Abstract：
PURPOSE:To evaluate the importance of complete epithelial removal before riboflavin-ultraviolet-A (UVA) corneal collagen crosslinking therapy. SETTING:School of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom. METHODS:Riboflavin eyedrops were applied at 5-minute intervals for 35 minutes to the anterior corneal surface of 36 porcine eyes (12 with no epithelial trauma but treated with tetracaine eyedrops, 12 with superficial epithelial trauma but with an intact basal epithelium, and 12 with a fully removed epithelium). The corneal surface of 6 tetracaine-treated eyes, 6 eyes with superficial epithelial trauma, and 6 eyes with a fully removed epithelium was exposed to UVA light for 30 minutes during riboflavin administration. The light transmission spectra of the enucleated corneas were analyzed with a spectrophotometer and compared with those of 9 untreated porcine corneas. RESULTS:Corneas with a fully removed epithelium treated with riboflavin showed an abnormal dip in the transmission spectrum between 400 nm and 510 nm (P<.01). This was attributed to the presence of riboflavin in the corneal stroma. The spectra of riboflavin-treated corneas with no epithelial trauma but tetracaine administration and those with superficial epithelial trauma did not differ from those of the non-riboflavin-treated controls. Exposure to UVA following riboflavin administration did not alter corneal light transmission. CONCLUSIONS:Complete removal of the corneal epithelium is an essential component of riboflavin-UVA crosslinking therapy as superficial epithelial trauma and tetracaine administration alone are not sufficient to permit the penetration of riboflavin into the corneal stroma. Failure to achieve adequate stromal absorption of riboflavin may impair the efficacy of the crosslinking process.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Hayes S,O'Brart DP,Lamdin LS,Doutch J,Samaras K,Marshall J,Meek KMdoi
10.1016/j.jcrs.2008.02.002subject
Has Abstractpub_date
2008-04-01 00:00:00pages
657-61issue
4eissn
0886-3350issn
1873-4502pii
S0886-3350(08)00111-9journal_volume
34pub_type
杂志文章abstract：PURPOSE:To use ultra-high-resolution optical coherence tomography (OCT) subclinical anatomic alterations to explain suboptimum vision despite pseudophakic cystoid macula edema (CME) resolution. SETTING:University of California-Davis, Sacramento, California, USA. DESIGN:Case study. METHODS:This study comprised patien...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.09.018
更新日期：2014-04-01 00:00:00
abstract：:We present 2 cases of toric intraocular lens implantation for keratoconus: A 55-year-old man with forme fruste keratoconus with a preoperative uncorrected distance visual acuity (UDVA) of 20/800 and a refraction of -6.50-3.00x135 and a 46-year-old man with a claw-shaped topographic pattern, a family history of keratoc...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.05.043
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To assess the efficacy, stability, and safety of photoastigmatic refractive keratectomy (PARK) in treating post-cataract myopic anisometropia to restore binocularity and to describe a comprehensive method for analyzing the results of refractive surgery. SETTING:St. Paul's Eye Center, Royal Liverpool Hospital, ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00362-4
更新日期：2000-02-01 00:00:00
abstract：PURPOSE:To describe the indications, motivations, and outcomes of artificial iris exchange. SETTING:Stein Eye Institute. DESIGN:Consecutive case series. METHODS:Review of medical records of patients implanted with an artificial iris device who underwent a subsequent artificial iris exchange. RESULTS:Five patients w...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000321
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy, safety, predictability, and surgically induced astigmatism (SIA) of laser in situ keratomileusis (LASIK) for the correction of myopia and myopic astigmatism. SETTING:Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. METHODS:This retrospective study com...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)01071-9
更新日期：2001-12-01 00:00:00
abstract：:Over 100 cases of standard extracapsular cataract extraction with intraocular lens implantation were reviewed and the effects of two commercially available pharmacological agents were compared. The treatment groups received either acetylcholine chloride (Miochol) or carbachol (Miostat). Intraocular pressures were meas...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(89)80008-2
更新日期：1989-03-01 00:00:00
abstract：PURPOSE:To evaluate alterations in corneal power parameters after Descemet-stripping automated endothelial keratoplasty (DSAEK) using rotating Scheimpflug imaging. SETTING:University of Texas, Southwestern Medical Center, Dallas, Texas, USA. METHODS:Eyes that had DSAEK were evaluated with a rotating Scheimpflug imagi...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.01.032
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:The use of monochromatic light in the assessment of intraocular lenses (IOLs) has been criticized for not representing the real-world situation. This study aimed to measure and compare the image quality of 3 extended depth-of-focus (EDOF) IOL models in monochromatic and polychromatic light. SETTING:David J App...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000037
