[Obesity, inflammation and insulin resistance: role of gp 130 receptor ligands].


:Obesity can be considered as a low grade inflammatory disease, characterized by increased plasma levels of proinflammatory cytokines such as tumoral necrosis factor-a (TNF-a), and acute phase reactant proteins like C-reactive protein. In this context, some cytokines of the interleukin-6 (IL-6) family have been involved in the inflammatory processes associated to obesity. In addition to IL-6, the IL-6 cytokine family includes IL-11, ciliary neurotrophic factor (cntf), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), leukemia inhibitory factor (LIF) y Oncostatin M (OsM). These proteins are also known as gp130 cytokines because all of them exert their action via the glycoprotein 130 (gp130) as a common transducer protein within their functional receptor complexes. However, their role in obesity and related disorders is controversial; thus, whereas some studies have described the involvement of gp130 cytokines in the development of obesity and its related cluster of pathophysiologic conditions like insulin-resistance, fatty liver and cardiovascular diseases, other trials have proposed the gp130 receptor ligands as therapeutic targets in the treatment of obesity and its related disorders. In fact, CNTF treatment has demonstrated to be effective in the reduction of body weight, by promoting the inhibition of food intake and the activation of the energy expenditure, together with an improvement of insulin sensitivity. This review analyzes the potential therapeutic role of some of the gp130 ligands in obesity and related diseases.


An Sist Sanit Navar


Marcos-Gómez B,Bustos M,Prieto J,Martínez JA,Moreno-Aliaga MJ




Has Abstract


2008-05-01 00:00:00










  • Problem solving for depressed suicide attempters and depressed individuals without suicide attempt.

    abstract:BACKGROUND:Next to feelings of hopelessness, certain cognitive features such as problem solving deficiency, attentional bias and reduced future positive thinking are involved in the development and maintenance of suicidal behavior. The aim of this study was to examine feelings of hopelessness and problem solving abilit...

    journal_title:Psychiatria Danubina

    pub_type: 杂志文章


    authors: Roskar S,Zorko M,Bucik V,Marusic A

    更新日期:2007-12-01 00:00:00

  • Difference in risk of gastrointestinal complications between users of enteric-coated and buffered low-dose aspirin.

    abstract:OBJECTIVE:Difference in the risk of gastrointestinal (GI) complications between users of enteric-coated and buffered low-dose aspirin (LDA) is unclear. The purpose of the study is to examine the difference in risk of GI damage between enteric-coated and buffered LDA products. METHODS:A large and chronologically organi...

    journal_title:International journal of clinical pharmacology and therapeutics

    pub_type: 杂志文章


    authors: Takada M,Fujimoto M,Hosomi K

    更新日期:2014-03-01 00:00:00

  • [Heterozygotic alpha-1 antitrypsin deficiency. A case report].

    abstract::The clinical, analytical (including phenotypical) and histologic (optical and ultrastructural) data of a 34-years-old male patient attended for evaluation of moderate hypertransaminasemia discovered following a company screening examination. The existence of an alpha-1-antitrypsin heterozygotic deficit (MZ) was detect...

    journal_title:Gastroenterologia y hepatologia

    pub_type: 杂志文章


    authors: Bataller Sifre R,Vicente Ull R,Llombart Bosch A,Carda Batalla C,Gabriel Botella F,Bataller Alberola R,Galindo Puerto J

    更新日期:1996-06-01 00:00:00

  • Assessment of Pericardial Disease with Cardiovascular MRI.

    abstract::Disorders of the pericardium are common and can result in significant morbidity and mortality. Advances in multimodality imaging have enhanced our ability to diagnose and stage pericardial disease and improve our understanding of the pathophysiology of the disease. Cardiovascular MRI (CMR) can be used to define perica...

    journal_title:Heart failure clinics

    pub_type: 杂志文章,评审


    authors: Ho N,Nesbitt G,Hanneman K,Thavendiranathan P

    更新日期:2021-01-01 00:00:00

  • Mycotoxins occurrence and fungal populations in different types of silages for dairy cows in Spain.

    abstract::Silages constitute a major component of the feed ration for dairy cows, being a potential source of mycotoxins due to the possible contamination by filamentous fungi capable of producing these toxic compounds. In this study, samples of different kinds of silages collected from farms located in four regions of Spain, w...

    journal_title:Fungal biology

    pub_type: 杂志文章


    authors: Rodríguez-Blanco M,Ramos AJ,Sanchis V,Marín S

    更新日期:2021-02-01 00:00:00

  • Ultrastructural localization of aluminum in hepatocytes of hemodialyzed patients.

