Abstract:
OBJECTIVE:To summarise evidence on the attributable risk of infertility after chlamydial infection in women. METHODS:Twelve databases were searched, limited to peer-reviewed literature published from January 1970 to September 2007. Conference abstracts and reference lists from reviews published since 2000 and from key articles were hand-searched. Studies were selected for review if they met the following criteria: (1) the study population comprised women of child-bearing age (defined as 15-45 years) and incorporated a comparison group of women documented as "chlamydia negative"; (2) the study outcomes included either infertility or successful pregnancy; and (3) the study design was one of the following: cohort, randomised controlled trial, "before and after" study, screening trial and systematic review. Studies were excluded if they described genital infections that either did not include Chlamydia trachomatis or described genital chlamydial co-infection, in which no data were available for C trachomatis infection alone. RESULTS:3349 studies were identified by the search. One study satisfied the inclusion criteria, a longitudinal investigation measuring pregnancy rates in adolescent women with and without current chlamydial infection at baseline. That study reported no significant difference in subsequent pregnancy rates; however, it had serious methodological limitations, which restricted its conclusions. CONCLUSIONS:This systematic review demonstrates the absence of valid evidence on the attributable risk of post-infective tubal factor infertility after genital chlamydial infection. The findings contribute empirical data to the growing debate surrounding previous assumptions about the natural history of chlamydial infection in women.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Wallace LA,Scoular A,Hart G,Reid M,Wilson P,Goldberg DJdoi
10.1136/sti.2007.026047subject
Has Abstractpub_date
2008-06-01 00:00:00pages
171-5issue
3eissn
1368-4973issn
1472-3263pii
sti.2007.026047journal_volume
84pub_type
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/sti.2006.023283
更新日期:2007-06-01 00:00:00
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更新日期:2012-11-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
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更新日期:2016-02-01 00:00:00
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