Abstract:
:Our purpose was to study necrosis and apoptosis of hepatocellular carcinoma (HCC) cells after preoperative transcatheter arterial chemoembolization (TACE) with use of low-dose and high-dose anticancer drugs in HCCs. Fifty-four patients with advanced but surgically resectable HCC were studied. Thirty-four patients who elected to undergo preoperative superselective TACE were randomized to low- and high-dose TACE. Patients in group A (n = 16) received low-dose anticancer drugs: 2 mg mitomycin C (MMC), 10 mg epirubicin (EPI), and 100 mg carboplatin (CBP). Patients in group B (n = 18) were given high doses of anticancer drugs (10 mg MMC, 40 mg EPI, and 300 mg CBP). Hepatic resection was subsequently performed. Group C comprised 20 patients who underwent resection without TACE. In all patients the necrosis rates and apoptosis index of tumor cells were evaluated by pathologic examinations and terminal deoxynucleotidyl transferase-mediated nick-end labeling assay. There was no significant difference between group A and group B in tumor response (p [ 0.05) after TACE. Necrosis rates in groups A, B, and C were 88.4 +/- 11.1%, 87.1 +/- 12.5%, and 7.3 +/- 3.5%, respectively. There was no significant difference between group A and group B (p [ 0.05), while statistical difference was found between group A and group C (p \ 0.001) and between group B and group C (p \ 0.001). Apoptosis indexes in the three groups were 11.0 +/- 4.0%, 10.7 +/- 3.9%, and 5.6 +/- 2.6%, respectively. Statistical difference exhibited between group A and group C (p \ 0.001) and group B versus group C (p \ 0.001). No significant difference was observed between group A and group B (p [ 0.05). In conclusion, superselective TACE with low- and high-dose chemotherapeutic agents induced similar degrees of cellular apoptosis and necrosis.
journal_name
Cardiovasc Intervent Radioljournal_title
Cardiovascular and interventional radiologyauthors
Lu W,Li YH,He XF,Zhao JB,Chen Y,Mei QLdoi
10.1007/s00270-008-9379-4subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1133-40issue
6eissn
0174-1551issn
1432-086Xjournal_volume
31pub_type
杂志文章,随机对照试验abstract::The purpose of this investigation was to determine if addition of infragenicular steady-state (SS) magnetic resonance angiography (MRA) to first-pass imaging improves diagnostic performance compared with first-pass imaging alone in patients with peripheral arterial disease (PAD) undergoing whole-body (WB) MRA. Twenty ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9759-4
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To evaluate the effects of neoadjuvant intra-arterial chemotherapy (NAIC) for locally advanced uterine cervical cancer, and to analyze factors influencing the response to the chemotherapy. METHODS:Thirty-four patients with invasive cervical cancer more than 4 cm in diameter were enrolled in this study. NAIC wa...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-003-0506-y
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:The effects of nitric acid (NO) on vessel response to injury include the inhibition of platelet adhesion, platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation. Releasing NO from a stent might reduce the clinical problem of restenosis. The present study was designed to examine whether...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0206-2
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To evaluate the protective effect of using thermo-sensitive basement membrane extract (Matrigel) for hydrodissection to minimize thermal injury to nearby structures and to evaluate its heat sink effect on the ablation zone in radiofrequency ablation (RFA) of the liver. MATERIALS AND METHODS:First, the viscosit...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1617-1
更新日期:2017-07-01 00:00:00
abstract::The aim of the present study was to determine whether there is a linear relation between the doses measured above and those measured under the lead apron of the radiologists performing interventional procedures. To monitor radiation exposure the International Commission of Radiological Protection (ICRP) recommends the...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-008-9307-7
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:Long-term data on aneurysm treatment with flow-diverting stents are still sparse, and follow-up protocols differ widely between institutions. We present long-term results, with a focus on the usefulness of contrast-enhanced MR angiography (ceMRA). MATERIALS AND METHODS:Interventions and follow-up imaging of pa...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1732-z
更新日期:2017-11-01 00:00:00
abstract::Two infants with severe colonic strictures secondary to necrotizing enterocolitis (NEC) were successfully dilated with balloon catheters. The procedures were performed under mild sedation, with fluoroscopic guidance. Results were sustained for more than 4 years follow-up. This procedure proved to be a safe and effecti...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02602971