    abstract::The livers of 7 hemodialyzed patients have been studied by electron microscopy and electron probe X-ray microanalysis. In 6 patients dialyzed for a long time (at least 39 months), aluminum has been detected in high concentrations in phagolysosomes of hepatocytes; in these lysosomes aluminum is associated with phosphor...

    journal_title:Annales de pathologie

    pub_type: 杂志文章


    authors: Galle P,Giudicelli CP,Nebout T,Baglin A,Fries D

    更新日期:1987-01-01 00:00:00

  • Life-threatening hyperkalaemia developing following excessive ingestion of orange juice in a patient with baseline normal renal function.

    abstract::Hyperkalaemia is a less-recognised life-threatening cause of paralysis. We describe a 51-year-old African-American man, who suffered from muscle weakness progressing to ascending symmetric paralysis, and inability to masticate. Physical examination revealed flaccid paralysis with areflexia of the four limbs. Computed ...

    journal_title:Singapore medical journal

    pub_type: 杂志文章


    authors: Javed RA,Marrero K,Rafique M,Khan MU,Jamarai D,Vieira J

    更新日期:2007-11-01 00:00:00

  • Effect of ELF-EMF on number of apoptotic cells; correlation with reactive oxygen species and HSP.

    abstract::It is by now accepted that extremely low frequency electromagnetic fields ELF-EMF (0-300 Hz) affect biological systems although the mechanism has not been elucidated yet. In this study the effect of ELFEMF on the number of apoptotic cells of K562 human leukemia cell line induced or not with oxidative stress and the co...

    journal_title:Acta biologica Hungarica

    pub_type: 杂志文章


    authors: Garip AI,Akan Z

    更新日期:2010-06-01 00:00:00

  • Phosphatidylserine receptor-targeting therapies for the treatment of cancer.

    abstract::Asymmetric distribution of phospholipids across the plasma membrane is a unique characteristic of eukaryotic cells. Phosphatidylcholine and sphingomyelin are exposed in the outer leaflet, and phosphatidylserine (PS) is predominantly located in the inner leaflet. Redistribution of PS to the cell surface can be observed...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章,评审


    authors: Park M,Kang KW

    更新日期:2019-07-01 00:00:00

  • The management of male subfertility by in vitro fertilisation techniques.

    abstract::Although IVF was developed for the treatment of tubal infertility, it is clear that it has a significant application in treatment of couples where the problem is one of male subfertility. This is particularly relevant because, despite the developments in reproductive medicine, in most males there is no identifiable ca...

    journal_title:Australian family physician

    pub_type: 杂志文章


    authors: Kovacs G,McLachlan R,deKretser D

    更新日期:1995-03-01 00:00:00

  • Kinetics and molecular docking of dihydroxanthyletin-type coumarins from Angelica decursiva that inhibit cholinesterase and BACE1.

    abstract::In the present study, we investigated the anti-Alzheimer's disease (AD) potential of six dihydroxanthyletin-type coumarins, 4'-hydroxy Pd-C-III (1), decursidin (2), Pd-C-I (3), 4'-methoxy Pd-C-I (4), Pd-C-II (5), and Pd-C-III (6) from Angelica decursiva by evaluating their ability to inhibit acetylcholinesterase (AChE...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Ali MY,Seong SH,Jung HA,Jannat S,Choi JS

    更新日期:2018-07-01 00:00:00

  • Comparison of fungal communities among ten macrophyte rhizospheres.

    abstract::The fungal community composition, size and several physico-chemical properties were individually investigated in ten macrophyte rhizospheric substrates using nested PCR-denaturing gradient gel electrophoresis and soil chemical methods. Results indicated that both Dothideomycetes and Sordariomycetes were dominant fungi...

    journal_title:Fungal biology

    pub_type: 杂志文章


    authors: Guan M,Pan XC,Wang S,Wei XL,Zhang CB,Wang J,Liu WL,Liu SY,Chang J

    更新日期:2018-09-01 00:00:00

  • Analysis of postcytokinetic roles of cytokinetic components in Caenorhabditis elegans.

    abstract::Cytokinesis requires the interplay between the cytoskeleton and plasma membrane. Emerging evidence indicates that some cytokinetic components are essential for the postcytokinetic events such as epithelium organization and neural development. We have recently developed live cell imaging and conditional knockout techni...

    journal_title:Methods in cell biology

    pub_type: 杂志文章


    authors: Chai Y,Tian D,Li W,Ou G

    更新日期:2017-01-01 00:00:00

  • [Progabide treatment of a case of the syndrome of painful legs and moving toes].

