当前位置： SCI文献检索 > DIABETES & METABOLISM期刊下所有文献 > Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes.

Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes.

Abstract：

AIMS:Estimation of glomerular filtration rate (GFR) is recommended to diagnose and stratify chronic kidney disease (CKD). Can cystatin-C (cysC) assay improve the results in diabetic patients? METHODS:In 124 diabetic patients with a wide range of GFR, as determined by 51Cr-EDTA clearance (i-GFR), we estimated 'e-GFR' by: the recommended Cockcroft-Gault (CG) formula and Modification of Diet in Renal Disease (MDRD) study equation; the new Mayo Clinic quadratic (MCQ) equation; the recently proposed composite estimation including both serum creatinine and cysC; and a simplified approach dividing the MDRD by cysC if less than 1.10mg/L. RESULTS:The highest diagnostic accuracy (receiver operating characteristic [ROC] curves) and the highest proportions of well-stratified patients were obtained by cysC and the MDRD which, however, underestimated i-GFR for patients without CKD (-17%, P<0.001). The CG overestimated GFR in KDOQI stages 1 and 2, ignored stage 5 and was the least accurate. The MCQ equation overrepresented stage 2, overestimating GFR at this stage (+23%, P<0.005). The composite estimation (54.7+/-27.0mL per minute 1.73m(2)) correlated best with i-GFR (56.1+/-35.3; r=0.90, P<0.001), and did not significantly differ from it across the entire population and within each Kidney Disease Outcome Quality Initiative (KDOQI) stage but was also biased (Bland-Altman procedure). Simply dividing the MDRD by cysC ifless than1.10mg/L produced a comparable performance and eliminated the bias. CONCLUSION:The recommended creatinine-based estimations of GFR need to be improved. CysC assay helps in the diagnosis and stratification of CKD and leads to better estimates of GFR in diabetic patients without any substantial increase in complexity.

journal_name

Diabetes Metab

journal_title

Diabetes & metabolism

authors

Rigalleau V,Beauvieux MC,Le Moigne F,Lasseur C,Chauveau P,Raffaitin C,Perlemoine C,Barthe N,Combe C,Gin H

doi

10.1016/j.diabet.2008.03.004

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

482-9

issue

5

eissn

1262-3636

issn

1878-1780

pii

S1262-3636(08)00146-8

journal_volume

34

pub_type

杂志文章

相关文献

DIABETES & METABOLISM文献大全
  • Insulin-dependent diabetes and human leucocyte antigens.

    abstract：:The association of diabetes with HLA class I alleles in the early 1970s and with HLA class II alleles in the late 1970s provided a crucial, though indirect, indication of the role of immune phenomena in the development of insulin-dependent diabetes mellitus (IDDM). Genotyping of HLA alleles in the mid-1980s opened up ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Boitard C,Caillat-Zucman S,Timsit J

    更新日期：1997-03-01 00:00:00

  • [Diabetic retinopathy in children and adolescents].

    abstract：:Diabetic retinopathy rarely occurs before puberty and is never proliferative in prepubescent children. On the opposite, puberty and adolescence are high-risk periods for diabetic retinopathy progression, and call for strict ophthalmologic monitoring. The period between 16 and 18 years of age is particularly critical. ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Ben Mehidi A,Massin P,Guyot-Argenton C,Erginay A,Guillausseau PJ,Gaudric A

    更新日期：2003-06-01 00:00:00

  • When should ultrasonography be used to detect asymptomatic carotid atheroma in diabetic patients?

    abstract：INTRODUCTION:While guidelines for detection of silent myocardial and lower limb ischemia are established, data on screening asymptomatic carotid lesions remain scarce. However, such screening would be costly. Since the prevalence of diabetes increases constantly, it is necessary to keep screening costs low by setting u...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/S1262-3636(07)70321-X

    authors： Duval M,Altman JJ

    更新日期：2006-12-01 00:00:00

  • Incretin-based therapy in combination with basal insulin: a promising tactic for the treatment of type 2 diabetes.

    abstract：:Incretin therapies such as dipeptidyl peptidase-4 inhibitors (DPP-4Is) and GLP-1 receptor agonists (GLP-1RAs) have become well-established treatments for type 2 diabetes. Both drug classes reduce blood glucose through physiological pathways mediated by the GLP-1 receptor, resulting in glucose-dependent enhancement of ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2012.08.002

    authors： Vora J,Bain SC,Damci T,Dzida G,Hollander P,Meneghini LF,Ross SA

    更新日期：2013-02-01 00:00:00

  • Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

    abstract：:The goal of this review is to think about how to incorporate the GLP-1 based agents, represented by the dipeptidyl peptidase-4 (DPP-4) inhibitors or the glucagon-like peptide-1 (GLP-1) analogs, in the guidelines for the management of type 2 diabetes (T2DM). Orally administered DPP-4 inhibitors, such as sitagliptin and...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(08)73399-8

    authors： Penfornis A,Borot S,Raccah D

    更新日期：2008-02-01 00:00:00

  • Long-term outcome in children of mothers with gestational diabetes.

