Regulation of FLT3 and its ligand in normal hematopoietic progenitor cells.

abstract：:Obesity is a well-known risk factor for the development of cancer, but its influence on the course of disease is still controversial. We investigated the influence of body mass index (BMI) on overall survival (OS) in 502 patients with indolent non-Hodgkin's lymphoma or mantle cell lymphoma in a subgroup analysis of th...

journal_title：Annals of hematology

authors： Weiss L,Melchardt T,Egle A,Hopfinger G,Hackl H,Greil R,Barth J,Rummel M

更新日期：2017-07-01 00:00:00

abstract：:Cryoglobulinemia is uncommon in Southern Chinese in Hong Kong, with tropical climates and low incidence of hepatitis C virus (HCV) infection. Eight positive cases were detected among 481 patients screened for cryoglobulins over a 10-year period. Three HCV carriers (38%) ran benign courses. The others included two carr...

journal_title：Annals of hematology

authors： Au WY,Kwok JS,Chu KM,Ma ES

更新日期：2005-02-01 00:00:00

abstract：:To elucidate the role of hematopoietic growth factors (HGFs) and other cytokines in the autocrine or paracrine regulation of inducible hematopoiesis we studied cytokine gene expression in the bone marrow (BM) of patients after myelosuppressive treatment. Furthermore, we studied the cytokine gene expression profile in ...

journal_title：Annals of hematology

authors： Cluitmans FH,Esendam BH,Veenhof WF,Landegent JE,Willemze R,Falkenburg JH

更新日期：1997-07-01 00:00:00

abstract：:Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk p...

journal_title：Annals of hematology

authors： Aranda N,Viteri FE,Montserrat C,Arija V

更新日期：2010-08-01 00:00:00

abstract：:Renal failure is one of the worst complications occurring in multiple myeloma (MM) patients. It does not affect survival if reverted by a prompt chemotherapy before the damage becomes irreversible; therefore, the early diagnosis of renal dysfunction is crucial. High and low molecular weight urinary proteins have prove...

journal_title：Annals of hematology

authors： Corso A,Zappasodi P,Pascutto C,Bosoni T,Mangiacavalli S,Lorenzi A,Rusconi C,Lazzarino M

更新日期：2003-08-01 00:00:00

abstract：:In this report we show that serum has differentiation-inducing effects on primitive hematopoietic progenitor cells with the CD34++CD38- immunophenotype. Using the pre-colony forming unit (pre-CFU) assay as a model for early myelopoiesis, we compared the effects of serum-containing and serum-free media and evaluated di...

journal_title：Annals of hematology

authors： Willems R,Henckaerts E,Lenjou M,Nijs G,Rodrigus I,Moulijn AC,Slegers H,Berneman ZN,Van Bockstaele DR

更新日期：2001-01-01 00:00:00

abstract：:The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...

journal_title：Annals of hematology

authors： Gómez-Seguí I,Cervera J,Such E,Martínez-Cuadrón D,Luna I,Ibáñez M,López-Pavía M,Gascón A,Roig M,Martínez J,Sanz J,Montesinos P,Martín-Aragonés G,Lorenzo I,Senent L,Barragán E,Cordón L,Sempere A,Sanz GF,Sanz MA

更新日期：2012-01-01 00:00:00

abstract：:Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean p...

journal_title：Annals of hematology

authors： Ceyhan T,Beyan C,Başer I,Kaptan K,Güngör S,Ifran A

更新日期：2006-05-01 00:00:00

abstract：:The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory ...

journal_title：Annals of hematology

authors： Nybo M,Friis-Hansen L,Felding P,Milman N

更新日期：2007-09-01 00:00:00

abstract：:Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentat...

journal_title：Annals of hematology

authors： Laurentino MR,Parente Filho SLA,Parente LLC,da Silva Júnior GB,Daher EF,Lemes RPG

更新日期：2019-12-01 00:00:00

abstract：:Established risk factors for thrombosis in essential thrombocythemia (ET) include age (≥ 60 years) and previous vascular events. Recently, also leukocytosis has been proposed in risk stratification of ET patients. We report a retrospective study on 532 ET patients followed for a median of 7.6 years. Sixty-four patient...

