Clinical management of focal liver lesions: the key role of real-time contrast-enhanced US.

Abstract:

:Ultrasonography (US) is the most commonly used liver imaging modality worldwide. Unfortunately, it has limited sensitivity in the detection of small tumor nodules. Moreover, US findings are often nonspecific, as appearances of benign and malignant liver lesions overlap. The introduction of microbubble contrast agents and the development of contrast-specific techniques have opened new prospects in liver US. The advent of second-generation agents that enable continuous real-time contrast-enhanced imaging has been instrumental in improving the acceptance and reproducibility of the examination. With the publication of guidelines for the use of contrast agents in liver US by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB), contrast-enhanced US has entered clinical practice. The guidelines define the indications and recommendations for the use of contrast agents in focal liver lesion detection, characterization, and posttreatment follow-up. Recently, the clinical value of contrast US as a reliable alternative to CT or MR imaging in characterizing hepatocellular carcinoma in cirrhosis has been endorsed by the practice guideline document issued by the American Association for the Study of Liver Diseases and the 2005 Monothematic Conference on Hepatocellular Carcinoma of the European Association for the Study of the Liver. In this article, the current role of contrast US in the diagnostic management of focal liver lesions is discussed with regard to the following clinical scenarios: (1) characterization of incidental findings; (2) diagnosis of hepatocellular carcinoma in patients with cirrhosis; and (3) identification of hepatic metastases in oncology patients; (4) guidance and monitoring of tumor ablation procedures.

journal_name

Eur Radiol

journal_title

European radiology

authors

Lencioni R,Della Pina C,Crocetti L,Bozzi E,Cioni D

doi

10.1007/s10406-007-0231-8

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

F73-9

eissn

0938-7994

issn

1432-1084

journal_volume

17 Suppl 6

pub_type

杂志文章,评审
  • Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring?

    abstract::Advanced bronchial carcinomas by means of perfusion and peak enhancement using dynamic contrast-enhanced multislice CT are characterized. Twenty-four patients with advanced bronchial carcinoma were examined. During breathhold, after injection of a contrast-medium (CM), 25 scans were performed (1 scan/s) at a fixed tab...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-004-2288-2

    authors: Kiessling F,Boese J,Corvinus C,Ederle JR,Zuna I,Schoenberg SO,Brix G,Schmähl A,Tuengerthal S,Herth F,Kauczor HU,Essig M

    更新日期:2004-07-01 00:00:00

  • Concomitant chronic venous insufficiency in patients with peripheral artery disease: insights from MR angiography.

    abstract:OBJECTIVES:The clinical presentation of peripheral artery disease (PAD) and chronic venous insufficiency (CVI) can overlap and the conditions may co-exist. The purpose of our study was to investigate the prevalence and clinical significance of concomitant CVI in patients with PAD examined with run-off MR angiography (M...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-06696-x

    authors: Ammermann F,Meinel FG,Beller E,Busse A,Streckenbach F,Teichert C,Weinrich M,Neumann A,Weber MA,Heller T

    更新日期:2020-07-01 00:00:00

  • Automated two-point dixon screening for the evaluation of hepatic steatosis and siderosis: comparison with R2-relaxometry and chemical shift-based sequences.

    abstract:OBJECTIVES:To evaluate the automated two-point Dixon screening sequence for the detection and estimated quantification of hepatic iron and fat compared with standard sequences as a reference. METHODS:One hundred and two patients with suspected diffuse liver disease were included in this prospective study. The followin...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-014-3528-8

    authors: Henninger B,Zoller H,Rauch S,Schocke M,Kannengiesser S,Zhong X,Reiter G,Jaschke W,Kremser C

    更新日期:2015-05-01 00:00:00

  • Gd-EOB-DTPA MRI for focal nodular hyperplasia-like lesions in pediatric cancer survivors.

