The role of high-dose chemotherapy supported by hematopoietic stem cell transplantation in patients with multiple myeloma: implications for nursing.

Abstract:

:Multiple myeloma (MM), a neoplastic proliferation of plasma cells originating from the B-cell line, is associated with deleterious complications and poor outcomes. The failure of conventional combination chemotherapies to improve the overall survival of patients with MM has led to the use of high-dose chemotherapy supported by stem cell transplantation (SCT). Although several novel therapies have emerged since the late 1990s, their survival benefits are undetermined. High-dose chemotherapy with SCT provides better response rates compared to conventional chemotherapy and yields a trend toward greater survival benefits, especially with the use of a tandem (two successive) transplantation strategy. This article discusses standard SCT in patients with MM and some of the new transplantation strategies, including tandem autologous SCTs and reduced-intensity nonmyeloablative allogeneic SCT, and their implications for nursing.

journal_name

Clin J Oncol Nurs

authors

Rodriguez AL,Tariman JD,Enecio T,Estrella SM

doi

10.1188/07.CJON.579-589

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

579-89

issue

4

eissn

1092-1095

issn

1538-067X

pii

36K8X85141442644

journal_volume

11

pub_type

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