Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.

abstract：:RhoA and Rac1 regulate formation of stress fibers and intercellular junctions, thus modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular function. The role of RhoA and Rac1 carboxyl methylati...

journal_title：Circulation research

authors： Lu Q,Harrington EO,Hai CM,Newton J,Garber M,Hirase T,Rounds S

更新日期：2004-02-20 00:00:00

abstract：:We have shown previously that tyrosine 319 in a conserved YIPP motif in the C terminus of angiotensin II (Ang II) type 1 receptors (AT(1)Rs) is essential for transactivation of epidermal growth factor receptor (EGFR) in vitro. We hypothesized that the signaling mechanism mediated through the specific amino acid sequen...

journal_title：Circulation research

authors： Zhai P,Galeotti J,Liu J,Holle E,Yu X,Wagner T,Sadoshima J

更新日期：2006-09-01 00:00:00

abstract：:In a freshly isolated endothelial cell preparation from rabbit aorta, the regulation of the acetylcholine (ACh)-sensitive intracellular Ca2+ store and the effects of the Ca(2+)-induced Ca2+ release agonists ryanodine and caffeine were studied using fura 2 imaging fluorescence microscopy. ACh (10 mumol/L) caused a tran...

journal_title：Circulation research

authors： Wang X,Lau F,Li L,Yoshikawa A,van Breemen C

更新日期：1995-07-01 00:00:00

abstract：:Astrocyte signals can modulate arteriolar tone, contributing to regulation of cerebral blood flow, but specific intercellular communication mechanisms are unclear. Here we used isolated cerebral arteriole myocytes, astrocytes, and brain slices to investigate whether carbon monoxide (CO) generated by the enzyme heme ox...

journal_title：Circulation research

authors： Li A,Xi Q,Umstot ES,Bellner L,Schwartzman ML,Jaggar JH,Leffler CW

更新日期：2008-02-01 00:00:00

abstract：:The present study was undertaken to determine the mechanism of neointima formation in rabbit arteries subjected to extensive endothelial desquamation. Endothelial cells were selectively removed from the abdominal aorta by passing an inflated balloon catheter through the vessel. The healing response was then studied se...

journal_title：Circulation research

authors： Spaet TH,Stemerman MB,Veith FJ,Lejnieks I

更新日期：1975-01-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion...

journal_title：Circulation research

authors： Takano H,Tang XL,Qiu Y,Guo Y,French BA,Bolli R

更新日期：1998-07-13 00:00:00

abstract：:Although Ca(2+) waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca(2+) waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and int...

journal_title：Circulation research

authors： Kaneko T,Tanaka H,Oyamada M,Kawata S,Takamatsu T

更新日期：2000-05-26 00:00:00

abstract：:We report the hemodynamic parameters of stage 18, 21, 24, and 27 chick embryos (from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic d...

journal_title：Circulation research

authors： Clark EB,Hu N

更新日期：1982-12-01 00:00:00

abstract：:As described in earlier reviews in this series on the molecular basis of hypertrophic cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders to be understood at the molecular level. Twenty years after the discovery of the first HCM disease gene, genetic studies still confirm that HCM is ...

journal_title：Circulation research

authors： Ashrafian H,McKenna WJ,Watkins H

更新日期：2011-06-24 00:00:00

abstract：:To test the hypothesis that the capacity to develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aort...

journal_title：Circulation research

authors： Isoyama S,Wei JY,Izumo S,Fort P,Schoen FJ,Grossman W

更新日期：1987-09-01 00:00:00

abstract：RATIONALE:Diabetes mellitus is frequently complicated by cardiovascular disease, such as vascular calcification and endothelial dysfunction, which have been associated with bone morphogenetic proteins (BMPs). OBJECTIVE:To determine whether hyperglycemia in vitro and diabetes in vivo promote vascular BMP activity and c...

journal_title：Circulation research

authors： Boström KI,Jumabay M,Matveyenko A,Nicholas SB,Yao Y

更新日期：2011-02-18 00:00:00

abstract：:The major goal of this study was to determine the interactions of VLDL surface and core lipids with the artery wall. We first demonstrated in vitro that surface lipid in VLDL could be traced using the phospholipid-like fluorescent probe 1,1'-dioctadecyl-3,3, 3',3'-tetramethyl-indocarbocyanine (DiI). The core of VLDL p...

journal_title：Circulation research

authors： Rutledge JC,Mullick AE,Gardner G,Goldberg IJ

更新日期：2000-04-14 00:00:00

abstract：:Transcriptional thyroid hormone responsiveness of the cardiac alpha-myosin heavy chain (alpha-MHC) gene has been demonstrated in transfections into fetal and neonatal cardiomyocytes and in transgenic mice. However, the correspondence between the regulation of MHC expression in dissociated cells with that in the intact...

journal_title：Circulation research

authors： Buttrick PM,Kaplan ML,Kitsis RN,Leinwand LA

更新日期：1993-06-01 00:00:00

abstract：:The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates optimal force transduction, electric transmission, intercellular communication, and metabolic exchange within the myocardial microenvir...

journal_title：Circulation research

authors： Li AH,Liu PP,Villarreal FJ,Garcia RA

更新日期：2014-02-28 00:00:00

abstract：:Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-associated variants li...

journal_title：Circulation research

authors： van Ouwerkerk AF,Hall AW,Kadow ZA,Lazarevic S,Reyat JS,Tucker NR,Nadadur RD,Bosada FM,Bianchi V,Ellinor PT,Fabritz L,Martin JF,de Laat W,Kirchhof P,Moskowitz IP,Christoffels VM