    abstract:OBJECTIVES:To investigate the hepatobiliary enhancement patterns of gadoxetic acid (Gd-EOB-DTPA) MRI and the temporal evolution of focal nodular hyperplasia (FNH)-like lesions in pediatric cancer survivors. METHODS:We retrospectively included pediatric cancer survivors who had new liver lesions detected during surveil...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-07157-1

    authors: Gu K,Jeon TY,Yoo SY,Kim JH

    更新日期:2021-01-01 00:00:00

  • Integrated diagnostic imaging of primary thoracic rhabdomyosarcoma.

    abstract::We report a rare case of primary thoracic rhabdomyosarcoma in a girl who was referred with acute chest pain, hacking cough, and wheezing. A chest X-ray revealed a complete opacity of the right hemithorax. Ultrasound revealed a right-sided pleural effusion and a solid mass above the liver dome, suggesting a neoplastic ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300000507

    authors: Almberger M,Iannicelli E,Matrunola M,Schiavetti A,Capocaccia P

    更新日期:2001-01-01 00:00:00

  • Management of intussusception.

    abstract::Intussusception represents the most common abdominal emergency in infancy. The classical clinical triad, consisting of abdominal colics, red jelly stools and a palpable mass, is only present in approximately 50% of cases, 20% of patients are symptom free at clinical presentation. Primary imaging modality of choice is ...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-003-2033-2

    authors: Sorantin E,Lindbichler F

    更新日期:2004-03-01 00:00:00

  • Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

    abstract:OBJECTIVES:To assess if the administration of gadoxetate disodium (Gd-EOB-DTPA) significantly affects hepatic magnetic resonance elastography (MRE) measurements in the delayed hepatobiliary phase (DHBP). METHODS:A total of 47 patients (15 females, 32 males; age range 23-78 years, mean 54.28 years) were assigned to sta...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-018-5616-7

    authors: Plaikner M,Kremser C,Zoller H,Steurer M,Glodny B,Jaschke W,Henninger B

    更新日期:2019-02-01 00:00:00

  • Single-phase DECT with VNCT compared with three-phase CTU in patients with haematuria.

    abstract:OBJECTIVE:To retrospectively evaluate the diagnostic performance of single-phase dual-energy CT (DECT) with virtual non-contrast CT (VNCT) compared with three-phase CT urography (CTU) in patients with haematuria. METHODS:A total of 296 patients underwent three-phase CTU (NCT at 120 kVp; nephrographic phase and excreto...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4206-9

    authors: Park JJ,Park BK,Kim CK

    更新日期:2016-10-01 00:00:00

  • Digital chest radiography with a large-area flat-panel silicon X-ray detector: clinical comparison with conventional radiography.

    abstract::This was a radiologists' preference study to compare a digital chest radiography system that utilizes a large-area silicon flat-panel detector with conventional radiography for visualizing anatomic regions of the chest. Conventional and digital posteroanterior (PA) and lateral chest radiographs were obtained in 115 pa...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300000795

    authors: Hennigs SP,Garmer M,Jaeger HJ,Classen R,Jacobs A,Gissler HM,Christmann A,Mathias K

    更新日期:2001-01-01 00:00:00

  • Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging.

    abstract::Superparamagnetic iron oxide MR imaging contrast agents have been the subjects of extensive research over the past decade. The iron oxide particle size of these contrast agents varies widely, and influences their physicochemical and pharmacokinetic properties, and thus clinical application. Superparamagnetic agents en...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300100908

    authors: Wang YX,Hussain SM,Krestin GP

    更新日期:2001-01-01 00:00:00

  • Perianal complications of Crohn disease: MR imaging findings.

    abstract::The aim of this study was to revisit anal anatomy, to explain surgical terminology in perianal complications of Crohn disease, and to show the MR imaging findings of perianal fistulas and abscesses. To this end more than 200 patients were studied using surface coils (Helmholtz; phased array) at 1.0 and 1.5 T. Transver...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050248

    authors: Laniado M,Makowiec F,Dammann F,Jehle EC,Claussen CD,Starlinger M

    更新日期:1997-01-01 00:00:00

  • Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with an IVIM Model.

