Abstract:
OBJECTIVES:To compare the circulating levels of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitors of metalloproteinase (TIMP)-1, TIMP-2, and the MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in preeclampsia and gestational hypertension with those found in normotensive pregnancies. DESIGN AND METHODS:We studied 83 pregnant women (30 healthy pregnant women with uncomplicated pregnancies, 26 with gestational hypertension, and 27 with preeclampsia) and 30 healthy nonpregnant women in a cross-sectional study. MMP and TIMP concentrations were measured in plasma samples by gelatin zymography and ELISA, respectively. RESULTS:We found higher plasma pro-MMP-9 levels, and higher pro-MMP-9/TIMP-1 ratios in women with gestational hypertension (95%-CI: 1.031 to 2.357, and 0.012 to 0.031, respectively), but not with preeclampsia, compared with those found in normotensive pregnant women (95%-CI: 0.810 to 1.350, and 0.006 to 0.013, respectively; both P<0.05). We found no significant differences in pro-MMP-2 levels (P>0.05). CONCLUSIONS:The higher net MMP-9 (but not MMP-2) activity in gestational hypertension compared with normotensive pregnancy suggests that MMP-9 plays a role in the pathophysiology of gestational hypertension. Conversely, the lack of such alterations in preeclampsia is consistent with the notion that different pathophysiological mechanisms are involved in these hypertensive disorders.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Palei AC,Sandrim VC,Cavalli RC,Tanus-Santos JEdoi
10.1016/j.clinbiochem.2008.04.015subject
Has Abstractpub_date
2008-07-01 00:00:00pages
875-80issue
10-11eissn
0009-9120issn
1873-2933pii
S0009-9120(08)00171-9journal_volume
41pub_type
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更新日期:1976-12-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:2002-11-01 00:00:00
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doi:10.1016/s0009-9120(78)90434-4
更新日期:1978-08-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2006-08-01 00:00:00
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更新日期:2009-04-01 00:00:00
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更新日期:1991-06-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2005.04.004
更新日期:2005-07-01 00:00:00
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更新日期:2010-09-01 00:00:00