Fuller Albright. His concept of postmenopausal osteoporosis and what came of it.

Abstract:

:Fifty years ago Albright contributed the following to understanding osteoporosis: (1) He recognized it as a deficiency of formation, not of mineralization of bone matrix; (2) he observed that 40 of 42 patients with osteoporosis before age 65 were women past menopause or young women postoophorectomy; (3) he concluded that estrogen stimulates osteoblasts (a conclusion later challenged); (4) he demonstrated by metabolic balance studies that estrogen causes a positive calcium balance in postmenopausal osteoporosis; (5) he introduced periodic progesterone to prevent or treat endometrial hyperplasia from prolonged estrogen therapy; and (6) he showed that long-term therapy arrested vertebral damage and height loss in postmenopausal osteoporosis and prevented them if started early. Since Albright's time, more sensitive methods of assessing bone density have replaced conventional roentgenograms. Some large scale trials of estrogen have indicated increased bone density and fewer fractures. Unopposed estrogen increases risk of endometrial cancer and decreases mortality from other cancers, myocardial infarction, stroke, and osteoporosis. Trials of calcitonin, diphosphonates, fluoride, vitamin D, and high calcium intake have not proved more effective than estrogen.

journal_name

Clin Orthop Relat Res

authors

Forbes AP

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

128-41

issue

269

eissn

0009-921X

issn

1528-1132

pub_type

传,历史文章,杂志文章
  • Porosity of rat femora following intramedullary reaming and nailing.

    abstract::The present study evaluated cortical porosity and thickness of intact rat femora 12 weeks after intramedullary reaming and nailing. The right femora were reamed and received either flexible polyacetal nails or rigid stainless steel nails. A third group was reamed but not nailed. The left femora were used as controls. ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Husby OS,Gjerdet NR,Erichsen ES,Rykkje JM,Mølster AO

    更新日期:1989-09-01 00:00:00

  • The relationship between degenerative changes and osteoporosis in the lumbar spine.

    abstract::Degenerative changes in the spine, specifically disc degeneration and facet arthrosis, and osteoporosis are conditions that primarily affect the elderly and may significantly impact the quality of life. The relationship between osteoporosis and degenerative changes in the hip joint has been studied, but their correlat...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-199603000-00017

    authors: Margulies JY,Payzer A,Nyska M,Neuwirth MG,Floman Y,Robin GC

    更新日期:1996-03-01 00:00:00

  • Fracture of the axis arch. "Hangman's fracture" of the cervical spine.

    abstract::Fifteen patients with fracture of the axis arch ("Hangman's Fracture" of the cervical spine) reviewed with regard to the clinical features, mechanism of injury and management, present a relatively high rate of cord involvement (11 patients) and injuries around the jaw (5 patients). All of the injuries occurred in civi...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-197501000-00024

    authors: Marar BC

    更新日期:1975-01-01 00:00:00

  • Pelvic reconstruction/total hip arthroplasty for metastatic acetabular insufficiency.

    abstract::Four cases of pathologic periacetabular insufficiency/fracture in patients with extensive neoplastic metastatic involvement of the hemipelvis were treated by pelvic reconstruction with hemipelvis pin reinforcement with total hip arthroplasty (THA). Reconstruction was reserved for patients with limited other bony or vi...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Walker RH

    更新日期:1993-09-01 00:00:00

  • Thigh pain and total hip arthroplasty: scintigraphy with 2.5-year followup.

    abstract::From January 1988 to May 1990, 60 patients underwent 68 total hip arthroplasties at the Eisenhower Army Medical Center. The authors excluded 11 patients (11 hips) in whom infection developed, who were lost to followup, or who had incomplete records, leaving 49 patients (57 hips) as the study population. The 35 uncemen...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-199703000-00022

    authors: Herzwurm PJ,Simpson SL,Duffin S,Oswald SG,Ebert FR

    更新日期:1997-03-01 00:00:00

  • Classification of tibial shaft fractures and correlation with results after rigid internal fixation.

    abstract::A classification of tibial shaft fractures based on etiology, morphology, and clinical features is documented in a series of 291 fractures treated by AO/ASIF rigid internal fixation. The fractures were placed in nine main fracture groups, each with three subgroups according to location in the proximal, middle, or dist...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Johner R,Wruhs O