    abstract::There is presently no recognised therapy for the painful legs and moving toes syndrome. Treatment by progabide, a GABA-agonist, was successful in one case: a gradual improvement was observed during four weeks and the movements have now disappeared after six months of progabide therapy. ...

    journal_title:Revue neurologique

    pub_type: 杂志文章


    authors: Bovier P,Hilleret H,Tissot R

    更新日期:1985-01-01 00:00:00

  • Kidney health in the Middle East.

    abstract::Chronic kidney disease (CKD) is a common and costly health problem in the Middle East. The incidence of CKD is still unknown, and the incidence of end-stage renal disease (ESRD) is estimated at 100 - 140 incident cases per million population in the Middle East countries. Most of the available statistics about prevalen...

    journal_title:Clinical nephrology

    pub_type: 杂志文章


    authors: Shaheen FA,Souqiyyeh MZ

    更新日期:2010-11-01 00:00:00

  • Dorsal sensory impairment in hands and feet of people affected by Hansen's disease in Israel.

    abstract:INTRODUCTION:Sensory testing in people affected by Hansen's disease is usually performed on palms and soles only. In Israel, both palmar/plantar and dorsal aspects of limbs are routinely tested. OBJECTIVES:The aim of this study was to describe the magnitude of dorsal sensory impairment (SI) in limbs and compare the fr...

    journal_title:Leprosy review

    pub_type: 杂志文章


    authors: Wexler R,Melchior H

    更新日期:2007-12-01 00:00:00

  • Synthesis and anticonvulsant activity of new spirosuccinimides differently substituted at the imide nitrogen atom.

    abstract::In the present study the series of spirosuccinimides with the aromatic ring at the imide nitrogen atom was synthesized. All the compounds were tested for their anticonvulsant activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. The neurotoxic properties were determined applyi...

    journal_title:Acta poloniae pharmaceutica

    pub_type: 杂志文章


    authors: Obniska J,Kamiński K,Chlebek I

    更新日期:2009-11-01 00:00:00

  • Adverse reactions of fluoroquinolones to central nervous system and rational drug use in nursing care.

    abstract::.Fluoroquinolones are a kind of synthetic drugs commonly used in clinical treatment. They have good broad-spectrum antimicrobial properties. They are not only convenient to administer, but also have remarkable therapeutic effects. In this paper, we selected 70 patients with adverse reactions of central nervous system ...

    journal_title:Pakistan journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Haiping L,Ziqiang J,Qina Z,Yuhua D

    更新日期:2019-01-01 00:00:00

  • Polymorphism of dextromethorphan oxidation in Polish population.

    abstract::Determination of oxidation phenotype is used to obtain the best results of pharmacotherapy and to explain a lower efficiency of some drugs in particular patients. The purpose of the present study was to determine the distribution of CYP2D6 metabolizer status in subjects from central Poland, using dextromethorphan as t...

    journal_title:Acta poloniae pharmaceutica

    pub_type: 杂志文章


    authors: Skretkowicz J,Wojtczak A,Rychlik-Sych M

    更新日期:2008-09-01 00:00:00

  • [Paraplegia and bilharziasis. A propos of 4 cases (including 2 confirmed cases of bilharzial myelitis].

    abstract::Four observations of paraplegia of bilharzians are presented. In two of them the anatomical proof of medullar localization of parasitosis was obtained, once in vivo, only once after a post-mortem. Medical study enables us to spot 55 cases of bilharzian paraplegia, of which 25 sufficiently explicit on the clinical poin...

    journal_title:Revue neurologique

    pub_type: 杂志文章


    authors: Pannier S,Got C,Bourgeois-Gavardin M,Lacert P,Piera JB,Grossiord A

    更新日期:1977-03-01 00:00:00

  • Patient characteristics in relation to dental care payment model: capitation vs fee for service.

    abstract:Objective:To analyse patient profiles in two payment models, the capitation (DCH) and the fee-for-service (FFS) systems, in relation to socioeconomic status, self-reported health and health behavior, as well as patient attitudes to and satisfaction with the DCH model in the Public Dental Service (PDS) in Sweden. Resea...

    journal_title:Community dental health

    pub_type: 杂志文章


    authors: Hakeberg M,Wide Boman U

    更新日期:2016-12-01 00:00:00

  • An efficient synthesis of risperidone via stille reaction: antipsychotic, 5-HT2, and dopamine-D2-antagonist.

    abstract::Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperi...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Kim DM,Kang MS,Kim JS,Jeong JH

    更新日期:2005-09-01 00:00:00

  • ["Red flags": when to be alerted and how to explore?].

