Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer.

Abstract:

:Iron-sulfur [Fe-S] clusters are ubiquitous ancient prosthetic groups that are required to sustain fundamental life processes. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Different types of [Fe-S] cluster assembly systems have been discovered. All of them have in common the requirement of a cysteine desulfurase and the participation of [Fe-S] scaffold proteins. The purpose of this review is to discuss various aspects of the molecular mechanisms of [Fe-S] cluster assembly in living organisms: (i) mechanism of sulfur donor enzymes, namely the cysteine desulfurases; (ii) mechanism by which clusters are preassembled on scaffold proteins and (iii) mechanism of [Fe-S] cluster transfer from scaffold to target proteins.

journal_name

Arch Biochem Biophys

authors

Fontecave M,Ollagnier-de-Choudens S

doi

10.1016/j.abb.2007.12.014

subject

Has Abstract

pub_date

2008-06-15 00:00:00

pages

226-37

issue

2

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(07)00607-8

journal_volume

474

pub_type

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