The influence of breast cancer treatment on the occurrence of hot flashes.


:Approximately 65% of women report hot flashes (HFs) during or following breast cancer treatment. However, few studies have compared the occurrence of vasomotor symptoms according to the type of adjuvant treatment received, and little is known about other risk factors for HFs among this population. This longitudinal study aimed to: 1) compare the frequency and severity of HFs in breast cancer patients according to treatment regimen; 2) evaluate the potential contribution of hormone therapy on the frequency and severity of HFs; and 3) identify other potential risk factors for HFs in breast cancer patients. Forty-one women receiving radiation therapy and chemotherapy and 40 women receiving radiation therapy without chemotherapy completed a daily diary of HFs for seven days, and the vasomotor scale of the Menopause-Specific Quality of Life Questionnaire prior to and following each type of treatment, and at a three-month follow-up evaluation. Z-scores and percentiles computed from an age-matched control group (n=45) without a history of cancer revealed a higher frequency and severity of HFs among breast cancer patients compared with control participants. Chemotherapy and hormone therapy were both associated with increased HFs. Past use of hormone replacement therapy (HRT) and a lower body mass index (BMI) were significantly associated with more severe vasomotor symptoms. This study highlights the clinical significance of HFs among breast cancer patients, particularly in women receiving chemotherapy and hormone therapy, and the necessity to offer effective therapeutic strategies to relieve HFs in this population.


J Pain Symptom Manage


Savard MH,Savard J,Quesnel C,Ivers H




Has Abstract


2009-04-01 00:00:00














  • Multidimensional problems among advanced cancer patients in Cuba: awareness of diagnosis is associated with better patient status.

    abstract::Cancer is one of the major causes of death in Cuba, and in current practice, patients are not usually informed of their diagnosis. Palliative care is an emerging discipline in this country. Cuban cancer patients with advanced disease completed the Palliative Outcome Scale (POS), and the researcher elicited patients' k...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Justo Roll I,Simms V,Harding R

    更新日期:2009-03-01 00:00:00

  • A randomized, double-blind, multi-site, crossover, placebo-controlled equivalence study of morning versus evening once-daily sustained-release morphine sulfate in people with pain from advanced cancer.

    abstract::Diurnal variation in pain perception is recognized. The question of whether opioid prescribing should be adjusted to account for diurnal variation can be tested with the advent of once-daily sustained-release morphine. The study recruited 45 people with opioid-responsive pain on stable doses of analgesics and advanced...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Currow DC,Plummer JL,Cooney NJ,Gorman D,Glare PA

    更新日期:2007-07-01 00:00:00

  • Determining Palliative Care Penetration Rates in the Acute Care Setting.

    abstract:CONTEXT:Intermountain Healthcare, in collaboration with Cerner Corporation, developed a hospital-based electronic palliative care algorithm. OBJECTIVES:This study aims to improve identification of patients who would benefit from palliative care services, and calculate palliative care penetration rates. METHODS:This s...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Gruhler H,Krutka A,Luetke-Stahlman H,Gardner E

    更新日期:2018-02-01 00:00:00

  • Patient autonomy problems in palliative care: systematic development and evaluation of a questionnaire.

    abstract::No instrument to assess autonomy problems in palliative care is currently available. The purpose of this study was to develop a comprehensive and concise questionnaire to measure autonomy problems in palliative cancer patients and to study its validity and reliability. We systematically developed a questionnaire throu...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Vernooij-Dassen MJ,Osse BH,Schadé E,Grol RP

    更新日期:2005-09-01 00:00:00

  • Meaninglessness in terminally ill cancer patients: a validation study and nurse education intervention trial.

    abstract::Recent empirical studies revealed that fostering patients' perception of meaning in their life is an essential task for palliative care clinicians. However, few studies have reported the effects of training programs for nurses specifically aimed at improving skills to relieve the meaninglessness of terminally ill canc...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Morita T,Murata H,Hirai K,Tamura K,Kataoka J,Ohnishi H,Akizuki N,Kurihara Y,Akechi T,Uchitomi Y,Japanese Spiritual Care Task Force.