    abstract：OBJECTIVES:To assess the long-term outcomes (type 2 diabetes, overweight, cardiovascular disorders, metabolic syndrome and neurological manifestations) from human epidemiological studies of foetuses exposed to gestational diabetes. METHOD:A literature search on Medline was performed for the period from 01 January 1990...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2010.11.018

    authors： Burguet A

    更新日期：2010-12-01 00:00:00

  • Optimal nephroprotection: use, misuse and misconceptions about blockade of the renin-angiotensin system. Lessons from the ONTARGET and other recent trials.

    abstract：:Results from the ONTARGET trial remind us that acute haemodynamically mediated renal dysfunction, triggered by low arterial pressure or volume depletion, can occur in high-risk cardiovascular patients (who usually have some degree of diseased intrarenal vessels) treated with renin-angiotensin system (RAS) blockers (es...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2009.05.003

    authors： Halimi JM,Asmar R,Ribstein J

    更新日期：2009-12-01 00:00:00

  • Short-term intensive insulin therapy in insulin-requiring diabetes: effectiveness and factors predicting success.

    abstract：:Insulin-requiring diabetes (IRD) is a condition of permanent blood glucose imbalance which occurs despite a regulated diet and treatment with maximum doses of oral anti-diabetic drugs (glibenclamide 15 mg/d + metformin 1,700 mg/d). This report describes the results of a 2-year prospective study in 75 IRD patients trea...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章

    doi：

    authors： Meyer L,Grulet H,Guerci B,Gross A,Durlach V,Leutenegger M

    更新日期：1997-02-01 00:00:00

  • Significant Association between Blood Lead (Pb) Level and Haemoglobin A1c in Non-diabetic Population.

    abstract：:Although many heavy metals are necessary for normal biological function, a subset of heavy metals have no role in human physiology, such as lead (Pb) and arsenic (As). Such elements have deleterious effects on physiology and be associated with the incidence of diabetes and related metabolic syndromes. Haemoglobin A1c ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2021.101233

    authors： Chang CW,Wang CW,Wu DW,Lee WH,Chen YC,Liu YH,Li CH,Tsai CC,Lin WY,Chen SC,Hung CH,Kuo CH,Su HM

    更新日期：2021-01-23 00:00:00

  • Hypoglycaemia unawareness.

    abstract：:Hypoglycaemia unawareness, a frequent syndrome in insulin-dependent diabetes mellitus (IDDM), involves a decrease or absence of perception of specific symptoms which normally inform the subject that plasma glucose is decreasing to dangerous levels leading to neuroglycopenia. Without warning symptoms, IDDM patients are...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：

    authors： Bolli GB

    更新日期：1997-09-01 00:00:00

  • The metabolic syndrome and cancer: Is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components?

    abstract：AIMS:The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than the sum of its individual components, which components drive the association, or if the MetS predicts future cancer risk. MATERIALS AND METHODS:We linked 20,648 participants from the ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2015.04.006

    authors： Harding J,Sooriyakumaran M,Anstey KJ,Adams R,Balkau B,Briffa T,Davis TM,Davis WA,Dobson A,Giles GG,Grant J,Knuiman M,Luszcz M,Mitchell P,Pasco JA,Reid C,Simmons D,Simons L,Tonkin A,Woodward M,Shaw JE,Magliano DJ

    更新日期：2015-12-01 00:00:00

  • Interest of pronostic score for optimal clinical management of obese patients.

    abstract：OBJECTIVE:The aim of this retrospective study was to identify key factors favoring weight regain. METHODS:Therefore, prognostic factors for weight loss and regain have been retrieved and identified among 186 obese patients (40 +/- 2 y and 34 +/- 0.3 kg/m(2)) through the use of a simple questionnaire which considered p...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70053-8

    authors： Ybarra J,de Stefano M,Kammer A,de Tonnac N,Lehmann T,Golay A

    更新日期：2003-09-01 00:00:00

  • Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity.

    abstract：OBJECTIVES:Tumor necrosis factor alpha (TNFalpha) is expressed primarily in adipocytes and elevated levels of this cytokine have been linked to obesity and insulin resistance. Several studies have shown statistical evidence of linkage between obesity and the chromosomal region encompassing the TNFalpha gene, suggesting...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/s1262-3636(07)70104-0

    authors： Zouari Bouassida K,Chouchane L,Jellouli K,Chérif S,Haddad S,Gabbouj S,Danguir J

