The efficacy of intravenous indomethacin in prevention of postoperative pain.


:Since intravenous prophylactic anti-inflammatory agents have been suggested to reduce or even replace opiates in postoperative pain therapy, we studied the demand for morphine in 45 patients recovering from abdominal surgery who had received a baseline infusion of either indomethacin, morphine or saline placebo. When extubated after inhalational anaesthesia, each patient received an i.v. bolus of either 0.5 indomethacin, 0.07 morphine or saline placebo. Thereafter a 20-h infusion of the same test analgesic was started, either 0.1 indomethacin, 0.03 morphine or saline placebo. For additional analgesia, a patient-controlled analgesia device (PCA) delivering 5-mg boluses of morphine was used. For the first 5 postoperative hours, significantly more (P less than 0.05) PCA morphine was needed in the indomethacin group (35 mg) than in the morphine group (24 mg), while the placebo group demanded mean 30 mg. For equal analgesia (measured by VAS and VRS) between 5-20 h, similar amounts (mean 23 and 19 mg) of PCA morphine were required in the indomethacin and morphine groups, in contrast to the placebo group (mean 40 mg) (P less than 0.001). Morphine infusion increased the total consumption of morphine by 25% as compared to placebo. We conclude that, following abdominal surgery, the analgesic effect of indomethacin infusion became apparent after the first 5 postoperative hours, thereafter reducing the demand for PCA morphine by about 40%. Continuous morphine infusion diminishes the postoperative demand for PCA morphine, but also increases the total morphine consumption.


Tigerstedt I,Tammisto T,Neuvonen PJ




Has Abstract


1991-08-01 00:00:00












  • Ketorolac or fentanyl continuous infusion for post-operative analgesia in children undergoing ureteroneocystostomy.

    abstract:BACKGROUND:children undergoing ureteroneocystostomy suffer from post-operative pain due to the surgical incision and bladder spasm. A single-shot caudal block is a common technique for paediatric analgesia, but a disadvantage is the limitation of a short duration in spite of the additives co-administered. A few clinica...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Jo YY,Hong JY,Choi EK,Kil HK

    更新日期:2011-01-01 00:00:00

  • Combining the EndoFlex tube with fiberoptic bronchoscopy in difficult intubation.

    abstract::We applied a combination technique using the EndoFlex tube with fiberoptic bronchoscopy for a 69-year-old man presenting with limited mouth opening and neck movement. Awake nasotracheal intubation was performed under conscious sedation with propofol and fentanyl. After positioning the tip of the EndoFlex tube in the o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Sugiyama K,Takahashi N,Kohjitani A

    更新日期:2009-08-01 00:00:00

  • Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia.

    abstract:BACKGROUND:Myocardial dysfunction occurs commonly in septic shock. It is not known whether this is due to local ischaemia and metabolic disturbances. Our hypothesis was that endotoxaemic myocardial dysfunction may be associated with interstitial ischaemic and metabolic changes, measured using interstitial microdialysis...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Chew MS,Johansson A,Anderson C,Ersson A,Tønnesen E

    更新日期:2008-08-01 00:00:00

  • Studies on intra-pulmonary gas distribution in the extremely obese. Influence of anaesthesia and artificial ventilation with and without positive end-expiratory pressure.

    abstract::Intrapulmonary gas distribution was studied in 10 extremely obese patients: (1) during spontaneous breathing awake; (2) during anaesthesia with controlled ventilation and zero end-expiratory pressure (ZEEP), and (3) as under (2) but with a positive end-expiratory pressure of approximately 15 cmH2O (PEEP). Gas distribu...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Hedenstierna G,Santesson J

    更新日期:1977-01-01 00:00:00

  • Parenteral nutrition in preterm neonates with and without carnitine supplementation.

    abstract::The effects of carnitine supplementation on fat and glucose metabolism and carnitine balance were studied in 12 preterm neonates receiving full or partial parenteral nutrition (PN) for 5 to 21 days. The gestational age ranged from 27 to 32 weeks and the birth weight from 790 to 2090 g. The neonates were assigned at ra...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Larsson LE,Olegård R,Ljung BM,Niklasson A,Rubensson A,Cederblad G