    abstract:OBJECTIVES:To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS:Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-5049-8

    authors: Qi LP,Yan WP,Chen KN,Zhong Z,Li XT,Cai K,Sun YS,Zhou XJ

    更新日期:2018-03-01 00:00:00

  • Non-traumatic abdominal emergencies: imaging and intervention in acute biliary conditions.

    abstract::Imaging is the standard method for the evaluation of emergency bile ducts and gallbladder diseases. Imaging may help to treat the patient also. In acute cholecystitis, association of clinical and sonographic data is accurate for the diagnosis, even when the patient is examined by a junior radiologist. Computed tomogra...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-002-1613-x

    authors: Menu Y,Vuillerme MP

    更新日期:2002-10-01 00:00:00

  • Radiographic features of multifocal endosteal thickening of the femur in patients on long-term bisphosphonate therapy.

    abstract:OBJECTIVES:To describe the characteristics of multifocal endosteal thickening in patients on bisphosphonate therapy. METHOD:A retrospective study of 68 patients with atypical femoral fractures (as defined by ASBMR) whilst on bisphosphonate therapy was performed. Femoral radiographs were assessed for: focal endosteal t...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-012-2587-y

    authors: Mohan PC,Howe TS,Koh JS,Png MA

    更新日期:2013-01-01 00:00:00

  • Nitroglycerine use in transcatheter arterial (chemo)embolization in patients with hepatocellular carcinoma and dual-energy CT assessment of Lipiodol retention.

    abstract:OBJECTIVES:To investigate whether the addition of nitroglycerine to transcatheter arterial (chemo)embolization (TAE/TACE) can increase the delivery and effectiveness of TAE/TACE in patients with hepatocellular carcinoma (HCC) by dual-energy CT. METHODS:HCC patients (BCLC stage A or B) were randomized to (n = 51) or no...

    journal_title:European radiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00330-012-2484-4

    authors: Liu YS,Chuang MT,Tsai YS,Tsai HM,Lin XZ

    更新日期:2012-10-01 00:00:00

  • Gadoxetic acid-enhanced MR imaging for hepatocellular carcinoma: molecular and genetic background.

    abstract::Gadoxetic acid-enhanced magnetic resonance imaging (MRI) plays important roles in diagnosis of hepatic lesions because of its superiority in the detectability of small lesions, its differentiation ability, and its utility for the early diagnosis of hepatocellular carcinoma (HCC). In HCC, expression of organic anion tr...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-020-06687-y

    authors: Kitao A,Matsui O,Yoneda N,Kozaka K,Kobayashi S,Koda W,Inoue D,Ogi T,Yoshida K,Gabata T

    更新日期:2020-06-01 00:00:00

  • CT findings in severe thoracic sarcoidosis.

    abstract::Severe thoracic sarcoidosis includes manifestations with significant clinical and functional impairment and a risk of mortality. Severe thoracic sarcoidosis can take on various clinical presentations and is associated with increased morbidity. The purpose of this article was to describe the CT findings in severe thora...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-004-2480-4

    authors: Hennebicque AS,Nunes H,Brillet PY,Moulahi H,Valeyre D,Brauner MW

    更新日期:2005-01-01 00:00:00

  • The prevalence and significance of renal perfusion defects in early kidney transplants quantified using 3D contrast enhanced ultrasound (CEUS).

    abstract:OBJECTIVES:Vascular complications are one of the most common causes of early kidney transplant dysfunction. Contrast enhanced ultrasound increases sensitivity to vascular changes. The aim of this study was to assess the prevalence and size of vascular abnormalities in early renal transplants using 3D CEUS and the signi...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-4871-3

    authors: Stenberg B,Wilkinson M,Elliott S,Caplan N

    更新日期:2017-11-01 00:00:00

  • Laser ablation of lung metastases: results according to diameter and location.

