Abstract：
PURPOSE:To assess the potential effect of intravitreal bevacizumab (IVB) (Avastin) on retinal function and anatomic recovery in eyes with choroidal neovascularization attributable to pathological myopia (mCNV). DESIGN:Retrospective case series. METHODS:setting: Institutional. patient population: Sixty-three eyes of 63 patients were treated with IVB for mCNV. intervention procedure: 1 mg of bevacizumab was injected into the vitreous via the pars plana. IVB was repeated after two to three months if there was fluorescein leakage in fluorescein angiogram (FA), apparent subretinal fluid in optical coherence tomography (OCT) persisted, or both. main outcome measurement: Best-corrected visual acuity (BCVA) and CNV size measured on FA. RESULTS:IVB was performed one to six times during the first 12 months (mean, 2.4 +/- 1.4 times). The size of the mCNV decreased and the BCVA improved significantly (P < .01 for both comparisons). The BCVA improved more than three lines in 25 eyes (40%), worsened more than three lines in three eyes (5%), and was unchanged in 35 (56%) eyes 12 months after. Fluorescein leakage from the mCNV ceased in 30 eyes (48%), diminished in 28 (44%), and was unchanged in five (8%) eyes. Stepwise analysis showed that the number of IVB (P < .01), macular atrophy associated with mCNV (P < .05), and myopic atrophy (P < .05) were significant predictive factors for BCVA at 12 months. CONCLUSIONS:Although the current study lacked a control group, IVB seems to be an effective treatment for mCNV after a long-term. The absence of chorioretinal atrophy and that of recurrence and persistency of mCNV are positive predictive factors.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Ikuno Y,Sayanagi K,Soga K,Sawa M,Tsujikawa M,Gomi F,Tano Ydoi
10.1016/j.ajo.2008.07.017subject
Has Abstractpub_date
2009-01-01 00:00:00pages
94-100.e1issue
1eissn
0002-9394issn
1879-1891pii
S0002-9394(08)00544-8journal_volume
147pub_type
杂志文章abstract：PURPOSE:To compare polymerase chain reaction (PCR) to microbial culture for the detection and identification of bacterial and fungal pathogens in microbial keratitis. DESIGN:Prospective cohort study. METHODS:A total of 108 consecutive corneal ulcers were cultured and analyzed by PCR using pan-bacterial and pan-fungal...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.06.009
更新日期：2008-11-01 00:00:00
abstract：:We studied accommodation and vergence eye movements in a patient with a left middle cerebral artery embolism. Accommodation was monitored by an infrared optometer with the accommodative target being controlled by a microcomputer. Computed tomography showed low-density areas in the left cortex, with intact brainstem. T...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76389-5
更新日期：1988-07-15 00:00:00
abstract：:Forty-three patients who initially presented with Krikenberg's spindles but with no glaucomatous field defects were observed for an average of 5.8 years in an attempt to evaluate the prognostic implication of spindle presence. Twenty-two of the patients had been followed for a minimum of five years. Analysis of the st...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(75)90075-6
更新日期：1975-02-01 00:00:00
abstract：PURPOSE:To evaluate changes in anterior chamber depth (ACD) and angle width after neodymium-yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy. DESIGN:Prospective interventional case series. METHODS:In a single institution, 43 eyes of 43 consecutive pseudophakic patients with symptomatic posterior capsule opacificati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.08.008
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:To assess the risk of diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM) diagnosed at a very early age. DESIGN:Observational case series. METHODS:The records of 51 patients were identified through the diabetes database of the Division of Pediatric Endocrinology and Metabolism at Washin...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.05.023
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability, in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery. DESIGN:Retrospective case-control study. METHODS:A total of 68 eyes of 56 ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2017.09.003
更新日期：2017-11-01 00:00:00
abstract：:Ocular abnormalities were present in five of 11 patients with Freeman-Sheldon syndrome. The predominant ocular findings were strabismus and blepharoptosis. Stiffness of the extraocular muscles, demonstrated in three patients by forced duction testing, made surgery difficult. Two patients underwent frontalis muscle sli...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(86)90009-7
更新日期：1986-09-15 00:00:00
