Cannabis; adverse effects from an oromucosal spray.

Abstract:

BACKGROUND:An oromucosal spray has been developed from the major components of marijuana (cannabis), including tetrahydrocannabinol (THC) and cannabidiol (CBD), in alcohol with a peppermint flavouring, designed to be administered as a spray under the tongue or on the buccal mucosa to relieve pain in multiple sclerosis. Although the available evidence indicates its efficacy in this respect, some patients develop oral burning sensation, stinging or white lesions, probably burns. OBJECTIVE:To investigate the oral side-effects of oromucosal cannabis spray in multiple sclerosis (MS) patients. DESIGN:A small open observational study. SUBJECTS AND METHODS:A series of nine patients with MS who had been using a marijuana oromucosal spray for at least four weeks, were asked to attend for oral examination. Patients were asked whether they had ever experienced symptoms (dryness; bad taste; stinging) associated with use of the spray. A standard oral examination was carried out using a dental light, and the presence of any mucosal lesions recorded. Where mucosal lesions were present, patients were advised to discontinue the spray and re-attend after four weeks for re-examination. For ethical reasons, biopsies were not undertaken at the first visit. RESULTS:Of nine patients invited to participate, eight attended. All admitted to a stinging sensation on using the oromucosal cannabis spray, and four had visible oral mucosal white lesions in the floor of the mouth. CONCLUSIONS:Although the white lesions observed were almost certainly burns, resolving or improving on discontinuation of use of the medication, the high alcohol concentration of the oromucosal cannabis spray raises concern in relation to chronic oral use.

journal_name

Br Dent J

journal_title

British dental journal

authors

Scully C

doi

10.1038/bdj.2007.749

subject

Has Abstract

pub_date

2007-09-22 00:00:00

pages

E12; discussion 336-7

issue

6

eissn

0007-0610

issn

1476-5373

pii

bdj.2007.749

journal_volume

203

pub_type

杂志文章
  • Contemporary operative caries management: consensus recommendations on minimally invasive caries removal.

    abstract::The International Caries Consensus Collaboration (ICCC) presented recommendations on terminology, on carious tissue removal and on managing cavitated carious lesions. It identified 'dental caries' as the name of the disease that dentists should manage, and the importance of controlling the activity of existing cavitat...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2017.672

    authors: Banerjee A,Frencken JE,Schwendicke F,Innes NPT

    更新日期:2017-08-11 00:00:00

  • The use of light-cured resin and orthodontic archwire to immobilise a transplanted maxillary canine.

    abstract::A technique is presented which uses light-activated bonding materials and orthodontic archwire to immobilise a surgically transplanted impacted maxillary canine. The technique is quick and effective. It uses materials commonly available in the dental surgery and does not require technical laboratory support. The treat...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4807505

    authors: Willmot DR,Davies SJ

    更新日期:1991-04-06 00:00:00

  • Ecstasy--dental implications.

    abstract::Ecstasy (also known as 'love drug', 'XTC' or 'E') is the name commonly used for the illegal designer drug related to amphetamine, 3,4 methylenedioxy-methamphetamine (MDMA). MDMA was patented in 1914 as an appetite suppressant, has been investigated as a mood modifying agent, but with its predecessor 3,4 methylenedioxy...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4808200

    authors: Duxbury AJ

    更新日期:1993-07-10 00:00:00

  • Current concepts on the management of tooth wear: part 3. Active restorative care 2: the management of generalised tooth wear.

    abstract::Paper 3 of this series on the current concepts of tooth wear management will focus on the provision of active restorative intervention for cases presenting with generalised tooth wear. The use of both contemporary adhesive and traditional conventional techniques applied to treat cases of generalised tooth wear will be...

    journal_title:British dental journal

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bdj.2012.97

    authors: Mehta SB,Banerji S,Millar BJ,Suarez-Feito JM

    更新日期:2012-02-10 00:00:00

  • International benchmarking of hospitalisations for impacted teeth: a 10-year retrospective study from the United Kingdom, France and Australia.

