Abstract:
PURPOSE:To evaluate the beneficial effect of intravenous thrombolysis aiming at rapid restoration of blood flow during the early hours of a central retinal artery occlusion (CRAO). DESIGN:Interventional case series. METHODS:In the present study, we prospectively evaluated the visual outcome after thrombolytic treatment with low-dose (50 mg) rt-PA (recombinant tissue plasminogen activator) and concomitant intravenous heparinization in patients with acute CRAO, best-corrected visual acuity (BCVA) < or = 20/100, and onset of symptoms within 12 hours prior to treatment. RESULTS:Twenty-eight patients (28 eyes) were included in this study. Final visual acuity was improved three or more lines in nine eyes (32%), stable in 18 (64%), and worse in one eye. Time to treatment < or = 6.5 hours was associated with a better gain of lines of vision (P = .004). Seven of 17 eyes (41%) that received thrombolytic treatment within the first 6.5 hours achieved a final BCVA > or = 20/50, compared to none in the subgroup of patients with onset to treatment >6.5 hours (P = .023). We observed no serious adverse events. CONCLUSIONS:Our findings indicate that thrombolytic treatment with intravenous low-dose rt-PA is of value for an improved visual recovery in patients with acute CRAO, if administered within the first 6.5 hours after the onset of symptoms.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Hattenbach LO,Kuhli-Hattenbach C,Scharrer I,Baatz Hdoi
10.1016/j.ajo.2008.06.016subject
Has Abstractpub_date
2008-11-01 00:00:00pages
700-6issue
5eissn
0002-9394issn
1879-1891pii
S0002-9394(08)00482-0journal_volume
146pub_type
杂志文章abstract:PURPOSE:The effectiveness of diffusion trace value analysis for non-invasive assessment of retinal ganglion cell (RGC) axonal degeneration at multiple anatomic levels along the human visual pathway under clinical setting was evaluated. DESIGN:Imaging study. METHODS:Ten patients with unilateral chronic optic neuropath...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.05.042
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma. DESIGN:Analytical nonexperimental study of published peer-reviewed data. METHODS:Literature search and analysis of pertinent articles published between January 1, 1980 and J...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,meta分析
doi:10.1016/j.ajo.2009.01.023
更新日期:2009-07-01 00:00:00
abstract::We treated 19 eyes of 16 patients who had filamentary keratitis associated with various diseases of the cornea with 5% sodium chloride eyedrops, administered three to four times daily. Filaments associated with acute or traumatic diseases of the cornea responded in all nine cases, with rapid resolution of symptoms and...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(82)90135-0
更新日期:1982-04-01 00:00:00
abstract:PURPOSE:To assess the long-term stability of sutured scleral-fixated posterior chamber intraocular lenses (PCIOLs) performed in combination with pars plana vitrectomy. DESIGN:Retrospective, consecutive, interventional case series. METHODS:Retrospective single-surgeon study of 118 eyes of 111 patients seen at Retina C...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2018.01.034
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:To assess low-contrast visual acuity (LCVA) after photorefractive keratectomy in relation to ocular higher-order wavefront aberration and corneal subepithelial haze. DESIGN:Prospective, cross-sectional analysis. METHODS:Photorefractive keratectomy was performed in 51 eyes of 27 subjects with myopic refractive...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.06.015
更新日期:2004-10-01 00:00:00
abstract::Of nine patients (five men and four women, 25 to 55 years old) with localized orbital neurofibromas, only one had other systemic findings consistent with neurofibromatosis. The neurofibromas originated from sensory nerves of the orbit, producing gradual proptosis with expansion of the orbital walls in most cases. Mild...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(85)90514-8
更新日期:1985-09-15 00:00:00
abstract:PURPOSE:To evaluate persistency of pharmacotherapy in primary open-angle glaucoma suspects (glaucoma suspects) treated with latanoprost and timolol. DESIGN:Retrospective, cohort study using the Protocare Sciences managed care database; approximately 3 million members in commercial health maintenance organizations and ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2003.10.034
更新日期:2004-01-01 00:00:00
abstract::A 65-year-old white man had an unusual disseminated lymphoid tumor that first appeared in the subconjunctival tissues of the right eye. The tumor later appeared in the skin, lymph nodes, and left upper eyelid and orbit. A monoclonal serum IgA spike was present although the urine did not contain Bence Jones proteins. T...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90082-3
更新日期:1975-02-01 00:00:00
abstract:PURPOSE:To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment. METHODS:Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, re...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)71701-5
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To analyze the comparative safety and efficacy of two techniques of corneal neurotization (CN) (direct corneal neurotization [DCN] vs indirect corneal neurotization [ICN]) for the treatment of neurotrophic keratopathy (NK). DESIGN:Multicenter interventional prospective comparative case series. METHODS:This st...