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To compare the relative degrees of adherence of a clinical strain of Pseudomonas aeruginosa to the optic material of four intraocular lenses (IOLs). SETTING:Center for Applied and Environmental Microbiology, Georgia State University, Atlanta, Georgia, USA. METHODS:Intraocular lens optics made of poly(methyl m...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80085-0
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:To compare the visual, refractive, and adverse outcomes of femtosecond laser-assisted cataract surgery and conventional phacoemulsification cataract surgery. SETTING:Cataract surgery clinics in 9 European countries and Australia (femtosecond-assisted) and 18 European countries and Australia (conventional). DE...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2016.10.013
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To examine the role of high vacuum and aspiration settings on efficiency using a transversal ultrasound (US) machine. SETTING:John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, Utah, USA. DESIGN:Experimental study. METHODS:Porcine lens nuclei were incubated in formalin for 2 hours and t...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2018.05.031
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To determine the precision and accuracy of an artificial anterior chamber and a manual microkeratome in obtaining corneal lenticules for lamellar keratoplasty. SETTING:Department of Ophthalmology, Cornea, External Diseases and Refractive Surgery Service, University of California Irvine, Irvine, California, USA...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)00896-3
更新日期：2001-10-01 00:00:00
abstract：PURPOSE:To determine whether there is a difference in intraocular pressure (IOP) control between extracapsular cataract extraction (ECCE) and phacoemulsification performed after successful trabeculectomy. SETTING:Eye Unit, St. Woolos Hospital, Newport, United Kingdom. METHODS:This retrospective study comprised 55 pat...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00321-1
更新日期：2000-01-01 00:00:00
abstract：:We report a case of Candida infection after laser in situ keratomileusis (LASIK) and review the literature for reports of post-LASIK fungal infections. Risk factors may include postoperative surgical intervention and extended use of topical steroids. ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(03)00217-7
更新日期：2003-10-01 00:00:00
abstract：:We report a case of toxic anterior segment syndrome (TASS) that developed after cataract surgery. A 78-year-old woman had uneventful phacoemulsification via a clear corneal incision with implantation of an acrylic intraocular lens. One day postoperatively, diffuse corneal edema and anterior chamber inflammation were e...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.07.052
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:To evaluate intrastromal concentrations of riboflavin with and without epithelium to ensure the efficacy and safety of corneal crosslinking (CXL) by the standard and transepithelial procedures. SETTING:Department of Ophthalmology and Department of Pharmacology G. Segre, Siena University, Siena, Italy. METHODS...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.01.009
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:To assess the accuracy of intraocular lens (IOL) power calculation formulas in Chinese eyes with axial lengths (ALs) longer than 26.0 mm. SETTING:Department of Cataract Surgery, Shanxi Eye Hospital, China. DESIGN:Prospective case series. METHODS:This study evaluated (1) two new formulas (Barrett Universal II...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2019.01.018
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To compare postoperative pain associated with advanced surface ablation versus traditional photorefractive keratectomy (PRK). SETTING:Codet-Aris Vision Institute, Tijuana, Mexico. METHODS:This prospective double-masked randomized study included 56 eyes of 28 myopic patients who received traditional PRK in 1 e...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.jcrs.2004.11.046
更新日期：2005-07-01 00:00:00
abstract：PURPOSE:To evaluate whether laser-assisted subepithelial keratectomy (LASEK) achieves effective targeted myopic correction with less post-treatment corneal haze than observed with photorefractive keratectomy (PRK) in children who fail traditional forms of treatment for myopic anisometropic amblyopia and high myopia. S...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.06.025
更新日期：2004-12-01 00:00:00
abstract：:I describe a technique of slitlamp needle revision in eyes with capsular block syndrome (CBS) with distention of the capsular bag and forward displacement of the intraocular lens (IOL) in the capsular bag. After topical anesthesia and povidone-iodine are applied to the eye, a 30-gauge needle is introduced in a beveled...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.04.013
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:Previous studies have reported conflicting results on the influence of seasons on post-cataract surgery endophthalmitis incidences. This study aimed to investigate the seasonality associated with the incidence of postoperative endophthalmitis, and to evaluate its association with climate variables in South Kore...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2019.07.022
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:To compare the outcomes of implantation of 2 models of intrastromal corneal ring segments (ICRS) to manage keratoconus. SETTING:Kartal Training and Research Hospital, Istanbul, Turkey. METHODS:This study evaluated eyes with keratoconus that had implantation of Keraring ICRS (Group A) or Intacs ICRS (Group B)....