更新日期:1993-07-01 00:00:00
abstract::We present two patients with life-threatening, massive, lower gastrointestinal (GI) bleeding and locally advanced cervical carcinoma. Selective pelvic arteriography demonstrated that the site of bleeding originated from a pseudoaneurysm of the right internal iliac artery with fistulous communication to the sigmoid col...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900312
更新日期:1998-11-01 00:00:00
abstract::We implanted stents in three patients who had traumatic abdominal aortic dissections, complicated by right limb ischemia in one case. The circulating false channel extended to the left iliac artery in one case and to both iliac arteries in the last case. Diagnosis and radiological follow-up included ultrasound, comput...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s002709900197
更新日期:1997-11-01 00:00:00
abstract::Predicting the wall stress in abdominal aortic aneurysm (AAA) using computational modeling may be a useful adjunct to traditional clinical parameters that indicate the risk of rupture. Maximum diameter has been shown to have many limitations, and using current technology it is possible to provide a patient-specific co...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-014-0864-7
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to describe imaging appearances of hepatocellular carcinoma (HCC) supplied exclusively by the hepatic falciform artery (HFA) and safety of chemoembolization via the HFA. METHODS:During the past 6 years, we have performed chemoembolization for the treatment of 12 patients with HCCs...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0236-5
更新日期:2012-08-01 00:00:00
abstract::Retrievable inferior vena cava filters are being increasingly used for the prevention of life-threatening pulmonary emboli in patients who have temporary contraindications to anticoagulation therapy. We report two cases of failure to remove these devices. ...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-005-0145-6
更新日期:2006-01-01 00:00:00
abstract::In the last two decades, a substantial number of articles have been published to provide diagnostic solutions for patients with carotid atherosclerotic disease. These articles have resulted in a shift of opinion regarding the identification of stroke risk in patients with carotid atherosclerotic disease. In the recent...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-010-9828-8
更新日期:2010-08-01 00:00:00
abstract::In this article, we study in vitro evaluation of needle artefacts and image quality for musculoskeletal laser-interventions in an open high-field magnetic resonance imaging (MRI) scanner at 1.0T with vertical field orientation. Five commercially available MRI-compatible puncture needles were assessed based on artefact...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-009-9676-6
更新日期:2010-04-01 00:00:00
abstract::The renal transplant vascularity of 72 patients was investigated by intravenous digital subtraction angiography (IV DSA). The procedure was combined with selective venous renin sampling of the transplant and native kidneys to identify the source of hypertension in these patients. Abnormalities were found on IV DSA exa...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02552439
更新日期:1983-01-01 00:00:00
abstract::Carotid artery stenting (CAS) is a revascularization modality that is an alternative to carotid endarterectomy. The efficacy of CAS in primary and secondary prevention from ischemic stroke has been demonstrated in various trials. Acute thrombosis of CAS is a rare complication that can lead to dramatic and catastrophic...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-014-0959-1
更新日期:2015-08-01 00:00:00
abstract::A renal pseudotumor caused by a small portion of normal spleen receiving blood supply from a renal capsular artery is described. CT with nonselective enhancement and liver/spleen scan may fail to delineate this previously unreported finding. CT angiography, however, can establish the diagnosis. The consideration of th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02578632
更新日期:1990-10-01 00:00:00
abstract::Although current techniques for percutaneous biliary stone extraction are highly successful, many patients require manipulation of the calculi before such extraction is possible. This article describes several adjunctive techniques for biliary stone retrieval that have proven to be effective. These include the modific...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02578013
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:Comparison of the biocompatibility of self-expanding polyethylene terephthalate (PET) stents with self-expanding metallic stents (Wallstents). METHODS:Diameter- and length-matched PET stents and Wallstents were symmetrically implanted in the paired iliac arteries of 13 crossbred domestic swine. Stent deploymen...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/BF02577615