    更新日期：2004-04-01 00:00:00

  • Vasopressin and urinary concentrating activity in diabetes mellitus.

    abstract：:In diabetes mellitus (DM), the high urine flow rate suggests that urinary concentrating capacity is impaired. However, several studies have shown that vasopressin is elevated in DM and the consequences of this elevation have not yet been characterized. This study reevaluated renal function and water handling in male W...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Ahloulay M,Schmitt F,Déchaux M,Bankir L

    更新日期：1999-09-01 00:00:00

  • Looking for an insulin pill? Use the BRET methodology!

    abstract：:Insulin exerts its biological effects through a plasma membrane receptor that possesses a tyrosine-kinase activity. This tyrosine-kinase activity depends on the autophosphorylation of the receptor on tyrosine residues and on its dephosphorylation by protein tyrosine-phosphatases. The discovery of pharmacological agent...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/s1262-3636(07)70016-2

    authors： Issad T,Boute N,Boubekeur S,Lacasa D,Pernet K

    更新日期：2003-04-01 00:00:00

  • Use of GLP-1 receptor agonists for type 2 diabetes treatment intensification after basal insulin failure.

    abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels b...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(17)30071-X

    authors： Joubert M,Reznik Y

    更新日期：2017-04-01 00:00:00

  • Insulin therapy for type 2 diabetes: premixed or basal-prandial?

    abstract：:It is logical to begin type 2 insulin therapy with an injection of an intermediate-acting or a long-acting insulin at bedtime, but one should treat to target, i.e. aim at fasting glycaemias lower than 1.20 g/l to obtain an HbA(1c) close to 7%. Nevertheless, basal insulin therapy does not prevent progression to insulin...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.01.005

    authors： Halbron M,Jacqueminet S,Sachon C,Bosquet F,Hartemann-Heurtier A,Grimaldi A

    更新日期：2007-09-01 00:00:00

  • Type 2 diabetes treatment intensification in general practice in France in 2008-2009: the DIAttitude Study.

    abstract：AIMS:To evaluate the current procedures in French general practice of intensifying hypoglycaemic treatment in orally treated type 2 diabetic patients, according to the French recommendations. METHODS:Type 2 diabetic patient characteristics, HbA(1c) values, hypoglycaemic treatment and physician characteristics were col...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/S1262-3636(12)71532-X

    authors： Balkau B,Bouée S,Avignon A,Vergès B,Chartier I,Amelineau E,Halimi S

    更新日期：2012-03-01 00:00:00

  • Factors associated with screening for glucose abnormalities after gestational diabetes mellitus: baseline cohort of the interventional IMPACT study.

    abstract：INTRODUCTION:Although it is important to screen women who have had gestational diabetes mellitus (GDM) for abnormal post-partum glucose levels, such testing is rarely performed. The aim of this study was to use data from the first observational phase of the IMPACT study to determine rates of screening within 6 months o...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.diabet.2013.12.002

    authors： Bihan H,Cosson E,Khiter C,Vittaz L,Faghfouri F,Leboeuf D,Carbillon L,Dauphin H,Reach G,Valensi P

    更新日期：2014-04-01 00:00:00

  • Vascular placental abnormalities and newborn death in a pregnant diabetic woman with familial partial lipodystrophy type 3: a possible role for peroxisome proliferator-activated receptor γ.

    abstract：:The peroxisome proliferator-activated receptor protein gamma (PPARγ), a nuclear receptor involved in adipocyte differentiation, energy homoeostasis and fat storage, can lead, in rare cases of coding mutations, to familial partial lipodystrophy type 3 (FPLD3) with severe insulin resistance. PPARγ is also highly express...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2012.02.012

    authors： Castell AL,Hiéronimus S,Lascols O,Fournier T,Fénichel P

    更新日期：2012-10-01 00:00:00

  • [From external to implantable insulin pump, can we close the loop?].

    abstract：:The project to finalize a 'closed loop' insulin delivery according to blood glucose level, i.e. an implanted artificial beta cell, is born from the development of the first miniaturized portable insulin pumps during the 1970s. Continuous improvements in micro-electronics, as well as in the development of biomaterials ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Renard E,Costalat G,Bringer J

    更新日期：2002-09-01 00:00:00

  • Fetal macrosomia and maternal weight gain during pregnancy.

    abstract：BACKGROUND:To calculate an adjusted maternal weight gain during pregnancy including infant and placental weights to the actual weight gain and secondarily examine its influence on the occurrence of fetal macrosomia. METHODS:The corrected weight gain was calculated as follows: maternal body weight at the last prenatal ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Lepercq J,Hauguel-De Mouzon S,Timsit J,Catalano PM

    更新日期：2002-09-01 00:00:00

  • Incretins: what is known, new and controversial in 2013?

    abstract：:Glucagon-like peptide (GLP)-1 action involves both endocrine and neural pathways to control peripheral tissues. In diabetes the impairment of either pathway may define different subsets of patients: some may be better treated with GLP-1 receptor agonists that are more likely to directly stimulate beta-cells and extrap...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2013.02.005

    authors： Burcelin R,Thorens B,European Club for the study of GLP-1 (EuCSGLP-1).