    abstract::The diagnosis of Parkinson's disease (PD) requires ruling out other causes of parkinsonism. Among various "other" causes of parkinsonism, neurodegenerative causes or "atypical parkinsonism" are the most difficult to diagnose. Most common diseases are "synucleinopathies": multiple system atrophy and dementia with Lewy ...

    journal_title:Revue neurologique

    pub_type: 杂志文章,评审


    authors: Tison F

    更新日期:2010-10-01 00:00:00

  • Treatment of acute leukaemia: implications of recent findings in cell biology.

    abstract::Some aspects of the cell biology of normal and leukaemic haematopoietic cells are reviewed. Important points are: (a) normal and possibly also leukaemic stem cells differ from more mature cells in the kinetics as well as in cell surface antigens and other properties; (b) leukaemic cells are subject to a population siz...

    journal_title:Folia biologica

    pub_type: 杂志文章


    authors: Benestad HB

    更新日期:1978-01-01 00:00:00

  • Articulatory kinematics in the dysarthria associated with Friedreich's ataxia.

    abstract::Electromagnetic articulography (EMA) was used to investigate the tongue kinematics in the dysarthria associated with Friedreich's ataxia (FRDA). The subject group consisted of four individuals diagnosed with FRDA. Five nonneurologically impaired individuals, matched for age and gender, served as controls. Each partici...

    journal_title:Motor control

    pub_type: 杂志文章


    authors: Folker JE,Murdoch BE,Cahill LM,Rosen KM,Delatycki MB,Corben LA,Vogel AP

    更新日期:2011-07-01 00:00:00

  • Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure-activity relationship studies.

    abstract::In efforts to develop effective anticancer therapeutics with greater selectivity toward cancerous cell and reduced side-effects, such as emetic effects due to detrimental action of the drug toward the intestinal flora, a series of linear diarylheptanoids (LDHs) were designed and synthesized in 7 steps with good-to-mod...

    journal_title:Archives of pharmacal research

    pub_type: 杂志文章


    authors: Motiur Rahman AFM,Lu Y,Lee HJ,Jo H,Yin W,Alam MS,Cha H,Kadi AA,Kwon Y,Jahng Y

    更新日期:2018-12-01 00:00:00

  • [Epstein-Barr virus research by in situ hybridization in 65 cutaneous T cell epidermotropic lymphomas].

    abstract:BACKGROUND:The Epstein-Barr virus (EBV) is a highly mutagenic virus known to be the cause of several types of lymphoma. There has been some controversy concerning EBV in cutaneous T-cell lymphomas. The aim of this study was to search for EBV with a sensitive method: in situ hybridization in 65 patients with cutaneous T...

    journal_title:Annales de dermatologie et de venereologie

    pub_type: 杂志文章


    authors: Jumbou O,Huet S,Bureau B,Litoux P,Dréno B

    更新日期:1998-02-01 00:00:00

  • [Confluent and reticulated Gougerot-Carteaud papillomatosis: a case report of an excellent response to minocycline].

    abstract::Confluent and reticulated Gougerot-Carteaud papillomatosis is an uncommon dermatological condition that affects adolescents, especially young women with dark skin types. It presents itself as asymptomatic pigmented patches with a papillomatous texture that coalesce to form reticular plaques localized in the neck and i...

    journal_title:Gaceta medica de Mexico

    pub_type: 杂志文章


    authors: Rodríguez-Carreón AA,Arenas-Guzmán R,Fonte-Avalos V,Gutiérrez-Mendoza D,Vega-Memije ME,Domínguez-Cherit J

    更新日期:2008-01-01 00:00:00

  • Avidin-biotin technology ten years on: has it lived up to its expectations?

    abstract::Following the practical success attributed to avidin-biotin technology, researchers are now returning to the basics to try to understand the structural and functional requirements for the high-affinity avidin-biotin interaction. ...

    journal_title:Trends in biochemical sciences

    pub_type: 杂志文章,评审


    authors: Wilchek M,Bayer EA

    更新日期:1989-10-01 00:00:00

  • Unsuccessful transjugular intrahepatic portosystemic shunt for a patient with right heart failure and portal hypertension.

    abstract::A 60-year-old women with a history of congenital pulmonary valve stenosis developed right heart failure, cardiac cirrhosis and end-stage renal disease requiring renal replacement therapy. Cirrhosis was complicated by portal hypertension, resulting in intractable gastro-intestinal bleedings despite optimal treatment wi...

    journal_title:Acta gastro-enterologica Belgica

    pub_type: 杂志文章


    authors: Graus L,Verresen L,De Vusser P,Verbrugge FH,Caenepeel P

    更新日期:2017-01-01 00:00:00