Abstract:
:To design new antimicrobial peptides, we have focused on various proteins which are not essential for self-defense but carry important responsibilities for biosystems. Previously, we reported that highly efficient antimicrobial properties or antiviral properties are inherent in the nuclear translocation signals and binding sites on laminin receptors. Here we introduce microtubule binding sites on tau proteins as new components for antimicrobial peptides. Strong antimicrobial activities against Staphylococcus aureus and Escherichia coli were found in tandem sequences of the binding sites on tau proteins. Moreover, the binding sites obtained significantly strong antimicrobial activities against bacteria and fungi when combined with a nuclear localization signal (NLS) and/or a peptide derived from a binding site of a laminin receptor. The antimicrobial activities of some of the tau-derived peptides were not affected by salt, cations, or serum that simulate the natural environment present in blood. Tau proteins so far have only been known as one of the microtubule-associated proteins (MAPs) which are especially abundant in the central nervous system within the brain. Our finding demonstrates that the binding sites on tau proteins possess high potential for becoming components in antimicrobial peptides. Designs based on binding sites of various proteins could become a useful method in peptide antibiotic research.
journal_name
Biocontrol Scijournal_title
Biocontrol scienceauthors
Kobayashi N,Masuda J,Kudoh J,Shimizu N,Yoshida Tdoi
10.4265/bio.13.49subject
Has Abstractpub_date
2008-06-01 00:00:00pages
49-56issue
2eissn
1342-4815issn
1884-0205journal_volume
13pub_type
杂志文章abstract:: Linear alkylbenzene sulfonate (LAS) and polyoxyethylene lauryl ether (POLE) are major surfactants contained in the laundry detergents. In the present study, the antibacterial activities of the surfactants to aquatic microorganisms were compared. When freshwater samples from a small river in Okayama city were treated ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.22.229
更新日期:2017-01-01 00:00:00
abstract::The thermal death of the spores of Bacillus subtilis 168 in oil-water systems including emulsions and separated layers consisting of phosphate buffer and soybean oil or n-hexadecane was investigated. The resultant survivor curve consisted of two phases, an initial rapid reduction followed by a slow reduction, possibly...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.15.27
更新日期:2010-03-01 00:00:00
abstract:: We compared the TBT-resistant ability of resting cells prepared from isolates that formed colonies on nutrient agar plates containing 100 µM tributyltin (TBT) chloride, such as Photobacterium sp. TKY1, Halomonas sp. TKY2, and Photobacterium sp. NGY1, with those from taxonomically similar type strains. Photobacterium ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.22.89
更新日期:2017-01-01 00:00:00
abstract::Vibrio cholerae isolates from environmental and clinical origins in the Bengal region in which epidemics of cholera break out periodically were analyzed with particular emphasis on the molecular epidemiological features. The presence of the virulence genes (ctxA, tcpA and toxR) in the isolates was analyzed by the PCR ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.13.1
更新日期:2008-03-01 00:00:00
abstract::Fate of Escherichia coli O157 cells was evaluated when inoculated into each step after production of lightly pickled Chinese cabbage. The efficacy of surface sterilization by 100 mg/L of chlorine water for 10 min on raw leaves (6.0 log CFU/g) was 2.2 log CFU/g reduction. No meaningful change of the population of E. co...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.21.51
更新日期:2016-01-01 00:00:00
abstract::The genus Arthrospira is a nonheterocystous filamentous cyanobacterium inhabiting diverse environments including those of high salinity. In the present study, Arthrospira strains were isolated from freshwater and brackish lakes in Myanmar, and their osmoprotective adaptation was investigated as it was for the genus Sy...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.16.55
更新日期:2011-06-01 00:00:00
abstract::A biological indicator (BI) is a useful product to confirm sterility assurance after a sterilization procedure. In ISO 11138 and 14161, the concrete procedures regarding the use of BI are described for BI manufacturers and users, respectively. There are several problems involving BI use which must be addressed. These ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.12.77
