Abstract:
:Iron-sulfur [Fe-S] clusters are ubiquitous ancient prosthetic groups that are required to sustain fundamental life processes. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Different types of [Fe-S] cluster assembly systems have been discovered. All of them have in common the requirement of a cysteine desulfurase and the participation of [Fe-S] scaffold proteins. The purpose of this review is to discuss various aspects of the molecular mechanisms of [Fe-S] cluster assembly in living organisms: (i) mechanism of sulfur donor enzymes, namely the cysteine desulfurases; (ii) mechanism by which clusters are preassembled on scaffold proteins and (iii) mechanism of [Fe-S] cluster transfer from scaffold to target proteins.
journal_name
Arch Biochem Biophysjournal_title
Archives of biochemistry and biophysicsauthors
Fontecave M,Ollagnier-de-Choudens Sdoi
10.1016/j.abb.2007.12.014subject
Has Abstractpub_date
2008-06-15 00:00:00pages
226-37issue
2eissn
0003-9861issn
1096-0384pii
S0003-9861(07)00607-8journal_volume
474pub_type
杂志文章,评审abstract::Apocynin has been used as an efficient inhibitor of the NADPH oxidase complex and its mechanism of inhibition is linked to prior activation through the action of peroxidases. Here we studied the oxidation of apocynin catalyzed by myeloperoxidase (MPO) and activated neutrophils. We found that apocynin is easily oxidize...
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journal_title:Archives of biochemistry and biophysics
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更新日期:2006-08-01 00:00:00
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journal_title:Archives of biochemistry and biophysics
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