Abstract:
:Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Ma CM,Kully M,Khan JK,Hattori M,Daneshtalab Mdoi
10.1016/j.bmc.2007.07.038subject
Has Abstractpub_date
2007-11-01 00:00:00pages
6830-3issue
21eissn
0968-0896issn
1464-3391pii
S0968-0896(07)00649-9journal_volume
15pub_type
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