更新日期:2007-06-01 00:00:00
abstract:: Exact evaluation of the performance of surgical masks and biohazard protective clothing materials against pathogens is important because it can provide helpful information that healthcare workers can use to select suitable materials to reduce infection risk. Currently, to evaluate the protective performance of nonwov...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.23.61
更新日期:2018-01-01 00:00:00
abstract::The effect of an oxygen-releasing compound (ORC) magnesium peroxide (MgO(2)) on the changes in the bacterial community in organically polluted sediment of aquaculture farms was tested in a microcosm experiment. The sediment, to which fish feed was added, was treated with 1% or 5% MgO(2). The addition of fish feed indu...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.18.41
更新日期:2013-01-01 00:00:00
abstract:: Malodorants in the human axilla are produced from human biogenic precursors by axillary bacterial enzymes. In the present study, we used pyrosequencing analysis to identify the axillary bacterial microbiota of 13 Japanese male subjects with cumin-like, spicy body odor (C type), and 9 with milky, skin-based body odor ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.23.1
更新日期:2018-01-01 00:00:00
abstract::We assessed the properties of biofilms (BFs) formed by mono- and co-cultures of Listeria monocytogenes and Pseudomonas aeruginosa (L+P-BF) at low temperatures and examined their sensitivity to several antibacterial substances. L. monocytogenes viable counts comprised only 1-10% of total L+P-BF viable counts at 10℃ and...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.23.107
更新日期:2018-01-01 00:00:00
abstract::An identified class of antifreeze, a xylomannan-based thermal hysteresis (TH)-producing glycolipid, has been discovered from diverse taxa, including plants, insects, and amphibians. We isolated xylomannan from the mycelium and fruit body of the basidiomycete Flammulina velutipes using successive hot extraction with wa...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.21.153
更新日期:2016-01-01 00:00:00
abstract:: Agaricus is known to have immunostimulatory and anti-tumor effects. However, the antiviral effects of Agaricus have not yet been examined. In the present study, the antiviral effects of an extract of Agaricus brasiliensis KA21 (AE) on the H1N1 influenza virus (PR8 strain) were investigated. The anti-influenza virus e...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.22.171
更新日期:2017-01-01 00:00:00
abstract::Vibrio vulnificus is a halophilic estuarine bacterium, but this species causes fatal septicemia in humans. V. vulnificus may encounter many kinds of stresses either in the natural environment or in the human body. One of the striking stresses is the exposure to the reactive oxygen species including nitric oxide (NO). ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.20.199
更新日期:2015-01-01 00:00:00
abstract:: With the object of developing new biocides milder for human use than the current antiseptics, we synthesized a series of bis-quaternary ammonium compounds (bis-QACs). The antimicrobial activity of the newly synthesized bis-QACs and common biocides used as antiseptics was compared by examining minimum inhibitory conce...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.21.231
更新日期:2016-01-01 00:00:00
abstract::Pseudomonas fluorescens strain LRB3W1 inhibited the mycelial growth of Fusarium oxysporum f. sp. lycopersici and suppressed the Fusarium wilt of tomato. The chemical fungicide, benomyl, did not suppress the disease incidence at low concentrations. However, the disease incidence was decreased by the combined applicatio...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.11.75
更新日期:2006-06-01 00:00:00
abstract::An outbreak of Escherichia coli O157:H7 occurred due to the consumption of sweet dumplings in Japan. We examined the survival of E. coli O157:H7 inoculated into several types of sweet dumplings to evaluate the progress of the residual contaminating pathogens after the production or packing processes. For all 4 types o...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.20.285
更新日期:2015-01-01 00:00:00
abstract::Mathematical models are essentially needed to quantitatively predict microbial growth in food products during their production and distribution. Recently we developed a new logistic model for microbial growth. The model is an extended logistic model, which shows a sigmoid curve on a semi-log plot. The model could prec...