    更新日期:2007-08-01 00:00:00

  • Palliative sedation: a review of the research literature.

    abstract::The overall aim of this paper is to systematically review the following important aspects of palliative sedation: prevalence, indications, survival, medication, food and fluid intake, decision making, attitudes of physicians, family experiences, and efficacy and safety. A thorough search of different databases was con...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Claessens P,Menten J,Schotsmans P,Broeckaert B

    更新日期:2008-09-01 00:00:00

  • Integrating palliative care into national policies.

    abstract::Good policies lay the groundwork for an effective health care system and society. They facilitate the implementation of palliative care programs aimed at providing care for all people in need of these services, and they ensure equitable access to affordable medications and therapies. The lack of good policies can lead...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Stjernswärd J,Foley KM,Ferris FD

    更新日期:2007-05-01 00:00:00

  • Symptom experience in Korean patients with liver cirrhosis.

    abstract::This study was done to examine the level of symptom experience, and symptom variation in relation to demographic and clinical variables, in Korean patients with liver cirrhosis (LC). Symptom experience was measured using a scale developed by the researchers through a literature review on LC. Participants were 129 pati...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Kim SH,Oh EG,Lee WH,Kim OS,Han KH

    更新日期:2006-04-01 00:00:00

  • Tools for assessment of pain in nonverbal older adults with dementia: a state-of-the-science review.

    abstract::To improve assessment and management of pain in nonverbal older adults with dementia, an effective means of recognizing and evaluating pain in this vulnerable population is needed. The purpose of this review is to critically evaluate the existing tools used for pain assessment in this population to provide recommendat...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Herr K,Bjoro K,Decker S

    更新日期:2006-02-01 00:00:00

  • Olanzapine for the prevention of chemotherapy-induced nausea and vomiting in patients receiving highly or moderately emetogenic chemotherapy: a randomized, double-blind, placebo-controlled study.

    abstract:CONTEXT:Chemotherapy-induced nausea and vomiting (CINV) can severely impair patients' quality of life (QOL). Psychotropics, especially olanzapine, have a strong antiemetic effect. OBJECTIVES:To determine whether olanzapine could reduce the frequency of CINV and improve patients' QOL during chemotherapy. METHODS:This ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Mizukami N,Yamauchi M,Koike K,Watanabe A,Ichihara K,Masumori N,Yamakage M

    更新日期:2014-03-01 00:00:00

  • Oral ketamine as an adjuvant to oral morphine for neuropathic pain in cancer patients.

    abstract::To evaluate the role of oral ketamine as an adjuvant to oral morphine in cancer patients experiencing neuropathic pain, 9 cancer patients (5 men, 4 women) taking maximally tolerated doses of either morphine, amitriptyline, sodium valproate, or a combination of these drugs for intractable neuropathic pain, and reportin...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章


    authors: Kannan TR,Saxena A,Bhatnagar S,Barry A

    更新日期:2002-01-01 00:00:00

  • Triaging the Terminally Ill-Development of the Responding to Urgency of Need in Palliative Care (RUN-PC) Triage Tool.

    abstract:CONTEXT:Evidence-based resource allocation is receiving increasing attention as we strive for equity, transparency, and cost-effectiveness across health care. In the context of finite resources, which of our patients with terminal illness should be prioritized for urgent palliative care? OBJECTIVES:To develop the scor...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Russell B,Vogrin S,Philip J,Hennessy-Anderson N,Collins A,Burchell J,Le B,Brand C,Hudson P,Sundararajan V

    更新日期:2020-01-01 00:00:00

  • Fatigue During and After Breast Cancer Therapy-A Prospective Study.

    abstract:CONTEXT:Chronic fatigue (CF) in breast cancer (BC) survivors is multifactorial and may be caused by immune activation triggered by BC or its treatment. In the Neoadjuvant Avastin in Breast Cancer study, BC patients received neoadjuvant chemotherapy (FEC100→taxane) ± bevacizumab, a monoclonal antibody with fatigue as a ...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Reinertsen KV,Engebraaten O,Loge JH,Cvancarova M,Naume B,Wist E,Edvardsen H,Wille E,Bjøro T,Kiserud CE

    更新日期:2017-03-01 00:00:00

  • Ondansetron in multiple sclerosis.

    abstract::Two young women with chronic nausea and vertigo caused by multiple sclerosis responded to the introduction and maintenance of the 5HT3 receptor antagonist, ondansetron. Palliative care is a neglected aspect of management of degenerative neurological diseases and these cases highlight the approaches that may be used to...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Macleod AD

    更新日期:2000-11-01 00:00:00

  • A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patients.

