Susceptibility of congenitally immunodeficient mice to a nonencapsulated strain of Cryptococcus neoformans.

Abstract:

:The susceptibility of congenitally immunodeficient mice to a nonencapsulated strain of Cryptococcus neoformans (strain M7) was evaluated. Gnotobiotic mice with defined congenital defects in innate immunity (beige) or cell-mediated immunity (athymic) or with combined defects in innate and cellular immunity (beige athymic) were i.v. challenged with C. neoformans M7. The nonencapsulated strain of C. neoformans produced a persistent low-grade infection in the brains of all immunodeficient and immunocompetent mice used in this study. Immunocompetent mice (nu/+;bg/+) and immunodeficient bg/bg mice readily cleared nonencapsulated cryptococci from their kidneys, liver, lungs, and spleen. In contrast to nu/+ mice, nu/nu mice had a reduced capacity to clear nonencapsulated cryptococci from their kidneys and liver after i.v. challenge. Both bg/bg-nu/nu and bg/bg-nu/+ mice developed a low-grade infection in their kidneys, liver, lungs, and spleen, which was maintained throughout the 21-day study. Persistent infections were not due to reversion to an encapsulated state. These data indicate that a capsule may not always be necessary for C. neoformans to survive, in vivo, in tissues of immunodeficient and immunocompetent mice.

journal_name

Can J Microbiol

authors

Salkowski CA,Balish E

doi

10.1139/m91-144

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

834-9

issue

11

eissn

0008-4166

issn

1480-3275

journal_volume

37

pub_type

杂志文章
  • Molecular techniques and their potential application in monitoring the microbiological quality of indoor air.

    abstract::Health effects associated with poor indoor air quality have created a need for accurate, reproducible methods of monitoring the microbiological content of indoor air. Improved methods of detection may allow researchers to clarify the effect of individual species present in the indoor environment on human health. This ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章,评审

    doi:10.1139/m95-091

    authors: MacNeil L,Kauri T,Robertson W

    更新日期:1995-08-01 00:00:00

  • Phylogenetic study and identification of human pathogenic Vibrio species based on partial hsp60 gene sequences.

    abstract::The use of hsp60 gene sequences for phylogenetic study and identification of pathogenic marine vibrios was investigated. A 600-bp partial hsp60 gene was amplified by PCR and sequenced from 29 strains representing 15 Vibrio species within the family Vibrionaceae. Sequence comparison of the amplified partial hsp60 gene ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w02-089

    authors: Kwok AY,Wilson JT,Coulthart M,Ng LK,Mutharia L,Chow AW

    更新日期:2002-10-01 00:00:00

  • Fetal bovine serum induces changes in fatty acid composition of Trypanosoma cruzi phosphoinositides.

    abstract::Fetal bovine serum (FBS) is a necessary constituent of the culture media employed to foster the growth of Trypanosoma cruzi epimastigote forms. In different laboratories, the serum is used at final concentrations of 5 or 10%. We have normally supplemented the complex medium with 10% FBS. Under this condition we have d...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m95-132

    authors: Racagni G,de Lema MG,Hernández G,Machado-Domenech EE

    更新日期:1995-10-01 00:00:00

  • Antioxidant, antihypertensive, and antibacterial properties of endophytic Pestalotiopsis species from medicinal plants.

    abstract::Pestalotiopsis species were most dominant endophytic species isolated from four medicinal plants including Terminalia arjuna, Terminalia chebula, Azadirachta indica, and Holarrhena antidysenterica. Thirty Pestalotiopsis species isolated from different parts of the medicinal plants were selected for the study. The anti...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w08-070

    authors: Tejesvi MV,Kini KR,Prakash HS,Subbiah V,Shetty HS

    更新日期:2008-09-01 00:00:00

  • Numerical taxonomy of heavy metal-tolerant bacteria isolated from an estuary.

    abstract::A total of 230 strains of metal-tolerant bacteria from water and sediment samples collected in Chesapeake Bay were isolated on a medium containing cobalt, lead, mercury, or molybdenum. In addition, a set of 71 cultures were simultaneously isolated on glucose tryptone yeast extract agar medium without metals. Twenty-th...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m77-212

    authors: Austin B,Allen DA,Mills AL,Colwell RR

    更新日期:1977-10-01 00:00:00

  • Antigenic analysis of Pasteurella multocida (serotype 1) by crossed immunoelectrophoresis: characterization of cytoplasmic and cell envelope associated antigens.

