当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN GERIATRICS SOCIETY期刊下所有文献 > Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos.

Apolipoprotein E epsilon4, Alzheimer's disease, and cognitive performance in elderly Mexican Mestizos.

Abstract：

OBJECTIVES:To determine the relationship between apolipoprotein E (APOE) epsilon4 and Alzheimer's disease (AD) in the Mexican Mestizo population, as well as its effects on the cognitive profile of AD and elderly Mestizos without dementia. DESIGN:Cross-sectional analysis of a cohort study. SETTING:Evaluations were conducted at the geriatrics clinic of an academic medical hospital in Mexico City. PARTICIPANTS:Forty-nine elderly subjects with AD and 141 controls selected from a representative sample of Mexican Mestizos aged 65 to 96 who participated in the Prevalence Survey of Dementia in the Mexico City Elderly Population cohort. MEASUREMENTS:All subjects underwent APOE genotypification and a comprehensive clinical and neuropsychological evaluation. RESULTS:There were no significant differences in epsilon3 and epsilon4 frequencies between the subjects with and without AD and a tendency toward higher epsilon4 and lower epsilon3 allele frequencies in subjects aged 75 and older. No association was found between APOE epsilon4 and the presence of AD. The age-, sex-, and education-adjusted risk for AD associated with at least one epsilon4 allele was 1.01 (95% confidence interval=0.45-2.23). Performance on a long-term visual memory test was significantly worse in APOE epsilon4 carriers than in APOE epsilon3 carriers only in the group with AD. CONCLUSION:APOE epsilon4 did not increase the risk for AD in this Mexican Mestizo elderly urban population sample, although the presence of this allele seems to modify its clinical expression.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Villalpando-Berumen JM,Mejia-Arango S,Aguilar-Salinas CA,Ordonez-Sanchez ML,Gutierrez-Robledo LM

doi

10.1111/j.1532-5415.2007.01606.x

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

677-82

issue

4

eissn

0002-8614

issn

1532-5415

pii

JGS1606

journal_volume

56

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY文献大全
  • Spinal Fractures in Older Adult Patients Admitted After Low-Level Falls: 10-Year Incidence and Outcomes.

    abstract：OBJECTIVES:To evaluate the incidence of spinal fractures and their outcomes in the elderly who fall from low-levels in a suburban county. DESIGN:Retrospective county-wide trauma registry review from 2004 to 2013. SETTING:Suburban county with regionalized trauma care consisting of 11 hospitals. PARTICIPANTS:Adult tra...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.14669

    authors： Jawa RS,Singer AJ,Rutigliano DN,McCormack JE,Huang EC,Shapiro MJ,Fields SD,Morelli BN,Vosswinkel JA

    更新日期：2017-05-01 00:00:00

  • Dementia and other competing risks for mortality in the institutionalized aged.

    abstract：:The relative importance of dementia, gender, age and functional status (FS) was examined for relationships to mortality within five years after admission of the subjects to a New York City nursing home for the aged. Using a random sample of 212 of the nursing home's patients, a statistical model was developed to estim...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1981.tb03354.x

    authors： Vitaliano PP,Peck A,Johnson DA,Prinz PN,Eisdorfer C

    更新日期：1981-11-01 00:00:00

  • Leadership, Inside and Out: The Tideswell-AGS-ADGAP Emerging Leaders in Aging Program.

    abstract：BACKGROUND/OBJECTIVES:To optimize health and well-being for all older people, we must collectively develop leaders to pioneer models of care, educate the healthcare workforce, advance research, and engage the community. METHODS:The Emerging Leaders in Aging (ELIA) program was created to train a multiprofessional cadre...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.15702

    authors： Chang A,Lundebjerg NE,Abrams J,Barnes DE,Fain MJ,Hall WJ,Johnson TM 2nd,Michael Harper G,Williams B,Ritchie CS

    更新日期：2019-03-01 00:00:00

  • Japan's universal long-term care system reform of 2005: containing costs and realizing a vision.

    abstract：:Japan implemented a mandatory social long-term care insurance (LTCI) system in 2000, making long-term care services a universal entitlement for every senior. Although this system has grown rapidly, reflecting its popularity among seniors and their families, it faces several challenges, including skyrocketing costs. Th...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,评审

    doi：10.1111/j.1532-5415.2007.01281.x

    authors： Tsutsui T,Muramatsu N

    更新日期：2007-09-01 00:00:00

  • Testing the effect of function-focused care in assisted living.

