Genetic Polymorphism of CYP2C19 gene in the Stanislas cohort. A link with inflammation.

Abstract:

:CYP2C19, a member of the cytochrome P450 family, metabolises arachidonic acid to produce epoxyeicosanoid acids, which are involved in vascular tone and inflammation. Thus, this study describes the possible relationship between a CYP2C19 polymorphism (681G>A) and three inflammatory markers: interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and high sensitivity C-reactive protein (hs-CRP) in healthy individuals. In a sub-sample of 178 men and 181 women from the Stanislas study, we quantified plasma IL-6 and TNF-alpha concentrations by using an enzyme-linked immunosorbent assay, and serum hs-CRP concentration by immunonephelometry. The CYP2C19 681G>A polymorphism was genotyped using the kinetic thermocycling allele specific PCR method. In the Stanislas cohort, the frequency of the allele CYP2C19*2 (681A) was 17.8%. Circulating levels of inflammatory factors were increased in individuals homozygous for the defective allele CYP2C19*2 (A) notably IL-6 in the whole sample (P= 0.0008) and hs-CRP only in women (P= 0.008), with a significant interaction with sex (P= 0.005), in comparison to carriers of one copy or more of the wild type allele CYP2C19*1 (G). Only a trend of association (P= 0.089) was found between this polymorphism and TNF-alpha concentration in the whole sample. The association between CYP2C19*2 polymorphism and inflammatory markers' concentrations could suggest that CYP2C19 may be considered as a new candidate gene for cardiovascular risks via inflammation.

journal_name

Ann Hum Genet

journal_title

Annals of human genetics

authors

Bertrand-Thiébault C,Berrahmoune H,Thompson A,Marie B,Droesch S,Siest G,Foernzler D,Visvikis-Siest S

doi

10.1111/j.1469-1809.2007.00417.x

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

178-83

issue

Pt 2

eissn

0003-4800

issn

1469-1809

pii

AHG417

journal_volume

72

pub_type

杂志文章
  • Using case-parent triads to estimate relative risks associated with a candidate haplotype.

    abstract::Estimating haplotype relative risks in a family-based study is complicated by phase ambiguity and the many parameters needed to quantify relative risks for all possible diplotypes. This problem becomes manageable if a particular haplotype has been implicated previously as relevant to risk. We fit log-linear models to ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.2009.00515.x

    authors: Shi M,Umbach DM,Weinberg CR

    更新日期:2009-05-01 00:00:00

  • A study of the population of Paraguay through isonymy.

    abstract::In order to describe the isonymic structure of Paraguay, the distribution of 4,843,868 surnames of 2,882,163 persons was studied in the 18 departments and 237 districts of the nation. The correlations between isonymic and geographic distances for departments were r = 0.713 ± 0.052 for Euclidean distance, 0.597 ± 0.074...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.2011.00676.x

    authors: Dipierri J,Rodriguez-Larralde A,Alfaro E,Scapoli C,Mamolini E,Salvatorelli G,Caramori G,De Lorenzi S,Sandri M,Carrieri A,Barrai I

    更新日期:2011-11-01 00:00:00

  • Rates of mutant and inherited structural cytogenetic abnormalities detected at amniocentesis: results on about 63,000 fetuses.

    abstract::We report data on diagnoses made on amniotic fluid specimens from 1977 to 1984 as reported to the New York State Chromosome Registry. The rate of all de novo (presumed mutant) abnormalities was about 2 per 1,000 in about 61,000 fetuses in which results are unlikely to be biased by the reason for amniocentesis (except ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1987.tb00864.x

    authors: Hook EB,Cross PK

    更新日期:1987-01-01 00:00:00

  • Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene.

    abstract::Alpha2-HS glycoprotein (AHSG), which is equivalent to fetuin in other species, is a protein found in human plasma. AHSG is polymorphic with two common alleles and many variants. To examine the intragenic haplotypes and their diversity at this locus, a contiguous genomic DNA sequence (10.3 kb) was analyzed in 20 sample...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1046/j.1469-1809.2001.6510027.x

    authors: Osawa M,Yuasa I,Kitano T,Henke J,Kaneko M,Udono T,Saitou N,Umetsu K

    更新日期:2001-01-01 00:00:00

  • Linkage between the loci for peptidase D and cytochrome P-450 (CYP1) on chromosome 19.

    abstract::Families segregating for PEPD have been investigated for linkage between PEPD and CYP1. The results provide evidence for close linkage between PEPD and CYP1 in males. ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1987.tb00862.x

    authors: Davis MB

    更新日期:1987-01-01 00:00:00

  • PTPN22 gene polymorphism (C1858T) is associated with susceptibility to type 1 diabetes: a meta-analysis of 19,495 cases and 25,341 controls.