    更新日期:1983-09-01 00:00:00

  • Experimental arthritis in rabbit knees: a study of relief of pressure on one tibial plateau in immature and mature rabbits.

    abstract::The Hall model of experimental arthritis of the knee (excision of the lateral femoral condyle) offers a unique way of investigating the earliest changes of degenerative arthritis. Predictable degeneration of the lateral tibial plateau occurs when there is lack of contact with an opposing surface. Previous work by Hall...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Engh GA,Chrisman OD

    更新日期:1977-06-01 00:00:00

  • VEGF improves skeletal muscle regeneration after acute trauma and reconstruction of the limb in a rabbit model.

    abstract:BACKGROUND:Complicated tibial fractures with severe soft tissue trauma are challenging to treat. Frequently associated acute compartment syndrome can result in scarring of muscles with impaired function. Several studies have shown a relationship between angiogenesis and more effective muscle regeneration. Vascular endo...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-012-2456-7

    authors: Frey SP,Jansen H,Raschke MJ,Meffert RH,Ochman S

    更新日期:2012-12-01 00:00:00

  • T1ρ Hip Cartilage Mapping in Assessing Patients With Cam Morphology: How Can We Optimize the Regions of Interest?

    abstract:BACKGROUND:T1ρ MRI has been shown feasible to detect the biochemical status of hip cartilage, but various region-of-interest strategies have been used, compromising the reproducibility and comparability between different institutions and studies. QUESTIONS/PURPOSES:The purposes of this study were (1) to determine repr...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-016-5011-0

    authors: Anwander H,Rakhra KS,Melkus G,Beaulé PE

    更新日期:2017-04-01 00:00:00

  • C7--T1 bilateral facet dislocation: a rare lesion presenting with the syndrome of acute anterior spinal cord injury.

    abstract::Dislocation of the cervicothoracic junction, between the C7 and T1 vertebrae, occurred in a 46-year-old inebriated man. The C7--T1 junction is difficult to visualize on roentgenographs even when the upper extremities are pulled down. This injury is uncommon and often undiagnosed immediately after injury (Fig. 7). The ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Pick RY,Segal D

    更新日期:1980-07-01 00:00:00

  • Syndesmotic disruption in low fibular fractures associated with deltoid ligament injury.

    abstract::Low fibular fractures that were associated with deltoid ligament disruption and inferior tibiofibular syndesmotic disruption were studied. All of the patients had a Type B Weber fibular fracture associated with a deltoid ligament injury. It was difficult to detect the syndesmosis disruption on the initial assessment o...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/01.blo.0000052935.71325.30

    authors: Ebraheim NA,Elgafy H,Padanilam T

    更新日期:2003-04-01 00:00:00

  • Is synovial C-reactive protein a useful marker for periprosthetic joint infection?

    abstract:BACKGROUND:Serum C-reactive protein (CRP) is a general marker of inflammation, and recent studies suggest that measurement of CRP in synovial fluid may be a more accurate method for diagnosing periprosthetic joint infection (PJI). QUESTIONS/PURPOSES:We aimed to (1) determine if there is a correlation between serum and...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-014-3828-y

    authors: Tetreault MW,Wetters NG,Moric M,Gross CE,Della Valle CJ

    更新日期:2014-12-01 00:00:00

  • Perioperative Risk Adjustment for Total Shoulder Arthroplasty: Are Simple Clinically Driven Models Sufficient?

    abstract:BACKGROUND:There is growing interest in value-based health care in the United States. Statistical analysis of large databases can inform us of the factors associated with and the probability of adverse events and unplanned readmissions that diminish quality and add expense. For example, increased operating time and hig...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-016-5147-y

    authors: Bernstein DN,Keswani A,Ring D

    更新日期:2017-12-01 00:00:00

  • The influence of distal clavicle resection and rotator cuff repair on the effectiveness of anterior acromioplasty.

    abstract::Anterior acromioplasty, described by Neer in 1972, is generally accepted as the procedure of choice for symptomatic subacromial impingement. Subsequent authors have written little about the prolonged length of postoperative rehabilitation, residual strength deficits, and the effect of the addition of a distal clavicle...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Daluga DJ,Dobozi W

