Abstract：
:Despite the numerous efforts of randomized studies on advanced gastric cancer, no globally accepted standard regimen has yet been established. Two triplet regimens have already demonstrated significant survival prolongation in Western studies. However, the benefit seems to be marginal, and these regimens may be replaced by recently published newer generation regimens for which favorable survival is reported. At present, the combination of 5-fluorouracil (5-FU) and platinum analog is still the most widely accepted standard regimen worldwide: 5-FU can be replaced by S-1 or capecitabine, and cisplatin by oxaliplatin. In Japan, S-1 plus cisplatin is the most reasonable first-line standard, based on recent randomized studies. Some early clinical studies using molecular targeting agents have shown promising activity, particularly in combination with cytotoxic agents for gastric cancer. Several targeting agents such as trastuzumab, bevacizumab, and lapatinib are now under investigation in international randomized studies, including in Japan. These agents have shown a survival benefit in other tumor types. The next-generation targeting agents, including mammalian target of rapamycin inhibitor and a c-Met tyrosine kinase inhibitor, are also being evaluated in early clinical studies in association with biology research. Such agents can be advantageously used in gastric cancer studies, which, because of the ease with which tumor tissues can be obtained by endoscopy and the high incidence of gastric cancer in Japan, might advance the frontiers of biologic therapy. These efforts should result not only in further clinical advances but also in tailored medicine.
journal_name
J Gastroenteroljournal_title
Journal of gastroenterologyauthors
Ohtsu Adoi
10.1007/s00535-008-2177-6subject
Has Abstractpub_date
2008-01-01 00:00:00pages
256-64issue
4eissn
0944-1174issn
1435-5922journal_volume
43pub_type
杂志文章,评审abstract：:The present study was carried out to examine the effects of submucosal administration of endothelin on gastric mucosal integrity in rats. Injection of endothelin-3 into the submucosal space of the stomach induced gastric mucosal damage dose-dependently and site-specifically. The gastric injury was localized only at th...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02936360
更新日期：1997-04-01 00:00:00
abstract：:Our objective was to determine whether the prevalence of vacuolating cytotoxin production differed among Helicobacter pylori isolates obtained from patients with chronic gastritis, gastric ulcer, or duodenal ulcer. We examined the vacuolating cytotoxin production of 114 clinical H. pylori isolates in rabbit gastic epi...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:Neovascularization was shown to be critically involved in the progression of multiple cancers, and treatment approaches targeting tumor-associated neovascularization provide convincing results in recent years in some tumor entities. However, little is known about the tumor-associated neovascularization in hi...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-008-2255-9
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The most commonly used methods for bowel preparation are polyethylene glycol-electrolyte lavage solution (PEG-ELS) and sodium phosphate. Both are problematic in children. The use of bisacodyl together with fleet enema has been suggested as an alternative; however, its use without dietary restriction is infer...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-006-1958-z
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) occurs in chronic hepatitis B (CH-B) patients even after treatment with nucleos(t)ide analogues (NAs) by a mechanism involving an association between the oncogenic factors of integrated HBV and liver fibrosis. An association has been demonstrated between advanced chronic liver ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-017-1386-2
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Experimental evidence and clinical studies suggest that the renin-angiotensin system and its inhibitors may play a role in regulating the mechanisms of liver fibrosis development. The present study aimed to verify whether carriage of specific angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) all...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-007-2040-1
更新日期：2007-07-01 00:00:00
abstract：:We report a 54-year-old Japanese woman who developed liver tumors 102 months after hepatic resection for hepatocellular carcinoma (HCC) and percutaneous transluminal angioplasty (PTA) for membranous obstruction of the inferior vena cava (MOVC), which is one form of Budd-Chiari syndrome. In the present admission workup...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-004-1365-2
更新日期：2004-07-01 00:00:00
abstract：:We report a patient who survived total colonic type ulcerative colitis (UC) complicated by toxic megacolon (TM), disseminated intravascular coagulation (DIC), methicillin-resistant Staphylococcus aureus infection, and phlebothrombosis. A 69-year-old man was treated for about 4 months under the diagnosis of ischemic co...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s005350050282
更新日期：1999-06-01 00:00:00
abstract：:Patients with longstanding extensive colitis, both ulcerative colitis and Crohn's colitis, have an increased risk of developing colorectal cancer. Because of this risk, colonoscopic surveillance for neoplasia is recommended by most authorities. Although there has been no randomised controlled trial to demonstrate surv...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-010-0309-2
更新日期：2011-01-01 00:00:00
abstract：:We simultaneously recorded gastric emptying of radio-opaque markers (ROMs) and monitored serial changes in plasma acetaminophen (AAP) levels to demonstrate the relationship between the ROM and the AAP methods, and we investigated the effect of a single intravenous dose of erythromycin (EM) on gastric emptying in healt...
