Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia.

Abstract:

:Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.

journal_name

Emerg Infect Dis

authors

Klempa B,Tkachenko EA,Dzagurova TK,Yunicheva YV,Morozov VG,Okulova NM,Slyusareva GP,Smirnov A,Kruger DH

doi

10.3201/eid1404.071310

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

617-25

issue

4

eissn

1080-6040

issn

1080-6059

journal_volume

14

pub_type

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