    abstract::The European Association for Palliative Care guidelines for treatment of cancer pain recommend a double dose (DD) of immediate-release morphine at bedtime instead of single doses (SD) repeated every four hours throughout the night. A previous open controlled study reported more side effects after DD than after SD. The...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,随机对照试验


    authors: Dale O,Piribauer M,Kaasa S,Moksnes K,Knobel H,Klepstad P

    更新日期:2009-01-01 00:00:00

  • Integrating Supportive Care Principles Into Dialysis Decision Making: A Primer for Palliative Medicine Providers.

    abstract::Despite advances in predialysis care and dialysis technology, patients with advanced chronic kidney disease and end-stage renal disease continue to experience multiple comorbidities, a high symptom burden, a shortened life expectancy, and substantial physical, emotional, and spiritual suffering. Patients with acute ki...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Moss AH

    更新日期:2017-03-01 00:00:00

  • A survey of joint and muscle aches, pain, and stiffness comparing women with and without breast cancer.

    abstract:CONTEXT:Joint and muscle aches, pain, and stiffness have been reported to be a problem for some women after adjuvant breast cancer treatment; however, the extent and impact of this problem are unknown. OBJECTIVES:The purpose of this study was to determine the prevalence of this problem in comparison with women of a si...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Fenlon D,Addington-Hall JM,O'Callaghan AC,Clough J,Nicholls P,Simmonds P

    更新日期:2013-10-01 00:00:00

  • An Analysis of Palliative Care Development in Africa: A Ranking Based on Region-Specific Macroindicators.

    abstract:CONTEXT:To date, there is no study comparing palliative care (PC) development among African countries. OBJECTIVES:To analyze comparatively PC development in African countries based on region-specific indicators. METHODS:Data were obtained from the African PC Association Atlas of PC in Africa, and a comparative analys...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Rhee JY,Garralda E,Namisango E,Luyirika E,de Lima L,Powell RA,López-Fidalgo J,Centeno C

    更新日期:2018-08-01 00:00:00

  • The Cancer Care Monitor: psychometric content evaluation and pilot testing of a computer administered system for symptom screening and quality of life in adult cancer patients.

    abstract::Technology is making the routine screening of symptoms and the measurement of quality of life (QoL) more feasible at the point of care. However, most existing symptom screening scales and QoL measures were not developed for clinical use and were not formatted and validated for administration through computerized mediu...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Fortner B,Okon T,Schwartzberg L,Tauer K,Houts AC

    更新日期:2003-12-01 00:00:00

  • Cancer Pain With a Neuropathic Component: A Cross-sectional Study of Its Clinical Characteristics, Associated Psychological Distress, Treatments, and Predictors at Referral to a Cancer Pain Clinic.

    abstract:CONTEXT:In patients with cancer pain, identifying a neuropathic pain component (NPC) may inform the selection of subsequent therapeutic interventions. OBJECTIVES:The objective of this study was to determine the prevalence, clinical characteristics, associated psychological distress, pre-referral treatment, and predict...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Reis-Pina P,Acharya A,Lawlor PG

    更新日期:2018-02-01 00:00:00

  • Psychiatric symptoms of pediatric cancer pain.

    abstract::This study investigated the contribution of pain to psychiatric symptoms in 43 hospitalized children and adolescents referred for psychiatric evaluation in a pediatric cancer center during a 1-yr period. Procedures included determination of the primary reason for referral, child and parent diagnostic interviews assess...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Steif BL,Heiligenstein EL

    更新日期:1989-12-01 00:00:00

  • The evidence for pharmacologic treatment of neuropathic cancer pain: beneficial and adverse effects.

    abstract:CONTEXT:The prevalence of neuropathic pain in patients with cancer pain has been estimated to be around 40%. Neuropathic pain may be caused by tumor invasion and is considered as mixed nociceptive-neuropathic pain, or caused by an anticancer treatment and considered as purely neuropathic pain. The use of adjuvant analg...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,meta分析,评审


    authors: Jongen JL,Huijsman ML,Jessurun J,Ogenio K,Schipper D,Verkouteren DR,Moorman PW,van der Rijt CC,Vissers KC

    更新日期:2013-10-01 00:00:00

  • Development and validation of the breakthrough pain assessment tool (BAT) in cancer patients.

    abstract:CONTEXT:The successful management of breakthrough pain depends on a combination of adequate assessment, appropriate (individualized) treatment, and adequate re-assessment. Currently, there is no fully validated clinical assessment tool for breakthrough pain in cancer patients. OBJECTIVES:The aim of this project was to...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Webber K,Davies AN,Zeppetella G,Cowie MR

