Venous oxygen measurements in the inferior vena cava in neonates with respiratory failure.


:BACKGROUND: The present study was undertaken to examine the feasibility of venous oxygen measurements in the inferior vena cava (IVC) via a catheter through the umbilical vein. This may serve as a proxy for mixed venous oxygenation and the complications of right atrial cannulation can be avoided at the same time. It has the added advantage of not being affected by atrial right-left shunting. RESULTS: The study included 22 neonates requiring mechanical ventilation for respiratory insufficiency. The success rate of catheterization of the IVC via the umbilical vein was 81% and there was no catheter-related complications. Fifty paired blood samples were obtained and analyzed while the patients were hemodynamically stable. Linear regression analysis showed a poor correlation between arterial oxygen tension (PaO2) and the arterial-venous oxygen content difference [C(a-v)O2], r = -0.005, and between PaO2 and the fractional oxygen extraction (FOE), r = -0.114. There was also a poor correlation between arterial oxygen saturation (SaO2) and C(a-v)O2, r = -0.057, and between SaO2 and FOE, r =-0.139. The correlations between venous oxygen tension (PvO2) and C(a-v)O2 and between PvO2 and FOE were r = -0.528 and r = 0.592, respectively. There were good correlations between various oxygen saturation (SvO2) and C(a-v)O2, r = -0.634, and between SvO2 FOE, r = -0.712. CONCLUSION: Venous oxygen measurement in the IVC via an umbilical vein catheter is a simple and safe procedure and provides information about the tissue oxygenation status of critically ill neonates.


Crit Care


Plötz FB,van Lingen RA,Bos AP





Has Abstract


1998-01-01 00:00:00












  • Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programme data

    abstract:INTRODUCTION:This study pools data from the UK Intensive Care National Audit and Research Center (ICNARC) Case Mix Programme (CMP) to evaluate the case mix, outcome and activity for 17,326 patients with severe acute kidney injury (AKI) occurring during the first 24 hours of admission to intensive care units (ICU). MET...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Kolhe NV,Stevens PE,Crowe AV,Lipkin GW,Harrison DA

    更新日期:2008-01-01 00:00:00

  • Dynamic hyperinflation and intrinsic positive end-expiratory pressure in ARDS patients.

    abstract:BACKGROUND:In ARDS patients, changes in respiratory mechanical properties and ventilatory settings can cause incomplete lung deflation at end-expiration. Both can promote dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP). The aim of this study was to investigate, in a large population of ARDS...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Coppola S,Caccioppola A,Froio S,Ferrari E,Gotti M,Formenti P,Chiumello D

    更新日期:2019-11-27 00:00:00

  • Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality.

    abstract:INTRODUCTION:In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission. METHODS:We conducted a prospective observational study enrolling patients admitted to the ICU with severe se...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Garnacho-Montero J,Gutiérrez-Pizarraya A,Escoresca-Ortega A,Fernández-Delgado E,López-Sánchez JM

    更新日期:2015-08-27 00:00:00

  • In vivo validation of the adequacy calculator for continuous renal replacement therapies.

    abstract:INTRODUCTION:The study was conducted to validate in vivo the Adequacy Calculator, a Microsoft Excel-based program, designed to assess the prescription and delivery of renal replacement therapy in the critical care setting. METHODS:The design was a prospective cohort study, set in two intensive care units of teaching h...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Ricci Z,Salvatori G,Bonello M,Pisitkun T,Bolgan I,D'Amico G,Dan M,Piccinni P,Ronco C

    更新日期:2005-06-01 00:00:00

  • Year in review 2013: Critical Care--sepsis.

    abstract::This review presents key publications from the research field of sepsis published in Critical Care and other relevant journals during 2013. The results of these experimental studies and clinical trials are discussed in the context of current scientific and clinical background. The discussion highlights and summarises ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: de Montmollin E,Annane D

    更新日期:2014-10-15 00:00:00

  • Effect of bladder volume on measured intravesical pressure: a prospective cohort study.

    abstract:INTRODUCTION:Correct bedside measurement of intra-abdominal pressure (IAP) is important. The bladder method is considered as the gold standard for indirect IAP measurement, but the instillation volumes reported in the literature vary substantially. The aim of this study was to evaluate the effect of instillation volume...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Malbrain ML,Deeren DH

    更新日期:2006-01-01 00:00:00

  • Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study.