journal_title:Biocontrol science
pub_type: 杂志文章,评审
doi:10.4265/bio.15.75
更新日期:2010-09-01 00:00:00
abstract::The antifungal activities of diglycerin monoester of fatty acids (DGCs), which have been employed as food emulsifiers, were examined against three yeasts, Saccharomyces cerevisiae, Candida albicans and Candida utilis and were compared with those of sucrose monoester of palmitic acid (SC16) as another type of emulsifie...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.21.123
更新日期:2016-01-01 00:00:00
abstract::Anti-VRE and anti-MRSA activities of new quinolone derivatives [The two quinolone derivatives are 8- [3-[(ethylamino) methyl]-1-pyrrodinyl] -7-fluoro-9, 1-[(N-methylimino)methano]-5-oxo-5H-thiazolo[3,2-a]quinolone-4-carboxylic acid (compound A) and 7-fluoro-8-morpholino-9,1-[(N-methylimino) methanol-5-oxo-5H-thiazolo ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.13.103
更新日期:2008-09-01 00:00:00
abstract::A small-sized generator of ozonated water was developed using an electro-conductive diamond. We studied the optimum conditions for producing ozonated water. As a result, we developed a small-sized generator of ozonated water driven by a dry-cell for use in the average household. This generator was easily able to produ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.13.119
更新日期:2008-12-01 00:00:00
abstract::The antifungal activity of scallop-shell powder heated at 1000 degrees C for 1 h against Trichophyton was kinetically investigated and the possibility of applying the powder to the treatment of dermatophytosis was examined. The death rate of T. mentagrophytes NBRC5466 in the heated shell powder slurry increased with p...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.11.125
更新日期:2006-09-01 00:00:00
abstract::The overproduction of enzymes was performed by manipulating the medium components. In our study, solvent-tolerant thermophilic lipase-producing Bacillus coagulans was isolated from soil samples and a stepwise optimization strategy was employed to increase the lipase production using coconut oil cake basal medium. In t...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.20.125
更新日期:2015-01-01 00:00:00
abstract::Tap water contamination is a growing concern in healthcare facilities, and despite chlorination, tap water in these facilities contains several pathogenic microorganisms causing healthcare-associated waterborne infections or nosocomial outbreaks. Shower units are particularly prone to contamination as they are conduci...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.25.223
更新日期:2020-01-01 00:00:00
abstract::Hinokitiol, the major component of Aomori Hiba (Thujopsis dolabrata Sieb. et Zucc. var. hondai M(AKINO)) has already been found to show strong antibacterial activity. In this study, its mechanism of action was examined using Escherichia coli IFO 3301 and Staphylococcus aureus IFO 12732. As a result, it was suggested t...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.12.101
更新日期:2007-09-01 00:00:00
abstract::This study compared the antifungal activities of bronopol and 2-methyl-4-isothiazolin-3-one (MT) against members of the genus Saprolegnia in the family saprolegniaceae, which have the ability to infect fish. The minimum inhibitory concentration of bronopol was 100-200 mg/l but for MT it was 31 mg/l. Concerning fungici...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.12.145
更新日期:2007-12-01 00:00:00
abstract::Density gradient centrifugation (DGC) is useful for the separation of living microbial cells from food samples that are not filterable. After DGC, however, careful operation is necessary to collect each density layer. For a simple and reproducible collection after DGC, we have developed a seamless operation system com...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.15.39
更新日期:2010-06-01 00:00:00
abstract::Ultraviolet-A (UV-A) can damage microbes by generating reactive oxygen species (ROS), singlet oxygen, superoxides, hydrogen peroxide and hydroxyl radicals. These species readily react with lipids, proteins, DNA and other constituents of cells, leading to oxidative deterioration and the eventual death of the microbe. H...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.20.27
更新日期:2015-01-01 00:00:00
abstract::Pseudomonas aeruginosa strains were isolated from 45 of 370 (12.2%) cockroaches captured in hospitals. By cockroach species, the bacterial strains were isolated from 39 of 181 (21.5%) Periplaneta fuliginosa and 6 of 183 (3.3%) Blattella germanica, showing a significant difference (p<0.01). Many P. aeruginosa-carrying ...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.14.155
更新日期:2009-12-01 00:00:00
abstract::The antimicrobial activity of isothiocyanates (ITCs) extracted from horseradish root was investigated against oral microorganisms: 6 strains of facultative anaerobic bacteria, Streptococcus mutans, Streptococcus sobrinus, Lactobacillus casei, Staphylococcus aureus, Enterococcus faecalis and Aggregatibacter actinomycet...
journal_title:Biocontrol science
pub_type: 杂志文章
doi:10.4265/bio.18.163
更新日期:2013-01-01 00:00:00