更新日期：2020-06-19 00:00:00

abstract：RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous response after myocardial infarction (MI). Extracellular matrix undergoes dramatic changes after MI and therefore might be linked to CPC-mediated repair. OBJECTIV...

journal_title：Circulation research

authors： Konstandin MH,Toko H,Gastelum GM,Quijada P,De La Torre A,Quintana M,Collins B,Din S,Avitabile D,Völkers M,Gude N,Fässler R,Sussman MA

更新日期：2013-07-05 00:00:00

abstract：:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodiu...

journal_title：Circulation research

authors： Gilmore JP,Zucker IH

更新日期：1978-02-01 00:00:00

abstract：:Prolongation of the action potential has been postulated to be a major reason for the altered diastolic relaxation of the heart in patients with severe heart failure. To investigate the electrophysiological basis for this action potential prolongation in terminal heart failure, K+ currents were recorded in single vent...

journal_title：Circulation research

authors： Beuckelmann DJ,Näbauer M,Erdmann E

更新日期：1993-08-01 00:00:00

abstract：:Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its expansion in obesity results in increased mortality and morbidity, with contributions to cardiovascular disease, diabetes mellitus, fatty liver disease, and cancer. Obesity prevalence is at an all-time high and is projected to b...

journal_title：Circulation research

authors： Weinstock A,Moura Silva H,Moore KJ,Schmidt AM,Fisher EA

更新日期：2020-05-22 00:00:00

abstract：:This study examined intracellular signal events of arterial cells following balloon catheter injury to rat carotid artery. Within 30 minutes, a marked increase in extracellular signal-regulated kinase-1/2 (ERK1/2) activity was observed. This activity remained elevated for 12 hours but had decreased to control levels b...

journal_title：Circulation research

authors： Koyama H,Olson NE,Dastvan FF,Reidy MA

更新日期：1998-04-06 00:00:00

abstract：:Activation of protein kinase C has been implicated in the regulation of a variety of cellular reactions. Although we, and others, have found protein kinase C and its substrate proteins to be present in both membrane and cytosolic fractions in the heart, the physiologic role of this kinase in the regulation of cardiac ...

journal_title：Circulation research

authors： Yuan SH,Sunahara FA,Sen AK

更新日期：1987-09-01 00:00:00

abstract：:Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with crit...

journal_title：Circulation research

authors： Momomura S,Bradley AB,Grossman W

更新日期：1984-08-01 00:00:00

abstract：:Although the ultrasonic pulsatility index (PI) is used as a test of arterial inflow, the relationship between proximal arterial stenosis and PI has not been fully evaluated. In a series of experiments on dogs, over 200 measurements of pressure, flow (using an indwelling electromagnetic flowmeter), and PI were made dis...

journal_title：Circulation research

authors： Evans DH,Barrie WW,Asher MJ,Bentley S,Bell PR

更新日期：1980-04-01 00:00:00

abstract：:We studied alpha- and beta-adrenoceptor-mediated responses of rabbit facial vein rings to adrenergic stimulation to determine the location of the two types of receptors in relation to the sympathetic nerve terminals. Transmural electrical nerve stimulation (TNS) at low frequency elicited large beta-receptor-mediated r...

journal_title：Circulation research

authors： Winquist RJ,Bevan JA

更新日期：1981-08-01 00:00:00

abstract：:Increases in free Mg2+ from 0.04 to 10.0 mM with constant pH 7.0 TO 0.10 M ionic strength, and 2 mM MgATP2- caused a rightward shift of the free Ca-relative ATPase relation for both cardiac skeletal myofibrils. The specific activity of cardiac myofibrillar ATPase over a wide range of free Ca2+ was, however, depressed ...

journal_title：Circulation research

authors： Solaro RJ,Shiner JS

更新日期：1976-07-01 00:00:00

abstract：:The influence of inhibition of the Na+ pump, with secondary stimulation of Na+-Ca++ exchange, on cellular Ca++ distribution is examined using the on-line scintillation disk technique and cultured neonatal rat myocardial cells. Under control conditions, La+++ displaced 78.1 +/- 1.13% (SEM) of the total cell associated ...

journal_title：Circulation research

authors： Burt JM,Langer GA

更新日期：1982-11-01 00:00:00

abstract：:Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of cas...

journal_title：Circulation research

authors： Marchand EL,Der Sarkissian S,Hamet P,deBlois D

更新日期：2003-04-18 00:00:00

abstract：:Peripheral blood (PB)-derived CD14+ monocytes were shown to transdifferentiate into endothelial cell (EC) lineage cells and contribute to neovascularization. We investigated whether bone marrow (BM)- or PB-derived CD34-/CD14+ cells are involved in reendothelialization after carotid balloon injury. Although neither hem...

journal_title：Circulation research

authors： Fujiyama S,Amano K,Uehira K,Yoshida M,Nishiwaki Y,Nozawa Y,Jin D,Takai S,Miyazaki M,Egashira K,Imada T,Iwasaka T,Matsubara H

更新日期：2003-11-14 00:00:00

abstract：:The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR co...

journal_title：Circulation research

authors： Sciarretta S,Forte M,Frati G,Sadoshima J

更新日期：2018-02-02 00:00:00

abstract：:The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phe...

journal_title：Circulation research

authors： Loscalzo J

更新日期：2013-07-05 00:00:00