Abstract：
:It is shown that phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil can modulate pulmonary arterial hypertension (PAH) via increasing the level of guanosine-3,5-cyclic monophosphate (cGMP) and decreases pulmonary artery pressure (PAP). In this study we determined the effectiveness of sildenafil and compared its efficacy with inhaled nasal oxygen (O2) during cardiac catheterization in patients with congenital heart diseases (CHD) and PAH, as a test of feasibility for surgical repair of the patients. We studied 15 patients, 9 male and 6 female, with a mean age of 8.3 years. Hemodynamic measurements were made at baseline, after O2 administration for 20 min (5 L/min by mask), and then 45 min after administration of a single dose of sildenafil (0.5 mg/kg orally or via nasogastric tube). Mean PAP at baseline was 72.2 +/- 12.54 mm Hg and was reduced by sildenafil to 52.5 +/- 9.6 and by O2 to 61.3 +/- 10.39. Both sildenafil and O2 decreased PAP effectively (p = 0.08 and p = 0.04, respectively). Pulmonary vascular resistance (PVR) was calculated for 12 patients, with a baseline level of 9.08 +/- 1.09 mm Hg . L(-1) . min, which was significantly decreased by O2, to 3.74 +/- 0.43, and by sildenafil, to 5.93 +/- 0.75 (p = 0.005 and p = 0.05, respectively). Sildenafil, as a single oral dose, can effectively reduce PAP and PVR. This novel PDE5 inhibitor can be used for assessment of feasibility of operation for patients with CHD and PAH when inhaled NO is not available.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Ajami GH,Borzoee M,Radvar M,Amoozgar Hdoi
10.1007/s00246-007-9139-2subject
Has Abstractpub_date
2008-05-01 00:00:00pages
552-5issue
3eissn
0172-0643issn
1432-1971journal_volume
29pub_type
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
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journal_title：Pediatric cardiology
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更新日期：2004-07-01 00:00:00
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journal_title：Pediatric cardiology
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更新日期：2016-01-01 00:00:00
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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abstract：:Ionizing radiation exposure is a necessary risk entailed during congenital cardiac catheterizations. The congenital catheterization lab at Yale New Haven Children's Hospital employed quality improvement strategies to minimize radiation exposure in this vulnerable population. In two phases, we implemented six intervent...
journal_title：Pediatric cardiology
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