    更新日期：2013-04-01 00:00:00

  • Muscle infarction in a young woman with brittle type 1 diabetes.

    abstract：:We present the first case of muscle infarction in a 30-year-old woman who had a 5-year history of type 1 diabetes mellitus that was not complicated by nephropathy, retinopathy or neuropathy. All common causes of muscle infarction were excluded, particularly microangiopathy and a hypercoagulable state. The differential...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.06.003

    authors： Virally M,Laloi-Michelin M,Médeau V,Meas T,Kévorkian JP,Mouly S,Guillausseau PJ

    更新日期：2007-12-01 00:00:00

  • Added benfluorex in obese insulin-requiring type 2 diabetes.

    abstract：:To determine the effect of benfluorex on glycaemic control in obese insulin-requiring Type 2 diabetes, 76 patients (aged 53.8 +/- 12.8 years) receiving insulin (> or = 0.5 IU/kg) and an appropriate low-calorie diet were evaluated after a 1-month run-in followed by a 3-month double-blind treatment period (3 tablets dai...

    journal_title：Diabetes & metabolism

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Leutenegger M,Bauduceau B,Brun JM,Guillon-Metz F,Martin C,Nicolino-Peltier C,Richard JL,Vannereau D

    更新日期：1998-02-01 00:00:00

  • Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

    abstract：:ATP-sensitive potassium channels (K(ATP)) couple cell metabolism to electrical activity by regulating potassium movement across the membrane. These channels are octameric complex with two kind of subunits: four regulatory sulfonylurea receptor (SUR) embracing four poreforming inwardly rectifying potassium channel (Kir...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/S1262-3636(07)70311-7

    authors： Flechtner I,de Lonlay P,Polak M

    更新日期：2006-12-01 00:00:00

  • Skeletal muscle magnesium content in identical twins, discordant for type 2 diabetes.

    abstract：BACKGROUND:Low magnesium (Mg) status has been implied as a factor in the development of type 2 diabetes mellitus (DM) and its complications. We therefore studied Mg-status in identical twins, discordant for type 2 DM and in matched controls. Through correlation analysis, possible associations between Mg-status and gluc...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：

    authors： Djurhuus MS,Vaag A,Altura BM,Altura BT,Klitgaard NA

    更新日期：2002-06-01 00:00:00

  • OPHDIAT: a telemedical network screening system for diabetic retinopathy in the Ile-de-France.

    abstract：OBJECTIVE:International and national guidelines recommend an annual funduscopic examination for all diabetic patients, but such annual fundus examinations are not sufficiently performed in France. Non-mydriatic fundus photography is a valid method of evaluation for diabetic retinopathy (DR) and a viable alternative to ...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章

    doi：10.1016/j.diabet.2007.12.006

    authors： Massin P,Chabouis A,Erginay A,Viens-Bitker C,Lecleire-Collet A,Meas T,Guillausseau PJ,Choupot G,André B,Denormandie P

    更新日期：2008-06-01 00:00:00

  • Effects of glucose-lowering agents on vascular outcomes in type 2 diabetes: a critical reappraisal.

    abstract：:Type 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular complications, especially coronary artery disease. Numerous epidemiological studies have shown a close relationship between major cardiovascular events and glycaemia, and several pathophysiological mechanisms have been described that explain ho...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,评审

    doi：10.1016/j.diabet.2014.03.004

    authors： Scheen AJ,Charbonnel B

    更新日期：2014-06-01 00:00:00

  • The metabolic syndrome in smokers. The D.E.S.I.R. study.

    abstract：OBJECTIVES:To test the hypothesis that smokers have a higher frequency of the metabolic syndrome, and a syndrome with different characteristics than non-smokers. MATERIAL AND METHODS:The 2,569 men and 2,637 women included in the D.E.S.I.R. study, aged 30-64 years, volunteers from ten French Social Security Health Exam...

    journal_title：Diabetes & metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1016/s1262-3636(07)70031-9

    authors： Geslain-Biquez C,Vol S,Tichet J,Caradec A,D'Hour A,Balkau B,D.E.S.I.R. Study Group.

    更新日期：2003-06-01 00:00:00