journal_title：Journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02936948
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:Musashi-1 (Msi-1) is a RNA-binding protein, known as a putative marker of intestinal stem cells (ISCs). However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-008-2284-4
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Hereditary pancreatitis (HP) is a rare cause of chronic pancreatitis. We here report a nationwide survey to clarify the epidemiological, genetic, and clinical features of HP in Japan. METHODS:Target subjects were patients with HP and their family members who had visited selected hospitals between 2005 and 2...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-017-1388-0
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Drug resistance in colorectal cancers is assumed to be mediated by changes in the expression of microRNAs, but the specific identities and roles of microRNAs are largely unclear. We examined the effect of 5-fluorouracil (5-FU) resistance on microRNA expression. METHODS:Two types of 5-FU-resistant colon canc...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-012-0547-6
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:Recent routine testing for liver function and anti-mitochondrial antibodies has increased the number of newly diagnosed patients with primary biliary cirrhosis (PBC). This study investigated the prognosis of asymptomatic PBC patients, focusing on age difference, to clarify its effect on the prognosis of PBC pat...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-009-0090-2
更新日期：2009-01-01 00:00:00
abstract：:Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a pro...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-006-1928-5
更新日期：2007-01-01 00:00:00
abstract：:5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-020-01713-8
更新日期：2020-11-01 00:00:00
abstract：:Preoperative biliary drainage (PBD) has been thought to be preferable regardless of the site of biliary strictures, e.g., distal or proximal strictures because PBD by endoscopy or interventional radiology decreases postoperative mortality and morbidity rates. However, recently, several studies have revealed that PBD s...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.1007/s00535-015-1096-6
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy is the current standard of care for patients with chronic hepatitis C. Determining precisely the risk of serious adverse events (SAEs) and mortality from a single study is rather difficult because of the infrequency of such events. The aim of this s...
journal_title：Journal of gastroenterology
pub_type： 杂志文章,meta分析
doi：10.1007/s00535-012-0631-y
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Mucosal breaks induced by gastroesophageal reflux of gastric contents were more frequently found on the right anterior wall of the lower esophagus. Bleeding from esophageal varices may be also derived from gastroesophageal reflux. The circumferential location of the ruptured esophageal varices was evaluated ...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-008-2232-3
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:At present, squamous cell carcinoma accounts for most esophageal cancers in Japan; however, there is concern that the incidence of esophageal adenocarcinoma in Japan is increasing in comparison to Western countries. Akita Prefecture, with a population of 1 million, has the highest rate of esophageal cancer-a...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-017-1412-4
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Superior mesenteric artery syndrome (SMAS) is caused by compression of the third part of the duodenum between the superior mesenteric artery and the aorta. It occurs most frequently in patients with rapid weight loss. METHODS:We report two young patients, who each presented with a longstanding history of po...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350200101
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan. METHODS:We examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sa...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-009-0194-8
更新日期：2010-02-01 00:00:00
abstract：:A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody, have been used to treat...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s005350200122
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:The T-helper (Th)1 immune reaction is essential for the eradication of hepatitis C virus (HCV) during interferon (IFN) therapy in patients with chronic hepatitis C. Osteopontin is a cytokine crucial for the initiation of the Th1 response. Recently, we identified four single-nucleotide polymorphisms (SNPs) in...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-005-1558-3
更新日期：2005-04-01 00:00:00
abstract：:An association of hidradenitis suppurativa with Crohn's disease is supported by previous repent. We here report a patient with hidradenitis suppurativa who subsequently developed peripheral arthritis, sacroiliitis, and Crohn's disease. A significant attenuation of bowel, cutaneous, and joint symptoms was achieved afte...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-003-1185-9
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Patients with psoriasis show a greater prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than their counterparts with NAFLD and without psoriasis. The link between...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-012-0678-9
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japan...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-015-1135-3
更新日期：2016-07-01 00:00:00
abstract：:We investigated the effect of intravenous infusions of the therapeutically available amino acid solutions Moripron and Morihepamin (Roussel Morishita, Osaka, Japan) on gallbladder contraction and cholecystokinin (CCK) release in healthy male volunteers. Plasma CCK levels were measured by radioimmunoassay, using the an...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02355059
更新日期：1996-08-01 00:00:00
abstract：:We used positron emission tomography with 2-deoxy-2-[(18)F]fluoro- d-glucose (FDG-PET) in the diagnosis of two cases of malignant intraductal papillary mucinous tumor (IPMT) of the pancreas. A 56-year-old man and a 72-year-old man, both with tumors in the pancreatic head, were referred to Akita University Medical Cent...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/s00535-003-1230-8
更新日期：2003-01-01 00:00:00
abstract：:Small bowel transit time (SBTT) in 15 young and 13 elderly women was assessed by measuring breath hydrogen concentrations after they had consumed a solid test meal. The meal consisted of 200 g cooked rice, 50 ml miso (made from fermented soy bean curd) soup, a boiled egg, and 95.5 g of cooked soy beans with mixed vege...
journal_title：Journal of gastroenterology
pub_type： 杂志文章
doi：10.1007/BF02934082
更新日期：1997-08-01 00:00:00