    abstract：OBJECTIVES:To develop and test the Function-Focused Care in Assisted Living (FFC-AL) intervention so as to alter the decline that older adults in AL experience. DESIGN:Cluster-randomized controlled trial using repeated measures to test the effect of FFC-AL. SETTING:Four AL facilities with at least 100 beds. PARTICIP...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1532-5415.2011.03699.x

    authors： Resnick B,Galik E,Gruber-Baldini A,Zimmerman S

    更新日期：2011-12-01 00:00:00

  • Electrocardiogram Monitoring After the Food and Drug Administration Warnings for Citalopram: Unheeded Alerts?

    abstract：OBJECTIVES:To evaluate national trends in electrocardiogram (EKG) monitoring in Veterans Affairs (VA) beneficiaries prescribed high-dose citalopram before and after the 2011-12 Food and Drug Administration (FDA) safety warnings. DESIGN:Interrupted time-series analyses. SETTING:National VA healthcare system data linke...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.15420

    authors： Gerlach LB,Kim HM,Yosef M,Kales HC,Henry J,Zivin K

    更新日期：2018-08-01 00:00:00

  • Understanding advance care planning as a process of health behavior change.

    abstract：OBJECTIVES:To explore whether models of health behavior change can help to inform interventions for advance care planning (ACP). DESIGN:Qualitative cross-sectional study. SETTING:Community. PARTICIPANTS:Sixty-three community-dwelling persons aged 65 and older and 30 caregivers with experience as surrogate decision-m...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2009.02396.x

    authors： Fried TR,Bullock K,Iannone L,O'Leary JR

    更新日期：2009-09-01 00:00:00

  • The effect of culture-positive influenza type A on resource use and adverse events in nursing home residents.

    abstract：OBJECTIVES:To determine adverse clinical events and resource utilization associated with culture-positive influenza A in nursing home residents. DESIGN:A retrospective cohort study with cases and controls. SETTING:Seven hundred twenty-one-bed skilled nursing facility. PARTICIPANTS:One hundred fifty-four residents (2...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1046/j.1532-5415.2002.50364.x

    authors： Drinka PJ,Krause P,Nest L,Dissing M,Gravenstein S,Goodman BM

    更新日期：2002-08-01 00:00:00

  • Low serum vitamin d does not predict new disability or loss of muscle strength in older women.

    abstract：OBJECTIVES:To determine whether serum levels of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) predict accelerated decline in muscular strength or onset of new disability in mobility and upper extremity functioning over a 3-year follow-up. DESIGN:A community-based prospective cohort study. PARTICIPANTS:S...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1046/j.1532-5415.2002.50219.x

    authors： Verreault R,Semba RD,Volpato S,Ferrucci L,Fried LP,Guralnik JM

    更新日期：2002-05-01 00:00:00

  • Use of Electronic Health Records by Older Adults, 85 Years and Older, and Their Caregivers.

    abstract：BACKGROUND:Healthcare providers may not offer patient portal (PP) access to electronic health records (EHRs) to their patients older than 85 years, due to the false impression that they do not utilize technology. It is imperative that older adults be given equal opportunity to use technology in regard to their healthca...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.16393

    authors： Ramirez-Zohfeld V,Seltzer A,Xiong L,Morse L,Lindquist LA

    更新日期：2020-05-01 00:00:00

  • Newer psychotropic medication use in nursing home residents.

    abstract：OBJECTIVE:To evaluate the use of newer psychotropic agents in nursing home residents in the era of new Health Care Financing Administration (HCFA) guidelines. DESIGN:Retrospective chart review of referrals to an on-site geriatric psychiatry service in seven Eastern Massachusetts facilities during 1995-1996. SUBJECTS:...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1998.tb02540.x

    authors： Lasser RA,Sunderland T

    更新日期：1998-02-01 00:00:00

  • Development of a geriatric behavioral self-assessment scale.

    abstract：:Described is the development of a self-rating geriatric behavioral scale modeled after the Sandoz Clinical Assessment-Geriatric (SCAG). This new Self-Assessment Scale-Geriatric (SASG) provides a valid and reliable measure of behavioral pathologic changes for the selective screening of elderly patients who manifest mil...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1981.tb02193.x

    authors： Yesavage JA,Adey M,Werner PD

    更新日期：1981-06-01 00:00:00

  • Use of a vacuum tumescence device in the management of impotence in men with a history of penile implant or severe pelvic disease.

    abstract：PURPOSE:To evaluate the use of a vacuum tumescence device in the treatment of impotence in couples wishing to restore coital function, whose male partners had unsatisfactory results from penile implants or in whom the man was impotent following treatment for prostate or colon carcinoma. SUBJECTS:Convenience sample of ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1992.tb01831.x

    authors： Korenman SG,Viosca SP

    更新日期：1992-01-01 00:00:00

  • Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort.

