Abstract：
OBJECTIVE:To describe the successful treatment and long-term outcomes of primary ocular surface squamous neoplasia (OSSN) with topical interferon alfa-2b or surgical excision. DESIGN:Retrospective, comparative, interventional case series. PARTICIPANTS:Twenty-nine consecutive patients with OSSN never before treated. INTERVENTION:Patients with primary OSSN chose topical interferon alfa-2b or excision with wide surgical margins, with crossover to surgery in those interferon-treated patients whose OSSN failed to regress within 2 months after beginning therapy. MAIN OUTCOME MEASURES:Successful resolution of clinical disease at 2 months after topical interferon treatment and time to recurrence after either topical interferon or surgical excision. RESULTS:Of 29 patients with primary OSSN, 15 elected topical interferon and 14 chose surgical excision. Two patients in the interferon group subsequently underwent surgical excision for apparent lack of response to interferon. No patient in either group developed a recurrence during the study period (disease-free follow-up: interferon group, mean, 35.6 months [95% confidence interval, 21.9-49.3]; surgery group, mean, 35.6 months [22.9-48.3]). CONCLUSIONS:Both topical interferon alfa-2b and aggressive surgical excision appear to be effective for primary OSSN.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Sturges A,Butt AL,Lai JE,Chodosh Jdoi
10.1016/j.ophtha.2008.01.006subject
Has Abstractpub_date
2008-08-01 00:00:00pages
1297-302, 1302.e1issue
8eissn
0161-6420issn
1549-4713pii
S0161-6420(08)00011-0journal_volume
115pub_type
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