    abstract::Lung tumour ablation with a thin-calibre laser applicator system was evaluated. We quantified feasibility, technical success and complication rates in relation to lesion diameter and location. Forty-two patients with 64 lung tumours were treated (39 patients with metastases and three with primary tumours). Mean follow...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-006-0171-z

    authors: Weigel C,Rosenberg C,Langner S,Fröhlich CP,Hosten N

    更新日期:2006-08-01 00:00:00

  • Accuracy of automated volumetry of pulmonary nodules across different multislice CT scanners.

    abstract::The purpose of this study was to compare the accuracy of an automated volumetry software for phantom pulmonary nodules across various 16-slice multislice spiral CT (MSCT) scanners from different vendors. A lung phantom containing five different nodule categories (intraparenchymal, around a vessel, vessel attached, ple...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-006-0562-1

    authors: Das M,Ley-Zaporozhan J,Gietema HA,Czech A,Mühlenbruch G,Mahnken AH,Katoh M,Bakai A,Salganicoff M,Diederich S,Prokop M,Kauczor HU,Günther RW,Wildberger JE

    更新日期:2007-08-01 00:00:00

  • Comparison of complications between transjugular and axillosubclavian approach for placement of tunneled, central venous catheters in patients with hematological malignancy: a prospective study.

    abstract::This study was designed to compare the incidence of mechanical, thrombotic and infective complications in transjugular (IJV) and axillosubclavian (SCV) central venous catheters (CVC) in patients with hematological malignancy. In a prospective observational trial, 131 consecutive patients were classified into two group...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-005-2641-0

    authors: Lee SH,Hahn ST

    更新日期:2005-06-01 00:00:00

  • Gadoxetate-enhanced versus diffusion-weighted MRI for fused Ga-68-DOTANOC PET/MRI in patients with neuroendocrine tumours of the upper abdomen.

    abstract:OBJECTIVES:To compare fused gadoxetate-enhanced Ga-68-DOTANOC PET/MRI and Ga-68-DOTANOC PET/DWI (diffusion-weighted imaging) for the assessment of abdominal neuroendocrine tumours (NETs). METHODS:Eighteen patients with suspected or histologically proven NETs of the abdomen were enrolled in this retrospective study. Al...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-013-2785-2

    authors: Mayerhoefer ME,Ba-Ssalamah A,Weber M,Mitterhauser M,Eidherr H,Wadsak W,Raderer M,Trattnig S,Herneth A,Karanikas G

    更新日期:2013-07-01 00:00:00

  • The RETAIN project: DICOM teleradiology over an ATM-based network. Radiological Examinations Transfer on an ATM Integrated Network.

    abstract::The RETAIN project (Radiological Examinations Transfer on an ATM Integrated Network) has aimed at testing videoconferencing and DICOM image transfers to get advice about difficult radiological cases over an asynchronous transfer mode (ATM)-based network, which affords a more comfortable interface than narrow-band netw...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050029

    authors: Heautot JF,Eichelberg M,Gibaud B,Tréguier C,Lemoine D,Scarabin JM,Piqueras J,Carsin M,Gandon Y

    更新日期:2000-01-01 00:00:00

  • Combined hepatocellular-cholangiocarcinoma: can we use contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) to predict the patient's survival?

    abstract:OBJECTIVES:To evaluate the relationship between contrast-enhanced (CE) ultrasound Liver Reporting and Data System (LI-RADS) classification of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and their histopathological component predominance, and to determine if the CEUS LI-RADS category can be used to predict the...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-07656-1

    authors: Yang J,Huang JY,Chen X,Ling WW,Luo Y,Shi YJ,Liu JB,Lu Q,Lyshchik A

    更新日期:2021-01-25 00:00:00

  • Endorectal magnetic resonance imaging of prostatic cancer: comparison between fat-suppressed T2-weighted fast spin echo and three-dimensional dual-echo, steady-state sequences.