    abstract:INTRODUCTION:Resuscitation with saline is a standard initial response to hypotension or shock of almost any cause. Saline resuscitation is thought to generate an increase in cardiac output through a preload-dependent (increased end-diastolic volume) augmentation of stroke volume. We sought to confirm this to be the mec...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Kumar A,Anel R,Bunnell E,Zanotti S,Habet K,Haery C,Marshall S,Cheang M,Neumann A,Ali A,Kavinsky C,Parrillo JE

    更新日期:2004-06-01 00:00:00

  • Statistics review 2: samples and populations.

    abstract::The previous review in this series introduced the notion of data description and outlined some of the more common summary measures used to describe a dataset. However, a dataset is typically only of interest for the information it provides regarding the population from which it was drawn. The present review focuses on...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Whitley E,Ball J

    更新日期:2002-04-01 00:00:00

  • New versus old blood - the debate continues.

    abstract::Since the inception of blood banking, refinements in laboratory processes have allowed for progressively longer storage times of red blood cells. Whilst advantageous for the logistics of stock management, the clinical impact of the duration of red blood cell storage prior to transfusion remains uncertain, and a topic ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Laurie J,Wyncoll D,Harrison C

    更新日期:2010-01-01 00:00:00

  • Respiratory support withdrawal in intensive care units: families, physicians and nurses views on two hypothetical clinical scenarios.

    abstract:INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Fumis RR,Deheinzelin D

    更新日期:2010-01-01 00:00:00

  • Estimation of the diameter and cross-sectional area of the internal jugular veins in adult patients.

    abstract:INTRODUCTION:Unawareness of an asymmetry between the right and left internal jugular vein (IJV) and methodological pitfalls in previous studies raise concerns about such asymmetry. Hence the aim of this prospective non-interventional study was to validate the hypothesis that right IJV diameter is greater than those of ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Tartière D,Seguin P,Juhel C,Laviolle B,Mallédant Y

    更新日期:2009-01-01 00:00:00

  • Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis.

    abstract:INTRODUCTION:Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen (HLA)-DR expression and reduced production of proinflammatory cytokines. Recently, diminished numbers of dend...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Poehlmann H,Schefold JC,Zuckermann-Becker H,Volk HD,Meisel C

    更新日期:2009-01-01 00:00:00

  • Procalcitonin as a marker of bacterial infection in the emergency department: an observational study.

    abstract:INTRODUCTION:Procalcitonin (PCT) has been proposed as a marker of infection in critically ill patients; its level is related to the severity of infection. We evaluated the value of PCT as a marker of bacterial infection for emergency department patients. METHODS:This prospective observational study consecutively enrol...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chan YL,Tseng CP,Tsay PK,Chang SS,Chiu TF,Chen JC

    更新日期:2004-02-01 00:00:00

  • Prediction of fluid challenge effect: filling pressure when left ventricular function is abnormal, diastolic volume when left ventricular function is normal.

    abstract::Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Payen D

    更新日期:2011-01-01 00:00:00

  • Clinical review: extracorporeal blood purification in severe sepsis.

    abstract::Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Venkataraman R,Subramanian S,Kellum JA

    更新日期:2003-04-01 00:00:00

  • Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy.

    abstract:INTRODUCTION:Intravenous (IV) voriconazole is not recommended in patients with creatinine clearance <50 ml/min to avoid potentially toxic accumulation of sulfobutylether-β-cyclodextrin (SBECD). The purpose of this study was to evaluate the pharmacokinetics of SBECD, voriconazole, and voriconazole N-oxide in critically ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Kiser TH,Fish DN,Aquilante CL,Rower JE,Wempe MF,MacLaren R,Teitelbaum I

    更新日期:2015-02-03 00:00:00

  • Delirium prediction in the intensive care unit: comparison of two delirium prediction models.

    abstract:BACKGROUND:Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use of early preventive strategies and stratification of ICU patients by delirium risk in clinical research, but the optimal delirium prediction model to use is unclear. We compared the predictive performance and user c...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Wassenaar A,Schoonhoven L,Devlin JW,van Haren FMP,Slooter AJC,Jorens PG,van der Jagt M,Simons KS,Egerod I,Burry LD,Beishuizen A,Matos J,Donders ART,Pickkers P,van den Boogaard M

    更新日期:2018-05-05 00:00:00

  • Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?

    abstract::Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known a...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Souza-Fonseca-Guimaraes F,Cavaillon JM,Adib-Conquy M

    更新日期:2013-08-27 00:00:00

  • Is access to intensive care equitable?

    abstract:: ...

    journal_title:Critical care (London, England)

    pub_type: 社论


    authors: Martin CM

    更新日期:2018-11-03 00:00:00

  • The practice of intensive care in Latin America: a survey of academic intensivists.