journal_title:American journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ajo.2020.07.003
更新日期:2020-12-01 00:00:00
abstract::Eight patients were treated for Pseudomonas endophthalmitis associated with the implantation of contaminated intraocular lenses. All patients showed clinical signs of infection (loss of red reflex, diminished visual acuity, and intraocular lens coagulum) and P. aeruginosa was isolated from vitreous aspirates and unuse...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(79)90569-5
更新日期:1979-11-01 00:00:00
abstract:PURPOSE:To evaluate low- vs high-dose plaque brachytherapy for juxtapapillary choroidal melanoma. DESIGN:Retrospective interventional case series. METHODS:Setting: Single institution. STUDY POPULATION:Forty-seven patients with juxtapapillary choroidal melanoma. INTERVENTION:Iodine-125 plaque brachytherapy. Eyes wer...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2017.11.008
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG). DESIGN:Cross-sectional study. METHODS:One hundred ninety-two eyes of 120 subjects from ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2020.12.002
更新日期:2020-12-10 00:00:00
abstract:PURPOSE:To clinically validate and ascertain the repeatability of a short questionnaire for dry eye syndrome (DES), consisting of two questions pertaining to symptoms (dryness and irritation) and one question regarding previous history of clinically diagnosed DES. DESIGN:Clinical validation study with repeated assessm...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.02.038
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To determine the incidence of outer foveal defects after macular hole surgery and to evaluate the relationship between the defect and visual outcome. DESIGN:Retrospective, observational case series. METHODS:A retrospective analysis was performed on 50 eyes from 50 patients who underwent macular hole surgery w...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2010.08.034
更新日期:2011-02-01 00:00:00
abstract::Communication between the retinal and the choroidal circulation occurred in one case of proliferative diabetic retinopathy and one case of Leber's disease (multiple miliary aneurysms) after argon laser photocoagulation treatment to eliminate abnormal retinal vasculature. In both instances rapid-sequence fluorescein an...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(76)90426-8
更新日期:1976-08-01 00:00:00
abstract:PURPOSE:Low docosahexaenoic acid (DHA) in X-linked retinitis pigmentosa (XLRP) may influence retinal function. The goals of this study were to elevate blood DHA levels and determine the effect on the rate of disease progression. DESIGN:In a 4-year prospective randomized clinical trial, male patients with XLRP (mean ag...