    abstract:BACKGROUND:The United Kingdom and its national healthcare system represent a unique comparison for many other developed countries (such as Australia and France), as the practice of prophylactic removal of third molars in the United Kingdom has been discouraged for nearly two decades, with clear guidelines issued by the...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2014.251

    authors: Anjrini AA,Kruger E,Tennant M

    更新日期:2014-04-01 00:00:00

  • Checklists for safe prescribing in oral medicine clinics.

    abstract::Introduction Prescribing checklists are a means of managing risk related to systemic medications in oral medicine practice.Methods Checklists for workup and monitoring for azathioprine, mycophenolate mofetil (MMF) and dapsone were introduced to an oral medicine clinic. Compliance with the checklists was audited at six...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2017.887

    authors: Shephard MK,Nova CV,Thakrar P,Hodgson T

    更新日期:2017-12-01 00:00:00

  • Personalising patient care within dentistry.

    abstract::Putting patients' interests first should always be at the forefront of a dental practitioner's mind. When treatment planning, it can be possible to lose sight of the patient: their primary concerns, ability to cope with treatment and what they regard success to be. Introducing key concepts such as a 'problem list' and...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/s41415-019-0519-9

    authors: Patel K,Walshaw E

    更新日期:2019-07-01 00:00:00

  • Introduction to email.

    abstract::Email is a computer based method of sending messages from one computer to another. From its humble beginnings 40 years, it has matured to become a crucial tool in utilising the power of the Internet. More people have access to email than to any other Internet application, and despite the problems with spam email and v...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/bdj.2007.271

    authors: Downes PK

    更新日期:2007-04-14 00:00:00

  • Early years postgraduate learning and training in prosthodontic dentistry: 2019 and beyond.

    abstract::The intended outcome of dental education is to produce dental clinicians who have the knowledge, technical skills, personal attributes, values and professional outlook to deliver the highest level of patient care. Due to the development and improvement of dental materials and clinical techniques, combined with a stead...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/s41415-019-0317-4

    authors: Movahedi S,Eliyas S,Fisher N

    更新日期:2019-05-01 00:00:00

  • What is quality primary dental care?

    abstract::In the first paper of a series exploring quality in primary dental care a definition for quality in dentistry is sought. There is a little agreement in academic literature as to what quality really means in primary dental care and without a true understanding it is difficult to measure and improve quality in a systema...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2013.740

    authors: Campbell S,Tickle M

    更新日期:2013-08-01 00:00:00

  • Dental standards: fifty years of development.

    abstract::Dental standards play a vital and important role in society by contributing to the quality and safety levels of products used in dental treatments by dental professionals as well as the hygiene products used by the general public. Few members of the public or indeed many dentists fully appreciate the contribution made...

    journal_title:British dental journal

    pub_type: 历史文章,杂志文章

    doi:10.1038/sj.bdj.2012.835

    authors: Jones DW

    更新日期:2012-09-01 00:00:00

  • Psychiatric disorders in a dental clinic.

    abstract::This paper describes the psychiatric disorders seen in 138 consecutive attenders at a psychiatric clinic in a dental hospital. The disorders were rated using a standardised interview, and assigned a diagnosis in accordance with a multiaxial classification known as the DSM-III. The rate of psychiatric disorder seen in ...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4806683

    authors: Hughes AM,Hunter S,Still D,Lamey PJ

    更新日期:1989-01-07 00:00:00

  • Sugar consumption and dental caries: evidence from 90 countries.

    abstract::An examination is made of data on dental caries amongst 12-year-old children and sugar consumption of the total population for 90 countries. For the whole data set, DMFT score tends to rise with sugar consumption. The linear relationship between the logarithm of DMFT and sugar is estimated to have a slope of 0.021 per...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4808437

    authors: Woodward M,Walker AR

    更新日期:1994-04-23 00:00:00

  • Interceptive extractions for first permanent molars: a clinical protocol.

