Immunological studies on the antitumor components of the basidiocarps ofAgrocybe cylindracea.


:The effects of cylindan, a polysaccharide isolated from the basidiocarps ofAgrocybe cylindracea, on murine sarcoma 180 tumor and murine immune cells were examined after intraperitoneal administration. Cylindan exhibited a marked life extension effect in mice against ascite forms of sarcoma 180 and Lewis lung carcinoma at a dose of 50 mg/kg/day, although it did not show any direct cytotoxicity against sarcoma 180, X5563, and MM46 murine tumor cells. Cylindan increased numbers of bone marrow stem cells as well as peritoneal exudate cells in flow cytometry using monoclonal antibodies. The tumor bearing mice group apparently showed the increase of macrophages and cytotoxic T lymphocytes in mouse spleen cells during the early stage of tumor growth. But during the later stage, the control group decreased immune cells and cylindan restored the decreased immune cells in the tumor bearing mice to the normal level. In non-specific immune response, cylindan stimulated the bacterial phagocytosis and acid phosphatase production in macrophages. It also activated components of the alternative complement pathway and natural killer activity against YAC-1 lymphoma. In humoral immunity, cylindan had a mitogenic effect against splenocytes and increased the number of plasma cells as token of stimulation of the differentiation of B lymphocytes. In cellular immunity, cylindan restored the depressed response of delayed type hypersensitivity in the tumor bearing mice to 60% of the normal level and increased the interleukin-2 (IL-2) responsiveness in the IL-2 dependent CTLL-2 cells. These results suggest that cylindan did not show direct cytotoxic effects on tumor cells but restored the decreased immune response of the tumor bearing mice.


Arch Pharm Res


Kim BK,Hyun JW,Yoon JM,Choi EC




Has Abstract


1997-04-01 00:00:00










  • [Spontaneous right primary iliac arteriovenous fistula and an unrecognized aorto-caval fistula located above an aneurysm].

    abstract::A patient admitted for treatment of an aorto-iliac aneurism presented himself with swelling of the lower extremities and a low grade bruit over the abdomen continuous throughout systole and diastole. Aortography demonstrated the presence of a suspected ilio-caval fistula. Surgical treatment consisted of closure of the...

    journal_title:Acta chirurgica Belgica

    pub_type: 杂志文章


    authors: Van de Berg L,Jambor GY,Delhez JM

    更新日期:1979-07-01 00:00:00

  • Clinical significance of serum and urinary neopterins in patients with chronic renal disease.

    abstract::To determine the clinical significance of serum and urinary neopterins in patients with chronic renal disease, we measured these values using IMMUtest Neopterin RIA kits. Serum neopterin levels in patients with chronic glomerulonephritis (CGN) (10.2 +/- 8.1 nmol/l) and in those with chronic renal failure (CRF) (109 +/...

    journal_title:Clinical nephrology

    pub_type: 杂志文章


    authors: Godai K,Uemasu J,Kawasaki H

    更新日期:1991-09-01 00:00:00

  • New surgical techniques and informed consent--safety first.

    abstract::Surgical techniques always imply uncertainty about risks and outcome. Many law systems explicitly recognise the patient's right with respect to informed decision-making. This right refers to information about the risks and benefits, the experience of the surgeon, and the performance of the surgical team. In practice, ...

    journal_title:Acta chirurgica Belgica

    pub_type: 杂志文章


    authors: de Mol BA

    更新日期:2000-07-01 00:00:00

  • [Amebiasis: implications of the recognition of Entamoeba dispar and the identification of Entamoeba moshkovskii in humans].

    abstract::The history of Entamoeba histolytica is very confuse and shows several wrong concepts about the parasite and its relationship with the host. The poor correlation between the prevalence of asymptomatic and symptomatic amebiasis originated the proposal of three explicative hypothesis, among them was the concept of Brump...

    journal_title:Investigacion clinica

    pub_type: 历史文章,杂志文章


    authors: Chacín-Bonilla L

    更新日期:2010-06-01 00:00:00

  • Human cytomegalovirus salivary antibodies as related to stress.

    abstract::Human cytomegalovirus (HCMV) is prevalent in 50-80% of the population worldwide. After primary infection it remains in a latent state until reactivation. Stressful events induce the release of corticosteroids which activate HCMV. The effect of examination stress on HCMV reactivation among first year female students wa...

    journal_title:Clinical laboratory

    pub_type: 杂志文章


    authors: Sarid O,Anson O,Yaari A,Margalith M

    更新日期:2002-01-01 00:00:00

  • A clinical study on SSP (silver spike point) electro-therapy combined with splint therapy for temporo-mandibular joint dysfunction.