    abstract：OBJECTIVES:To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and subgroups with MCI. DESIGN:Prospective cohort; 10 years of follow...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2005.53566.x

    authors： Purser JL,Fillenbaum GG,Pieper CF,Wallace RB

    更新日期：2005-11-01 00:00:00

  • Nurses Improving the Care of Healthsystem Elders: creating a sustainable business model to improve care of hospitalized older adults.

    abstract：:The Nurses Improving the Care of Healthsystem Elders (NICHE) program helps its more than 450 member sites to build the leadership capabilities to enact system-level change that targets the unique needs of older adults and embeds evidence-based geriatrics knowledge into practice. NICHE received expansion funding to est...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.12324

    authors： Capezuti EA,Bricoli B,Boltz MP

    更新日期：2013-08-01 00:00:00

  • Infections in long-term care populations in the United States.

    abstract：OBJECTIVES:To estimate infection prevalence and explore associated risk factors in nursing home (NH) residents, individuals receiving home health care (HHC), and individuals receiving hospice care. DESIGN:Cross-sectional. SETTING:Nationally representative samples of 1,174 U.S. NHs in the 2004 National Nursing Home Su...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,多中心研究

    doi：10.1111/jgs.12153

    authors： Dwyer LL,Harris-Kojetin LD,Valverde RH,Frazier JM,Simon AE,Stone ND,Thompson ND

    更新日期：2013-03-01 00:00:00

  • Predictors of change in walking velocity in older adults.

    abstract：OBJECTIVE:To determine factors that predict change in walking velocity in older people using a multivariate model. DESIGN:Longitudinal observational study. SUBJECTS:A total of 588 persons older than age 60, including subjects residing in a continuing care retirement community (CCRC) (n = 248), and homebound (n = 79) ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1996.tb02427.x

    authors： Gibbs J,Hughes S,Dunlop D,Singer R,Chang RW

    更新日期：1996-02-01 00:00:00

  • Permanent cardiac pacemakers in the elderly.

    abstract：OBJECTIVE:To review (1) Changes in cardiac impulse generation, conduction, and ventricular filling in normal aging and disease; (2) Pacemaker technology and nomenclature; (3) Expert guidelines about pacemaker use; (4) Studies of pacemaker effectiveness and utilization. DESIGN:Articles were identified through a Medline...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,评审

    doi：10.1111/j.1532-5415.1994.tb01760.x

    authors： Bush DE,Finucane TE

    更新日期：1994-03-01 00:00:00

  • Assessing environmentally determined mobility disability: self-report versus observed community mobility.

    abstract：OBJECTIVES:To examine the test-retest reliability and concurrent validity of a new self-report measure of mobility function by comparing it with observed mobility, self-reported activity of daily living (ADL) function, and performance-based measures of gait and balance. DESIGN:Cross-sectional study involving two group...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1532-5415.2005.53222.x

    authors： Shumway-Cook A,Patla A,Stewart AL,Ferrucci L,Ciol MA,Guralnik JM

    更新日期：2005-04-01 00:00:00

  • A comparative study of the use of four fall risk assessment tools on acute medical wards.

    abstract：OBJECTIVES:To compare the effectiveness of four falls risk assessment tools (STRATIFY, Downton, Tullamore, and Tinetti) by using them simultaneously in the same environment. DESIGN:Prospective, open, observational study. SETTING:Two acute medical wards admitting predominantly older patients. PARTICIPANTS:One hundred...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2005.53316.x

    authors： Vassallo M,Stockdale R,Sharma JC,Briggs R,Allen S

    更新日期：2005-06-01 00:00:00

  • Recommendations for (Discontinuation of) Statin Treatment in Older Adults: Review of Guidelines.

    abstract：OBJECTIVES:As a person's age increases and his/her health status declines, new challenges arise that may lead physicians to consider deprescribing statins. We aimed to provide insight into recommendations available in international cardiovascular disease prevention guidelines regarding discontinuation of statin treatme...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.16219

    authors： van der Ploeg MA,Floriani C,Achterberg WP,Bogaerts JMK,Gussekloo J,Mooijaart SP,Streit S,Poortvliet RKE,Drewes YM

    更新日期：2020-02-01 00:00:00

  • Incorporating Geriatric Assessment into a Nephrology Clinic: Preliminary Data from Two Models of Care.