journal_title：Annals of hematology

authors： Palandri F,Polverelli N,Catani L,Ottaviani E,Baccarani M,Vianelli N

更新日期：2011-08-01 00:00:00

abstract：:Patients previously diagnosed with invasive aspergillosis (IA) have been considered to be at risk for relapse of mycosis during subsequent hematopoietic transplant. Even with prophylactic measures, reactivation of the infection occurs in 29% of patients undergoing bone marrow transplantation (BMT). A period of neutrop...

journal_title：Annals of hematology

authors： Sevilla J,Hernandez-Maraver D,Aguado MJ,Ojeda E,Morado M,Hernandez-Navarro F

更新日期：2001-08-01 00:00:00

abstract：:This study aimed to determine the clinical characteristics and prognostic significance of the meningioma 1 (MN1) gene and MN1-associated microRNA expression in Chinese adult de novo acute myeloid leukemia (AML) patients. The expression level of MN1, microRNA-20 (miR-20a), and microRNA-181b (miR-181b) in bone marrow mo...

journal_title：Annals of hematology

authors： Xiang L,Li M,Liu Y,Cen J,Chen Z,Zhen X,Xie X,Cao X,Gu W

更新日期：2013-08-01 00:00:00

abstract：:This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...

journal_title：Annals of hematology

authors： Radujkovic A,Hegenbart U,Müller-Tidow C,Herfarth K,Dreger P,Luft T

更新日期：2020-04-01 00:00:00

abstract：:Autoantibody against erythrocytes has occasionally been observed in patients with de novo acute myelocytic leukemia (AML). However, it is not clear whether this autoantibody in AML patients induces frank hemolysis (autoimmune hemolytic anemia, AIHA), as seen in lymphoid neoplasms. We present two de novo AML patients w...

journal_title：Annals of hematology

authors： Tamura H,Ogata K,Yokose N,An E,Kamikubo K,Dan K,Kajii E,Nomura T

更新日期：1996-01-01 00:00:00

abstract：:Genetic and morphological markers are well-established prognostic factors in acute myeloid leukemia (AML). However, further reliable markers are urgently needed to improve risk stratification in AML. CD318 (CDCP1) is a transmembrane protein which in solid tumors promotes formation of metastasis and correlates with poo...

journal_title：Annals of hematology

authors： Heitmann JS,Hagelstein I,Hinterleitner C,Roerden M,Jung G,Salih HR,Märklin M,Kauer J

更新日期：2020-03-01 00:00:00

abstract：:We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...

journal_title：Annals of hematology

authors： Mo XD,Zhang XH,Xu LP,Wang Y,Yan CH,Chen H,Chen YH,Han W,Wang FR,Wang JZ,Liu KY,Huang XJ

更新日期：2018-07-01 00:00:00

abstract：:The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...

journal_title：Annals of hematology

authors： Ahn JS,Kim HJ,Kim YK,Jung SH,Yang DH,Lee JJ,Kim NY,Choi SH,Jung CW,Jang JH,Kim HJ,Moon JH,Sohn SK,Won JH,Kim SH,Kim DD

更新日期：2016-03-01 00:00:00

abstract：:A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriam...

journal_title：Annals of hematology

authors： Shitara T,Suetake N,Yugami S,Sotomatu M,Oshima Y,Ijima H,Kuroume T,Nakazawa S

更新日期：1992-12-01 00:00:00

abstract：:The current phase-II trial was initiated to assess the efficacy and toxicity of the Ida-FLAG regimen in patients with poor-risk acute myeloid leukemia (AML). Three subgroups of patients with AML were eligible for the study: (a) refractory, (b) first relapse, or (c) secondary AML (i.e., signs of trilineage myelodysplas...

journal_title：Annals of hematology

authors： Steinmetz HT,Schulz A,Staib P,Scheid C,Glasmacher A,Neufang A,Franklin J,Tesch H,Diehl V,Dias Wickramanayake P