    abstract::When the functional limits of the muscles related to the temporo-mandibular joint and adjacent tissue exceed their anatomical capability, pain, crepitation, and functional abnormality appear as the main complaints. Although the precise nature of the condition is unknown, pain at the temporo-mandibular joint sometimes ...

    journal_title:Acupuncture & electro-therapeutics research

    pub_type: 杂志文章


    authors: Sugimoto K,Konda T,Shimahara M,Hyodo M,Kitade T

    更新日期:1995-01-01 00:00:00

  • SEM and profilometric evaluation of enamel surface after air rotor stripping--an in vitro study.

    abstract::The aim of the study was to evaluate roughness of the enamel surface after Air Rotor Stripping (ARS). Thirty interproximal surfaces of human premolars were used as the biological material. Research was conducted using a contact profilometer and a scanning electron microscope (SEM). Sets of 3D parameters and topographi...

    journal_title:Acta of bioengineering and biomechanics

    pub_type: 杂志文章


    authors: Mikulewicz M,Szymkowski J,Matthews-Brzozowska T

    更新日期:2007-01-01 00:00:00

  • Nutrition and health literacy: a systematic review to inform nutrition research and practice.

    abstract::Health literacy is defined as the degree to which individuals obtain, process, and understand basic health information and services to make informed health decisions. Health literacy is a stronger predictor of health than age, income, employment, education, and race. Although the field has grown during the past decade...

    journal_title:Journal of the Academy of Nutrition and Dietetics

    pub_type: 杂志文章,评审


    authors: Carbone ET,Zoellner JM

    更新日期:2012-02-01 00:00:00

  • Clinical breast examination of asymptomatic women - attitudes and clinical practice.

    abstract:BACKGROUND:Well woman health checks are offered in general practice and may include breast examination. METHODS:The authors explored the attitudes of general practitioners toward clinical breast examination as a screening test in asymptomatic women. Twenty-seven GPs were interviewed about their current practice and op...

    journal_title:Australian family physician

    pub_type: 杂志文章


    authors: Thistlethwaite J,Stewart R,Evans R

    更新日期:2008-05-01 00:00:00

  • Cancer stem-like cells directly participate in vasculogenic mimicry channels in triple-negative breast cancer.

    abstract:Objective:Vasculogenic mimicry (VM) channels that are lined by tumor cells are a functional blood supply in malignant tumors. However, the role of VM-initiating cells remains poorly understood. Cancer stem-like cells (CSCs) are positively correlated with VM. In this study, triple-negative breast cancer (TNBC) enriched ...

    journal_title:Cancer biology & medicine

    pub_type: 杂志文章


    authors: Sun H,Yao N,Cheng S,Li L,Liu S,Yang Z,Shang G,Zhang D,Yao Z

    更新日期:2019-05-01 00:00:00

  • [Primary angiosarcoma of the male breast].

    abstract::We report an exceptional case of primary breast angiosarcoma in a 58-year-old man. This is a very rare breast tumor (0.04% of breast tumors) which may be difficult to diagnose. Treatment is now standardized: radical mastectomy associated with adjuvant chemotherapy for grade III or poorly differentiated tumors. Prognos...

    journal_title:Annales de pathologie

    pub_type: 杂志文章


    authors: Granier G,Lemoine MC,Mares P,Pignodel C,Marty-Double C

    更新日期:2005-06-01 00:00:00

  • Gallyas- and tau-positive glial structures in motor neuron disease with dementia.

    abstract::We have studied Gallyas- and tau-positive glial structures in three autopsied cases of motor neuron disease with dementia (MND-D). Gallyas-positive, tau-immunoreactive thread-like structures in the neuropil and crescent/coiled inclusions in the glial cells were mainly observed in the hippocampus, parahippocampal gyrus...

    journal_title:Clinical neuropathology

    pub_type: 杂志文章


    authors: Noda K,Katayama S,Watanabe C,Yamamura Y,Nakamura S

    更新日期:1999-09-01 00:00:00

  • Tumour cell toxicity for the targets of natural killer cells.

    abstract::Cells of intraperitoneally transplanted murine leukaemias and sarcomas (L-1210, EL-4, MC-11 and SA-1), were found to be toxic for target cells usually employed for assaying NK cells (K-562, EL-4, YAC-1). The 3H-uridine-ribonuclease method used in our study, in contrast to the 51Cr assay, revealed not only cytotoxicity...

    journal_title:Folia biologica

    pub_type: 杂志文章


    authors: Fuchs BB,Sterlina AG,Spirande IV,Zedginidze MS,Kogarko YN

    更新日期:1983-01-01 00:00:00

  • Primary extradural spinal ganglioneuroblastoma: a case report.

