Abstract：
:Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evolutionarily conserved, a Maf1 ortholog also serves to restrain transcription in mouse and human cells. Understanding the mechanism of the regulation has been made possible by recent studies showing that Maf1 is a nuclear/cytoplasmic protein whose subcellular distribution and hence negative regulation of Pol III transcription is mediated by the nutrient-sensing signaling pathways, TOR and RAS. Under stress conditions and during growth in a nonfermentable carbon source Maf1 is dephosphorylated and imported to the nucleus. In its non-phosphorylated form, Maf1 interacts with the polymerase III transcription machinery. Phosphorylation serves to locate Maf1 to the cytoplasm under favorable growth conditions, thereby preventing it from non-negatively regulating polymerase III when high levels of tRNA transcription are required. Relocation of Maf1 to the cytoplasm is dependent on Msn5, a carrier responsible for export of several other phosphoproteins out of the nucleus. The absence of Maf1-mediated control of tRNA synthesis impairs yeast viability in nonfermentable carbon sources. Moreover, in cells grown in a nonfermentable carbon source, Maf1 regulates the levels of different tRNAs to various extents. This differential regulation may contribute to the physiological role of Maf1.
journal_name
Acta Biochim Poljournal_title
Acta biochimica Polonicaauthors
Cieśla M,Boguta Msubject
Has Abstractpub_date
2008-01-01 00:00:00pages
215-25issue
2eissn
0001-527Xissn
1734-154Xpii
20081648journal_volume
55pub_type
杂志文章,评审abstract：:Monoclonal antibodies (MAb 1-7-1) directed against the isoenzymes of rat liver cytochrome P-450 induced by methylcholanthrene, inhibited benzo(a)pyrene hydroxylase less strongly at low (0.04 mM) than at high (2 mM) NADH concentration. Inhibition of NADPH dependent hydroxylation was the same irrespective of NADPH conce...
journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章,评审
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更新日期：1995-01-01 00:00:00
abstract：:Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cyt...
journal_title：Acta biochimica Polonica
pub_type： 杂志文章,评审
doi：10.18388/abp.2015_1089
更新日期：2015-01-01 00:00:00
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journal_title：Acta biochimica Polonica
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doi：
更新日期：1984-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章,评审
doi：024903597
更新日期：2002-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Acta biochimica Polonica
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doi：
更新日期：2010-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
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更新日期：1979-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：10.18388/abp.2020_5203
更新日期：2020-06-19 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：10.18388/abp.2016_1364
更新日期：2017-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：10.18388/abp.2020_5209
更新日期：2020-03-19 00:00:00
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doi：
更新日期：1982-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章,评审
doi：035003573
更新日期：2003-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
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更新日期：2019-07-09 00:00:00
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journal_title：Acta biochimica Polonica
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doi：
更新日期：2009-01-01 00:00:00
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Acta biochimica Polonica
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更新日期：2012-01-01 00:00:00
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更新日期：2021-01-22 00:00:00
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更新日期：2018-12-13 00:00:00
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doi：
更新日期：2013-01-01 00:00:00
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journal_title：Acta biochimica Polonica
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doi：
更新日期：2011-01-01 00:00:00
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journal_title：Acta biochimica Polonica
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doi：10.18388/abp.2019_2883
更新日期：2019-12-27 00:00:00
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journal_title：Acta biochimica Polonica
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doi：
更新日期：2008-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Acta biochimica Polonica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