    abstract::Treatment planning for compromised first permanent molars (FPM) can be difficult. In this paper, we present a clinical protocol to support decision-making. Interceptive loss of an FPM should be considered: where the restoration required to repair the compromised FPM is likely to be large; if the FPM is compromised bec...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/s41415-019-0561-7

    authors: Ashley P,Noar J

    更新日期:2019-08-01 00:00:00

  • Advances in periodontal diagnosis. 6. Proteolytic and hydrolytic enzymes of inflammatory cell origin.

    abstract::Potential proteolytic and hydrolytic enzymes of inflammatory cell origin might serve as biomarkers of periodontal disease activity. The role of these enzymes in periodontal pathology, particularly in respect of collagen and proteoglycan degradation, is discussed. The cellular location of these enzymes and their normal...

    journal_title:British dental journal

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bdj.4809599

    authors: Eley BM,Cox SW

    更新日期:1998-03-28 00:00:00

  • A survey of dental hygienists in the United Kingdom in 2011. Part 1--demographics and working patterns as dental hygienists.

    abstract:AIMS:The aims of this survey were to establish the demographic profile of dental hygienists (DHs) and dental hygienist/therapists (DH/Ts) in the United Kingdom in 2011 and their patterns of practice as DHs. METHODS:A 10% sample of all those registered with the General Dental Council as DHs or DH/Ts in April 2011 were ...

    journal_title:British dental journal

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bdj.2012.1041

    authors: Eaton KA,Harris M,Ross MK,Arevalo C

    更新日期:2012-11-01 00:00:00

  • Using a situational judgement test for selection into dental core training: a preliminary analysis.

    abstract::Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic att...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2017.410

    authors: Rowett E,Patterson F,Cousans F,Elley K

    更新日期:2017-05-12 00:00:00

  • Can audit improve antibiotic prescribing in general dental practice?

    abstract:OBJECTIVE:To investigate whether clinical audit can improve general dental practitioners' prescribing of antibiotics. DESIGN:An intervention study carried out in general dental practice in the North West of England. METHOD:Information was collected over an initial six-week period from 175 general dental practitioners...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4801156a

    authors: Palmer NA,Dailey YM,Martin MV

    更新日期:2001-09-08 00:00:00

  • A clinical evaluation of all-ceramic bridges placed in UK general dental practices: first-year results.

    abstract:PURPOSE:To report the results at year one of a three-year evaluation of the performance of fixed all-ceramic bridges, constructed with a yttrium tetragonal zirconia polycrystal substructure placed in adult patients in UK general dental practices and cemented using a self-adhesive resin-based cement. METHODS:Ethical ap...

    journal_title:British dental journal

    pub_type: 杂志文章,多中心研究

    doi:10.1038/sj.bdj.2008.937

    authors: Crisp RJ,Cowan AJ,Lamb J,Thompson O,Tulloch N,Burke FJ

    更新日期:2008-11-08 00:00:00

  • Developing professional status: an investigation into the working patterns, working relationships and vision for the future of UK clinical dental technicians.

    abstract:AIMS:To investigate the working patterns and patient base of registered clinical dental technicians (CDTs); their relationships with dentists and other professionals in the dental team; their willingness to work within the NHS and their expectations for the future as a new professional group. METHODS:Face-to-face qual...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2013.55

    authors: Leyssen W,Clark RK,Gallagher JE,Radford DR

    更新日期:2013-01-01 00:00:00

  • PET-CT surveillance versus neck dissection in advanced head and neck cancer.

    abstract::Despite less surgery, quality-of-life measurements were not superior in patients who received PET-CT-guided surveillance, compared with that group who received routine neck dissection. ...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2016.327

    authors:

    更新日期:2016-05-13 00:00:00

  • Articaine buccal infiltration vs lidocaine inferior dental block - a review of the literature.

    abstract:AIM:This paper aims to compare the effectiveness of articaine buccal infiltrations (BIs) and lidocaine inferior alveolar nerve blocks (IANBs) for inducing pulpal anaesthesia in mandibular molars. METHOD:Studies which compared articaine BIs with lidocaine IANBs were identified by completing a full literature search usi...

    journal_title:British dental journal

    pub_type: 杂志文章,评审

    doi:10.1038/sj.bdj.2016.93

    authors: Bartlett G,Mansoor J

    更新日期:2016-02-12 00:00:00

  • Can HIV be transmitted from dental personnel to patients by dentistry?