    更新日期:1989-10-01 00:00:00

  • Do patients with a failed metal-on-metal hip implant with a pseudotumor present differences in their peripheral blood lymphocyte subpopulations?

    abstract:BACKGROUND:Early adverse tissue reactions around metal-on-metal (MoM) hip replacements, especially pseudotumors, are a major concern. Because the causes and pathomechanisms of these pseudotumors remain largely unknown, clinical monitoring of patients with MoM bearings is challenging. QUESTIONS/PURPOSES:The purpose of ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-015-4466-8

    authors: Catelas I,Lehoux EA,Hurda I,Baskey SJ,Gala L,Foster R,Kim PR,Beaulé PE

    更新日期:2015-12-01 00:00:00

  • Some new trends of biomechanical studies in traumatology and orthopedics.

    abstract::This article presents four recent areas of research in biomechanics with clinical application. The first area describes quantification of the functional condition of the lower extremity using biomechanical parameters based on theoretical assumptions for a new mathematical model of walking. The second area describes th...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Belenky VE,Akivis MF,Aiderman LB

    更新日期:1991-05-01 00:00:00

  • Nonoperative treatment of an os peroneum fracture in a high-level athlete: a case report.

    abstract:BACKGROUND:The os peroneum is a sesamoid bone in the peroneus longus tendon. Fractures of the os peroneum are rare. Some authors recommend surgery for active patients. CASE DESCRIPTION:A 41-year-old male professional tennis coach sustained a minimally displaced fracture of the os peroneum. He was treated with restrict...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章,评审

    doi:10.1007/s11999-011-1812-3

    authors: Smith JT,Johnson AH,Heckman JD

    更新日期:2011-05-01 00:00:00

  • Immunomodulatory Peptide IDR-1018 Decreases Implant Infection and Preserves Osseointegration.

    abstract:BACKGROUND:Innate defense regulator peptide-1018 (IDR-1018) is a 12-amino acid, synthetic, immunomodulatory host defense peptide that can reduce soft tissue infections and is less likely to induce bacterial resistance than conventional antibiotics. However, IDRs have not been tested on orthopaedic infections and the im...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-015-4301-2

    authors: Choe H,Narayanan AS,Gandhi DA,Weinberg A,Marcus RE,Lee Z,Bonomo RA,Greenfield EM

    更新日期:2015-09-01 00:00:00

  • Roentgenographic findings in pigmented villonodular synovitis of the knee.

    abstract::Twenty-nine cases of pigmented villonodular synovitis (PVS) of the knee in 27 patients were reviewed to determine characteristic roentgenographic findings. All cases met strict histologic criteria for diagnosis. Four cases were localized PVS (LPVS), and 25 cases were diffuse PVS (DPVS). Roentgenographic findings were ...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Flandry F,McCann SB,Hughston JC,Kurtz DM

    更新日期:1989-10-01 00:00:00

  • A method for short- and long-term in vivo study of the bone-implant interface.

    abstract::A screw-shaped titanium chamber has been designed for serial in vivo observations of the bone-implant interface. First, the chamber is implanted; later a test substance, e.g. bone cement, is inserted in the chamber and brought in contact with the bone with minimal trauma. Both acute and long-term effects can be intrav...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Albrektsson T,Linder L

    更新日期:1981-09-01 00:00:00

  • Supramalleolar osteotomy in the management of the rheumatoid hindfoot.

    abstract::Supracondylar osteotomy is an alternative to other procedures for realignment of the rheumatoid hindfoot. Of 64 hindfoot operations performed since 1964, 12 were supracondylar osteotomies. The specific indication for this procedure was an ankylosed rheumatoid foot with equinovarus deformity and limited range of tarsal...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Heywood AW

    更新日期:1983-07-01 00:00:00

  • The risk of revision after TKA is affected by previous HTO or UKA.

    abstract:BACKGROUND:High tibial osteotomy (HTO) and unicompartmental arthroplasty (UKA) are reconstructive surgeries advocated for younger patients. In case of failure or progression of osteoarthritis, they can both be converted to a total knee arthroplasty (TKA). QUESTIONS/PURPOSES:We used registry data to answer if the risks...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-014-3712-9

    authors: Robertsson O,W-Dahl A

    更新日期:2015-01-01 00:00:00

  • Early failure of noncemented porous coated anatomic total hip arthroplasty.