    abstract::The protein tyrosine phosphatase N22 (PTPN22) gene C1858T polymorphism has been reported to be associated with susceptibility to type 1 diabetes (T1D) in relatively small sample sizes. This study aimed at investigating the pooled association by carrying out a meta-analysis on the published studies. The Medline, EBSCO,...

    journal_title:Annals of human genetics

    pub_type: 杂志文章,meta分析

    doi:10.1111/ahg.12016

    authors: Xuan C,Lun LM,Zhao JX,Wang HW,Zhu BZ,Yu S,Liu Z,He GW

    更新日期:2013-05-01 00:00:00

  • Search for the PARK3 founder haplotype in a large cohort of patients with Parkinson's disease from northern Germany.

    abstract::A founder haplotype on chromosome 2p for autosomal dominant Parkinson's disease (PD) has been postulated for two families of Northern European descent, and a new mutation in the alpha-synuclein gene (Ala30Pro) has been found in a German PD family. We evaluated 85 German PD patients and 85 ethnically matched controls f...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1046/j.1469-1809.1999.6340285.x

    authors: Klein C,Vieregge P,Hagenah J,Sieberer M,Doyle E,Jacobs H,Gasser T,Breakefield XO,Risch NJ,Ozelius LJ

    更新日期:1999-07-01 00:00:00

  • Genetics of Hunter syndrome: carrier detection, new mutations, segregation and linkage analysis.

    abstract::We have investigated 31 families segregation for Hunter Syndrome in order to advance our understanding of the genetics of this disease. The hair root test for the diagnosis of carriers of Hunter Syndrome was improved by the adoption of a new diagnostic index that distinguishes between carrier and normal females better...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1986.tb01756.x

    authors: Chase DS,Morris AH,Ballabio A,Pepper S,Giannelli F,Adinolfi M

    更新日期:1986-10-01 00:00:00

  • Tests of gene-environment interaction for case-parent triads with general environmental exposures.

    abstract::As knowledge of the human genome continues to grow, more progress is being made towards not only identifying the genes involved in disease susceptibility but also in defining the synergistic role genes play with environmental exposures. The detection of gene-environment interactions is important as it can offer clinic...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1046/j.1529-8817.2003.00073.x

    authors: Lake SL,Laird NM

    更新日期:2004-01-01 00:00:00

  • Unusual XX/XY chimerism.

    abstract::Apparently identical twin boys are both XX/XY and have two populations, A1 and B, of cells in their peripheral blood. Chimerism in somatic tissue outside the blood cells can be demonstrated in only one of the twins. From analysis of chromosomes and many gene markers the mechanism of origin of the unusual twins remains...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1979.tb02000.x

    authors: Iselius L,Lambert B,Lindsten J,Tippett P,Gavin J,Daniels G,Yates A,Ritzén M,Sandstedt B

    更新日期:1979-10-01 00:00:00

  • A collaborative study of the aetiology of Turner syndrome.

    abstract::Data on Turner Syndrome from four sources were analysed for possible associations with several aetiological factors. Two classes of liveborn propositae were included, those with a non-mosaic 45, X karyotype (XO) and those with an isochromosome of the long arm of the X (iso-X). The numbers were 288 and 84 respectively ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1980.tb01570.x

    authors: Carothers AD,Frackiewicz A,De Mey R,Collyer S,Polani PE,Osztovics M,Horváth K,Papp Z,May HM,Ferguson-Smith MA

    更新日期:1980-05-01 00:00:00

  • Genetic history of the population of Crete.

    abstract::The medieval history of several populations often suffers from scarcity of contemporary records resulting in contradictory and sometimes biased interpretations by historians. This is the situation with the population of the island of Crete, which remained relatively undisturbed until the Middle Ages when multiple wars...

    journal_title:Annals of human genetics

    pub_type: 历史文章,杂志文章

    doi:10.1111/ahg.12328

    authors: Drineas P,Tsetsos F,Plantinga A,Lazaridis I,Yannaki E,Razou A,Kanaki K,Michalodimitrakis M,Perez-Jimenez F,De Silvestro G,Renda MC,Stamatoyannopoulos JA,Kidd KK,Browning BL,Paschou P,Stamatoyannopoulos G

    更新日期:2019-11-01 00:00:00

  • Racial heterogeneity of DNA polymorphisms linked to the A and the O alleles of the ABO blood group gene.