    abstract::We report a case of ganglioneuroblastoma of the spinal cord in a 25-year-old man. Clinical history was short with paraparesis and bladder involvement. The MRI picture was that of an extradural solid tumor with extension to both intervertebral foramina, more suggestive of nerve sheath tumour rather than malignant embry...

    journal_title:Turkish neurosurgery

    pub_type: 杂志文章


    authors: Patnaik A,Mishra SS,Mishra S,DAS S,Deo RC

    更新日期:2014-01-01 00:00:00

  • [Reflections in our 55th anniversary].

    abstract::Investigación Clínica has been published uninterruptedly for 55 years and for this reason, the University of Zulia has recognized the work of its editorial team with the imposition of the Order "Jesus Enrique Lossada". Despite some financial and structural problems we are optimistic because our journal has been includ...

    journal_title:Investigacion clinica

    pub_type: 社论,历史文章


    authors: Ryder E

    更新日期:2015-03-01 00:00:00

  • Clinical observation of ropivacaine compuled with sufentanil for painless childbirth.

    abstract::This study aimed to explore the effect of ropivacaine combined with sufentanil on maternal lactation and infant, which were used by different anesthesia method for painless childbirth. 284 cases of voluntary acceptance of painless childbirth pregnant were involved in this study and divided into control group and obser...

    journal_title:Pakistan journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: He ZY,Jiao QL,Miao Y,Sun Y

    更新日期:2016-03-01 00:00:00

  • HPLC determination of malondialdehyde in ECV304 cell culture medium for measuring the antioxidant effect of vitexin-4''-O-glucoside.

    abstract::To investigate the antioxidant effect of vitexin-4''-O-glucoside, a flavone glycoside, isolated from the leaves of Crataegus pinnatifida Bge. var. major, we developed a simple and sensitive high-performance liquid chromatography (HPLC) method to determine levels of malondialdehyde (MDA) in ECV304 cell culture medium a...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Ying XX,Li HB,Chu ZY,Zhai YJ,Leng AJ,Liu X,Xin C,Zhang WJ,Kang TG

    更新日期:2008-07-01 00:00:00

  • Oxidative stress in schizophrenia - focusing on the main markers.

    abstract::Oxidative stress is the condition arising from imbalance between toxic reactive oxygen species and antioxidant systems. It is believed that increased oxidative stress may be relevant to the pathophysiology of schizophrenia. In this way, the main markers of the lipid peroxidation processes include 4-hydroxynonenal and ...

    journal_title:Psychiatria Danubina

    pub_type: 杂志文章,评审


    authors: Ciobica A,Padurariu M,Dobrin I,Stefanescu C,Dobrin R

    更新日期:2011-09-01 00:00:00

  • From the journals.

    abstract::Donor site healing under alginate and porcine xenografts Assessing varicose veins Regulating tumour necrosis factor-α production The uses of video image analysis Pressure sores and nutrition. ...

    journal_title:Journal of wound care

    pub_type: 杂志文章


    authors: Lawrence JC,Whiston RJ,Roberts GP,Melhuish JM,Banks V

    更新日期:1992-07-02 00:00:00

  • [Affective disorders in the child].

    abstract::The existence of a depressive syndrome in childhood has been ignored or minimized until recently. In Geneva, a transversal study of the consulting population has confirmed the presence of a depressive syndrome, taking different clinical forms. It has also allowed us to describe an hypomaniac syndrome in children. An e...

    journal_title:Annales medico-psychologiques

    pub_type: 杂志文章,评审


    authors: Manzano J

    更新日期:1993-05-01 00:00:00

  • Anti-hyperalgesic and anti-inflammatory effects of ketorolac tromethamine gel using pulsed ultrasound in inflamed rats.

    abstract::The aim of this study was to determine if a ketorolac tromethamine (KT) gel solution could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic and anti-inflammatory effects in a rat carrageenan inflammation model. 1% carrageenan was injected into th...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Yang JH,Kim TY,Lee JH,Yoon SW,Yang KH,Shin SC

    更新日期:2008-04-01 00:00:00

  • Laparoscopic ventral hernia repair using a composite mesh with polypropylene and expanded polytetrafluoroethylene: a prospective, multicentre registry.

    abstract:BACKGROUND:Abdominal wall hernias are a common problem. Composite meshes placed intraperitoneally for abdominal wall hernia repair are widely used. This registry evaluated the safety and efficacy of one specific composite mesh with polypropylene and expanded polytetrafluoroethylene (Intramesh® T1) in laparoscopic ventr...