    更新日期:1990-08-01 00:00:00

  • Diagnostic accuracy of bedside ultrasonography in the ICU: feasibility of detecting pulmonary effusion and lung contusion in patients on respiratory support after severe blunt thoracic trauma.

    abstract:BACKGROUND:Blunt thoracic trauma is a major concern in critically ill patients. Repeated lung diagnostic evaluations are needed in order to follow up the clinical situation and the results of the therapeutic strategies. The aim of this prospective clinical study was to evaluate the possible role of lung ultrasound (LU)...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Rocco M,Carbone I,Morelli A,Bertoletti L,Rossi S,Vitale M,Montini L,Passariello R,Pietropaoli P

    更新日期:2008-07-01 00:00:00

  • Effect of adding midazolam to bupivacaine during rectus sheath block: a randomised controlled trial.

    abstract:BACKGROUND:Various adjuvants have been tried to improve quality and increase duration of local anaesthetics during various nerve blocks. We aimed to evaluate the effect of adding midazolam to bupivacaine on rectus sheath (RS) block in patients undergoing umbilical or epigastric hernia repair. METHODS:In all, 60 adult ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Ammar A,Mahmoud K,Kasemy Z

    更新日期:2018-07-01 00:00:00

  • Prediction of post-operative pain by an electrical pain stimulus.

    abstract:BACKGROUND:Treatment of post-operative pain is still a significant problem. Recently, interest has focused on pre-operative identification of patients who may experience severe post-operative pain in order to offer a more aggressive analgesic treatment. The nociceptive stimulation methods have included heat injury and ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Nielsen PR,Nørgaard L,Rasmussen LS,Kehlet H

    更新日期:2007-05-01 00:00:00

  • Effects of organic nitrate vasodilators on platelet function before and after cardiopulmonary bypass.

    abstract::Various in vitro, ex vivo and in vivo tests have shown that organic nitrates attenuate platelet function. Because organic nitrates are commonly administered to patients undergoing cardiac surgery, the postoperative bleeding tendency observed in these patients might be strengthened by nitrates. Therefore, we compared t...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Muikku O,Kuitunen A,Hynynen M

    更新日期:1995-07-01 00:00:00

  • The cytokine response in a patient undergoing surgery for an ACTH-producing tumor.

    abstract::The administration of glucocorticoids has been used to inhibit the cytokine production in patients undergoing cardiac surgery during cardiopulmonary bypass. In this case report the cytokine response in a 43-year-old man undergoing operation for an ACTH-producing lung tumor is presented. There had been clinical symptom...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Höhndorf K,Toft P,Tønnesen E

    更新日期:1997-02-01 00:00:00

  • Optimal cut-off for hourly lactate reduction in ICU-treated patients with septic shock.

    abstract:BACKGROUND:A decrease in lactate concentration over time during septic shock is associated with favourable outcomes. However, if this applies to hourly intervals during the initial time period in the ICU is unknown. The aim of this study was to investigate whether there is an early hourly reduction rate of lactate that...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Promsin P,Grip J,Norberg Å,Wernerman J,Rooyackers O

    更新日期:2019-08-01 00:00:00

  • Clinical effects of regional intravenous guanethidine (Ismelin) in reflex sympathetic dystrophy.

    abstract::Twenty patients with documented reflex sympathetic dystrophy were treated with a series of regional intravenous guanethidine blocks. The mean delay between the first clinical symptoms and the start of guanethidine blocks was 3.6 months. The overall result was good in 11 patients, moderate in two patients and poor in s...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Driessen JJ,van der Werken C,Nicolai JP,Crul JF

    更新日期:1983-12-01 00:00:00

  • Effect of intra-aortic magnesium on renal function during and after abdominal aortic surgery: a pilot study.

    abstract:BACKGROUND:Infrarenal aortic cross-clamping causes renal vasoconstriction. Magnesium may protect against renal deterioration through its vasodilatory properties. METHODS:Thirty patients with normal preoperative renal function undergoing infrarenal aortic cross-clamping for elective aortic surgery received magnesium (4...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bäcklund M,Pere P,Lepäntalo M,Lehtola A,Lindgren L

    更新日期:2000-05-01 00:00:00

  • Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.

