Synthesis of chlorogenic acid derivatives with promising antifungal activity.

Abstract:

:Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.

journal_name

Bioorg Med Chem

authors

Ma CM,Kully M,Khan JK,Hattori M,Daneshtalab M

doi

10.1016/j.bmc.2007.07.038

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

6830-3

issue

21

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00649-9

journal_volume

15

pub_type

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