Primary tumor location impacts breast cancer survival.

Abstract:

BACKGROUND:The prognostic significance of tumor location in breast cancer remains unclear. To better understand this relationship, we evaluated the Department of Defense tumor registry. METHODS:Patients with infiltrating ductal adenocarcinoma or lobular carcinoma over a 10-year period were identified and analyzed. RESULTS:Of the 13,984 tumors, 7,871 (58%) originated from the upper-outer quadrant or axillary tail, whereas the remainder were found at the nipple complex (9%), upper-inner quadrant (14%), lower-inner quadrant (9%), and lower-outer quadrant (10%). Univariate analysis of cancer-specific survival revealed a significant difference based on location of the primary breast cancer. Upper-outer quadrant lesions were associated with an independent contribution toward a survival benefit. CONCLUSIONS:Upper-outer quadrant breast cancers have a more favorable survival advantage when compared with tumors in other locations. Factors that negatively impacted survival included high-grade tumors, advanced stage, and race.

journal_name

Am J Surg

authors

Sohn VY,Arthurs ZM,Sebesta JA,Brown TA

doi

10.1016/j.amjsurg.2007.12.039

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

641-4

issue

5

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(08)00102-5

journal_volume

195

pub_type

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