abstract：PURPOSE:To determine the natural history of asymptomatic, clinical rhegmatogenous retinal detachment. DESIGN:Single observer, prospective, consecutive, observational case series. METHODS:Consecutive patients were included who were referred to the author's clinical practice with rhegmatogenous retinal detachment exten...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.01.014
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:To describe the ocular features of a patient with an interstitial deletion of chromosome 12 and to determine the molecular boundaries of the deletion. DESIGN:Observational case report and laboratory investigation. METHODS:A patient with an interstitial deletion of chromosome 12 was clinically examined for ocu...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2005.09.024
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To describe the motivations, expectations, and other factors men with X-linked retinoschisis (XLRS) consider when making decisions to participate in an early phase ocular gene therapy clinical trial. DESIGN:Qualitative interview study. METHODS:Men with XLRS who were considering participation in a phase I/IIa ...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ajo.2019.03.009
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:To evaluate the ability of pituitary adenylate cyclase-activating polypeptide (PACAP) to induce growth of neuronal processes in cultured trigeminal ganglion cells, and to accelerate neurite outgrowth and recovery of corneal sensitivity after creation of a corneal flap in a rabbit model of laser-assisted in situ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2006.10.034
更新日期：2007-02-01 00:00:00
abstract：:We treated nontraumatic ectopia lentis with the irrigation and aspiration method in 30 children and the Keeler/SITE instrument in three. Preoperative visual acuities were 6/21 (20/70) or worse in all patients; postoperatively, visual acuities improved in 29 of the 30 eyes and were 6/18 (20/60) or better in 24 (80%). A...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(81)90354-8
更新日期：1981-01-01 00:00:00
abstract：:A 50-year-old man who had been taking betamethasone for 20 days experienced a slight bilateral decrease in visual acuity. There were localized dark-gray atrophic lesions at the posterior pole, accompanied by a diffuse detachment of the sensory retina. The retinal vessels appeared to be normal and only minimal anterior...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(82)90526-8
更新日期：1982-03-01 00:00:00
abstract：PURPOSE:To assess the risks of vitrectomy for the removal of primary and secondary vitreous opacities. DESIGN:Retrospective, nonrandomized, interventional case series. METHODS:We reviewed the results of 116 consecutive cases of vitrectomy for vitreous floaters. Eighty-six cases were primary and 30 cases were secondar...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2011.01.005
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:To determine the association between anticytomegalovirus (CMV) maintenance therapy after immune recovery and immune recovery uveitis in acquired immunodeficiency syndrome (AIDS) patients on highly active antiretroviral therapy (HAART). DESIGN:Observational cohort study. METHODS:Data were obtained on AIDS pati...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00335-0
更新日期：2003-10-01 00:00:00
abstract：:We have developed a new model of retinal neovascularization in the rabbit. After intravitreal autotransplantation of 250,000 tissue-cultured skin fibroblasts, we observed strand formation in the midvitreous cavity. These strands grew toward the vascularized part of the retina and attached to it. Once the attachment wa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)75913-6
更新日期：1981-07-01 00:00:00
abstract：:The transmission characteristics of a new filter combination for fluorescein angiography were selected on the basis of in vivo measurements of the excitation and emission spectra of fluorescein dye during its transit in the fundus. This combination of filters was characterized by separation of 530 nm between the spect...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(76)90542-0
更新日期：1976-10-01 00:00:00
abstract：PURPOSE:To study the inner surface of the retina in the presence of epiretinal membranes (ERMs) using a prototype spectral-domain optical coherence tomography (SD-OCT) device. DESIGN:Small case series, performed in the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of M...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2008.01.014
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:Report incidence and risk of retinal detachment (RD)after coaxial phacoemulsification in high myopic patients. DESIGN:Retrospective consecutive interventional study. METHODS: SETTING:Vissum-Instituto Oftalmologico de Alicante, Spain. PATIENT OR STUDY POPULATION: A total of 439 eyes from 274 high myopic patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2007.03.043