    abstract::The application of crossed immunoelectrophoresis to the analysis of a reference cytoplasm and cell envelope preparation from Pasteurella multocida serotype 1 revealed antigenic complexity not previously found. At least 55 cytoplasmic and 19 cell envelope antigens were clearly distinguished. Variation of anticytoplasm ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m80-118

    authors: Bhasin JL,Lapointe-Shaw L

    更新日期:1980-06-01 00:00:00

  • Evaluation of the antiserum agar method for the serogroup identification of Neisseria meningitidis.

    abstract::The antiserum agar method (ASA), which is based on the formation of immunoprecipitates around bacterial growth on agar containing meningococcal hyperimmune horse serum, was evaluated for serogroup identification of Neisseria meningitidis. Four hundred meningococcal stains were serogrouped by ASA employing horse antise...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m79-113

    authors: Ashton FE,Ryan A,Diena BB,Frasch CE

    更新日期:1979-06-01 00:00:00

  • Aerobic adaptation in yeast. I. Changes in metabolic intermediates during a step-down anaerobic-aerobic transfer.

    abstract::Early investigation into the mechanism of mitochondriogenesis in the facultative anaerobe Saccharomyces cerevisiae used anaerobic-aerobic transitions as model systems to study the in vivo assembly of these oxidative organelles. This methodology has become entrenched in the early literature and as a result a definitive...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m75-126

    authors: Bruver RM,Ball JS,Tustanoff ER

    更新日期:1975-06-01 00:00:00

  • Simplified procedures for releasing and concentrating microorganisms from soil for transmission electron microscopy viewing as thin-sectioned and frozen-etched preparations.

    abstract::A simplified procedure is presented for releasing and concentrating indigenous microbial cells from soil for viewing by transmission electron microscopy as thin sections or replicas of frozen-etched preparations. This procedure is compared with two others reported earlier, and their relative merits are discussed as co...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m75-036

    authors: Balkwill DL,Labeda DP,Casida LE Jr

    更新日期:1975-03-01 00:00:00

  • Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms.

    abstract::Dietary exposure to heavy metals may have detrimental effects on human and animal health, even at low concentrations. Specific probiotic bacteria may have properties that enable them to bind toxins from food and water. We assessed the interaction of probiotic bacteria with cadmium and lead in vitro as an initial scree...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w06-043

    authors: Ibrahim F,Halttunen T,Tahvonen R,Salminen S

    更新日期:2006-09-01 00:00:00

  • Origin of the eukaryotic nucleus: eukaryotes and eocytes are genotypically related.

    abstract::The origin of the eukaryotic nucleus is difficult to reconstruct. While eukaryotic organelles (chloroplast, mitochondrion) are eubacterial endosymbionts, the source of nuclear genes has been obscured by multiple nucleotide substitutions. Using evolutionary parsimony, a newly developed rate-invariant treeing algorithm,...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m89-017

    authors: Lake JA

    更新日期:1989-01-01 00:00:00

  • Microbial surfactant activities from a petrochemical landfarm in a humid tropical region of Brazil.

    abstract::The goal of this study was to assess the presence and surfactant potential of naturally occurring microbes from a tropical soil with petrochemical contamination. Microorganisms in a soil sample from a Brazilian landfarm were isolated and grown on petroleum as the sole carbon source. Of 60 isolates screened for petrole...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/W07-052

    authors: Maciel BM,Dias JC,Dos Santos AC,Filho RC,Fontana R,Loguercio LL,Rezende RP

    更新日期:2007-08-01 00:00:00

  • Hydrogen cyanide production by Pseudomonas aeruginosa at reduced oxygen levels.

    abstract::Hydrogen cyanide production by Pseudomonas aeruginosa growing in a synthetic medium required aerobosis but operated efficiently at low dissolved oxygen concentration. Half maximum levels of cyanogenesis occurred at 0.015 microM oxygen; maximum cyanogenesis occurred over a wide range, 0.1-180 microM, of oxygen concentr...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m83-209

    authors: Castric PA

    更新日期:1983-10-01 00:00:00

  • Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation.

    abstract::Streptomyces echinatus A8331 cultured on a maltose minimal salts medium normally produces a single antibiotic, echinomycin (quinomycin A), containing two quinoxaline-2-carbonyl chromophores. Echinomycin is powerfully active against experimental tumours and can be assayed by its activity against Gram-positive bacteria....