    abstract:BACKGROUND:Intensive care medicine is a relatively young discipline that has rapidly grown into a full-fledged medical subspecialty. Intensivists are responsible for managing an ever-increasing number of patients with complex, life-threatening diseases. Several factors may influence their performance, including age, tr...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Castro R,Nin N,Ríos F,Alegría L,Estenssoro E,Murias G,Friedman G,Jibaja M,Ospina-Tascon G,Hurtado J,Marín MDC,Machado FR,Cavalcanti AB,Dubin A,Azevedo L,Cecconi M,Bakker J,Hernandez G,Latin-American Intensive Care Net

    更新日期:2018-02-21 00:00:00

  • Oxygen deficit and H2S in hemorrhagic shock in rats.

    abstract:INTRODUCTION:Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemo...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Van de Louw A,Haouzi P

    更新日期:2012-10-02 00:00:00

  • Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis.

    abstract:BACKGROUND:Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic control in TBI requiring admission to an intensive care unit (ICU). METHODS:We systematically se...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析,评审


    authors: Hermanides J,Plummer MP,Finnis M,Deane AM,Coles JP,Menon DK

    更新日期:2018-01-19 00:00:00

  • Prognostic value of admission blood glucose level in patients with and without diabetes mellitus who sustain ST segment elevation myocardial infarction complicated by cardiogenic shock.

    abstract:INTRODUCTION:Admission blood glucose (BG) level is a predictor of mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, limited data are available relating admission BG to mortality in patients with STEMI complicated by cardiogenic shock, and it is not known whether diabetic status has...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Yang JH,Song PS,Song YB,Hahn JY,Choi SH,Choi JH,Lee SH,Jeong MH,Kim YJ,Gwon HC

    更新日期:2013-10-03 00:00:00

  • Carbon dioxide monitoring and evidence-based practice - now you see it, now you don't.

    abstract::Carbon dioxide has been monitored in the body using a variety of technologies with a multitude of applications. The monitoring of this common physiologic variable in medicine is an illustrative example of the different levels of evidence that are required before any new health technology should establish itself in cli...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Gattas D,Ayer R,Suntharalingam G,Chapman M

    更新日期:2004-08-01 00:00:00

  • Bench to bedside review: Extracorporeal carbon dioxide removal, past present and future.

    abstract::Acute respiratory distress syndrome (ARDS) has a substantial mortality rate and annually affects more than 140,000 people in the USA alone. Standard management includes lung protective ventilation but this impairs carbon dioxide clearance and may lead to right heart dysfunction or increased intracranial pressure. Extr...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Cove ME,MacLaren G,Federspiel WJ,Kellum JA

    更新日期:2012-09-21 00:00:00

  • Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality.

    abstract:BACKGROUND:The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood beca...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Greenberg JA,Hrusch CL,Jaffery MR,David MZ,Daum RS,Hall JB,Kress JP,Sperling AI,Verhoef PA

    更新日期:2018-04-25 00:00:00

  • Diagnostic potential of circulating cell-free DNA in patients needing mechanical ventilation: promises and challenges.

    abstract::Circulating cell-free DNA (cf-DNA) mainly comes from apoptotic cells and can reflect the extent of cellular damage. Increased plasma levels of cf-DNA have been found in many acute disorders, including septic and clinically ill patients, and usually correlate well with clinical outcome. Acute respiratory failure, the m...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Arnalich F,López-Collazo E,Montiel C

    更新日期:2011-01-01 00:00:00

  • Recent evolution of renal replacement therapy in the critically ill patient.

    abstract::The epidemiology of severe acute renal failure has dramatically changed in the past decade. Its leading cause is sepsis and the syndrome develops mostly in the intensive care unit as part of multiple organ dysfunction syndrome. After the significant improvements obtained from the mid 1970s to the mid 1990s, the past d...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Ronco C

    更新日期:2006-02-01 00:00:00

  • Leukodepleted versus nonleukodepleted red blood cell transfusion in septic patients: a microcirculatory vision.

    abstract::Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepleted RBC transfusion may reduce the incidence of infection and organ dysfunction. However, the influence of le...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Tanaka S,Harrois A,Duranteau J

    更新日期:2014-04-01 00:00:00

  • Automatic detection of ventilatory modes during invasive mechanical ventilation.

    abstract:BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Murias G,Montanyà J,Chacón E,Estruga A,Subirà C,Fernández R,Sales B,de Haro C,López-Aguilar J,Lucangelo U,Villar J,Kacmarek RM,Blanch L

    更新日期:2016-08-14 00:00:00