Abstract:
BACKGROUND:An oromucosal spray has been developed from the major components of marijuana (cannabis), including tetrahydrocannabinol (THC) and cannabidiol (CBD), in alcohol with a peppermint flavouring, designed to be administered as a spray under the tongue or on the buccal mucosa to relieve pain in multiple sclerosis. Although the available evidence indicates its efficacy in this respect, some patients develop oral burning sensation, stinging or white lesions, probably burns. OBJECTIVE:To investigate the oral side-effects of oromucosal cannabis spray in multiple sclerosis (MS) patients. DESIGN:A small open observational study. SUBJECTS AND METHODS:A series of nine patients with MS who had been using a marijuana oromucosal spray for at least four weeks, were asked to attend for oral examination. Patients were asked whether they had ever experienced symptoms (dryness; bad taste; stinging) associated with use of the spray. A standard oral examination was carried out using a dental light, and the presence of any mucosal lesions recorded. Where mucosal lesions were present, patients were advised to discontinue the spray and re-attend after four weeks for re-examination. For ethical reasons, biopsies were not undertaken at the first visit. RESULTS:Of nine patients invited to participate, eight attended. All admitted to a stinging sensation on using the oromucosal cannabis spray, and four had visible oral mucosal white lesions in the floor of the mouth. CONCLUSIONS:Although the white lesions observed were almost certainly burns, resolving or improving on discontinuation of use of the medication, the high alcohol concentration of the oromucosal cannabis spray raises concern in relation to chronic oral use.
journal_name
Br Dent Jjournal_title
British dental journalauthors
Scully Cdoi
10.1038/bdj.2007.749subject
Has Abstractpub_date
2007-09-22 00:00:00pages
E12; discussion 336-7issue
6eissn
0007-0610issn
1476-5373pii
bdj.2007.749journal_volume
203pub_type
杂志文章abstract::The International Caries Consensus Collaboration (ICCC) presented recommendations on terminology, on carious tissue removal and on managing cavitated carious lesions. It identified 'dental caries' as the name of the disease that dentists should manage, and the importance of controlling the activity of existing cavitat...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.672
更新日期:2017-08-11 00:00:00
abstract::A technique is presented which uses light-activated bonding materials and orthodontic archwire to immobilise a surgically transplanted impacted maxillary canine. The technique is quick and effective. It uses materials commonly available in the dental surgery and does not require technical laboratory support. The treat...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4807505
更新日期:1991-04-06 00:00:00
abstract::Ecstasy (also known as 'love drug', 'XTC' or 'E') is the name commonly used for the illegal designer drug related to amphetamine, 3,4 methylenedioxy-methamphetamine (MDMA). MDMA was patented in 1914 as an appetite suppressant, has been investigated as a mood modifying agent, but with its predecessor 3,4 methylenedioxy...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808200
更新日期:1993-07-10 00:00:00
abstract::Paper 3 of this series on the current concepts of tooth wear management will focus on the provision of active restorative intervention for cases presenting with generalised tooth wear. The use of both contemporary adhesive and traditional conventional techniques applied to treat cases of generalised tooth wear will be...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2012.97
更新日期:2012-02-10 00:00:00
abstract:BACKGROUND:The United Kingdom and its national healthcare system represent a unique comparison for many other developed countries (such as Australia and France), as the practice of prophylactic removal of third molars in the United Kingdom has been discouraged for nearly two decades, with clear guidelines issued by the...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2014.251
更新日期:2014-04-01 00:00:00
abstract::Introduction Prescribing checklists are a means of managing risk related to systemic medications in oral medicine practice.Methods Checklists for workup and monitoring for azathioprine, mycophenolate mofetil (MMF) and dapsone were introduced to an oral medicine clinic. Compliance with the checklists was audited at six...
journal_title:British dental journal
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doi:10.1038/sj.bdj.2017.887
更新日期:2017-12-01 00:00:00
abstract::Putting patients' interests first should always be at the forefront of a dental practitioner's mind. When treatment planning, it can be possible to lose sight of the patient: their primary concerns, ability to cope with treatment and what they regard success to be. Introducing key concepts such as a 'problem list' and...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-019-0519-9
更新日期:2019-07-01 00:00:00
abstract::Email is a computer based method of sending messages from one computer to another. From its humble beginnings 40 years, it has matured to become a crucial tool in utilising the power of the Internet. More people have access to email than to any other Internet application, and despite the problems with spam email and v...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.271
更新日期:2007-04-14 00:00:00
abstract::The intended outcome of dental education is to produce dental clinicians who have the knowledge, technical skills, personal attributes, values and professional outlook to deliver the highest level of patient care. Due to the development and improvement of dental materials and clinical techniques, combined with a stead...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-019-0317-4
更新日期:2019-05-01 00:00:00
abstract::In the first paper of a series exploring quality in primary dental care a definition for quality in dentistry is sought. There is a little agreement in academic literature as to what quality really means in primary dental care and without a true understanding it is difficult to measure and improve quality in a systema...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2013.740
更新日期:2013-08-01 00:00:00
abstract::Dental standards play a vital and important role in society by contributing to the quality and safety levels of products used in dental treatments by dental professionals as well as the hygiene products used by the general public. Few members of the public or indeed many dentists fully appreciate the contribution made...
