Abstract:
:Sarcoidosis is a multisystem disease of unknown etiology. Renal manifestation is rare and usually caused by hypercalcemia and nephrocalcinosis. Moreover, renal disease can occur as granulomatous interstitial nephritis (GIN), which is a histological diagnosis. We describe a case of sarcoidosis first presenting with multiple organ involvement including renal failure caused by severe GIN and subsequent remission on glucocorticoid therapy. After 18 months under low-dose prednisolone, the patient was readmitted with acute renal failure, histologically confirmed to be a relapse of renal sarcoidosis. Extrarenal manifestations of sarcoidosis were not present. Glucocorticoid dose was raised and kidney function again recovered significantly. Usual serologic markers of disease activity were not appropriate to indicate disease activity. Renal manifestation of sarcoidosis should be diagnosed by renal biopsy to guide therapy and probably requires larger glucocorticoid doses and prolonged treatment to prevent relapse.
journal_name
J Gen Intern Medjournal_title
Journal of general internal medicineauthors
Mayer C,Müller A,Halbritter J,Wirtz H,Stumvoll Mdoi
10.1007/s11606-008-0603-3subject
Has Abstractpub_date
2008-06-01 00:00:00pages
879-82issue
6eissn
0884-8734issn
1525-1497journal_volume
23pub_type
杂志文章abstract:BACKGROUND:The greater the severity of illness of a patient, the more likely the patient will have a poor hospital outcome. However, hospital-wide severity of illness scores that are simple, widely available, and not diagnosis-specific are still needed. Laboratory tests could potentially be used as an alternative to es...
journal_title:Journal of general internal medicine
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更新日期:2020-03-01 00:00:00
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更新日期:2020-10-31 00:00:00
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journal_title:Journal of general internal medicine
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:1998-02-01 00:00:00
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更新日期:2006-12-01 00:00:00
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journal_title:Journal of general internal medicine
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更新日期:1997-05-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2010-01-01 00:00:00
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doi:10.1007/s11606-008-0713-y
更新日期:2008-10-01 00:00:00
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doi:10.1007/s11606-007-0336-8
更新日期:2008-04-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1046/j.1525-1497.2003.20410.x
更新日期:2003-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11606-014-2784-2
更新日期:2014-06-01 00:00:00
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journal_title:Journal of general internal medicine
pub_type: 杂志文章
doi:10.1007/BF02599759
更新日期:1993-03-01 00:00:00
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journal_title:Journal of general internal medicine
pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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更新日期:2010-05-01 00:00:00
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更新日期:2015-10-01 00:00:00
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更新日期:2009-07-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2020-05-01 00:00:00
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更新日期:2009-11-01 00:00:00
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更新日期:2000-07-01 00:00:00
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更新日期:2020-02-01 00:00:00