Abstract：
:Medulloblastomas are brain tumors that arise in the cerebellum of children and contain stem cells in a perivascular niche thought to give rise to recurrence following radiation. We used several mouse models of medulloblastomas in parallel to better understand how the critical cell types in these tumors respond to therapy. In our models, the proliferating cells in the tumor bulk undergo radiation-induced, p53-dependent apoptotic cell death. Activation of Akt signaling via PTEN loss transforms these cells to a nonproliferating extensive nodularity morphology. By contrast, the nestin-expressing perivascular stem cells survive radiation, activate PI3K/Akt pathway, undergo p53-dependent cell cycle arrest, and re-enter the cell cycle at 72 h. Furthermore, the ability of these cells to induce p53 is dependent on the presence of PTEN. These cellular characteristics are similar to human medulloblastomas. Finally, inhibition of Akt signaling sensitizes cells in the perivascular region to radiation-induced apoptosis.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Hambardzumyan D,Becher OJ,Rosenblum MK,Pandolfi PP,Manova-Todorova K,Holland ECdoi
10.1101/gad.1627008subject
Has Abstractpub_date
2008-02-15 00:00:00pages
436-48issue
4eissn
0890-9369issn
1549-5477pii
22/4/436journal_volume
22pub_type
杂志文章abstract：:Gastrulation in mice is associated with the start of extreme proliferation and differentiation. The potential cost to the embryo of a very rapid proliferation rate is a high production of damaged cells. We demonstrate a novel surveillance mechanism for the elimination of cells damaged by ionizing radiation during mous...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-08-15 00:00:00
abstract：:MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from bo...
journal_title：Genes & development
pub_type： 杂志文章
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abstract：:We have developed a simple, effective genetic screen for mutant alleles of eukaryotic DNA topoisomerase I that manifest severely depressed or complete loss of enzymatic function. The screen is based on the extreme toxicity of vaccinia topoisomerase expression in the Escherichia coli lysogen strain BL21(DE3) and is not...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.4.4.515
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abstract：:A complex array of genetic factors regulates neuronal dendrite morphology. Epigenetic regulation of gene expression represents a plausible mechanism to control pathways responsible for specific dendritic arbor shapes. By studying the Drosophila dendritic arborization (da) neurons, we discovered a role of the double-br...
journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
abstract：:Nonhomologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. NHEJ repairs DSBs by ligation of cognate broken ends irrespective of homologous flanking sequences, whereas HR repairs DSBs using an undamaged homologous temp...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1204304
更新日期：2004-06-01 00:00:00
abstract：:Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profili...
journal_title：Genes & development
pub_type： 杂志文章
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journal_title：Genes & development
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journal_title：Genes & development
pub_type： 杂志文章
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2015-10-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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journal_title：Genes & development
pub_type： 评论,杂志文章,评审
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更新日期：2009-12-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：1996-11-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2013-01-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.1602607
更新日期：2007-12-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.23.2993
更新日期：1996-12-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.23.3182
更新日期：1997-12-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1898410
更新日期：2010-03-15 00:00:00
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更新日期：2003-01-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2006-08-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.227454.113
更新日期：2013-10-01 00:00:00
abstract：:Abcission, the natural shedding of leaves, flowers and fruits, is a fundamental component of plant development. Abscission is a highly regulated process that occurs at distinct zones of cells that undergo enlargement and subsequent separation. Although some components of abscission, including accumulation of the hormo...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal diffe...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.215802
更新日期：2002-01-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2012-09-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：1991-04-01 00:00:00
abstract：:Establishment of the steroid-producing Leydig cell lineage is an event downstream of Sry that is critical for masculinization of mammalian embryos. Neither the origin of fetal Leydig cell precursors nor the signaling pathway that specifies the Leydig cell lineage is known. Based on the sex-specific expression patterns...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.981202
更新日期：2002-06-01 00:00:00
abstract：:The initial steps of double-stranded break (DSB) repair by homologous recombination mediated by the 5'-3' exonuclease/annealing protein pairs, RecE/RecT and Redalpha/Redbeta, were analyzed. Recombination was RecA-independent and required the expression of both components of an orthologous pair, even when the need for ...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous substrates has rem...
journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2014-11-15 00:00:00
abstract：:The Wnt signaling cascade is a central regulator of cell fate determination during embryonic development, whose deregulation contributes to oncogenesis. Naked cuticle is the first Wnt-induced antagonist found in this pathway, establishing a negative-feedback loop that limits the Wnt signal required for early segmentat...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.328905
更新日期：2005-02-01 00:00:00