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m84-065

    authors: Gauvreau D,Waring MJ

    更新日期:1984-04-01 00:00:00

  • Real-time polymerase chain reaction for detection of encapsulated Haemophilus influenzae using degenerate primers to target the capsule transport gene bexA.

    abstract::A real-time polymerase chain reaction assay that uses degenerate primers and a dual-labelled probe was developed to detect the bexA gene of Haemophilus influenzae, including those belonging to non-b serotypes as well as clonal division II strains. This assay is sensitive and specific, detecting 20 copies of the gene, ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/cjm-2013-0040

    authors: Law DK,Tsang RS

    更新日期:2013-05-01 00:00:00

  • Heterokaryosis and parasexuality in Pyricularia oryzae Cavara.

    abstract::Auxotrophs in three different races of Pyricularia oryzae were obtained following ultraviolet mutagenesis, and tested for complementarity on minimal medium. Prototrophic growth resulted between combinations of different auxotrophs of single strains, but not between strains. The growth did not result form crossfeeding,...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m76-079

    authors: Genovesi AD,Magill CW

    更新日期:1976-04-01 00:00:00

  • [The effect of pyridoxal phosphate on the tryptophanases of five species of Enterobacteriaceae].

    abstract::Escherichia coli B and E. aurescens, Shigella alkalescens, and Proteus vulgaris et P. morganii tryptophanases (TPases) were studied for the spectral forms of the enzyme. The pH effect on the absorption spectrum and on the enzyme specific activity revealed that the coli group TPases are identical with but differ from P...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:

    authors: Simard C,Mardini A,Bordeleau LM

    更新日期:1975-06-01 00:00:00

  • Diagnosis of rubella virus infections. I. A comparison between Vero and BHK-21 cells for the detection of specific IgG and IgM antibodies by immunofluorescence.

    abstract::Vero cells were more suitable then BHK-21 cells for the detection of rubella-specific IgG antibodies because the nonspecific fluorescence was minimal. However, BHK-21 cells were found more sensitive than Vero cells for the detection of rubella-specific IgM antibodies. ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m75-041

    authors: Payment P,Roy L,Gilker JC,Chagnon A

    更新日期:1975-03-01 00:00:00

  • Mouse models of infection for Neisseria meningitidis B,2b and Haemophilus influenzae type b diseases.

    abstract::A disseminated and fatal infection was established in C57BL mice, injected intraperitoneally with either Neisseria meningitidis B,2b or Haemophilus influenzae type b bacteria plus enhancement factors. The effects of mucin, hemoglobin, and iron dextran as enhancement of bacterial infectivity in mice were evaluated indi...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m86-007

    authors: Brodeur BR,Tsang PS,Hamel J,Larose Y,Montplaisir S

    更新日期:1986-01-01 00:00:00

  • Evidence-based validation of quorum quenching from Lysinibacillus sphaericus and Geobacillus sp. in bioremediation of oil sludge.

    abstract::Many studies on quorum quenching focus on the discovery and characterization of novel acyl-homoserine lactonases (AHL-lactonases) because these enzymes could be used in the control of diseases caused by Gram-negative bacteria. The effects of quorum quenching are also remarkable in the performance of bacterial consorti...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/cjm-2016-0323

    authors: Gómez-Garzón C,Dussán J

    更新日期:2017-01-01 00:00:00

  • Methanogenic potential of tailings samples from oil sands extraction plants.

    abstract::Approximately 20% of Canada's oil supply now comes from the extraction of bitumen from the oil sands deposits in northeastern Alberta. The oil sands are strip-mined, and the bitumen is typically separated from sand and clays by an alkaline hot water extraction process. The rapidly expanding oil sands industry has mill...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w01-129

    authors: Fedorak PM,Coy DL,Salloum MJ,Dudas MJ

    更新日期:2002-01-01 00:00:00

  • DNA relatedness among aquatic yeasts of the genus Metschnikowia and proposal of the species Metschnikowia australis comb. nov.

    abstract::DNA hybridization studies were conducted to determine the taxonomic status of the aquatic group of Metschnikowia species and their varieties. Among the DNAs of the four varieties of Metschnikowia bicuspidata, that of Metschnikowia bicuspidata var. australis showed 37 to 51% relative binding with the DNAs of Metschniko...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m85-170

    authors: Mendonça-Hagler LC,Hagler AN,Phaff HJ,Tredick J

    更新日期:1985-10-01 00:00:00

  • Regulation and properties of an invertase from Clostridium pasteurianum.

