Abstract:
:A mathematical model is formulated to describe trends in biomass and penicillin formation as well as substrate consumption for fed-batch cultivations. The biomass is structured into three morphological compartments, and glucose and corn steep liquor are considered as substrates for growth. Penicillin formation is assumed to take place in the subapical compartment and in the growing region of the hyphal compartment. Furthermore, it is inhibited by glucose. Model parameters are estimated using an evolutionary algorithm and fitting the model to a standard fed-batch cultivation. The model is validated on experimental data from three different fed-batch cultivations, including two repeated fed-batch cultivations. The model predictions show good agreement with the measurements of biomass and pencillin concentrations for all fed-batch cultivations. (c) 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 56: 593-604, 1997.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Zangirolami TC,Johansen CL,Nielsen J,Jørgensen SBdoi
10.1002/(SICI)1097-0290(19971220)56:6<593::AID-BITsubject
Has Abstractpub_date
1997-12-20 00:00:00pages
593-604issue
6eissn
0006-3592issn
1097-0290journal_volume
56pub_type
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