    更新日期:2014-10-01 00:00:00

  • Factors to inform clinicians about the end of life in severe chronic obstructive pulmonary disease.

    abstract:CONTEXT:Palliative services have historically been offered to terminal patients with cancer, but much less so in other chronic illnesses such as chronic obstructive pulmonary disease (COPD) because of difficulties in predicting the trajectory to death. OBJECTIVES:The goal of this study was to determine if the change o...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章


    authors: Benzo R,Siemion W,Novotny P,Sternberg A,Kaplan RM,Ries A,Wise R,Martinez F,Utz J,Sciurba F,National Emphysema Treatment Trial Research Group.

    更新日期:2013-10-01 00:00:00

  • Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom Prevalence Group.

    abstract::The aims of this study were (a) to estimate the prevalence of pain and eight other common symptoms in a large population of patients with advanced cancer from different palliative care centers, and (b) to assess the differences in prevalence of the symptoms by primary site. In 1990-1991, the prevalence of eight major ...

    journal_title:Journal of pain and symptom management

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Vainio A,Auvinen A

    更新日期:1996-07-01 00:00:00

  • Fatigue, dyspnea, and cough comprise a persistent symptom cluster up to five years after diagnosis with lung cancer.

    abstract:CONTEXT:Aggregates of concurrent symptoms, known as symptom clusters (SxCls), have been described in predominantly cross-sectional samples of lung cancer (LC) patients undergoing treatment. OBJECTIVES:The objective of this study was to delineate SxCls in LC survivors up to five years after diagnosis, investigate their...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Cheville AL,Novotny PJ,Sloan JA,Basford JR,Wampfler JA,Garces YI,Jatoi A,Yang P

    更新日期:2011-08-01 00:00:00

  • Palliative care development: the Nepal model.

    abstract::Over the last few years, Nepali and international colleagues have been collaborating in the development of palliative care services in Nepal. The program continues to move forward amid the considerable social and political difficulties facing Nepal. Although a number of individuals and organizations have been involved...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,评审


    authors: Brown S,Black F,Vaidya P,Shrestha S,Ennals D,LeBaron VT

    更新日期:2007-05-01 00:00:00

  • Unfinished Business in Families of Terminally Ill With Cancer Patients.

    abstract:CONTEXT:Unfinished business often causes psychological issues after bereavement. Providing care for families of terminally ill patients with cancer to prevent unfinished business is important. OBJECTIVES:To clarify the prevalence and types of unfinished business in families of end-of-life patients with cancer admitted...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Yamashita R,Arao H,Takao A,Masutani E,Morita T,Shima Y,Kizawa Y,Tsuneto S,Aoyama M,Miyashita M

    更新日期:2017-12-01 00:00:00

  • Independent validation of the modified prognosis palliative care study predictor models in three palliative care settings.

    abstract:CONTEXT:Accurate prognostic information in palliative care settings is needed for patients to make decisions and set goals and priorities. The Prognosis Palliative Care Study (PiPS) predictor models were presented in 2011, but have not yet been fully validated by other research teams. OBJECTIVES:The primary aim of thi...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章,多中心研究


    authors: Baba M,Maeda I,Morita T,Hisanaga T,Ishihara T,Iwashita T,Kaneishi K,Kawagoe S,Kuriyama T,Maeda T,Mori I,Nakajima N,Nishi T,Sakurai H,Shimoyama S,Shinjo T,Shirayama H,Yamada T,Ono S,Ozawa T,Yamamoto R,Tsuneto S

    更新日期:2015-05-01 00:00:00

  • Burden and well-being among a diverse sample of cancer, congestive heart failure, and chronic obstructive pulmonary disease caregivers.

    abstract:CONTEXT:Three important causes of death in the U.S. (cancer, congestive heart failure, and chronic obstructive pulmonary disease) are preceded by long periods of declining health; often, family members provide most care for individuals who are living with serious illnesses and are at risk for impaired well-being. OBJE...

    journal_title:Journal of pain and symptom management

    pub_type: 杂志文章


    authors: Burton AM,Sautter JM,Tulsky JA,Lindquist JH,Hays JC,Olsen MK,Zimmerman SI,Steinhauser KE

    更新日期:2012-09-01 00:00:00