journal_title:British dental journal
pub_type: 历史文章,杂志文章
doi:10.1038/sj.bdj.2012.835
更新日期:2012-09-01 00:00:00
abstract::This paper describes the psychiatric disorders seen in 138 consecutive attenders at a psychiatric clinic in a dental hospital. The disorders were rated using a standardised interview, and assigned a diagnosis in accordance with a multiaxial classification known as the DSM-III. The rate of psychiatric disorder seen in ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4806683
更新日期:1989-01-07 00:00:00
abstract::An examination is made of data on dental caries amongst 12-year-old children and sugar consumption of the total population for 90 countries. For the whole data set, DMFT score tends to rise with sugar consumption. The linear relationship between the logarithm of DMFT and sugar is estimated to have a slope of 0.021 per...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808437
更新日期:1994-04-23 00:00:00
abstract::Treatment planning for compromised first permanent molars (FPM) can be difficult. In this paper, we present a clinical protocol to support decision-making. Interceptive loss of an FPM should be considered: where the restoration required to repair the compromised FPM is likely to be large; if the FPM is compromised bec...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-019-0561-7
更新日期:2019-08-01 00:00:00
abstract::Potential proteolytic and hydrolytic enzymes of inflammatory cell origin might serve as biomarkers of periodontal disease activity. The role of these enzymes in periodontal pathology, particularly in respect of collagen and proteoglycan degradation, is discussed. The cellular location of these enzymes and their normal...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.4809599
更新日期:1998-03-28 00:00:00
abstract:AIMS:The aims of this survey were to establish the demographic profile of dental hygienists (DHs) and dental hygienist/therapists (DH/Ts) in the United Kingdom in 2011 and their patterns of practice as DHs. METHODS:A 10% sample of all those registered with the General Dental Council as DHs or DH/Ts in April 2011 were ...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2012.1041
更新日期:2012-11-01 00:00:00
abstract::Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic att...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.410
更新日期:2017-05-12 00:00:00
abstract:OBJECTIVE:To investigate whether clinical audit can improve general dental practitioners' prescribing of antibiotics. DESIGN:An intervention study carried out in general dental practice in the North West of England. METHOD:Information was collected over an initial six-week period from 175 general dental practitioners...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4801156a
更新日期:2001-09-08 00:00:00
abstract:PURPOSE:To report the results at year one of a three-year evaluation of the performance of fixed all-ceramic bridges, constructed with a yttrium tetragonal zirconia polycrystal substructure placed in adult patients in UK general dental practices and cemented using a self-adhesive resin-based cement. METHODS:Ethical ap...
journal_title:British dental journal
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.bdj.2008.937
更新日期:2008-11-08 00:00:00
abstract:AIMS:To investigate the working patterns and patient base of registered clinical dental technicians (CDTs); their relationships with dentists and other professionals in the dental team; their willingness to work within the NHS and their expectations for the future as a new professional group. METHODS:Face-to-face qual...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2013.55
更新日期:2013-01-01 00:00:00
abstract::Despite less surgery, quality-of-life measurements were not superior in patients who received PET-CT-guided surveillance, compared with that group who received routine neck dissection. ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2016.327
更新日期:2016-05-13 00:00:00
abstract:AIM:This paper aims to compare the effectiveness of articaine buccal infiltrations (BIs) and lidocaine inferior alveolar nerve blocks (IANBs) for inducing pulpal anaesthesia in mandibular molars. METHOD:Studies which compared articaine BIs with lidocaine IANBs were identified by completing a full literature search usi...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2016.93
更新日期:2016-02-12 00:00:00
abstract::Over 19,000 patients treated by 57 HIV-infected health care workers (HCWs) have been tested for HIV. Apart from the notorious Florida dental case, no patient has been shown to be infected by treatment given by an HIV-infected HCW. Cases of 10 HIV-infected HCWs have been examined in some depth. The evidence indicates t...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808330
更新日期:1993-11-20 00:00:00
abstract::This study describes a pilot project in which peer assisted learning (PAL) is used to teach dental clinical skills. A cluster randomised controlled trial compared opinions of Bachelor of Dental Surgery (BDS) students from peer-led groups versus staff-led groups in a clinical (impression taking) and a pre-clinical (han...
journal_title:British dental journal
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.bdj.2015.722
更新日期:2015-09-25 00:00:00
abstract:AIM:The purpose of this study was to evaluate the onset of action of pulpal and soft tissue anaesthesia, and pain experience after buccal and palatal infiltrative injections with 4% articaine with 1:100,000 adrenaline, and 2% lignocaine with 1:100,000 adrenaline. METHOD:A double blind cross-over study was conducted wi...
journal_title:British dental journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bdj.4811422
更新日期:2004-07-10 00:00:00
abstract::This is the first of a multipart series on the internet aimed at dental practitioners. In this part I will try to answer the questions 'What is the Internet?' and 'How does it work?', the historical background of the internet will be discussed, and reasons will be given as to why dentists should consider connecting to...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809729
更新日期:1998-07-25 00:00:00
abstract::Simulation training involves reproducing the management of real patients in a risk-free environment. This study aims to assess the use of simulation training in the management of acutely ill patients for those in second year oral and maxillofacial surgery dental foundation training (DF2s). DF2s attended four full day ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2013.1143
更新日期:2013-12-01 00:00:00
abstract::Despite the extensive and regular use of dental elevators on a daily basis in both general dental and specialist oral and maxillofacial surgical practice, little is known about the history and origins of such instruments and this remains an intriguing question. This question has been the basis for the following articl...
journal_title:British dental journal
pub_type: 传,历史文章,杂志文章
doi:10.1038/sj.bdj.2008.933
更新日期:2008-11-08 00:00:00
abstract::This report describes root and alveolar bone resorption associated with a single tooth which had been subjected to occlusal trauma during bruxing activity. Management of this unusually severe case is described, including the provision of an occlusal splint, endodontic therapy and occlusal adjustment to the natural den...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4807584
更新日期:1991-06-22 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify which local anaesthetic solutions were used by general dental practitioners in the United Kingdom and to determine selection criteria. In addition, differences in anaesthetic choice between recent graduates (< or = 5 years) and more experienced practitioners were investig...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4813028
更新日期:2005-12-24 00:00:00