    abstract::Over 19,000 patients treated by 57 HIV-infected health care workers (HCWs) have been tested for HIV. Apart from the notorious Florida dental case, no patient has been shown to be infected by treatment given by an HIV-infected HCW. Cases of 10 HIV-infected HCWs have been examined in some depth. The evidence indicates t...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4808330

    authors: Scully C,Porter SR

    更新日期:1993-11-20 00:00:00

  • Peer assisted learning: teaching dental skills and enhancing graduate attributes.

    abstract::This study describes a pilot project in which peer assisted learning (PAL) is used to teach dental clinical skills. A cluster randomised controlled trial compared opinions of Bachelor of Dental Surgery (BDS) students from peer-led groups versus staff-led groups in a clinical (impression taking) and a pre-clinical (han...

    journal_title:British dental journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/sj.bdj.2015.722

    authors: Cameron DA,Binnie VI,Sherriff A,Bissell V

    更新日期:2015-09-25 00:00:00

  • Articaine and lignocaine efficiency in infiltration anaesthesia: a pilot study.

    abstract:AIM:The purpose of this study was to evaluate the onset of action of pulpal and soft tissue anaesthesia, and pain experience after buccal and palatal infiltrative injections with 4% articaine with 1:100,000 adrenaline, and 2% lignocaine with 1:100,000 adrenaline. METHOD:A double blind cross-over study was conducted wi...

    journal_title:British dental journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1038/sj.bdj.4811422

    authors: Oliveira PC,Volpato MC,Ramacciato JC,Ranali J

    更新日期:2004-07-10 00:00:00

  • An introduction to the Internet.

    abstract::This is the first of a multipart series on the internet aimed at dental practitioners. In this part I will try to answer the questions 'What is the Internet?' and 'How does it work?', the historical background of the internet will be discussed, and reasons will be given as to why dentists should consider connecting to...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4809729

    authors: Downes PK

    更新日期:1998-07-25 00:00:00

  • Simulation training for dental foundation in oral and maxillofacial surgery - a new benchmark.

    abstract::Simulation training involves reproducing the management of real patients in a risk-free environment. This study aims to assess the use of simulation training in the management of acutely ill patients for those in second year oral and maxillofacial surgery dental foundation training (DF2s). DF2s attended four full day ...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.2013.1143

    authors: Kalsi AS,Higham H,McKnight M,Dhariwal DK

    更新日期:2013-12-01 00:00:00

  • The history of commonly used dental elevators.

    abstract::Despite the extensive and regular use of dental elevators on a daily basis in both general dental and specialist oral and maxillofacial surgical practice, little is known about the history and origins of such instruments and this remains an intriguing question. This question has been the basis for the following articl...

    journal_title:British dental journal

    pub_type: 传,历史文章,杂志文章

    doi:10.1038/sj.bdj.2008.933

    authors: Bussell MA,Graham RM

    更新日期:2008-11-08 00:00:00

  • Treatment of root and alveolar bone resorption associated with bruxism.

    abstract::This report describes root and alveolar bone resorption associated with a single tooth which had been subjected to occlusal trauma during bruxing activity. Management of this unusually severe case is described, including the provision of an occlusal splint, endodontic therapy and occlusal adjustment to the natural den...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4807584

    authors: Rawlinson A

    更新日期:1991-06-22 00:00:00

  • A survey of local anaesthetic use among general dental practitioners in the UK attending postgraduate courses on pain control.

    abstract:OBJECTIVE:The aim of this study was to identify which local anaesthetic solutions were used by general dental practitioners in the United Kingdom and to determine selection criteria. In addition, differences in anaesthetic choice between recent graduates (< or = 5 years) and more experienced practitioners were investig...

    journal_title:British dental journal

    pub_type: 杂志文章

    doi:10.1038/sj.bdj.4813028

    authors: Corbett IP,Ramacciato JC,Groppo FC,Meechan JG

    更新日期:2005-12-24 00:00:00