    journal_title:Acta chirurgica Belgica

    pub_type: 杂志文章,多中心研究


    authors: Wen W,Majerus B,Van De Moortel M,Lobue S,Fobe D,Philippart P,Berwouts L,Coteur J,Gabriels K,Van der Speeten K

    更新日期:2017-10-01 00:00:00

  • Epigenetic regulation on gene expression induced by physical exercise.

    abstract::It is well established that physical exercise modulates the function of many physiological systems, such as the musculoskeletal, the cardiovascular and the nervous system, by inducing various adaptations to the increased mechanical load and/or metabolic stress of exercise. Many of these changes occur through epigeneti...

    journal_title:Journal of musculoskeletal & neuronal interactions

    pub_type: 杂志文章,评审


    authors: Ntanasis-Stathopoulos J,Tzanninis JG,Philippou A,Koutsilieris M

    更新日期:2013-06-01 00:00:00

  • Lack of pubertal influences on female dispersal in muriqui monkeys, Brachyteles arachnoides.

    abstract::The hormonal mediation of dispersal in female mammals is poorly understood, in part because of the difficulties of detecting the onset of ovarian cycling and puberty in dispersing individuals. We used noninvasive methods of faecal steroid assays to determine the timing of dispersal relative to puberty and ovarian cycl...

    journal_title:Animal behaviour

    pub_type: 杂志文章


    authors: Strier KB,Ziegler TE

    更新日期:2000-04-01 00:00:00

  • Off-pump coronary artery grafting in patients necessitating multiple distal anastomoses.

    abstract:OBJECTIVES:Off-pump surgery has become a valuable alternative if a small number of distal anastomoses is required. The aim of the present study was to test the hypothesis that outcome is not altered in multiple distal anastomoses. MATERIAL AND METHODS:During a 4 year period, 350 patients were operated off-pump. 187 pa...

    journal_title:Acta chirurgica Belgica

    pub_type: 杂志文章


    authors: Remes J,Goldstein JP,Vandenplas G,Verleyen P,Deuvaert FE

    更新日期:2007-11-01 00:00:00

  • Functions of IL-4 and Control of Its Expression.

    abstract::IL-4 has been called the "prototypic immunoregulatory cytokine." Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审


    authors: Brown MA,Hural J

    更新日期:2017-01-01 00:00:00

  • Protective effect of baicalin against multiple ultraviolet B exposure-mediated injuries in C57BL/6 mouse skin.

    abstract::Multiple exposures to solar ultraviolet (UV) radiation cause critical damage to skin that may lead to the development of several cutaneous disorders including skin cancer. Protection against sun-induced damage is therefore a highly desirable goal. Chemoprevention via plant-based agents may be a useful approach for the...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Zhou BR,Liu WL,Luo D

    更新日期:2011-02-01 00:00:00

  • Evaluating the design of a family practice healthcare clinic using discrete-event simulation.

    abstract::With increased pressures from governmental and insurance agencies, today's physician devotes less time to patient care and more time to administration. To assist physician clinics in evaluating potential operating procedures that improve operating efficiencies and better satisfy patients, an object-oriented discrete-e...

    journal_title:Health care management science

    pub_type: 杂志文章


    authors: Swisher JR,Jacobson SH

    更新日期:2002-04-01 00:00:00

  • Group 2 innate lymphoid cells exhibit progressively higher levels of activation during worsening of liver fibrosis.

    abstract:INTRODUCTION:The interleukin-33/interleukin-13 pathway is involved in the immunopathology of liver fibrosis and recently characterized group 2 innate lymphoid cells (ILC2) were identified as profibrotic immune cells in the liver of mouse models. Our aim was to elucidate whether ILC2 might be present in human liver tiss...

    journal_title:Annals of hepatology

    pub_type: 杂志文章


    authors: Gonzalez-Polo V,Pucci-Molineris M,Cervera V,Gambaro S,Yantorno SE,Descalzi V,Tiribelli C,Gondolesi GE,Meier D

    更新日期:2019-01-01 00:00:00

  • Human pulpal response to direct pulp capping with an adhesive system.

    abstract:PURPOSE:To evaluate clinically and microscopically the human pulp response when directly capped with an adhesive system or calcium hydroxide over short (9-12 days) and long (53-204 days) experimental periods. MATERIALS AND METHODS:Fifty-one sound human premolars scheduled for orthodontic extraction, had their pulp hor...

    journal_title:American journal of dentistry

    pub_type: 临床试验,杂志文章


    authors: Pereira JC,Segala AD,Costa CA

    更新日期:2000-06-01 00:00:00