Abstract:
:Iron-sulfur [Fe-S] clusters are ubiquitous ancient prosthetic groups that are required to sustain fundamental life processes. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Different types of [Fe-S] cluster assembly systems have been discovered. All of them have in common the requirement of a cysteine desulfurase and the participation of [Fe-S] scaffold proteins. The purpose of this review is to discuss various aspects of the molecular mechanisms of [Fe-S] cluster assembly in living organisms: (i) mechanism of sulfur donor enzymes, namely the cysteine desulfurases; (ii) mechanism by which clusters are preassembled on scaffold proteins and (iii) mechanism of [Fe-S] cluster transfer from scaffold to target proteins.
journal_name
Arch Biochem Biophysjournal_title
Archives of biochemistry and biophysicsauthors
Fontecave M,Ollagnier-de-Choudens Sdoi
10.1016/j.abb.2007.12.014subject
Has Abstractpub_date
2008-06-15 00:00:00pages
226-37issue
2eissn
0003-9861issn
1096-0384pii
S0003-9861(07)00607-8journal_volume
474pub_type
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更新日期:1995-02-20 00:00:00
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更新日期:1994-09-01 00:00:00
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更新日期:1986-08-01 00:00:00
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更新日期:1997-09-15 00:00:00
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更新日期:1999-06-15 00:00:00
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