Effects of bestatin (Ubenimex) on human T-cell colony formation.

Abstract:

:The antitumor action of bestatin is considered to be an indirect action mediated by T-cells. Therefore, we investigated the effects of bestatin on the differentiation and proliferation of human precursor T-cells using a colony formation technique. Bestatin did not increase the overall number of T-cell colonies, but it significantly increased in CD4+ cell and significantly decreased in CD8+ cell subpopulations. It also induced CD4+.8+ cells. These findings indicated that bestatin acts on precursor T-cells to induce the differentiation of these cells into CD4+ cells.

journal_name

Anticancer Drugs

journal_title

Anti-cancer drugs

authors

Wakabayashi Y,Hashimoto M,Saitoh K,Osawa H,Koike M,Hirose S

doi

10.1097/00001813-199102000-00005

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

39-43

issue

1

eissn

0959-4973

issn

1473-5741

journal_volume

2

pub_type

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