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.12.031
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To compare endothelial damage induced by different cataract incision sites and sizes using specular microscopy. SETTING:Department of Ophthalmology, Hospital of San Donà di Piave, Venice, Italy. METHODS:Eighty-one eyes having phacoemulsification were randomly assigned to 1 of 3 groups of 27 eyes each: 3.5 mm ...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0886-3350(01)00983-x
更新日期：2002-01-01 00:00:00
abstract：:A monolayer of proliferating lens epithelium on the anterior surface of an intraocular lens was found cytologically and confirmed histologically in a postmortem examination of one eye of a 57-year-old man. The man had had extracapsular cataract surgery five years earlier. This pathological finding confirms observation...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80353-7
更新日期：1993-11-01 00:00:00
abstract：PURPOSE:To compare the incidence of posterior capsule rupture and vitreous loss during phacoemulsification with and without the use of an anterior chamber maintainer (ACM) SETTING: Aristotle University Eye Clinic, Thessaloniki, Greece. METHODS:The surgical records of patients who had phacoemulsification by experienced...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/S0886-3350(03)00584-4
更新日期：2004-02-01 00:00:00
abstract：:In studies conducted by numerous investigators for 150 years, lenses regenerated following endocapsular lens extraction in New Zealand albino rabbits have been irregular in shape, appearing primarily doughnut-shaped as a result of lack of lens growth at the site of the anterior capsulotomy and its adhesion to the post...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80343-4
更新日期：1993-11-01 00:00:00
abstract：:Iris fixation of posterior chamber intraocular lenses (IOLs) is a technique that has been recommended for patients in whom a posterior chamber IOL is indicated but there is insufficient capsular support. We present 4 cases of iris-fixated posterior chamber IOLs with complications related to the procedure. Three patien...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2005.06.048
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:To report a case series of anterior uveitis after laser in situ keratomileusis (LASIK) and the incidence of anterior uveitis at a mean of 3 years. SETTING:Centro Medico Docente La Trinidad and Clinica Oftalmologica Centro Caracas, Caracas, Venezuela. METHODS:Five refractive surgeons and 18488 eyes that had su...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)01364-0
更新日期：2002-10-01 00:00:00
abstract：PURPOSE:To assess the repeatability and agreement of corneal power, corneal astigmatism, axis location, and astigmatic vector component measurements using an autokeratometer and a corneal topographer in healthy subjects. SETTING:Department of Ophthalmology, Kitasato University, Kanagawa, Japan. DESIGN:Evaluation of d...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.11.026
更新日期：2012-04-01 00:00:00
abstract：:The ocular response analyzer (ORA) (Reichert, Inc.) was used in the case of a middle-aged man who developed unilateral corneal ectasia after bilateral laser in situ keratomileusis (LASIK). The preoperative refraction was similar in the 2 eyes. Post-LASIK ectasia was central in the left eye; topography was oblate in th...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2007.11.018
更新日期：2008-03-01 00:00:00