    abstract::Except for subgroup A2 and minor A, O and B alleles (Ax, O2 and B(A)), which occur at low frequencies in the population, the major ABO alleles are considered to be homogeneous entities. The present study is the first demonstration of an extensive variability linked to the more common alleles of the blood A and O genes...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1996.tb01173.x

    authors: Zago MA,Tavella MH,Simões BP,Franco RF,Guerreiro JF,Santos SB

    更新日期:1996-01-01 00:00:00

  • Ancestry Informative Marker Panel to Estimate Population Stratification Using Genome-wide Human Array.

    abstract::Case-control studies are a powerful strategy to identify candidate genes in complex diseases. In admixed populations, association studies can be affected by population stratification, leading to spurious genetic associations. Ancestry informative markers (AIMs) can be used to minimise this effect. The aim of this work...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/ahg.12208

    authors: Barbosa FB,Cagnin NF,Simioni M,Farias AA,Torres FR,Molck MC,Araujo TK,Gil-Da-Silva-Lopes VL,Donadi EA,Simões AL

    更新日期:2017-11-01 00:00:00

  • Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study.

    abstract::Glycated hemoglobin (HbA1c) is used to classify glycaemia and type 2 diabetes (T2D). Body mass index (BMI) is a predictor of HbA1c levels and T2D. We tested 43 established BMI and obesity loci for association with HbA1c in a nationally representative multiethnic sample of young adults from the National Longitudinal St...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/ahg.12165

    authors: Lange LA,Graff M,Lange EM,Young KL,Richardson AS,Mohlke KL,North KE,Harris KM,Gordon-Larsen P

    更新日期:2016-09-01 00:00:00

  • Mutation and selection in the marker (X) syndrome. A hypothesis.

    abstract::Sherman et al. (1984) concluded from a cytogenetic and genetic analysis of families with the marker (X) syndrome that the rate of the mutation leading to this syndrome is extraordinarily high (7.2 X 10(-4) in male germ cells), and that these mutations occur exclusively in male germ cells. It is shown by some model cal...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1984.tb00846.x

    authors: Vogel F

    更新日期:1984-10-01 00:00:00

  • Genetics of LCAT (lecithin: cholesterol acyltransferase) deficiency.

    abstract::Since 1967 a syndrome characterized by renal disease, normochromic anaemia and corneal opacities has been described in 7 members of 3 different Norweigan families. The patients have low levels of esterified cholesterol and lack LCAT (lecithin: cholesterol acyltransferase) activity in plasma. The genetic basis of the d...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1975.tb00617.x

    authors: Teisberg P,Gjone E,Olaisen B

    更新日期:1975-01-01 00:00:00

  • Case-control association tests correcting for population stratification.

    abstract::In case-control association studies unobserved population stratification may act as a confounder, leading to an increased number of false positive results. Methods accounting for population structure by using additional genetic markers broadly follow one of two concepts: Genomic Control (GC) and Structured Association...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1529-8817.2005.00214.x

    authors: Köhler K,Bickeböller H

    更新日期:2006-01-01 00:00:00

  • Analysis of genetic variation in two human thyroxine-binding plasma proteins by immunodetection after isoelectric focusing.

    abstract::An immunological method for the detection of two thyroxine-binding plasma proteins, thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA), following polyacrylamide gel isoelectric focusing is described. Both proteins show complex electrophoretic patterns, attributable to post-translational glycosyla...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1985.tb01701.x

    authors: Whitehouse DB,Hopkinson DA,Hill AV,Bowden DK

    更新日期:1985-10-01 00:00:00

  • Linkage analysis and family classification under heterogeneity.

    abstract::Heterogeneity of the recombination fraction may or may not involve a mixture of two groups of elements. For the mixture situation (families with or without linkage between two gene loci), Morton's homogeneity test is compared with another test (Admixture test) with respect to significance level, power, parameter estim...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1983.tb01001.x

    authors: Ott J

    更新日期:1983-10-01 00:00:00

  • Tests of association between quantitative traits and haplotypes in a reduced-dimensional space.

    abstract::Candidate gene association tests are currently performed using several intragenic SNPs simultaneously, by testing SNP haplotype or genotype effects in multifactorial diseases or traits. The number of haplotypes drastically increases with an increase in the number of typed SNPs. As a result, large numbers of haplotypes...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1529-8817.2005.00216.x

    authors: Sha Q,Dong J,Jiang R,Zhang S

    更新日期:2005-11-01 00:00:00

  • Jacobsen syndrome and Beckwith-Wiedemann syndrome caused by a parental pericentric inversion inv(11)(p15q24).

