leukaemia.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:

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  • Comparison of hemorrhagic and ischemic stroke after allogeneic hematopoietic stem cell transplantation.

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    doi:

    authors: Canpolat C,Culbert S,Gardner M,Whimbey E,Tarrand J,Chan KW

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  • A novel reduced-intensity umbilical cord blood transplantation using a recombinant G-CSF combined with high-dose Ara-C for active myeloid malignancies.

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    journal_title:Bone marrow transplantation

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    doi:10.1038/bmt.2014.66

    authors: Gotoh M,Yoshizawa S,Katagiri S,Suguro T,Asano M,Kitahara T,Akahane D,Okabe S,Tauchi T,Ito Y,Ohyashiki K

    更新日期:2014-07-01 00:00:00

  • Mobilization of peripheral blood progenitor cells by high-dose Ara C, VP-16 and recombinant human granulocyte colony-stimulating factor: factors affecting progenitor cell yields.

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    journal_title:Bone marrow transplantation

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    doi:

    authors: Shimazaki C,Yamagata N,Tatsumi T,Hirata T,Oku N,Ashihara E,Goto H,Inaba T,Fujita N,Haruyama H

    更新日期:1995-05-01 00:00:00

  • Clonal cytogenetic changes and myeloma relapse after reduced intensity conditioning allogeneic transplantation.

    abstract::To identify a correlation between metaphase cytogenetics and relapse after reduced intensity conditioning (RIC) allotransplant for patients with multiple myeloma, data on 60 patients (median age 52) who received grafts from a sibling (n = 49) or unrelated donor (n = 11) were analyzed. Fifty-three patients (88%) showed...

    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1705267

    authors: Lee CK,Zangari M,Fassas A,Thertulien R,Talamo G,Badros A,Cottler-Fox M,van Rhee F,Barlogie B,Tricot G

    更新日期:2006-03-01 00:00:00