APE1/Ref-1 promotes the effect of angiotensin II on Ca2+ -activated K+ channel in human endothelial cells via suppression of NADPH oxidase.


:The effects of angiotensin II (Ang II) on whole-cell large conductance Ca(2+)-activated K(+) (BK(Ca)) currents was investigated in control and Apurinic/apyrimidinic endonuclease1/redox factor 1 (APE1/Ref-1)-overexpressing human umbilical vein endothelial cells (HUVECs). Ang II blocked the BK(Ca) current in a dose-dependent fashion, and this inhibition was greater in APE1/Ref-1-overexpressing HUVECs than in control HUVECs (half-inhibition values of 102.81+/-9.54 nM and 11.34+/-0.39 nM in control and APE1/Ref-1-overexpressing HUVECs, respectively). Pretreatment with the NADPH oxidase inhibitor diphenyleneiodonium (DPI) or knock down of NADPH oxidase (p22 phox) using siRNA increased the inhibitory effect of Ang II on the BK(Ca) currents, similar to the effect of APE1/Ref-1 overexpression. In addition, application of Ang II increased the superoxide and hydrogen peroxide levels in the control HUVECs but not in APE1/Ref-1-overexpressing HUVECs. Furthermore, direct application of hydrogen peroxide increased BK(Ca) channel activity. Finally, the inhibitory effect of Ang II on the BK(Ca) current was blocked by an antagonist of the Ang II type 1 (AT(1)) receptor in both control and APE1/Ref-1-overexpressing HUVECs. From these results, we conclude that the inhibitory effect of Ang II on BK(Ca) channel function is NADPH oxidase-dependent and may be promoted by APE1/Ref-1.


Arch Pharm Res


Park WS,Ko EA,Jung ID,Son YK,Kim HK,Kim N,Park SY,Hong KW,Park YM,Choi TH,Han J




Has Abstract


2008-10-01 00:00:00










  • [Hemiballismus and metastasis to the Luys' body. An anatomo-clinical case].

    abstract::A 55 year-old man complained of headaches, dizziness and vomiting. Neurological examination only showed a cerebellar syndrome. CT scan revealed two hyperdense round areas in the right frontal lobe and cerebellar vermis consistent with metastases and a lung carcinoma was diagnosed. Two months later he presented with ty...

    journal_title:Revue neurologique

    pub_type: 杂志文章


    authors: Salama J,Gray F,Kemeny JL,Gherardi R,Delaporte P

    更新日期:1986-01-01 00:00:00

  • [Epidemiology of cutaneous melanoma: descriptive data in France and Europe].

    abstract:INTRODUCTION:The incidence of melanoma and the resulting mortality have been the subject of many studies. However, controversy remains as to the interpretation of the number of cases observed and the existence of an actual "epidemic" of melanomas in fair-skinned populations. OBJECTIVES:Analyze the descriptive epidemio...

    journal_title:Annales de dermatologie et de venereologie

    pub_type: 杂志文章


    authors: Grange F

    更新日期:2005-12-01 00:00:00

  • Hereditary spherocytosis: a study of 16 patients from University Hospital, Kuala Lumpur.

    abstract::Hereditary spherocytosis is a rather uncommon disease in Malaysia as only 16 patients were seen in our hospital over a 13 year period. Pallor, jaundice and splenomegaly were common physical signs. Clinical severity of the disease was variable and more than half of them needed splenectomy. Complications including haemo...

    journal_title:Singapore medical journal

    pub_type: 杂志文章


    authors: Koh MT,Ng SC

    更新日期:1991-02-01 00:00:00

  • The NIT domain: a predicted nitrate-responsive module in bacterial sensory receptors.

    abstract::A nitrate- and nitrite-sensing (NIT) domain as found in the NasR protein, has been detected in various receptor components of signal transduction pathways in different bacterial lineages. Cellular functions controlled by receptors that contain this novel domain include regulation of gene expression (transcription anti...

    journal_title:Trends in biochemical sciences

    pub_type: 杂志文章


    authors: Shu CJ,Ulrich LE,Zhulin IB

    更新日期:2003-03-01 00:00:00

  • [Two diarrhea cases caused by Cyclospora cayetanensis].

    abstract::Cyclospora cayetanensis is an intestinal protozoon that has emerged as an important cause of endemic or epidemic diarrheal disease in children and adults worldwide. Cases of cyclosporiasis have been frequently missed, since it is difficult to detect the parasite in fecal sample, despite an increasing amount of data re...

    journal_title:Mikrobiyoloji bulteni

    pub_type: 杂志文章


    authors: Ciçek M,Uçmak F,Ozekinci T

    更新日期:2011-07-01 00:00:00

  • Course of a HBsAg positive liver transplantation in a hepatitis B and D virus coinfected recipient.