    abstract::Here we report on a male infant presenting the typical pattern of Jacobsen syndrome including trigonocephaly, thrombocytopenia, congenital heart defect, urethral stenosis, and partial agenesis of the corpus callosum. Conventional karyotyping, FISH, SKY and CGH analyses showed that the region distal to the MLL locus on...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.2006.00271.x

    authors: Gadzicki D,Baumer A,Wey E,Happel CM,Rudolph C,Tönnies H,Neitzel H,Steinemann D,Welte K,Klein C,Schlegelberger B

    更新日期:2006-11-01 00:00:00

  • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

    abstract::Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.2009.00560.x

    authors: Edwards TL,Scott WK,Almonte C,Burt A,Powell EH,Beecham GW,Wang L,Züchner S,Konidari I,Wang G,Singer C,Nahab F,Scott B,Stajich JM,Pericak-Vance M,Haines J,Vance JM,Martin ER

    更新日期:2010-03-01 00:00:00

  • Determining approximate estimates of inheritance parameters from sib-pair IBD proportions.

    abstract::The use of IBD proportions from a large set of affected sib-pair data to estimate some or all of the main parameters describing the inheritance of a disease susceptibility gene is here considered. We assume there is no recombination present and neglect ascertainment bias, and assume that there are four distinct parent...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1996.tb01186.x

    authors: Green JR,Shah S

    更新日期:1996-03-01 00:00:00

  • The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations.

    abstract::Polymorphisms of the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been reported to be potentially associated with the risks of developing frontotemporal lobar degeneration (FTLD), with inconsistent conclusions. This study aims to comprehensively investigate the potential role of TREM2 variants in...

    journal_title:Annals of human genetics

    pub_type: 杂志文章,meta分析

    doi:10.1111/ahg.12241

    authors: Su WH,Shi ZH,Liu SL,Wang XD,Liu S,Ji Y

    更新日期:2018-07-01 00:00:00

  • Subtypes of HLA-DQ and -DR defined by DQB1 and DRB1 RFLPs: allele frequencies in the general population and in insulin-dependent diabetes (IDDM) and multiple sclerosis patients.

    abstract::We have used the HLA-DQB1 gene as a Southern hybridization probe with TaqI-digested genomic DNA in a study of 600 haplotypes from unrelated individuals and have characterized HLA-DQB1 RFLP patterns associated with the DR specificities DR1-DRw10 and DN1. For six of the specificities (DR2, 4, w6, 7, w8 and 9), we have a...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1989.tb01802.x

    authors: Gogolin KJ,Kolaga VJ,Baker L,Lisak RP,Zmijewski CM,Spielman RS

    更新日期:1989-10-01 00:00:00

  • Predominance of extreme geographical proximity of the spouses of heirs to independent farms in a mountain valley in Norway between 1600 and 1850.

    abstract::The marriages contracted between 1600 and 1850 in the parishes Vang and Slidre in the mountain valley of Valdres in Norway were investigated, using the information in the genealogical and local history of the parishes and in various public archives. The parishes functioned as a marriage isolate, in spite of regular co...

    journal_title:Annals of human genetics

    pub_type: 历史文章,杂志文章

    doi:

    authors: Saugstad LF,Odegård O

    更新日期:1977-05-01 00:00:00

  • Using age of onset to distinguish between subforms of breast cancer.

    abstract::Information on family history and age of onset of breast cancer is examined in an attempt to distinguish between postulated early and late onset forms of breast cancer and to estimate the familial correlation between any subforms that may exist. Data are taken from the Cancer and Steroid Hormone Study, a multicentre, ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.1990.tb00373.x

    authors: Claus EB,Risch NJ,Thompson WD

    更新日期:1990-05-01 00:00:00

  • Influence of population stratification on population-based marker-disease association analysis.

    abstract::Population-based genetic association analysis may suffer from the failure to control for confounders such as population stratification (PS). There has been extensive study on the influence of PS on candidate gene-disease association analysis, but much less attention has been paid to its influence on marker-disease ass...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/j.1469-1809.2010.00588.x

    authors: Li T,Li Z,Ying Z,Zhang H

    更新日期:2010-07-01 00:00:00

  • Drug addiction and stress-response genetic variability: association study in African Americans.

    abstract::Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis-driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included ...

    journal_title:Annals of human genetics

    pub_type: 杂志文章

    doi:10.1111/ahg.12064

    authors: Levran O,Randesi M,Li Y,Rotrosen J,Ott J,Adelson M,Kreek MJ

    更新日期:2014-07-01 00:00:00