更新日期:1996-05-01 00:00:00
abstract::We report the case of a young break-dancer presenting with hammer syndrome. This syndrome has been correlated with many professional and recreational activities but this is, to our knowledge, the first description of hammer syndrome caused by break-dancing. The etiology, diagnosis and treatment modalities of this rare...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-002-1932-y
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To report our clinical practice regarding a case series of retained products of conception (RPOC) with marked vascularity (MV) managed with selective uterine artery embolization (UAE) as first-line treatment. METHODS:This was a monocentric, retrospective study of 31 consecutive cases of RPOC with MV diagnose...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-016-1543-7
更新日期:2017-04-01 00:00:00
abstract::The purpose of the study was to evaluate the efficacy of percutaneous drainage of intraperitoneal abscesses with attention to recurrence and failure rates. A retrospective analysis of percutaneous treatment of 300 intraperitoneal abscesses in 255 patients (147 male, 108 female; average age: 38 years; range: 40 days to...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0281-4
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To determine whether low total psoas muscle area (tPMA), as a surrogate for sarcopaenia, is a predictor of adverse outcomes in patients undergoing advanced EVAR. MATERIALS AND METHODS:A retrospective review of medical records was performed for 257 patients who underwent advanced EVAR (fenestrated or branched t...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-020-02721-0
更新日期:2021-01-03 00:00:00
abstract:PURPOSE:To report the first experience using the chimney technique in combination with the latest-generation low-profile stent-graft to seal abdominal aortic aneurysms having a very short neck (proximal sealing zone) and difficult access due to very small iliac vessels. MATERIALS AND METHODS:Use of an ultra low-profil...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-013-0748-2
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To compare the diagnostic accuracy of contrast-enhanced (CE) three-dimensional (3D) moving-table magnetic resonance (MR) angiography with that of selective digital subtraction angiography (DSA) for routine clinical investigation in patients with peripheral arterial occlusive disease. METHODS:Thirty-eight patie...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0309-9
更新日期:2006-09-01 00:00:00
abstract::The glycoprotein IIb-IIIa (GPIIb-IIIa) receptor inhibitors have established themselves as first line therapy in the treatment of acute coronary syndromes (ACS) and percutaneous coronary intervention (PCI). The benefit of these agents rests in their ability to attenuate the deleterious effects of platelet activation, b...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章,评审
doi:10.1007/s00270-001-0035-5
更新日期:2001-11-01 00:00:00
abstract::A type II endoleak (T2EL) is the most common endoleak after endovascular aneurysm repair (EVAR), and a persistent T2EL has been occasionally associated with aneurysmal enlargement. Typical findings of a T2EL consist of an endoleak cavity with inflow and outflow arteries of aortic branch vessels. However, an atypical T...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-017-1778-y
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To report the long-term outcomes of bovine ureter grafts as novel conduits for haemodialysis fistulas. MATERIALS AND METHODS:Thirty-five patients underwent placement of a total of 40 SynerGraft 100 (SG100; CryoLife Europa(®), Guildford, UK) bovine ureter grafts between April 2002 and February 2009. Prospective...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-011-0096-z
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:CT-guided ethanol-mediated renal sympathetic denervation in treatment of therapy-resistant hypertension was performed to assess patient safety and collect preliminary data on treatment efficacy. MATERIALS AND METHODS:Eleven patients with therapy-resistant hypertension (blood pressure of >160 mmHg despite th...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-015-1261-6
更新日期:2016-02-01 00:00:00
abstract::The aim of this article is to report our experience in the diagnosis of two cases of iliac artery endofibrosis or arteriopathy, a rare entity occurring in high-performance athletes, presenting with intermittent claudication (right-sided in both) after maximal exercise. External iliac artery endofibrosis or arteriopath...
journal_title:Cardiovascular and interventional radiology
pub_type: 杂志文章
doi:10.1007/s00270-004-0202-6
更新日期:2006-09-01 00:00:00