    abstract::The increasing demand for transplantation has led to consideration of liver grafts from donors exposed to hepatitis B virus (HBV). Six transplantations of liver grafts from hepatitis B surface antigen (HBsAg) positive donors have been reported; two recipients suffered from HBV/HDV (hepatitis Delta virus) coinfection a...

    journal_title:Annals of hepatology

    pub_type: 杂志文章


    authors: Bahde R,Hölzen JP,Wolters HH,Schmidt HH,Bock CT,Lügering A,Spieker T,Senninger N,Brockmann JG

    更新日期:2011-07-01 00:00:00

  • Interventions for tobacco cessation in the dental setting. A systematic review.

    abstract:UNLABELLED:Oral health professionals have a unique opportunity to increase tobacco abstinence rates among patients who use tobacco. OBJECTIVE:To assess the effectiveness of interventions for tobacco cessation offered to cigarette smokers and smokeless tobacco users in the dental office or community setting. RESEARCH ...

    journal_title:Community dental health

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    authors: Carr AB,Ebbert JO

    更新日期:2007-06-01 00:00:00

  • Retroperitoneal and aortic manifestations of immunoglobulin G4-related disease.

    abstract::Retroperitoneal fibrosis is one of the prototypic manifestations of immunoglobulin G4 (IgG4)-related disease (IgG4-RD), but there is growing evidence that the aorta is also involved. These 2 conditions are closely linked, and based on the epicenter of the disease, the clinical manifestations can be classified as retro...

    journal_title:Seminars in diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Zen Y,Kasashima S,Inoue D

    更新日期:2012-11-01 00:00:00

  • Combined regimens of one year duration in the treatment of multibacillary leprosy--II. Combined regimens with rifampicin administered during 6 months.

    abstract::From 1981 to 1983 all multibacillary patients presenting at the collaborating centres in Zaire and Rwanda were treated with one of the following regimens: 6 months supervised daily RMP 600 mg, ETH 500 mg and DDS 100 mg or CLO 100 mg followed by 6 months unsupervised daily DDS 100 mg or CLO 100 mg with ETH 500 mg added...

    journal_title:Leprosy review

    pub_type: 临床试验,杂志文章


    authors: Pattyn SR,Groenen G,Janssens L,Deverchin J,Ghys P

    更新日期:1989-06-01 00:00:00

  • Bartter syndrome type III with only a synonymous mutation of the CLCNKB gene

    abstract::Bartter syndrome (BS), a rare autosomal recessive disorder affecting renal tubular potassium handling, is characterized by hypokalemia, metabolic alkalosis, and renal salt wasting. In this report, we describe an adult patient with longstanding clinical symptoms of fatigue, polyuria, polydipsia, mental retardation, and...

    journal_title:Clinical nephrology

    pub_type: 杂志文章


    authors: Xue Y,Wang B,Tang R,Ni H,Chen P,Liu BC,Zhang X

    更新日期:2019-12-01 00:00:00

  • Local hypertrophic/hyperplastic changes of keratinizing squamous epithelium of pinna induced by concanavalin A and other immunomodulators in mice.

    abstract::Intradermal administration of concanavalin A, a potent T-cell mitogen, into an ear lap resulted in activation of chondrogenesis and stimulation of epidermis proliferation. This proliferation is sometimes invasive in character (pearls and epidermal nests form in the underlying connective tissue) but never turns into tr...

    journal_title:Folia biologica

    pub_type: 杂志文章


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    更新日期:1999-01-01 00:00:00

  • Postprandial alterations in arterial pressure control during hemodialysis in uremic patients.

    abstract::To test the hypothesis that eating may adversely affect the hemodynamic response to ultrafiltration-dialysis, we studied the effect of a standard snack (about 400 Kcal) in 13 patients on RDT. Each patient was studied in random order during two standard hemodialysis sessions (snack-HD and control-HD) performed at ident...

    journal_title:Clinical nephrology

    pub_type: 临床试验,杂志文章,随机对照试验


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  • [Effects of air pollution on human health and their importance in Mexico City].

    abstract::The impact of air pollution on human health is a complicated problem. In this review, we describe the main health effects of exposure to ozone, carbon monoxide, sulfur dioxide, nitrogen dioxide, lead and particulate matter. Geographical characteristics of the metropolitan area of Mexico City that favor pollutant persi...

    journal_title:Gaceta medica de Mexico

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    authors: Vallejo M,Jáuregui-Renaud K,Hermosillo AG,Márquez MF,Cárdenas M

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  • Receptor-mediated protein transport in the early secretory pathway.

    abstract::Many secretory proteins are thought to rely upon transmembrane cargo receptors for efficient endoplasmic reticulum (ER)-to-Golgi transport. These receptors recognize specific cargo-encoded sorting signals. Only a few such cargo receptors have been characterized in detail, most of them in yeast. The only well-defined c...