    abstract::An intracellular invertase was induced in cultures of Clostridium pasteurianum utilizing sucrose as its carbon source for growth. This enzyme synthesis could be repressed by the addition of fructose of a sucrose-growing culture. In contrast, invertase activity was not affected by the addition of glucose to sucrose-gro...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m75-251

    authors: Laishley EJ

    更新日期:1975-11-01 00:00:00

  • Mechanism of antibacterial activity of the white-rot fungus Hypholoma fasciculare colonizing wood.

    abstract::In a previous study it was shown that the number of wood-inhabiting bacteria was drastically reduced after colonization of beech (Fagus sylvatica) wood blocks by the white-rot fungus Hypholoma fasciculare, or sulfur tuft (Folman et al. 2008). Here we report on the mechanisms of this fungal-induced antibacterial activi...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w10-023

    authors: de Boer W,Folman LB,Gunnewiek PJ,Svensson T,Bastviken D,Oberg G,del Rio JC,Boddy L

    更新日期:2010-05-01 00:00:00

  • Nitrogen fixation by Rhizobium sp. 32H1. A morphological and ultrastructural comparison of asymbiotic and symbiotic nitrogen-fixing forms.

    abstract::The induction of nitrogenase (C2H2) activity in asymbiotically cultured Rhizobium sp. 32H1 was found to be associated with morphological changes in the cells which were more pronounced than those seen in bacteroids. Polyphosphate granules were found in both bacteroids and cultured cells, but poly-beta-hydroxybutyrate ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m79-055

    authors: van Brussel AA,Costerton JW,Child JJ

    更新日期:1979-03-01 00:00:00

  • Chromosomal mutants of Saccharomyces cerevisiae affecting the cell wall binding site for killer factor.

    abstract::Fifty-two killer, factor-resistant, nuclear mutants were isolated from sensitive strains of yeast and assorted into three functional groups. All but one mutant owed their resistance to an alteration in the cell wall binding site for killer. In several mutant strains, an alteration at the site of killer binding was ass...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/m78-041

    authors: Al-Aidroos K,Bussey H

    更新日期:1978-03-01 00:00:00

  • Diversification of Pseudomonas corrugata 2140 produces new phenotypes altered in GC-FAME, BIOLOG, and in vitro inhibition profiles and taxonomic identification.

    abstract::Bacteria are known to rapidly produce new phenotypes, but it is unclear how phenotype "plasticity" relates to studies on the population ecology of bacteria in complex environments. We characterised a collection of 14 spontaneous phenotype variants, derived from in vitro and in vivo cultures (wheat roots) of Pseudomona...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w99-006

    authors: Barnett SJ,Alami Y,Singleton I,Ryder MH

    更新日期:1999-04-01 00:00:00

  • Analysis of pFQ12, a 22.4-kb Frankia plasmid.

    abstract::Frankia are gram-positive, filamentous bacteria capable of fixing atmospheric dinitrogen in symbiosis with a wide variety of woody plants and shrubs. Some isolates of Frankia harbor plasmids of 8.5 (pFQ11) and 22.4 kb (pFQ12) that have no known function but are transmitted through many generations in culture. We have ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/w01-050

    authors: John TR,Rice JM,Johnson JD

    更新日期:2001-07-01 00:00:00

  • [Rubella virus. I. Morphology and structural proteins].

    abstract::Degradation of purified rubella virus by heat treatment (37, 45, or 56 degrees C) revealed the following structures. The viral envelope, a modified cellular membrane, bears spherical subunits, 5-6 nm in diameter, hexamers, or pentamers. Two glycoproteins, VP-2 (50 000 daltons) and VP-3 (63 000 daltons), are associated...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:

    authors: Payment P,Ajdukovic D,Pavilanis V

    更新日期:1975-05-01 00:00:00

  • Ethanol-induced stress response of Staphylococcus aureus.

    abstract::Transcriptional profiles of 2 unrelated clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates were analyzed following 10% (v/v) ethanol challenge (15 min), which arrested growth but did not reduce viability. Ethanol-induced stress (EIS) resulted in differential gene expression of 1091 genes, 600 common ...

    journal_title:Canadian journal of microbiology

    pub_type: 杂志文章

    doi:10.1139/cjm-2017-0221

    authors: Pando JM,Pfeltz RF,Cuaron JA,Nagarajan V,Mishra MN,Torres NJ,Elasri MO,Wilkinson BJ,Gustafson JE

    更新日期:2017-09-01 00:00:00