更新日期：2007-07-01 00:00:00
abstract：:On the basis of preoperative assessment of patient characteristics, intraoperative obtainment of a lens-capsule and epithelium specimen, histopathologic investigation of lens capsule and epithelium, and biochemical analysis of glutathione reductase in lens epithelium, age-related cataract was studied in 50 adult patie...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)76729-7
更新日期：1991-09-15 00:00:00
abstract：:Lamellar keratoplasty was done in 18 eyes with keratoconus in an attempt to obtain a more satisfactory postoperative refractive error than that after penetrating keratoplasty. The refractive error after lamellar keratoplasty was better than that after 7.5-mm penetrating keratoplasties, but the vision was not as good. ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(77)90563-3
更新日期：1977-04-01 00:00:00
abstract：PURPOSE:To estimate incidence of age-related macular degeneration (AMD) by subtype in American whites aged ≥50 years. DESIGN:Systematic review and meta-analysis. METHODS: SETTING:Prospective cohort studies of AMD incidence in populations of white European ancestry published in MEDLINE, EMBASE, and Web of Science. S...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.ajo.2015.04.003
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:To evaluate the long-term safety and efficacy, in a large series of patients, of polyacrylic intraocular lens implants 1 and 3 years after surgery, compared with polymethylmethacrylate intraocular lens implants. METHODS:This was a randomized, prospective study of 1,514 eyes of 1,202 patients that were examined...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0002-9394(00)00490-6
更新日期：2000-09-01 00:00:00
abstract：PURPOSE:To report a case of nodular scleritis and panuveitis associated with erythema elevatum diutinum, a rare immunocomplex-mediated skin disease. DESIGN:Observational case report. METHODS:A 22-year-old woman who was diagnosed with erythema elevatum diutinum developed nodular scleritis and panuveitis of the right e...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/S0002-9394(03)00907-3
更新日期：2004-02-01 00:00:00
abstract：:We reviewed the records of 1,323 patients with retinoblastoma treated here between 1922 and 1978. Twenty-eight patients underwent bilateral enucleation alone and received no additional treatment for their advanced tumors. Of the 28 patients, 22 (92%) survived. Four patients were lost to follow-up, and two died of meta...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/0002-9394(79)90293-9
更新日期：1979-05-01 00:00:00
abstract：PURPOSE:To characterize the progression of optical gaps and expand the known etiologies of this phenotype. DESIGN:Retrospective cohort study. METHODS:Thirty-six patients were selected based on the identification of an optical gap on spectral-domain optical coherence tomography (OCT) from a large cohort of patients (N...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2020.05.016
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:To report a patient with persistent subepithelial corneal opacities 18 months after adenoviral keratoconjunctivitis who underwent photorefractive keratectomy for the correction of myopia. METHODS:Case report, review of medical literature, and slit-lamp photography. RESULTS:The patient underwent photorefractiv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(98)00224-4
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:To determine the frequency of retinal thickening (RT) in eyes with iridocyclitis and to examine the correlations among anterior chamber (AC) inflammation, RT, and visual acuity. DESIGN:Retrospective, observational case series. METHODS:Records were reviewed of patients seen at the Duke University Eye Center Uv...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2009.03.034
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To report a case of migration of liquid silicone into the upper eyelid. DESIGN:Interventional case report. METHODS:A 32-year-old woman had an injection of liquid silicone into the subcutaneous tissue of the forehead. She developed a cystic mass in the upper eyelid 2 days postinjection. An excisional biopsy wa...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(03)00465-3
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:To report a novel mutation of the CYP1B1 gene in a Japanese patient with primary infantile glaucoma. METHODS:DNA was extracted from leukocytes of six unrelated patients with primary infantile glaucoma. The coding regions of the CYP1B1 gene were amplified by polymerase chain reaction, examined by agarose gel se...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(99)00143-9
更新日期：1999-09-01 00:00:00