    journal_title:Trends in biochemical sciences

    pub_type: 杂志文章,评审


    authors: Baines AC,Zhang B

    更新日期:2007-08-01 00:00:00

  • [The focal control of malaria. Focal treatment using chemoprophylaxis and home insecticide spraying for the control of malaria in southern Mexico].

    abstract::The efficacy of a focal control strategy for malaria was evaluated against a conventional scheme carried out in two groups of villages in the Soconusco, southern Chiapas, Mexico. Focal control consisted on the prophylactic administration of antimalarial drugs to people who had experienced malaria episodes two years pr...

    journal_title:Gaceta medica de Mexico

    pub_type: 杂志文章


    authors: Rodríguez López MH,Loyola Elizondo EG,Betanzos Reyes AF,Villarreal Treviño C,Bown DN

    更新日期:1994-09-01 00:00:00

  • Ergonomic intervention: its effect on working posture and musculoskeletal symptoms in female biomedical scientists.

    abstract::This study investigates the effect of ergonomic intervention on working posture and musculoskeletal symptoms in female biomedical scientists. The Nordic musculoskeletal questionnaire (NMQ), body discomfort chart (BDC) and rapid upper-limb assessment (RULA) are the tools for assessment. The study was conducted in three...

    journal_title:British journal of biomedical science

    pub_type: 临床试验,杂志文章


    authors: Kilroy N,Dockrell S

    更新日期:2000-01-01 00:00:00

  • Comparative studies of fresh and postmortem isolated rat cortical synaptosomes: uptake and potassium-evoked release of gamma-aminobutyric acid.

    abstract::Synaptosomal fractions were isolated from rat cerebral cortex immediately after decapitation and after 2 h and 4 h postmortem storage at room temperature. Uptake and release of [3H]GABA was compared between fresh and postmortem synaptosomal fractions. The results suggest that after a 2 h postmortem storage these funct...

    journal_title:Acta biologica Hungarica

    pub_type: 杂志文章


    authors: Kálmán M,Armenian AA,Chiflikian MD,Csillag A

    更新日期:1985-01-01 00:00:00

  • Symptom profile of delirium in older people with and without dementia.

    abstract::Clinical profiles of delirium in 717 older people with and without dementia age 75 years and older in 4 different types of care were studied. Delirium and dementia were diagnosed according to DSM-IV criteria. Delirious demented participants (n = 135) had more often had previous delirium episodes and were more often be...

    journal_title:Journal of geriatric psychiatry and neurology

    pub_type: 杂志文章


    authors: Edlund A,Lundström M,Sandberg O,Bucht G,Brännström B,Gustafson Y

    更新日期:2007-09-01 00:00:00

  • Phenotypic and genotypic diversity of airborne fungal spores in Demänovská Ice Cave (Low Tatras, Slovakia).

    abstract::This paper is the first aero-mycological report from Demänovská Ice Cave. Fungal spores were sampled from the internal and external air of the cave in June, 2014, using the impact method with a microbiological air sampler. Airborne fungi cultured on PDA medium were identified using a combination of classical phenotypi...


    pub_type: 杂志文章


    authors: Ogórek R,Kozak B,Višňovská Z,Tančinová D

    更新日期:2018-01-01 00:00:00

  • [Laboratory diagnosis of immunoglobulin deficiencies].

    abstract::This review deals with the diagnostics of immunoglobulin defects. The development of methods used to detect and quantitate concentrations of immunoglobulins and their subclasses was shortly discussed; following by the role of antibodies in the host defence. Seven out of the ten main immunodeficiencies with the prevale...

    journal_title:Postepy higieny i medycyny doswiadczalnej

    pub_type: 杂志文章,评审


    authors: Madaliński K,Gregorek H,Chrzanowska K,Michałkiewicz J,Bernatowska E

    更新日期:2002-01-01 00:00:00

  • Why did Sigmund Freud refuse to see Pierre Janet? Origins of psychoanalysis: Janet, Freud or both?

    abstract::Pierre Janet and Joseph Breuer were the true originators of psychoanalysis. Freud greatly elaborated on their findings. Freud initially admitted these facts but denied them in later life. Janet discovered the concept transference before Freud. ...

    journal_title:History of psychiatry

    pub_type: 历史文章,杂志文章


    authors: Fitzgerald M

    更新日期:2017-09-01 00:00:00

  • ICD detected patient activity is associated with arrhythmic events in heart failure patients.

    abstract:Background:Although implantable cardioverter-defibrillator (ICD) reduces mortality in heart failure patients with reduced left ventricle function, arrhythmic episodes are related with increased mortality. Aim: The aim of this study was to investigate whether low patient activity predicts arrhythmic events in the heart ...