    abstract::The aim of this study was to develop an endorectal MRI strategy for prostatic cancer. We evaluated the MR images from 44 consecutive prostatic cancer patients treated by radical prostatectomy. Each sequence from every examination was assessed separately with a specific tumor map drawn. Tumor localization, capsular pen...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300000598

    authors: Ikonen S,Kärkkäinen P,Kivisaari L,Salo JO,Taari K,Vehmas T,Tervahartiala P,Rannikko S

    更新日期:2001-01-01 00:00:00

  • 3D-black-blood 3T-MRI for the diagnosis of thoracic large vessel vasculitis: A feasibility study.

    abstract:OBJECTIVES:To evaluate the feasibility of T1w-3D black-blood turbo spin echo (TSE) sequence with variable flip angles for the diagnosis of thoracic large vessel vasculitis (LVV). METHODS:Thirty-five patients with LVV, diagnosed according to the current standard of reference, and 35 controls were imaged at 3.0T using 1...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4525-x

    authors: Treitl KM,Maurus S,Sommer NN,Kooijman-Kurfuerst H,Coppenrath E,Treitl M,Czihal M,Hoffmann U,Dechant C,Schulze-Koops H,Saam T

    更新日期:2017-05-01 00:00:00

  • Pancreatic MRI for the surveillance of cystic neoplasms: comparison of a short with a comprehensive imaging protocol.

    abstract:OBJECTIVES:The study aims were to evaluate: (1) whether a short-protocol (SP) MRI for the surveillance of pancreatic cystic neoplasms (PCN) provides equivalent clinical information as a comprehensive-protocol (CP), and (2) the cost reduction from substituting CP with SP for patient surveillance. METHODS:This retrospec...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4377-4

    authors: Pozzi-Mucelli RM,Rinta-Kiikka I,Wünsche K,Laukkarinen J,Labori KJ,Ånonsen K,Verbeke C,Del Chiaro M,Kartalis N

    更新日期:2017-01-01 00:00:00

  • Automated quantification of epicardial adipose tissue using CT angiography: evaluation of a prototype software.

    abstract:OBJECTIVES:This study evaluated the performance of a novel automated software tool for epicardial fat volume (EFV) quantification compared to a standard manual technique at coronary CT angiography (cCTA). METHODS:cCTA data sets of 70 patients (58.6 ± 12.9 years, 33 men) were retrospectively analysed using two differen...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-013-3052-2

    authors: Spearman JV,Meinel FG,Schoepf UJ,Apfaltrer P,Silverman JR,Krazinski AW,Canstein C,De Cecco CN,Costello P,Geyer LL

    更新日期:2014-02-01 00:00:00

  • Radial scars diagnosed at stereotactic core-needle biopsy: surgical biopsy findings.

    abstract::We retrospectively reviewed surgical biopsy findings of lesions diagnosed as radial scars (RS) at stereotactic core-needle biopsy (SCNB). RS was diagnosed in 52 of 1415 (3.7%) consecutive mammographically detected lesions that underwent 14-gauge automated SCNB. Subsequent surgical biopsy findings were available for 43...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-006-0196-3

    authors: López-Medina A,Cintora E,Múgica B,Operé E,Vela AC,Ibañez T

    更新日期:2006-08-01 00:00:00

  • Protective effect against repeat adverse reactions to iodinated contrast medium: Premedication vs. changing the contrast medium.

    abstract:OBJECTIVES:The purpose of this study was to assess the protective effect of premedication and changing contrast media (CM) against repeat adverse reactions (ARs) to iodinated CM. METHODS:Between January 2006 and September 2014, 771 cases with previous ARs to CM were administered CM. The same CM that had caused ARs pre...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-015-4028-1

    authors: Abe S,Fukuda H,Tobe K,Ibukuro K

    更新日期:2016-07-01 00:00:00