    abstract：:Older adults with advanced chronic kidney disease (CKD) experience functional impairment that can complicate CKD management. Failure to recognize functional impairment may put these individuals at risk of further functional decline, nursing home placement, and missed opportunities for timely goals-of-care conversation...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.14262

    authors： Hall RK,Haines C,Gorbatkin SM,Schlanger L,Shaban H,Schell JO,Gurley SB,Colón-Emeric CS,Bowling CB

    更新日期：2016-10-01 00:00:00

  • The effect of depression and cognitive impairment on enrollment in Medicare Part D.

    abstract：OBJECTIVES:To examine concerns that vulnerable populations, such as depressed or cognitively impaired beneficiaries would have challenges accessing Part D coverage. DESIGN:Logistic regression analysis was used to assess whether elderly Medicare beneficiaries with depression or cognitive impairment differentially plann...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2009.02348.x

    authors： Zivin K,Kabeto MU,Kales HC,Langa KM

    更新日期：2009-08-01 00:00:00

  • Applicability of depression scales to the old old person.

    abstract：:Depression is a major health problem in the elderly. The existing literature indicates that depression may be qualitatively different in this population. For example, a condition said to be prevalent among the elderly is masked depression which is marked by a cluster of vegetative symptoms without prominent dysphoria ...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1986.tb04206.x

    authors： Weiss IK,Nagel CL,Aronson MK

    更新日期：1986-03-01 00:00:00

  • Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.

    abstract：OBJECTIVES:To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN:Cross-sectional study. SETTING:French community-dwelling people. PARTICIPANTS:Elderly adults with...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/jgs.13530

    authors： de Souto Barreto P,Andrieu S,Payoux P,Demougeot L,Rolland Y,Vellas B,Multidomain Alzheimer Preventive Trial\/Data Sharing Alzheimer Study Group.

    更新日期：2015-08-01 00:00:00

  • Statin use and pain in older people with cancer: a cross-sectional study.

    abstract：OBJECTIVES:To investigate statin use and pain in people with cancer aged 70 to 79 and 80 and older. DESIGN:Cross-sectional. SETTING:Medical oncology outpatient clinic at the Royal Adelaide Hospital. PARTICIPANTS:Individuals aged 70 and older who presented consecutively between January 2009 and June 2010 (n = 385), o...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.13051

    authors： Turner JP,Shakib S,Singhal N,Hogan-Doran J,Prowse R,Johns S,Thynne T,Bell JS

    更新日期：2014-10-01 00:00:00

  • How the human brain responds to aging.

    abstract：:The characteristic morphologic changes frequently observed in the brain of an old adult include a decrease in weight and volume, a change in the pattern of cerebral cortical convolutions, and an increase in ventricular size. Cell loss varies from region to region in the brain, and may be intensified in Alzheimer's dis...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章,评审

    doi：10.1111/j.1532-5415.1976.tb03246.x

    authors： Samorajski T

    更新日期：1976-01-01 00:00:00

  • Management of isolated systolic hypertension in the elderly.

    abstract：:Now that the benefits of treating diastolic hypertension in the elderly have been convincingly proved, attention is turning to the need for, and the choice of, treatment of isolated systolic hypertension in this age group. The hemodynamic mechanism differs in the elderly, whose isolated systolic hypertension is likely...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.1986.tb05477.x

    authors： Gifford RW Jr

    更新日期：1986-02-01 00:00:00

  • Aging, the Medical Subspecialties, and Career Development: Where We Were, Where We Are Going.

    abstract：:Historically, the medical subspecialties have not focused on the needs of older adults. This has changed with the implementation of initiatives to integrate geriatrics and aging research into the medical and surgical subspecialties and with the establishment of a home for internal medicine specialists within the annua...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/jgs.14708

    authors： Hurria A,High KP,Mody L,McFarland Horne F,Escobedo M,Halter J,Hazzard W,Schmader K,Klepin H,Lee S,Makris UE,Rich MW,Rogers S,Wiggins J,Watman R,Choi J,Lundebjerg N,Zieman S

    更新日期：2017-04-01 00:00:00

  • The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health Study.

    abstract：OBJECTIVES:To examine the relationship between persistently high depressive symptoms and long-term changes in functional disability in elderly persons. DESIGN:A community-based, prospective, observational study. SETTING:Participant data from the Cardiovascular Health Study. PARTICIPANTS:From the overall sample of 5,...

    journal_title：Journal of the American Geriatrics Society

    pub_type： 杂志文章

    doi：10.1111/j.1532-5415.2005.53202.x

    authors： Lenze EJ,Schulz R,Martire LM,Zdaniuk B,Glass T,Kop WJ,Jackson SA,Reynolds CF 3rd

    更新日期：2005-04-01 00:00:00