    journal_title:Nigerian journal of clinical practice

    pub_type: 杂志文章


    authors: Ucar FM,Yilmaztepe MA

    更新日期:2020-11-01 00:00:00

  • [Endoscopic ultrasonography in the staging of esophageal cancer. Therapeutic implications].

    abstract::Endoscopic ultrasonography (EUS) provides accurate visualization of the different layers of the gastrointestinal wall and surrounding structures, allowing TN staging of tumors prior surgery. The aim of this study was to evaluate the sensitivity, specificity and accuracy of EUS in the staging of esophageal carcinoma as...

    journal_title:Gastroenterologia y hepatologia

    pub_type: 杂志文章


    authors: Ginès A,Bordas JM,Llach J,Mondelo F,Fernández J,Castells A,Pera M,Grande L,Piqué JM

    更新日期:1998-03-01 00:00:00

  • Study of pelvicaliceal anatomy by helical computerized tomography. Is it feasible?

    abstract:OBJECTIVE:To evaluate the role of 3-dimensional images produced by computerized tomography (CT), using intravenous contrast to study pelvicaliceal anatomy. This might be of help in endourological procedures. METHODS:The study was conducted in King Fahd Hospital of the University, King Faisal University, Dammam, Kingdo...

    journal_title:Saudi medical journal

    pub_type: 杂志文章


    authors: Al-Qahtani FN,Ali GA,Kamal BA,Taha SA

    更新日期:2003-12-01 00:00:00

  • [Musculoskeletal complications of Werner's syndrome].

    abstract:INTRODUCTION:Werner's syndrome, a rare autosomal recessive genetic disease, is a premature aging disease characterized by early onset of symptoms related to normal aging including short stature, cataracts, graying of the hair, skin ulcerations, diabetes, osteoporosis, atherosclerosis and predisposition to cancer. Muscu...

    journal_title:Annales de dermatologie et de venereologie

    pub_type: 杂志文章


    authors: Kluger N,Aractingi S,Aboukrat P,Vanderlinden I,Guillot B,Bessis D

    更新日期:2007-02-01 00:00:00

  • The proteasome and its inhibitors in immune regulation and immune disorders.

    abstract::The ubiquitin-proteasome pathway is a well-characterized mechanism deputed to the degradation of intracellular proteins. Proteasomal degradation intervenes in the regulation of numerous cellular functions including signal transduction, apoptosis, cell cycle, and antigen presentation. In vitro and in vivo studies have ...

    journal_title:Critical reviews in immunology

    pub_type: 杂志文章,评审


    authors: Nencioni A,Grunebach F,Patrone F,Ballestrero A,Brossart P

    更新日期:2006-01-01 00:00:00

  • [Neuronal and synaptic properties: fundamentals of network plasticity].

    abstract::Neurons, within the nervous system, are organized in different neural networks through synaptic connections. Two fundamental components are dynamically interacting in these functional units. The first one are the neurons themselves, and far from being simple action potential generators, they are capable of complex ele...

    journal_title:Revue neurologique

    pub_type: 杂志文章,评审


    authors: Le Masson G

    更新日期:2000-02-01 00:00:00

  • Prevalence of cleft lip and palate in births from 2003 - 2006 in Iran.

    abstract:OBJECTIVE:To determine the prevalence of cleft lip and palate in births taking place in hospitals in the Yazd province, Iran. METHOD:The records of 65,236 live births delivered at 12 hospitals in Yazd province, including Yazd city and four cities of the states, over a four year period from 2003 to 2006 were examined. ...

    journal_title:Community dental health

    pub_type: 杂志文章


    authors: Yassaei S,Mehrgerdy Z,Zareshahi G

    更新日期:2010-06-01 00:00:00

  • Mechanisms of hepatotoxicity of chloroacetonitrile - an end product of water chlorination.

    abstract::Chloroacetonitrile is a disinfectant by-product of chlorination of drinking water and is considered as a direct-acting mutagenic and carcinogenic agent. Time-course and dose-response studies were performed to examine the mechanism of chloroacetonitrile-induced hepatotoxicity. In the time-course study, animals were sca...

    journal_title:Pakistan journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Abo-Salem OM,Ghonaim MM,Al-Zahrani SS

    更新日期:2013-01-01 00:00:00

  • Polymeric vehicles for topical delivery and related analytical methods.

    abstract::Recently a variety of polymeric vehicles, such as micelles, nanoparticles, and polymersomes, have been explored and some of them are clinically used to deliver therapeutic drugs through skin. In topical delivery, the polymeric vehicles as drug carrier should guarantee non-toxicity, long-term stability, and permeation ...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章,评审


    authors: Cho HK,Cho JH,Jeong SH,Cho DC,Yeum JH,Cheong IW

    更新日期:2014-04-01 00:00:00