journal_title:American journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ajo.2003.10.045
更新日期:2004-04-01 00:00:00
abstract::We studied four patients with idiopathic dilated episcleral vessels. Three of these patients had asymmetric or unilateral open-angle glaucoma in the eye with the greater degree of episcleral vascular anomaly. The fourth patient showed dilated episcleral vessels, but the intraocular pressure (IOP) was not increased. In...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(78)90010-7
更新日期:1978-07-01 00:00:00
abstract:PURPOSE:To report endoscopic findings in the anterior chamber angle during injection of viscoelastic material in viscocanalostomy (VCS). DESIGN:Observational case reports. METHODS:Two cases of primary open-angle glaucoma were treated with VCS and cataract surgery. Immediately before and during injection of viscoelast...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2004.06.040
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:To describe a group of patients with dense visual field defects following macular hole surgery. METHODS:Nine (7%) of 125 patients reviewed noted onset of dense visual field defects following uncomplicated vitrectomy with gas-fluid exchange for the treatment of macular hole. Patient records were reviewed to inv...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)72064-1
更新日期:1996-09-01 00:00:00
abstract::A 61-year-old white woman, who had progressive arthritis over a two-year period, developed bilateral peripheral corneal degeneration. The superior cornea thinned to a thickness of approximately two thirds of normal. She died suddenly in the hospital and a primary occlusive vasculitis of the anterior ciliary arteries w...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77721-9
更新日期:1978-03-01 00:00:00
abstract:PURPOSE:To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT). DESIGN:Prospective, observational case series. METHODS:Thirty-nine full-term newborn infants underwent dilated retinal examinations by indirect ophthalmoscopy and retinal imaging ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2011.06.017
更新日期:2012-01-01 00:00:00
abstract::Pars plana vitrectomy and scleral buckling were performed on 22 eyes of 19 patients for treatment of perforating eye injuries from shotgun pellets. We reviewed the intraoperative findings at the time of vitrectomy to determine what factors might influence final visual acuity. The presence of a total retinal detachment...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)77416-1
更新日期:1992-07-15 00:00:00
abstract::In the elderly patient with a massive vitreous hemorrhage in one eye and senile macular choroidal degenerative changes in the fellow eye, a hemorrhagic disciform detachment causing this massive vitreous hemorrhage must be considered in the differential diagnosis. Ultrasonography selectively combined with radioactive p...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)75023-8
更新日期:1980-10-01 00:00:00
abstract::I used a recording medication monitor to obtain objective information on self-medication by date and hour from a group of 82 patients using pilocarpine three times daily to prevent visual loss from glaucoma. Doses meant to be taken during the day were missed more than twice as often as morning or evening doses. Of the...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74670-7
更新日期:1981-11-01 00:00:00
abstract:PURPOSE:To evaluate the long-term outcomes of laser in situ keratomileusis (LASIK) for high myopia. DESIGN:A long-term (10 years) follow-up retrospective interventional case series study. METHODS:The study included 196 myopic eyes of 118 patients with a mean preoperative spherical equivalent of -13.95 +/- 2.79 diopte...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2007.08.035
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To evaluate whether the full-field flicker test, a psychophysical test employing full-field flickering stimuli to measure temporal contrast sensitivity, can detect glaucomatous optic nerve damage in patients with increased intraocular pressure and glaucomatous optic disk abnormalities but normal visual fields. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)70126-6
更新日期:1997-03-01 00:00:00
abstract::A small piece of Ping-Pong ball material fitted to a Burian-Allen contact lens electrode provided a large field of evenly distributed light on the retina that resulted in larger electroretinographic amplitudes and more accurate measurement of b-wave latencies. ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/0002-9394(75)90148-8
更新日期:1975-08-01 00:00:00
abstract::Study of a father and son who had helicoid peripapillary chorioretinal degeneration suggests that a progressive tearing and retraction of the retinal pigment epithelium or of Bruch's membrane around the optic disk may be involved in the disorder's pathogenesis. We presume that this tearing results primarily from dyspl...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/s0002-9394(14)74552-0
更新日期:1990-03-15 00:00:00
abstract:PURPOSE:To report a case of pityriasis rubra pilaris (PRP)-induced bilateral lower eyelid cicatricial ectropion that resolved with systemic low-dose methotrexate. DESIGN:Observational case report. METHODS:A retrospective case review of a patient with cicatricial ectropion caused by PRP. RESULTS:A 82-year-old female ...
journal_title:American journal of ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ajo.2006.11.038
更新日期:2007-04-01 00:00:00