Abstract：
:The use of high-frequency ultrasound transducers combined with manometry in the gastrointestinal (GI) tract has yielded important findings concerning the anatomy, physiology, and pathophysiology of the high-pressure zone of the gastroesophageal junction and the sphincteric muscles within. These transducers have made previously invisible portions of the GI tract accessible to investigation. Three distinct high-pressure zones have been identified and correlated with anatomic structures: the extrinsic sphincter (crural diaphragm) and the two components of the intrinsic sphincter (an upper LES and a lower LES [the gastric sling fiber/clasp fiber complex]). This article discusses the possible underlying pathophysiology of gastroesophageal reflux disease; the biomechanics of the gastroesophageal junction high-pressure zone; and the mechanism of action of standard surgical and newer endoscopic therapies for gastroesophageal reflux disease.
journal_name
Gastroenterol Clin North Amjournal_title
Gastroenterology clinics of North Americaauthors
Miller L,Vegesna A,Kalra A,Besetty R,Dai Q,Korimilli A,Brasseur JGdoi
10.1016/j.gtc.2007.07.008subject
Has Abstractpub_date
2007-09-01 00:00:00pages
601-17, ixissue
3eissn
0889-8553issn
1558-1942pii
S0889-8553(07)00068-4journal_volume
36pub_type
杂志文章,评审abstract：:Hepatic angiosarcoma is the second most common primary malignant neoplasm of the liver. Although comprising only 2 per cent of all hepatic primary tumors, it represents a major clinical problem because of its strong association with industrial vinyl chloride exposure and its incurability. Strict ceilings on the amount...
journal_title：Gastroenterology clinics of North America
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doi：
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abstract：:Chronic intestinal pseudo-obstruction (CIPO) is a severe form of intestinal dysmotility disorder, characterized by the impairment of gastrointestinal propulsion of the gut content in the absence of fixed occluding lesions. CIPO is a rare disease that can develop in both children and adults. CIPO is classified as prima...
journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
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更新日期：1995-03-01 00:00:00
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1990-12-01 00:00:00
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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doi：10.1016/j.gtc.2004.02.010
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1988-09-01 00:00:00
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1988-12-01 00:00:00
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
doi：10.1016/j.gtc.2011.06.004
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章
doi：10.1016/j.gtc.2014.02.008
更新日期：2014-06-01 00:00:00
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journal_title：Gastroenterology clinics of North America
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更新日期：1994-09-01 00:00:00
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
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journal_title：Gastroenterology clinics of North America
pub_type： 杂志文章,评审
doi：
更新日期：1995-09-01 00:00:00