    abstract::In a controlled study, the effects of THIP (a synthetic gamma-aminobutyric-acid-agonist) on respiratory function (ventilatory response to CO2), first detection of stimulation (electrical stimulation of a tooth), pain threshold, magnitude of maximal tolerated pain stimulation, and plasma cortisol, prolactin and glucose...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Lindeburg T,Følsgård S,Sillesen H,Jacobsen E,Kehlet H

    更新日期:1983-02-01 00:00:00

  • Right ventricular end-systolic pressure-volume relation during propofol infusion.

    abstract::The effects of propofol on right ventricular function were studied in 11 ICU patients who needed sedation for acute respiratory failure or neurological diseases. Right ventricular function was studied using a thermodilution method at patients' bedside. Right ventricular ejection fraction (RVEF), cardiac output (CO), r...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Martin C,Perrin G,Saux P,Papazian L,Albanese J,Gouin F

    更新日期:1994-04-01 00:00:00

  • Rapid reversal of global left ventricular dysfunction after accidental injection of 0.75 mg epinephrine in a 20-year-old patient.

    abstract::We report an accidental injection of epinephrine before spinal anaesthesia in a 20-year-old patient who subsequently developed immediate myocardial ischemia and global left ventricular dysfunction (ejection fraction of 20%). Hemodynamic status dramatically improved after nitroglycerin, calcium antagonists, acetyl sali...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Meaudre E,Barbou F,Sallaberry M,Cantais E,Petit D,Palmier B

    更新日期:2004-08-01 00:00:00

  • Minimal alveolar concentration of sevoflurane for maintaining bispectral index below 50 in morbidly obese patients.

    abstract:BACKGROUND:Morbid obesity is associated with important differences in pharmacokinetics and pharmacodynamics. The aim of this study was to determine minimum alveolar concentration of sevoflurane for maintaining bispectral index (BIS) below 50 (MACBIS50 ) in morbidly obese patients undergoing bariatric surgery using the ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Zeidan A,Mazoit JX

    更新日期:2013-04-01 00:00:00

  • Intravenous sedation for retrobulbar injection and eye surgery: diazepam and/or propofol?

    abstract::Principle goals of sedation for eye surgery are to provide patient comfort and to allow the patient to stay calm during both retrobulbar injection and surgery. Insufficient sedation may not prevent the patient from moving during retrobulbar injection, whereas very deep sedation may result in respiratory complications ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hampl KF,Marsch SC,Erb T,Drewe J,Schneider MC

    更新日期:1996-01-01 00:00:00

  • Caudal analgesia for prostate biopsy.

    abstract:BACKGROUND:Although various local anesthesia techniques have been suggested to decrease pain and discomfort during a transrectal ultrasound (TRUS)-guided prostate biopsy, the best method has not yet been defined. The present prospective, double-blind, randomized study aims to investigate the clinical efficacy of 'walki...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验


    authors: Cesur M,Yapanoglu T,Erdem AF,Ozbey I,Alici HA,Aksoy Y

    更新日期:2010-05-01 00:00:00

  • Preoperative oral granisetron prevents postoperative nausea and vomiting.

    abstract:BACKGROUND:Postoperative nausea and vomiting (PONV) is a commonly observed adverse effect of anaesthesia. This study was designed to evaluate the efficacy of granisetron administered orally for preventing PONV in female patients undergoing major gynaecological surgery. METHODS:In a prospective, randomized, placebo-con...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验,收录出版


    authors: Fujii Y,Tanaka H,Toyooka H

    更新日期:1998-07-01 00:00:00

  • Influence of the type of anaesthesia on post-operative subjective physical well-being and mental function in elderly patients.

    abstract::Standardized behavioural observations were used to establish the influence of the type of anaesthesia on the mental function and the subjective physical well-being in 60 patients, all men, following urological surgery. The patients were randomized to two groups, receiving spinal or general anaesthesia. For evaluation ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Crul BJ,Hulstijn W,Burger IC

    更新日期:1992-10-01 00:00:00

  • Lidocaine-induced hemodynamic effects are enhanced by the inhibition of endothelium-derived relaxing factor in dogs.

    abstract:BACKGROUND:Lidocaine has been shown to have direct vasoconstrictive effects at low concentrations. Since lidocaine inhibits endothelium-dependent vasodilation in vitro, the vasoconstrictor effect of lidocaine may be due to inhibition of endothelium-derived relaxing factor(EDRF/NO). Therefore, the current study was desi...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Toyoyama H,Yukioka H,Hayashi M,Tatekawa S,Fujimori M