    abstract::From July 1984 through October 1987, 63 consecutive primary Porous Coated Anatomic total hip arthroplasties were performed. Follow-up observation ranged from one to four years, with a mean of 2.4 years. The mean postoperative Harris hip score in 81 cases was 38% excellent results, 23% good results, 6% fair results, an...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Maric Z,Karpman RR

    更新日期:1992-05-01 00:00:00

  • IVC filters may prevent fatal pulmonary embolism in musculoskeletal tumor surgery.

    abstract:UNLABELLED:To determine whether inferior vena cava (IVC) filter placement protects patients with musculoskeletal tumors from fatal pulmonary embolisms (PE), we retrospectively analyzed the records of 81 patients who underwent surgery for pelvic and lower extremity malignancies. All 81 patients received an IVC filter an...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1007/s11999-008-0607-7

    authors: Tuy B,Bhate C,Beebe K,Patterson F,Benevenia J

    更新日期:2009-01-01 00:00:00

  • Treatment of congenital pseudarthrosis of the tibia with direct current stimulation.

    abstract::Congenital pseudarthrosis of the tibia presents surgeons with one of the most challenging of all orthopedic problems. The results of various forms of surgical treatment are rarely successful. This is a preliminary report on an implanted direct current bone growth stimulator (DCBGS) for treatment of congential pseudart...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:

    authors: Paterson DC,Lewis GN,Cass CA

    更新日期:1980-05-01 00:00:00

  • Professionalism and professional values in orthopaedics.

    abstract::During a consensus conference in Fall, 1998, the Academic Orthopaedic Society identified the values and qualities of professionalism as defined by its members. One hundred eighty-six respondents rated 20 characteristics and values describing professionalism, based on the extent to which they believed each item was app...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-200009000-00015

    authors: Rowley BD,Baldwin DC Jr,Bay RC,Karpman RR

    更新日期:2000-09-01 00:00:00

  • Not all zirconia femoral heads degrade in vivo.

    abstract::Degradation of yttria-stabilized zirconia femoral heads in vivo has been linked to increased roughening and even fracture of the femoral head. To determine whether magnesia-stabilized zirconia is better suited to resist degradation, we characterized the monoclinic phase concentration, surface topography, and microhard...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/BLO.0b013e318158b4d3

    authors: Roy ME,Whiteside LA,Katerberg BJ,Steiger JA,Nayfeh T

    更新日期:2007-12-01 00:00:00

  • Press-fit metal-backed alumina sockets: a minimum 5-year followup study.

    abstract::Two hundred thirty-four consecutive alumina-on-alumina hip replacements using a press-fit metal-backed socket, performed on 214 patients (98 women, 116 men) have been reviewed. These included 201 primary procedures and 33 revision procedures. The median age of the patients at the time of surgery was 62 years (range, 2...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/00003086-200010000-00016

    authors: Bizot P,Larrouy M,Witvoet J,Sedel L,Nizard R

    更新日期:2000-10-01 00:00:00

  • Do shoulder vibration signals vary among asymptomatic volunteers?

    abstract::Numerous studies document vibrations emanating from joints during active or passive motion. It has been proposed these vibrations, termed vibroarthrographic signals, are associated with changes in the shape or quality of tissues in and around the joint. Vibroarthrographic signals in articular joints have been tested t...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/BLO.0b013e31802c3423

    authors: Kargus R,Bahu M,Kahugu M,Martin S,Atkinson P

    更新日期:2007-03-01 00:00:00

  • What Is the Association Between Hospital Volume and Complications After Revision Total Joint Arthroplasty: A Large-database Study.

    abstract:BACKGROUND:Studies of primary total joint arthroplasty (TJA) show a correlation between hospital volume and outcomes; however, the relationship of volume to outcomes in revision TJA is not well studied. QUESTIONS/PURPOSES:We therefore asked: (1) Are 90-day readmissions more likely at low-volume hospitals relative to h...

    journal_title:Clinical orthopaedics and related research

    pub_type: 杂志文章

    doi:10.1097/CORR.0000000000000684

    authors: Ricciardi BF,Liu AY,Qiu B,Myers TG,Thirukumaran CP

    更新日期:2019-05-01 00:00:00