更新日期：1999-09-01 00:00:00

abstract：:In this study, the immunologic abnormalities of Iranian beta-thalassemia major patients were characterized, considering their clinical parameters including splenectomy status and iron overload. Serum samples and peripheral blood mononuclear cells were collected from 28 patients and 30 age- and sex-matched healthy indi...

journal_title：Annals of hematology

authors： Gharagozloo M,Karimi M,Amirghofran Z

更新日期：2009-01-01 00:00:00

abstract：:The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively...

journal_title：Annals of hematology

authors： Byun JM,Kim YJ,Yoon HJ,Kim SY,Kim HJ,Yoon J,Min YH,Cheong JW,Park J,Lee JH,Hong DS,Park SK,Kim HJ,Ahn JS,Shin HJ,Chung JS,Lee WS,Lee SM,Park Y,Kim BS,Lee JH,Lee KH,Jung CW,Jang JH,Min WS,Park TS,AML\/M

更新日期：2016-08-01 00:00:00

abstract：:In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17) were sorted in CD34(+) and CD34(-) fractions and compared to no...

journal_title：Annals of hematology

authors： de Jonge-Peeters SD,van der Weide K,Kuipers F,Sluiter WJ,de Vries EG,Vellenga E

更新日期：2009-06-01 00:00:00

abstract：:B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, whose anti-tumor effects and the underlying mechanisms on B-ALL remain to be elucidated. Recently, Notch1 signali...

journal_title：Annals of hematology

authors： Shao N,Ma D,Wang J,Lu T,Guo Y,Ji C

更新日期：2013-01-01 00:00:00

abstract：:Several authors have described a particular potential of automated depolarization analysis in detecting malaria infection as part of the routine full blood count (FBC) performed by the Cell-Dyn 4000 analyzer. In these cases, abnormal depolarizing patterns are due to the presence of leukocyte-associated malaria hemozoi...

journal_title：Annals of hematology

authors： Crespo S,Palacios G,Scott S,Lago M,Puente S,Martínez M,Baquero M,Subirats M

更新日期：2004-05-01 00:00:00

abstract：:We conducted an investigation to clarify whether or not the levels of total, free, and functional protein S and C4-binding protein (C4bp) in plasma are decreased in systemic lupus erythematosus (SLE) patients, especially those with antiphospholipid antibody (aPL), which is known to be a causative factor of such compli...

journal_title：Annals of hematology

authors： Matsuda J,Gohchi K,Gotoh M,Tsukamoto M,Saitoh N

更新日期：1994-12-01 00:00:00

abstract：:Eculizumab is indicated for the therapy of patients with symptomatic paroxysmal nocturnal hemoglobinuria (PNH). Due to inhibition of terminal complement cascade, patients on eculizumab are susceptible to Neisseria meningitidis infections. The two mainstays to reduce the risk of infection are vaccination and antibiotic...

journal_title：Annals of hematology

authors： Alashkar F,Vance C,Herich-Terhürne D,Preising N,Dührsen U,Röth A

更新日期：2017-04-01 00:00:00

abstract：:To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

journal_title：Annals of hematology

authors： Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

更新日期：2020-06-01 00:00:00

abstract：:Methods to estimate bone marrow plasma cells (BMPC) basically include histopathology, cytomorphology, and flow cytometry. The present study compares the outcomes of these methods with special focus on the impact of BMPC-specific characteristics on their recovery by either method. Laboratory reports of diagnostic sampl...

journal_title：Annals of hematology

authors： Demyanets S,Kaider A,Simonitsch-Klupp I,Bayer G,Subasic A,Thalhammer R,Esterbauer H,Krauth MT,Agis H,Reiter T,Schwarzinger I

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. However, controversial data have been published regarding a protective role of variant alleles of MTHFR on MM. PATIENTS AND METHODS:To inve...

journal_title：Annals of hematology

authors： Chiusolo P,Farina G,Putzulu R,Reddiconto G,Fiorini A,De Stefano V,Rossi E,Palladino M,Leone G,Sica S

更新日期：2006-07-01 00:00:00