    更新日期:1997-06-01 00:00:00

  • Intermittent capnography during high-frequency jet ventilation for prolonged rigid bronchoscopy.

    abstract:BACKGROUND:Gas exchange during high-frequency jet ventilation (HFJV) for prolonged rigid bronchoscopy (RBS) is usually monitored by arterial blood gas analysis. Capnography of expired gases during brief HFJV discontinuation may be a reliable and noninvasive supplemental method. Capnography can be performed either for s...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Frietsch T,Krafft P,Becker HD,Buelzebruck H,Wiedemann K

    更新日期:2000-04-01 00:00:00

  • Biological correlates of mental stress related to anticipated caesarean section.

    abstract::The relationships between self-reported assessments of acute anxiety and several biochemical and physiological indicators of stress reaction were investigated in pregnant women at term in connection with spinal analgesia for caesarean section. Fear and apprehension were statistically significantly associated only with...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Scheinin M,Scheinin H,Ekblad U,Kanto J

    更新日期:1990-11-01 00:00:00

  • Pentoxifylline attenuates the increase in whole blood viscosity after transfusion.

    abstract:BACKGROUND:Pentoxifylline improves tissue oxygenation and intestinal blood flow in models of haemorrhagic shock, and it has been used for the treatment of intermittent claudication due to its beneficial effects on haemorheology. We investigated the effects of pentoxifylline on whole blood viscosity during packed red-bl...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bacher A,Eggensperger E,Koppensteiner R,Mayer N,Klimscha W

    更新日期:2005-01-01 00:00:00

  • Optimal time interval between pretreatment with alcuronium and suxamethonium during anaesthetic induction.

    abstract::Alcuronium 0.03 mg/kg was studied in a double-blind randomized fashion as a pretreatment before suxamethonium using different time intervals between the administration of the drugs in 78 patients (ASA I-II) undergoing otolaryngological surgery. Alcuronium was given 1, 2 or 3 min before suxamethonium 1.5 mg/kg. The con...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lindgren L,Klemola UM,Saarnivaara L

    更新日期:1988-04-01 00:00:00

  • The effect of isoflurane on cerebrospinal fluid pressure in patients undergoing neurosurgery.

    abstract::Ten patients with intracerebral tumours (TC) and 13 patients with subarachnoid haemorrhage (SAH) from a ruptured cerebral arterial aneurysm were studied before intracranial surgery, and during a 3-h postoperative period. Cerebrospinal fluid pressure (CSFP) determined by an intraventricular (TC group) or intraspinal (S...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Gordon E,Lagerkranser M,Rudehill A,von Holst H

    更新日期:1988-02-01 00:00:00

  • Regional cerebral glucose metabolism during sevoflurane anaesthesia in healthy subjects studied with positron emission tomography.

    abstract:BACKGROUND:The precise mechanism by which sevoflurane exerts its effects in the human brain remains unknown. In the present study, we quantified the effects of sevoflurane on regional cerebral glucose metabolism (rGMR) in the human brain measured with positron emission tomography. METHODS:Eight volunteers underwent tw...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Schlünzen L,Juul N,Hansen KV,Gjedde A,Cold GE

    更新日期:2010-05-01 00:00:00

  • Computer-aided ventilator resetting is feasible on the basis of a physiological profile.

    abstract:BACKGROUND:Ventilator resetting is frequently needed to adjust tidal volume, pressure and gas exchange. The system comprising lungs and ventilator is so complex that a trial and error strategy is often applied. Comprehensive characterization of lung physiology is feasible by monitoring. The hypothesis that the effect o...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章


    authors: Uttman L,Jonson B

    更新日期:2002-03-01 00:00:00

  • Post-operative cognitive dysfunction at 3 months in adults after non-cardiac surgery: a qualitative systematic review.

    abstract:BACKGROUND:Post-operative cognitive dysfunction is defined as a decline in cognitive functions that occurs after surgery, but different diagnostic criteria and incidences have been reported in medical literature. Our aim was to determine incidence of post-operative cognitive dysfunction 3 months after non-cardiac surge...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审


    authors: Paredes S,Cortínez L,Contreras V,Silbert B

    更新日期:2016-09-01 00:00:00